Search Result

Results for "

factor-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (2) Adenylate Cyclase (2) Akt (3) Antibiotic (7) AP-1 (1) Apoptosis (15) Autophagy (4) Bacterial (7) Bcl-2 Family (3) Beclin1 (2) Beta-lactamase (1) c-Fms (18) c-Kit (2) Caspase (1) CCR (1) CRFR (4) CXCR (2) DNA/RNA Synthesis (2) Endogenous Metabolite (3) Endothelin Receptor (2) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (1) Factor VIII (1) Ferroptosis (1) Fungal (2) Glucosidase (1) HBV (1) HIF/HIF Prolyl-Hydroxylase (15) HIV (1) HSP (8) IGF-1R (10) Influenza Virus (2) Insulin Receptor (4) Isotope-Labeled Compounds (4) JNK (2) Ligands for E3 Ligase (2) MicroRNA (3) MMP (2) Molecular Glues (2) mTOR (1) NF-κB (2) Phosphodiesterase (PDE) (1) Poly(ADP-ribose) Glycohydrolase (PARG) (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (2) Somatostatin Receptor (2) SRPK (1) TNF Receptor (1) Topoisomerase (2) VEGFR (6)
By Research Areas:	Cancer (58) Cardiovascular Disease (16) Endocrinology (13) Infection (7) Inflammation/Immunology (17) Metabolic Disease (9) Neurological Disease (12)

By Targets:

ADC Cytotoxin (2)

Adenylate Cyclase (2)

Akt (3)

Antibiotic (7)

AP-1 (1)

Apoptosis (15)

Autophagy (4)

Bacterial (7)

Bcl-2 Family (3)

Beclin1 (2)

Beta-lactamase (1)

c-Fms (18)

c-Kit (2)

Caspase (1)

CCR (1)

CRFR (4)

CXCR (2)

DNA/RNA Synthesis (2)

Endogenous Metabolite (3)

Endothelin Receptor (2)

Epigenetic Reader Domain (1)

Eukaryotic Initiation Factor (eIF) (1)

Factor VIII (1)

Ferroptosis (1)

Fungal (2)

Glucosidase (1)

HBV (1)

HIF/HIF Prolyl-Hydroxylase (15)

HIV (1)

HSP (8)

IGF-1R (10)

Influenza Virus (2)

Insulin Receptor (4)

Isotope-Labeled Compounds (4)

JNK (2)

Ligands for E3 Ligase (2)

MicroRNA (3)

MMP (2)

Molecular Glues (2)

mTOR (1)

NF-κB (2)

Phosphodiesterase (PDE) (1)

Poly(ADP-ribose) Glycohydrolase (PARG) (1)

Reactive Oxygen Species (1)

Small Interfering RNA (siRNA) (2)

Somatostatin Receptor (2)

SRPK (1)

TNF Receptor (1)

Topoisomerase (2)

VEGFR (6)

By Research Areas:

Cancer (58)

Cardiovascular Disease (16)

Endocrinology (13)

Infection (7)

Inflammation/Immunology (17)

Metabolic Disease (9)

Neurological Disease (12)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

132

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132935

BPR1R024	c-Fms	Inflammation/Immunology Cancer
BPR1R024 is an orally active and selective colony-stimulating factor-1 receptor (CSF1R) inhibitor. BPR1R024 has potent CSF1R inhibition activity with an IC₅₀ value of 0.53 nM. BPR1R024 can be used for the research of immuno-oncology ^[1].

HY-155001

CSF1R-IN-15	c-Fms	Others
CSF1R-IN-15 (compound 23) is an inhibitor targeting *CSF1R. The colony-stimulating factor-1* receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages ^[1].

HY-14132

BMS-665053	CRFR	Neurological Disease
BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC₅₀ = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC₅₀ = 4.9 nM) ^[1].

