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Results for "

esterases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Apoptosis (3) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (8) Chloride Channel (1) Cholinesterase (ChE) (8) Dopamine Receptor (4) Drug Metabolite (3) EAAT (1) Endogenous Metabolite (5) FAAH (1) Fluorescent Dye (22) HDAC (3) Histamine Receptor (1) HIV (1) Isotope-Labeled Compounds (1) Lipase (1) MetAP (1) Nucleoside Antimetabolite/Analog (2) Phosphatase (1) Phospholipase (1) PKC (1) Prostaglandin Receptor (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (5) Metabolic Disease (8) Neurological Disease (14)

By Targets:

Amyloid-β (2)

Apoptosis (3)

Autophagy (2)

Bacterial (2)

Biochemical Assay Reagents (8)

Chloride Channel (1)

Cholinesterase (ChE) (8)

Dopamine Receptor (4)

Drug Metabolite (3)

EAAT (1)

Endogenous Metabolite (5)

FAAH (1)

Fluorescent Dye (22)

HDAC (3)

Histamine Receptor (1)

HIV (1)

Isotope-Labeled Compounds (1)

Lipase (1)

MetAP (1)

Nucleoside Antimetabolite/Analog (2)

Phosphatase (1)

Phospholipase (1)

PKC (1)

Prostaglandin Receptor (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (1)

Infection (1)

Inflammation/Immunology (5)

Metabolic Disease (8)

Neurological Disease (14)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D2277

Fluorescein-CM2	Fluorescent Dye	Others
Fluorescein-CM2 is a fluorogenic molecule that can be used to rapidly screen esterase cut sites for protein-protein interaction-dependent (PPI-dependent) esterase activity in E. coli .

HY-E70100

Acetylxylan esterases AXEs	Others	Others
Acetylxylan esterases (AXEs) belongs to carbohydrate esterase family 4 (CE4). Acetylxylan esterases catalyzes the deacetylation of acetylated carbohydrates .

HY-124258

Valilactone

(-)-Valilactone
Others Metabolic Disease

Valilactone is a potent and effective inhibitor of esterase, produced by actinomycetes .
HY-156984

Monometacrine

Others Neurological Disease

Monometacrine is a cholesterol esterase inhibitor. Monometacrine has antidepressant effect .

Valilactone (-)-Valilactone	Others	Metabolic Disease
Valilactone is a potent and effective inhibitor of esterase, produced by actinomycetes .

Monometacrine	Others	Neurological Disease
Monometacrine is a cholesterol esterase inhibitor. Monometacrine has antidepressant effect .

HY-D1678

5(6)-Carboxynaphthofluorescein diacetate	Fluorescent Dye	Others
5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm) .

HY-143252

CEase-IN-1	Cholinesterase (ChE)	Metabolic Disease
CEase-IN-1 (Compound A1H3) is a potent and selective cholesterol esterase (CEase) inhibitor with an IC₅₀ of 0.36 μM. CEase-IN-1 can be used for the research of hypercholesterolemia .

HY-100085

21-Desacetyldeflazacort 21-desDFZ	Drug Metabolite	Inflammation/Immunology
21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-145127

ETZ C3-CA-DTZ	Fluorescent Dye	Neurological Disease
ETZ (C3-CA-DTZ) is a promising luciferase substrate (prosubstrate) activatable in vivo by nonspecific esterase to enhance the brain delivery of the luciferin .

HY-W275616

4-Methylumbelliferyl nonanoate	Others	Others
4-Methylumbelliferyl nonanoate is a fluorogenic substrate of esterases. 4-Methylumbelliferyl nonanoate can be hydrolyzed to 4-methylumbelliferone with bright blue fluorescence .

HY-126561

Green CMFDA CMFDA	Fluorescent Dye	Others
Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope .

HY-131131

5-CFDA-AM	Fluorescent Dye	Others
5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .

HY-19651B

Zanapezil fumarate TAK-147 fumarate	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD) .

