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Results for "

exposure

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Amyloid-β (1) Androgen Receptor (1) Antibiotic (2) Apoptosis (1) Bacterial (3) Bcl-2 Family (3) Biochemical Assay Reagents (5) Bradykinin Receptor (1) Casein Kinase (1) Cholinesterase (ChE) (1) DNA/RNA Synthesis (1) Drug Metabolite (5) Endogenous Metabolite (8) Enteropeptidase (1) Epoxide Hydrolase (2) ERK (1) Estrogen Receptor/ERR (1) FAAH (1) Factor Xa (1) Fatty Acid Synthase (FASN) (1) FGFR (2) FKBP (1) Fungal (2) Glucocorticoid Receptor (2) HCN Channel (1) HSV (1) Isotope-Labeled Compounds (6) Itk (1) MEK (1) mGluR (1) Myosin (1) nAChR (1) NAMPT (1) Parasite (1) PARP (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) PROTACs (1) RABV (1) Reactive Oxygen Species (1) ROCK (1) Sigma Receptor (1) Sodium Channel (1) Src (1) Wnt (1) γ-secretase (3)
By Research Areas:	Cancer (18) Cardiovascular Disease (5) Endocrinology (1) Infection (6) Inflammation/Immunology (6) Metabolic Disease (13) Neurological Disease (18)

By Targets:

5-HT Receptor (3)

Amyloid-β (1)

Androgen Receptor (1)

Antibiotic (2)

Apoptosis (1)

Bacterial (3)

Bcl-2 Family (3)

Biochemical Assay Reagents (5)

Bradykinin Receptor (1)

Casein Kinase (1)

Cholinesterase (ChE) (1)

DNA/RNA Synthesis (1)

Drug Metabolite (5)

Endogenous Metabolite (8)

Enteropeptidase (1)

Epoxide Hydrolase (2)

ERK (1)

Estrogen Receptor/ERR (1)

FAAH (1)

Factor Xa (1)

Fatty Acid Synthase (FASN) (1)

FGFR (2)

FKBP (1)

Fungal (2)

Glucocorticoid Receptor (2)

HCN Channel (1)

HSV (1)

Isotope-Labeled Compounds (6)

Itk (1)

MEK (1)

mGluR (1)

Myosin (1)

nAChR (1)

NAMPT (1)

Parasite (1)

PARP (1)

Phosphodiesterase (PDE) (1)

Potassium Channel (1)

PROTACs (1)

RABV (1)

Reactive Oxygen Species (1)

ROCK (1)

Sigma Receptor (1)

Sodium Channel (1)

Src (1)

Wnt (1)

γ-secretase (3)

By Research Areas:

Cancer (18)

Cardiovascular Disease (5)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (6)

Metabolic Disease (13)

Neurological Disease (18)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15043

ELN-441958	Bradykinin Receptor	Inflammation/Immunology Endocrinology
ELN-441958 is a potent, neutral, competitive and selective bradykinin B₁ receptor antagonist with a K_i of 0.26 nM against native human bradykinin B₁ receptor. ELN-441958 has high oral bioavailability, and has low CNS exposure in the mouse .

HY-156618

Irpagratinib ABSK011	FGFR	Cancer
Irpagratinib (ABSK011) is an orally active inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinase, targeting to FGFR4 (IC50<10 nM). Irpagratinib inhibits the auto-phosphorylation of FGFR4 and blocks signal transduction from FGFR4 to downstream pathway activation. Irpagratinib exhibits high exposure in PK study in mouse, rat and dog, and also shows antineoplastic/anti-tumor activity in subcutaneous xenograft tumor models .

HY-16100

BI 99179 1 Publications Verification	Fatty Acid Synthase (FASN)	Metabolic Disease Cancer
BI 99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC₅₀ of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats .

HY-110146

XAP044	mGluR	Neurological Disease
XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms .

HY-130609A

Aβ42-IN-1 free base	γ-secretase	Neurological Disease
Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC₅₀ value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease .

HY-155672

JPC0323	5-HT Receptor	Neurological Disease
JPC0323 is a dual 5-HT_2C/5-HT_2A receptor positive allosteric modulator. JPC0323 has on-target properties, acceptable plasma exposure and brain penetration. JPC0323 can be used for the research of neurological disease .

HY-W014075

1-Hydroxypyrene	Endogenous Metabolite	Metabolic Disease
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes .

HY-157455

AR antagonist 5	Androgen Receptor	Cancer
AR antagonist 5 (compound 30a) is a selective androgen receptor (AR) antagonist with an IC₅₀ value of 134.8 nM. AR antagonist 5 has favorable pharmacokinetic properties and shows a high skin exposure and low plasma exposure ^[1.

HY-142644

ATX inhibitor 7

Phosphodiesterase (PDE) Inflammation/Immunology

ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.
HY-141810

MT-134

Myosin Others

MT-134 is a SkMII-specific inhibitor and has excellent exposure in muscles.

ATX inhibitor 7	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.

MT-134	Myosin	Others
MT-134 is a SkMII-specific inhibitor and has excellent exposure in muscles.

HY-W014075S

1-Hydroxypyrene-d9	Endogenous Metabolite	Metabolic Disease
1-Hydroxypyrene-d₉ is the deuterium labeled 1-Hydroxypyrene[1]. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[2].

HY-W010255A

Phenylglyoxylic acid sodium Benzoylformic acid sodium	Others	Others
Phenylglyoxylic acid (sodium) is the sodium salt form of Phenylglyoxylic acid. Phenylglyoxylic acid as a biomarker of exposure to ethylbenzene and styrene (EB/S) .

HY-117290

BMS-962212	Factor Xa	Cardiovascular Disease
BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 is well tolerated, with fast onset of pharmacodynamic (PD) responses and rapid elimination. BMS-962212 increases exposure dependently in activated partial thromboplastin time, and decreases exposure dependently in FXI clotting activity .

HY-113247

trans-trans-Muconic acid	Endogenous Metabolite	Metabolic Disease
trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.

HY-116787

5-Hydroxythiabendazole

5-OHTBZ
Drug Metabolite Others

5-Hydroxythiabendazole (5-OHTBZ) is a biomarker of Thiabendazole (HY-B0263) exposure .

5-Hydroxythiabendazole 5-OHTBZ	Drug Metabolite	Others
5-Hydroxythiabendazole (5-OHTBZ) is a biomarker of Thiabendazole (HY-B0263) exposure .

HY-W010255

Phenylglyoxylic acid Benzoylformic acid	Endogenous Metabolite	Metabolic Disease
Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .

HY-W011848

Monobenzyl phthalate 2-((Benzyloxy)carbonyl)benzoic acid	Endogenous Metabolite	Metabolic Disease
Monobenzyl phthalate (2-((Benzyloxy)carbonyl)benzoic acid) is the urinary metabolite exposuring to phthalates, such as, diethylhexyl phthalate (DEHP) .

HY-12769

Mebeverine acid Mebeverine metabolite Mebeverine acid	Drug Metabolite	Neurological Disease
Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine .

HY-163087

PT-91

Others Neurological Disease Metabolic Disease

PT-91 is an agonist of GPR27. PT-91 exhibits high metabolic stability and brain exposure in mice .
HY-136612

DCBA

Drug Metabolite Others

DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET .

PT-91	Others	Neurological Disease Metabolic Disease
PT-91 is an agonist of GPR27. PT-91 exhibits high metabolic stability and brain exposure in mice .

DCBA	Drug Metabolite	Others
DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET .

HY-133668

Monoethyl phthalate	Drug Metabolite	Cancer
Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule .

HY-Y1097

Monomethyl phthalate 2-(Methoxycarbonyl)benzoic acid
Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .

HY-B1444

Isoconazole nitrate	Bacterial Fungal Antibiotic	Infection
Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential .

HY-163008

Dicamba-5-aminopentanoic acid	Others	Inflammation/Immunology
Dicamba-5-aminopentanoic acid (DCc) is an immunizing and heterologous hapten, designed using the carboxylic acid group of dicamba to introduce a spacer arm for a better exposure of the herbicide's structure .

HY-126816

Atrazine mercapturate	Endogenous Metabolite	Others
Atrazine mercapturate is a metabolite of herbicide Atrazine (HY-N7091), which is detectable in urinary excretion. Atrazine mercapturate serve as an unambiguous confirmation of human exposure to Atrazine .

HY-143368S

L-Phenylmercapturic acid-d5	Isotope-Labeled Compounds	Others
L-Phenylmercapturic acid-d₅is the deuterium labeledL-Phenylmercapturic acid(HY-143368) . L-Phenylmercapturic acid is often used as a biomarker for exposure to aniline compounds such as aniline and xylene .