HY-132935A

BPR1R024 mesylate	c-Fms	Inflammation/Immunology Cancer
BPR1R024 mesylate is an orally active and selective colony-stimulating factor-1 receptor (CSF1R) inhibitor. BPR1R024 mesylate is the equivalent of BPR1R024 (HY-132935). BPR1R024 has potent CSF1R inhibition activity with an IC₅₀ value of 0.53 nM. BPR1R024 can be used for the research of immuno-oncology ^[1].

HY-N6905

Acetylarenobufagin

HIF/HIF Prolyl-Hydroxylase Cancer

Acetylarenobufagin is a steroidal hypoxia inducible factor-1 (HIF-I) modulator ^[1].

Acetylarenobufagin	HIF/HIF Prolyl-Hydroxylase	Cancer
Acetylarenobufagin is a steroidal *hypoxia inducible factor-1* (HIF-I)** modulator ^[1].

HY-115613

ML-180 SR1848	Others	Cancer
ML-180 (SR1848) is a potent orphan nuclear receptor *liver receptor homolog 1 (LRH-1; NR5A2)* inverse agonist with an IC₅₀ of 3.7 µM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC₅₀>10 µM). ML-180 has the potential for LRH-1-dependent cancers ^[1] .

HY-15836

BAY 87-2243

15+ Cited Publications

HIF/HIF Prolyl-Hydroxylase Ferroptosis Cancer

BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.

BAY 87-2243 15+ Cited Publications	HIF/HIF Prolyl-Hydroxylase Ferroptosis	Cancer
BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.

HY-15494

Picropodophyllin 15+ Cited Publications AXL1717; Picropodophyllotoxin; PPP	IGF-1R Apoptosis	Endocrinology Cancer
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

HY-101526

GENZ-882706

RA03546849
c-Fms Inflammation/Immunology

GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1.
HY-119942

c-Fms-IN-8

c-Fms Cancer

c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC₅₀ of 9.1 nM ^[1].

GENZ-882706 RA03546849	c-Fms	Inflammation/Immunology
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1.

c-Fms-IN-8	c-Fms	Cancer
c-Fms-IN-8 (compound 4a) is a *colony stimulating factor-1* receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC₅₀** of 9.1 nM ^[1].

HY-114244

USL311	CXCR	Endocrinology Cancer
USL311 is a potent and selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4 ^[1].

HY-100472

ZYZ-488	Caspase	Cancer
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3 ^[1].

HY-P1888A

HIF-1 alpha (556-574) (TFA)	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-1 alpha (556-574) TFA is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis ^[1].

HY-18777

KC7F2 10+ Cited Publications	HIF/HIF Prolyl-Hydroxylase	Cancer
KC7F2 is a potent hypoxia inducible factor-1 (HIF-1) pathway inhibitor with an IC₅₀ of 20 μM in LN229-HRE-AP cells, and with potential as a cancer therapy agent ^[1].

HY-106101

Echinomycin 4 Publications Verification Quinomycin A; NSC-13502	HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial	Cancer
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC₅₀ of 29.4 pM ^[1] .

HY-15494S1

Picropodophyllin-d6 AXL1717-d₆; Picropodophyllotoxin-d₆; PPP-d₆	Isotope-Labeled Compounds IGF-1R Apoptosis	Endocrinology Cancer
Picropodophyllin-d₆ (AXL1717-d₆) is deuterium labeled Picropodophyllin. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

HY-126297

c-Fms-IN-10	c-Fms	Inflammation/Immunology Cancer
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulating factor-1 receptor, CSF-1R) with IC₅₀ of 2 nM. c-Fms-IN-10 has anti-tumor activity ^[1].

HY-153485A

Cimdelirsen sodium ISIS 766720 sodium; IONIS-GHR-LRx sodium	Small Interfering RNA (siRNA)	Others
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

HY-153485

Cimdelirsen ISIS 766720; IONIS-GHR-LRx	Small Interfering RNA (siRNA)	Others
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

HY-B0025

Voglibose	Glucosidase	Metabolic Disease
Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.