HY-19651

Zanapezil free base TAK-147 free base	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD) .

HY-135036

4-Methylumbelliferyl butyrate	Others	Others
4-Methylumbelliferyl butyrate (4-MUB) is a coumarin-based fluorogenic substrate used for the identification of M. catarrhalis C4- esterase. 4-Methylumbelliferyl butyrate can converse to the blue-emissive 4-methylumbelliferone (4-MU; HY-N0187) .

HY-18522

AA26-9	Phospholipase	Metabolic Disease
AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .

HY-116016

Etilevodopa L-DOPA ethyl ester; Levodopa ethyl ester	Dopamine Receptor Drug Metabolite	Neurological Disease
Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine .

HY-116016A

Etilevodopa hydrochloride L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride	Dopamine Receptor Drug Metabolite	Neurological Disease
Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine .

HY-W411215

1,4-Diacetoxy-2,3-dicyanobenzene	Fluorescent Dye	Others
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH .

HY-52112

BCDA 5-bromo-4-chloroindoxyl acetate	Fluorescent Dye	Others
BCDA (5-bromo-4-chloroindoxyl acetate) is a chromogenic substrate of esterase used to potently detect the activity of esterase .

HY-E70115

Feruloyl esterase	Others	Others
Feruloyl esterase plays a major role in the degradation of plant biomass. Feruloyl esterase catalyzes the cleavage and formation of ester bonds between plant cell wall polysaccharide and phenolic acid .

HY-P2879

*Cholesterol esterase, Pseudomonas*	Endogenous Metabolite	Metabolic Disease
Cholesterol esterase, Pseudomonas is an enzyme that hydrolyzes cholesterol ester to cholesterol and free fatty acid in the intestinal lumen. Cholesterol synthesized in the acinar cells and is stored in zymogen granules. Cholesterol esterase is also known as bile salt-stimulated lipase and carboxy ester lipasea, acts function for acceleration of cholesterol absorption .

HY-103610

4,4'-Dimethoxybenzil

p-Anisil
Others Cancer

4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with K_i of 70 nM.
HY-19861

SMP-028

SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC₅₀ of 1.01 μM.

4,4'-Dimethoxybenzil p-Anisil	Others	Cancer
4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with K_i of 70 nM.

SMP-028
SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC₅₀ of 1.01 μM.

HY-B1323

Dipivefrin hydrochloride Dipivefrine hydrochloride	Endogenous Metabolite	Neurological Disease
Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea .

HY-P2831

Esterase, pig liver CESs	Endogenous Metabolite	Metabolic Disease
Esterase, pig liver (CESs), namely carboxylate hydrolases, are widely distributed in nature, commonly found in mammalian liver, and often used in biochemical research. Esterase catalyzes the hydrolysis of a variety of endogenous and exogenous substrates, including esters, thioesters, carbamates, and amides, hydrolyzing carboxylic acid esters to the corresponding alcohols and carboxylic acids .

HY-145235

AChE-IN-4

Cholinesterase (ChE) Others

AChE-IN-4 shows the acetylcholine esterase inhibition (AChEI) with an IC₅₀ value of 24.1 μM.

AChE-IN-4	Cholinesterase (ChE)	Others
AChE-IN-4 shows the acetylcholine esterase inhibition (AChEI) with an IC₅₀ value of 24.1 μM.

HY-D0719

Fluorescein Diacetate 2 Publications Verification 3,6-Diacetoxyfluoran; Di-O-acetylfluorescein	Biochemical Assay Reagents	Others
Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.

HY-157797

SN-38-CM2	Others	Cancer
SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI)-dependent esterase to mediate cell death in MDA-MB-231 cells .

HY-102054

Acetylhydrolase-IN-1

FAAH Cardiovascular Disease

Acetylhydrolase-IN-1 is a 1-Alkyl-2-acetylglycerophosphocholine esterase (Alkylacetyl-GPC: acetylhydrolase) inhibtor.