HY-148177

Sutidiazine ZY-19489; MMV 253; AZ13721412	Parasite	Infection
Sutidiazine (ZY-19489) is an orally active and antimalarial agent. Sutidiazine inhibits parasitemia-induced infection. Sutidiazine shows short half-lives (approximately 7 h) and an exposure effect .

HY-W011848S

Monobenzyl phthalate-d4 2-((Benzyloxy)carbonyl)benzoic acid-d₄	Endogenous Metabolite	Metabolic Disease
Monobenzyl phthalate-d₄ is the deuterium labeled Monobenzyl phthalate. Monobenzyl phthalate (2-((Benzyloxy)carbonyl)benzoic acid) is the urinary metabolite exposuring to phthalates, such as, diethylhexyl phthalate (DEHP)[1].

HY-128419

Biguanidinium-porphyrin	Others	Others
Biguanidinium-porphyrin is a mitochondria-targeting photosensitizer. Biguanidinium-porphyrin distributes within cell membranes with a large component in vesicles that correlated to some extent with the lysosomes and, upon longer exposures, in mitochondria and the cytosolic membrane .

HY-161092

KIO-301 chloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light .

HY-W013989

1,3-Dicyclohexylurea	Epoxide Hydrolase	Cardiovascular Disease
1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats .

HY-P99792

Ormutivimab NM57; rhRIG	RABV	Infection
Ormutivimab (rhRIG) is a recombinant human monoclonal antibody, targeting rabies virus. Ormutivimab neutralizes a variety of rabies virus strains. Ormutivimab exhibits potent potency against rabies post-exposure prophylaxis (PEP) model .

HY-153494

Rosomidnar PNT100	Bcl-2 Family	Cancer
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-153494A

Rosomidnar sodium PNT100 sodium	Bcl-2 Family	Cancer
PNT100 sodium is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-131587

Integerrimine N-oxide	Others	Others
Integerrimine N-oxide, the main pyrrolizidine alkaloid found in the butanolic residue (BR) of Senecio brasiliensis. Prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delays in physical and behavioral development of the offspring .

HY-113247S1

Muconic acid-d4	Isotope-Labeled Compounds	Metabolic Disease
trans-trans-Muconic acid-d₄-1 is a deuterium labeled trans-trans-Muconic acid (HY-113247). trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.

HY-18237

KX1-004	Src	Others
KX1-004 is a potent and non-ATP competitive Src-PTK inhibitor with an IC₅₀ of 40 μM. KX1-004 protects the cochlea from hazardous noise and prevents noise-induced hearing loss (NIHL) .

HY-113247S

trans-trans-Muconic acid-d4	Endogenous Metabolite	Metabolic Disease
trans-trans-Muconic acid-d₄ is the deuterium labeled trans-trans-Muconic acid[1]. trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human[2].

HY-15234

Fluticasone furoate	Glucocorticoid Receptor	Inflammation/Immunology
Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a K_d of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment .

HY-B1855

cis-Heptachlor epoxide Epoxyheptachlor	Biochemical Assay Reagents	Others
(±)-cis-Heptachlor epoxides, are degradation products of heptachlor that can occur in or on soil and crops when treated with heptachlor, a pesticide. Heptachlor is readily formed upon exposure to air. Everett CJ, Thompson OM. Environmental Health Pastor. 2015;30(2):93-7.

HY-133668S

Monoethyl phthalate-d4	Isotope-Labeled Compounds	Cancer
Monoethyl phthalate-d₄ is the deuterium labeled Monoethyl phthalate[1]. Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule[2][3].

HY-14375

CB 300919	NAMPT	Cancer
CB 300919 is a quinazoline-based antitumour agent with high activity in the CH1 human ovarian tumour xenograft. CB 300919 has a continuous exposure (96 h) growth inhibition IC₅₀ value of 2 nM in human CH1 ovarian tumor xenograft .

HY-126316

Zapalog 1 Publications Verification	FKBP	Others
Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis .

HY-W010255S

Phenylglyoxylic acid-d5 Benzoylformic acid-d₅	Isotope-Labeled Compounds	Metabolic Disease
Phenylglyoxylic acid-d₅ (Benzoylformic acid-d₅) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .

HY-128431

Arochlor 1254	Reactive Oxygen Species	Neurological Disease Metabolic Disease
Arochlor 1254 is a polychlorinated biphenyl (PCB) mixture with biphenyl and 54% chlorine. Aroclor 1254 reduced cell viability and induced overproduction of intracellular reactive oxygen species in a dose-dependent manner. Arochlor 1254 exposure reduces calcium homeostasis, osteoblast differentiation and bone formation .

HY-B1444R

Isoconazole nitrate (Standard)	Bacterial Fungal Antibiotic	Infection
Isoconazole (nitrate) (Standard) is the analytical standard of Isoconazole (nitrate). This product is intended for research and analytical applications. Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential .

HY-130609

Aβ42-IN-1	γ-secretase	Neurological Disease
Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC₅₀ value of 0.091 µM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.

HY-116565

Usmarapride SUVN-D4010	5-HT Receptor	Neurological Disease
Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT₄ receptor partial agonist (EC₅₀=44 nM). Usmarapride (SUVN-D4010) can be used for the research of cognitive deficits associated with Alzheimer's disease .

HY-116565A

Usmarapride free base SUVN-D4010 free base	5-HT Receptor	Neurological Disease
Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT₄ receptor partial agonist (EC₅₀=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease .

HY-124713

ML372	DNA/RNA Synthesis	Neurological Disease
ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo .

Cat. No.	Product Name

HY-L178

Radioprotector Library

1785 Compounds compounds

Radiation sickness is a general term for various types and degrees of damage (or disease) occurring in the human body after exposure to ionizing radiation. Although small amounts of ionizing radiation can also cause the body to produce free radicals and ROS, causing oxidative stress, resulting in DNA damage and chromosomal aberration. Radioprotector are compounds with radiation protection that can be used to prevent/protect non-tumor cells from the harmful effects of radiation. Radioprotective compounds can prevent the damage of radioactive substances to the human body and reduce the clinical symptoms of various radioactive diseases. In addition, radioprotectors can protect normal cells from damage during radiation therapy. The ideal anti-radiation drug should not affect the sensitivity of tumor cells to radiation therapy while protecting normal cells.

MCE designs a unique collection of 1785 radioprotectors. Radioprotector Library is an effective tool for acute Radiation Syndrome, drug combination research with radiation drugs.

HY-L100

Tumorigenesis-Related Compound Library

128 compounds

Cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. The administration of chemical carcinogens is one of the most commonly used methods to induce tumors in several organs in laboratory animals in order to study oncologic diseases of humans. MCE offers a unique collection of 128 chemical carcinogens which have been identified with carcinogenic activity either in humans or in animal models. MCE Tumorigenesis-Related Compound Library is a powerful tool for studying oncologic diseases of humans. Standard opration based on safety data sheet will not cause harm to the body.

Cat. No.	Product Name	Type

HY-125920

Lauroylsarcosine sodium

Biochemical Assay Reagents

Lauroylsarcosine sodium is a surfactant commonly used in personal care and cosmetics such as shampoos, facial cleansers and toothpaste. It works by lowering the surface tension of water, allowing it to better penetrate and clean surfaces. Lauroylsarcosine sodium is considered safe for cosmetic use and is approved for use in several countries. However, it can cause skin irritation in high concentrations or with prolonged exposure.

HY-W099594

Benzalkonium bromide

Benzyldimethyldodecylammonium bromide

Biochemical Assay Reagents

N-Benzyl-N, N-dimethyldodecan-1-aminium bromide, also known as Benzalkonium Chloride (BAC), is a quaternary ammonium compound widely used as an antimicrobial and surfactant in various industries. BAC is commonly used as a disinfectant and antiseptic in a variety of products including hand sanitizers, disinfectant wipes and eye drops. Its ability to kill bacteria, viruses and fungi makes it an effective tool in preventing the spread of infection. BAC is also used as a preservative and disinfectant in the food industry. It is added to food packaging and processing equipment to prevent the growth of microorganisms and increase the shelf life of foods. Additionally, BACs are found in many household products such as cleaning solutions, fabric softeners and personal care products. Its surfactant properties allow it to be used to reduce surface tension and increase the effectiveness of cleaning agents. Although BAC has many uses, ingestion or exposure to high concentrations of BAC can cause skin irritation and other adverse effects.