HY-145110

IGF-1R inhibitor-2	IGF-1R	Cancer
IGF-1R inhibitor-2 (example 121) is an insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis ^[1].

HY-122906

JTE-952	c-Fms	Inflammation/Immunology
JTE-952 is a potent, oral active and selective Type II inhibitor of *colony stimulating factor-1* receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC₅₀** values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis ^[1].

HY-158148

CSF1R-IN-23	c-Fms	Neurological Disease Inflammation/Immunology
CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC₅₀ of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable ^[1].

HY-10524

GSK1904529A 5+ Cited Publications	IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), with IC₅₀s of 27 and 25 nM, respectively. GSK1904529A shows poor activity (IC₅₀>1 μM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity ^[1] .

HY-P2090

Angiopeptin	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research ^[1] .

HY-109086

Edicotinib 2 Publications Verification JNJ-40346527; JNJ-527	c-Fms	Neurological Disease Inflammation/Immunology
Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC₅₀ of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC₅₀ values of 20 nM and 190 nM, respectively ^[1]. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research ^[1] .

HY-131445

RJW100	MicroRNA	Endocrinology Cancer
RJW100 is a potent *liver receptor homolog 1 (LRH-1, NR5A2)* and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC₅₀s of 6.6 and 7.5, respectively ^[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter .

HY-19357

E3330 2 Publications Verification APX-3330	DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species	Cardiovascular Disease Neurological Disease Cancer
E3330 (APX-3330) is a direct, orally active and selective inhibitor of **Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α** in pancreatic cancer. E3330 shows anticancer activities ^[1] .

HY-P2090A

Angiopeptin TFA	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research ^[1] .

HY-B0239

Chloramphenicol 5+ Cited Publications	Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP	Infection Cancer
Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research ^[1] .

HY-135680

I-OMe-Tyrphostin AG 538 I-OMe-AG 538	IGF-1R	Metabolic Disease Cancer
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of *IGF-1R* (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC₅₀ of 1 µM ^[1].

HY-B0239S2

Threo-Chloramphenicol-d6	JNK Apoptosis VEGFR MMP Bacterial Akt Autophagy HIF/HIF Prolyl-Hydroxylase Antibiotic Beclin1
Threo-Chloramphenicol-d₆ is the deuterium labeled Chloramphenicol[1]. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research[2][3][4].

HY-P3601

*Brain Derived Basic Fibroblast Growth Factor (1-24)* FGF basic (1-24)	Bacterial HBV	Infection Inflammation/Immunology
Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) is a synthetic peptide, shows anti-bacterial and anti-HBV activities. Brain Derived Basic Fibroblast Growth Factor (1-24) can be used in infection disease and immune disease research ^[1].

HY-P2281

*Atrial natriuretic factor (1-28) (human, porcine)* Atrial natriuretic peptide (1-28)	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Atrial natriuretic factor (1-28) (human, porcine) is a potent suppressor of pro-opiomelanocortin (POMC) mRNA but a weak inhibitor of βEP-LI release ^[1] .

HY-10253

AG1024 4 Publications Verification Tyrphostin AG 1024	IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective *IGF-1R* inhibitor with an IC₅₀ of 7 μM. AG1024 inhibits phosphorylation of IR (IC₅₀=57 μM). AG1024 induces apoptosis and has anti-cancer activity ^[1] .

HY-N10330

7-Hydroxyneolamellarin A	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer ^[1].

HY-N2469

Xylotriose

Others Others

Xylotriose is a natural xylooligosaccharide, acts as a bifidogenic factor .
HY-16695

MIM1

Inhibitor of Mcl-1
Bcl-2 Family Cancer

MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).
HY-100872

KRIBB11

15+ Cited Publications

HSP Apoptosis Cancer

KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC₅₀ of 1.2 μM.
HY-112865

Octocog alfa

Factor VIII Others

Octocog alfa is a second-generation full-length recombinant factor VIII, as a antihemophilic factor .