Acetylhydrolase-IN-1	FAAH	Cardiovascular Disease
Acetylhydrolase-IN-1 is a 1-Alkyl-2-acetylglycerophosphocholine esterase (Alkylacetyl-GPC: acetylhydrolase) inhibtor.

HY-P6079A

Ac-IHIHIYI-NH2 TFA	Biochemical Assay Reagents	Others
Ac-IHIHIYI-NH2 TFA is an amyloid self-assembling peptide variant that can be used as a bioactive nanomaterial with esterase activity .

HY-114336

Enocyanin 1 Publications Verification	Phosphatase	Inflammation/Immunology
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-D0158

ZnAF-2 DA

Biochemical Assay Reagents Others

ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

ZnAF-2 DA	Biochemical Assay Reagents	Others
ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

HY-B1323S

Dipivefrin-d6 hydrochloride Dipivefrine-d₆ hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
Dipivefrin-d₆ (hydrochloride) is deuterium labeled Dipivefrin (hydrochloride). Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea[1][2].

HY-P2895

Clostripain Clostridiopeptidase B	Endogenous Metabolite	Others
Clostripain (Clostridiopeptidase B) is a proteolytic enzyme isolated from Clostridium histolyticum with esterase, amidase and protease activities and is a highly specific carboxypeptide targeting arginine key protease .

HY-D1758

Fura-5F AM	Fluorescent Dye	Others
Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.

HY-D1759

Fura-4F AM	Fluorescent Dye	Others
Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.

HY-W099563

4-Nitrophenyl stearate	Biochemical Assay Reagents	Others
4-Nitrophenyl stearate, which is an ester formed by the condensation of stearic acid and 4-nitrophenol, is commonly used as a substrate for enzymatic assays, where the hydrolysis of ester bonds by esterase and lipase can be measured by absorbance or ratio In addition, 4-Nitrophenyl stearate has been used as a model compound to study the enzymatic activity and selectivity of lipases and esterases from various sources. The long hydrophobic tail of the molecule makes it suitable for use in lipophilic Good solubility in the environment makes it a useful probe for studying lipid metabolism.

HY-13538

Gemcitabine elaidate 2 Publications Verification CP-4126; CO-101; Gemcitabine 5'-elaidate	Nucleoside Antimetabolite/Analog Autophagy Apoptosis	Cancer
Gemcitabine elaidate (CP-4126) is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity .

HY-13538A

Gemcitabine elaidate hydrochloride 2 Publications Verification CP-4126 hydrochloride; CO-101 hydrochloride; Gemcitabine 5'-elaidate hydrochloride	Nucleoside Antimetabolite/Analog Autophagy Apoptosis	Cancer
Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity .

HY-D1176

Calcium Green 1AM	Fluorescent Dye	Others
Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .

HY-B0305A

Roxatidine Acetate Hydrochloride HOE 760	Histamine Receptor	Metabolic Disease Inflammation/Immunology Cancer
Roxatidine Acetate Hydrochloride is a potent, selective, competitive and orally active histamine _H2-receptor antagonist. Roxatidine Acetate Hydrochloride has antisecretory potency against gastric acid secretion. Roxatidine Acetate Hydrochloride can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine Acetate Hydrochloride has antitumor activity .

HY-114879

DDAO 1 Publications Verification	Fluorescent Dye	Cancer
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .

HY-108751

Aripiprazole Lauroxil	Others	Neurological Disease
Aripiprazole lauroxil, an N-acyloxymethyl proagent of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.

HY-W399193

PGF2α 1,9-lactone Prostaglandin F2α 1,9-lactone	Others	Metabolic Disease
PGF2α 1,9-lactone (Prostaglandin F2α 1,9-lactone) is a prostaglandin lactone. PGF2α 1,9-lactone shows resistant to hydrolysis by plasma esterases .

HY-D0717

DAF-FM DA 5+ Cited Publications Diaminofluorescein-FM diacetate	Fluorescent Dye	Others
DAF-FM DA (Diaminofluorescein-FM diacetate) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) .