HY-B1855

cis-Heptachlor epoxide Epoxyheptachlor	Biochemical Assay Reagents
(±)-cis-Heptachlor epoxides, are degradation products of heptachlor that can occur in or on soil and crops when treated with heptachlor, a pesticide. Heptachlor is readily formed upon exposure to air. Everett CJ, Thompson OM. Environmental Health Pastor. 2015;30(2):93-7.

HY-W127739

Zineb Zinc ethylene-1, 2-bisdithiocarbamate	Biochemical Assay Reagents
Zineb is an agricultural fungicide of the dithiocarbamate class. Its toxicity is relatively low, and there is little evidence of human harm from exposure. Oxidative stress is one of the main factors contributing to diseases caused by Zineb. Zineb does not alter the activity of any superoxide dismutase enzymes. Catalase (CAT) activity was reduced only by Zineb.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W014075

1-Hydroxypyrene	Natural Products Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes .

HY-113247

trans-trans-Muconic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.

HY-W010255

Phenylglyoxylic acid Benzoylformic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .

HY-W011848

Monobenzyl phthalate 2-((Benzyloxy)carbonyl)benzoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Monobenzyl phthalate (2-((Benzyloxy)carbonyl)benzoic acid) is the urinary metabolite exposuring to phthalates, such as, diethylhexyl phthalate (DEHP) .

HY-133668

Monoethyl phthalate	Other disease Disease markers Endogenous metabolite	Drug Metabolite
Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule .

HY-131587

Integerrimine N-oxide	Sabina vulgaris Ant. Alkaloids Cupressaceae Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Integerrimine N-oxide, the main pyrrolizidine alkaloid found in the butanolic residue (BR) of Senecio brasiliensis. Prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delays in physical and behavioral development of the offspring .

HY-N4192

Toringin	Cardiovascular Disease Monophenols Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Plants Disease Research Fields Docyniopsis tschonoski Cancer	Others
Toringin, a bioflavonoid, is isolated from the bark of Docyniopsis tschonoski. Toringin progressively decreases not only the cis-effect of the expanded CTG repeats but cytotoxicity as well. Exposure to isosakuranetin, Toringin rescues PC12 neuronal cells. Flavonoids are efficacious for ameliorating the RNA gain of function caused by expanded CTG repeats, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies .

HY-12545

Brevetoxin-3 PbTx-3	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology	Sodium Channel
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺ channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

Cat. No.	Product Name	Chemical Structure

HY-W014075S

1-Hydroxypyrene-d9
1-Hydroxypyrene-d₉ is the deuterium labeled 1-Hydroxypyrene[1]. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[2].

HY-W011848S

Monobenzyl phthalate-d4
Monobenzyl phthalate-d₄ is the deuterium labeled Monobenzyl phthalate. Monobenzyl phthalate (2-((Benzyloxy)carbonyl)benzoic acid) is the urinary metabolite exposuring to phthalates, such as, diethylhexyl phthalate (DEHP)[1].

HY-113247S

trans-trans-Muconic acid-d4
trans-trans-Muconic acid-d₄ is the deuterium labeled trans-trans-Muconic acid[1]. trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human[2].

HY-143368S

L-Phenylmercapturic acid-d5
L-Phenylmercapturic acid-d₅is the deuterium labeledL-Phenylmercapturic acid(HY-143368) . L-Phenylmercapturic acid is often used as a biomarker for exposure to aniline compounds such as aniline and xylene .

HY-113247S1

Muconic acid-d4
trans-trans-Muconic acid-d₄-1 is a deuterium labeled trans-trans-Muconic acid (HY-113247). trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.

HY-133668S

Monoethyl phthalate-d4
Monoethyl phthalate-d₄ is the deuterium labeled Monoethyl phthalate[1]. Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule[2][3].

HY-W010255S

Phenylglyoxylic acid-d5
Phenylglyoxylic acid-d₅ (Benzoylformic acid-d₅) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .

HY-Y1097S

Monomethyl phthalate-d4
Monomethyl phthalate-d₄ (2-(Methoxycarbonyl)benzoic acid-d₄) is the deuterium labeled Monomethyl phthalate. Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .

HY-15234S

Fluticasone furoate-d3
Fluticasone furoate-d₃ is deuterium labeled Fluticasone furoate. Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment[1][2].

HY-B0815S

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

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