Xylotriose	Others	Others
Xylotriose is a natural xylooligosaccharide, acts as a bifidogenic factor .

MIM1 Inhibitor of Mcl-1	Bcl-2 Family	Cancer
MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).

KRIBB11 15+ Cited Publications	HSP Apoptosis	Cancer
KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC₅₀ of 1.2 μM.

Octocog alfa	Factor VIII	Others
Octocog alfa is a second-generation full-length recombinant factor VIII, as a antihemophilic factor .

HY-P3612

CTCE-0214	CXCR	Inflammation/Immunology
CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research ^[1] .

HY-14130

CP 376395

CRFR Neurological Disease Endocrinology

CP 376395 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist ^[1] .

CP 376395	CRFR	Neurological Disease Endocrinology
CP 376395 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist ^[1] .

HY-103379

CP 376395 hydrochloride	CRFR	Neurological Disease Endocrinology
CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist ^[1] .

HY-126076

VPC-80051 racemate

Others Others

VPC-80051 racemate is a racemate of VPC-80051. VPC-80051 is a prototype inhibitor of the hnRNP A1 splicing factor .

VPC-80051 racemate	Others	Others
VPC-80051 racemate is a racemate of VPC-80051. VPC-80051 is a prototype inhibitor of the hnRNP A1 splicing factor .

HY-16560

Camptothecin 35+ Cited Publications Campathecin; (S)-(+)-Camptothecin; CPT	Topoisomerase ADC Cytotoxin MicroRNA Influenza Virus Apoptosis Fungal Antibiotic	Infection Cancer
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM ^[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .

HY-103376

NBI-27914 hydrochloride	CRFR	Neurological Disease
NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a K_i value of 1.7 nM ^[1] .

HY-16669

Mcl1-IN-1

Bcl-2 Family Cancer

Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC₅₀=2.4 µM).
HY-160267

iPAF1C

DNA/RNA Synthesis HIV Infection

iPAF1C is a potent inhibitor of polymerase-associated factor 1 complex (PAF1C). iPAF1C has anti-HIV activity ^[1].

HY-16560S

Camptothecin-d5 Campathecin-d₅; (S)-(+)-Camptothecin-d₅; CPT-d₅	Topoisomerase ADC Cytotoxin MicroRNA Influenza Virus Apoptosis Fungal Antibiotic	Infection Cancer
Camptothecin-d₅ is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].

HY-15672

FM19G11	HIF/HIF Prolyl-Hydroxylase	Neurological Disease Cancer
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC₅₀ of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions ^[1] .

Cat. No.	Product Name

HY-L045

Oxygen Sensing Compound Library

2495 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 2495 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Target	Research Area

HY-P1888

HIF-1 alpha (556-574)	Peptides	Cardiovascular Disease
HIF-1 alpha (556-574) is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis ^[1].

HY-P2090A

Angiopeptin TFA	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research ^[1] .

HY-P3601

*Brain Derived Basic Fibroblast Growth Factor (1-24)* FGF basic (1-24)	Bacterial HBV	Infection Inflammation/Immunology
Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) is a synthetic peptide, shows anti-bacterial and anti-HBV activities. Brain Derived Basic Fibroblast Growth Factor (1-24) can be used in infection disease and immune disease research ^[1].

HY-P1888A

HIF-1 alpha (556-574) (TFA)	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
HIF-1 alpha (556-574) TFA is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis ^[1].

HY-P2090

Angiopeptin	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research ^[1] .

HY-P2281

*Atrial natriuretic factor (1-28) (human, porcine)* Atrial natriuretic peptide (1-28)	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Atrial natriuretic factor (1-28) (human, porcine) is a potent suppressor of pro-opiomelanocortin (POMC) mRNA but a weak inhibitor of βEP-LI release ^[1] .