HY-106409

Tefinostat 1 Publications Verification CHR-2845	HDAC Apoptosis	Cancer
Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .

HY-W320032

5-Bromo-1H-indol-3-yl octanoate	Fluorescent Dye	Others
5-Bromo-1H-indol-3-yl octanoate is a chromogenic substrate for esterase with C8 activity. 5-Bromo-1H-indol-3-yl octanoate yields a blue precipitate when cleaved.

HY-B0732

Itopride hydrochloride HSR803	Cholinesterase (ChE) Dopamine Receptor Bacterial	Neurological Disease
Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an *acetylcholine esterase* (AChE)** inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD) .

HY-126564

Ebelactone A	Lipase MetAP	Others Inflammation/Immunology
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for *esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis* .

HY-D1643

5,5'-Dinitro BAPTA AM	Biochemical Assay Reagents	Others
5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca ²⁺. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand .

Cat. No.	Product Name	Type

HY-D2277

Fluorescein-CM2	Fluorescent Dyes/Probes
Fluorescein-CM2 is a fluorogenic molecule that can be used to rapidly screen esterase cut sites for protein-protein interaction-dependent (PPI-dependent) esterase activity in E. coli .

HY-126561

Green CMFDA CMFDA	Fluorescent Dyes/Probes
Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope .

HY-131131

5-CFDA-AM

Fluorescent Dyes/Probes

5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .

HY-D1678

5(6)-Carboxynaphthofluorescein diacetate	Fluorescent Dyes/Probes
5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm) .

HY-W411215

1,4-Diacetoxy-2,3-dicyanobenzene	Fluorescent Dyes/Probes
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH .

HY-52112

BCDA 5-bromo-4-chloroindoxyl acetate	Chromogenic Substrates
BCDA (5-bromo-4-chloroindoxyl acetate) is a chromogenic substrate of esterase used to potently detect the activity of esterase .

HY-D0719

Fluorescein Diacetate 2 Publications Verification 3,6-Diacetoxyfluoran; Di-O-acetylfluorescein	Dyes Enzyme Substrates
Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.

HY-D1758

Fura-5F AM	Fluorescent Dyes/Probes
Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.

HY-D1759

Fura-4F AM	Fluorescent Dyes/Probes
Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.

HY-D1176

Calcium Green 1AM	Fluorescent Dyes/Probes
Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .

HY-114879

DDAO 1 Publications Verification	Fluorescent Dyes/Probes
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .

HY-D0717

DAF-FM DA 5+ Cited Publications Diaminofluorescein-FM diacetate	Chromogenic Assays
DAF-FM DA (Diaminofluorescein-FM diacetate) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) .

HY-W320032

5-Bromo-1H-indol-3-yl octanoate	Chromogenic Substrates
5-Bromo-1H-indol-3-yl octanoate is a chromogenic substrate for esterase with C8 activity. 5-Bromo-1H-indol-3-yl octanoate yields a blue precipitate when cleaved.

HY-D1739

DDAO phosphate diammonium	Fluorescent Dyes/Probes
DDAO phosphate diammonium is a fluorescent phosphatase substrate. DDAO phosphate diammonium has tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm). DDAO phosphate diammonium can be used to detect the activity of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.

HY-D0716

Fluo-3AM 5 Publications Verification Fluo-3-pentaacetoxymethyl ester	Fluorescent Dyes/Probes
Fluo-3 AM is a fluorecent Ca ²⁺ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .

HY-130575

Fura-FF AM	Fluorescent Dyes/Probes
Fura-FF AM is a cell-permeable acetoxymethyl ester of fura-FF, a dluorescent calcium indicator. Fura-FF AM is hydrolyzed by intracellular esterases to release fura-FF in cells. Fura-FF is a difluorinated derivative of the calcium indicator fura-2. Compared to fura-2, fura-FF has a low affinity for calcium and is suitable for studying compartments with high concentrations of calcium.

HY-101902

Quin-2AM Quin-2 acetoxymethyl ester	Fluorescent Dyes/Probes
Quin-2AM is a fluorecent Ca ²⁺ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .

HY-D1498

Mag-Fluo-4 AM 1 Publications Verification	Fluorescent Dyes/Probes
Mag-Fluo-4 AM is a fluorecent Ca ²⁺ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .

HY-D1746

EDTA-AM

EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester

Fluorescent Dyes/Probes

EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .

HY-D0722

5(6)-CFDA 5 Publications Verification 5-(6)-Carboxyfluorescein diacetate; CFDA	Fluorescent Dyes/Probes
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0041

Calcein-AM

Maximum Cited Publications

37 Publications Verification

Calcein acetoxymethyl ester

Fluorescent Dyes/Probes

Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .

HY-101898

Indo-1 AM

Indo-1 Acetoxymethyl ester

Fluorescent Dyes/Probes

Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .

HY-D1701

Mag-Fura-2 AM

Fluorescent Dyes/Probes

Cat. No.	Product Name	Type

HY-D0719

Fluorescein Diacetate 2 Publications Verification 3,6-Diacetoxyfluoran; Di-O-acetylfluorescein	Dyes Enzyme Substrates
Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.

HY-P2895

Clostripain Clostridiopeptidase B	Biochemical Assay Reagents
Clostripain (Clostridiopeptidase B) is a proteolytic enzyme isolated from Clostridium histolyticum with esterase, amidase and protease activities and is a highly specific carboxypeptide targeting arginine key protease .

HY-W099563

4-Nitrophenyl stearate

Biochemical Assay Reagents

4-Nitrophenyl stearate, which is an ester formed by the condensation of stearic acid and 4-nitrophenol, is commonly used as a substrate for enzymatic assays, where the hydrolysis of ester bonds by esterase and lipase can be measured by absorbance or ratio In addition, 4-Nitrophenyl stearate has been used as a model compound to study the enzymatic activity and selectivity of lipases and esterases from various sources. The long hydrophobic tail of the molecule makes it suitable for use in lipophilic Good solubility in the environment makes it a useful probe for studying lipid metabolism.

HY-15929

TBHBA 2,4,6-Tribromo-3-hydroxybenzoic acid	Biochemical Assay Reagents
The Boehringer Mannheim cholesterol esterase/cholesterol oxidase/peroxidase/3,4-dichlorophenol kinetic reagent was modified by the inclusion of TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) which reacts with hydrogen peroxide and 4-aminophenazone to produce a quinone-imine dye with a greater molar absorptivity than that produced with phenol.

HY-D0158

ZnAF-2 DA

Biochemical Assay Reagents

ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

HY-W014449

4-Nitrophenyl butyrate

Biochemical Assay Reagents

4-Nitrophenyl butyrate consists of butyric acid chains esterified with 4-nitrophenol groups, thus giving it a yellow color. This compound is commonly used as a substrate in enzyme assays to measure esterase and lipase activity. When these enzymes cleave the ester bond, the nitrophenol group is released and the color changes from yellow to orange. Thus, the rate of color change can be used to determine enzyme activity. In addition, 4-Nitrophenyl butyrate can also be used as organic synthesis reagent and dye intermediate.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1323

Dipivefrin hydrochloride Dipivefrine hydrochloride	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea .

HY-114336

Enocyanin 1 Publications Verification	Anthocyans Flavonoids Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields Inflammation/Immunology	Phosphatase
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-124258

Valilactone (-)-Valilactone	Alkaloids Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Others
Valilactone is a potent and effective inhibitor of esterase, produced by actinomycetes .

HY-126564

Ebelactone A	Structural Classification Natural Products Microorganisms Source classification	Lipase MetAP
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for *esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis* .

Cat. No.	Product Name	Chemical Structure

HY-B1323S

Dipivefrin-d6 hydrochloride
Dipivefrin-d₆ (hydrochloride) is deuterium labeled Dipivefrin (hydrochloride). Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea[1][2].

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