HY-P3612

CTCE-0214	CXCR	Inflammation/Immunology
CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research ^[1] .

HY-P1236

Atrial Natriuretic Peptide (ANP) (1-28), rat Atrial natriuretic factor (1-28) (rat)	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated *endothelin-1* secretion in a concentration-dependent manner.

HY-P3054

S6 peptide	Peptides	Cardiovascular Disease
S6 peptide is a potentially important lamin kinase. S6 peptide is involved in the process of cardiac hypertrophy induced by mechanical loading. S6 peptide can be activated by many kinds of growth factors .

HY-P1236A

Atrial Natriuretic Peptide (ANP) (1-28), rat TFA Atrial natriuretic factor (1-28) (rat) TFA	Endothelin Receptor	Cardiovascular Disease Endocrinology
Atrial Natriuretic Peptide (ANP) (1-28), rat (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated *endothelin-1* secretion in a concentration-dependent manner.

HY-P4657

Human Growth Hormone (1-43)	Peptides	Endocrinology
Human Growth Hormone (1-43) is an N-terminal fragment of human growth hormone with specific and pronounced insulin-like activity. Human Growth Hormone (1-43) can be used to study the function and metabolic pathways of growth hormone, a potential obesity-related factor .

HY-P2324

Gramicidin A 1 Publications Verification	Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic	Infection Cancer
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) ^[1] .

HY-P2324A

Gramicidin A TFA	Antibiotic Bacterial	Infection
Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) ^[1] .

HY-P1237

C-Type Natriuretic Peptide (CNP) (1-22), human 1 Publications Verification	Peptides	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P1237A

C-Type Natriuretic Peptide (CNP) (1-22), human TFA 1 Publications Verification	Peptides	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P3982

CKLF1-C19	CCR	Inflammation/Immunology
CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4 ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15494

Picropodophyllin 15+ Cited Publications AXL1717; Picropodophyllotoxin; PPP	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Endocrinology	IGF-1R Apoptosis
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

HY-B0025

Voglibose	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields Saccharides	Glucosidase
Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.

HY-B0239

Chloramphenicol 5+ Cited Publications	Structural Classification Classification of Application Fields Anti-aging Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Infection Human Gut Microbiota Metabolites Plant Cell Culture Microorganisms Antibiotics Resistance Selection Animal Husbandry Anticancer Disease Research Fields Cancer	Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP
Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research ^[1] .

HY-N6905

Acetylarenobufagin	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	HIF/HIF Prolyl-Hydroxylase
Acetylarenobufagin is a steroidal *hypoxia inducible factor-1* (HIF-I)** modulator ^[1].

HY-N10330

7-Hydroxyneolamellarin A	Structural Classification Animals Source classification Phenols	HIF/HIF Prolyl-Hydroxylase VEGFR
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer ^[1].

HY-N2469

Xylotriose	Zea mays L. Polysaccharides Classification of Application Fields Gramineae Source classification Other Diseases Plants Disease Research Fields Saccharides	Others
Xylotriose is a natural xylooligosaccharide, acts as a bifidogenic factor .

HY-16560

Camptothecin Maximum Cited Publications 38 Publications Verification Campathecin; (S)-(+)-Camptothecin; CPT	Infection Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields	Topoisomerase ADC Cytotoxin MicroRNA Influenza Virus Apoptosis Fungal Antibiotic
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM ^[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .

HY-113212

Ursocholic acid	Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Ursocholic acid, a bile acid found predominantly in bile of mammals, is transformed into deoxycholic acid by the intestinal microflora in mice. Ursodeoxycholic acid is an inhibitor of 7α-hydroxysteroid dehydrogenase and hepatocyte nuclear factor 1α ^[1].

HY-30267

4-Hydroxyphenyl acetate 4-HPA; 4-Acetoxyphenol	Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor .

HY-19356

Rocaglamide 15+ Cited Publications Roc-A; MG-002	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Plants Meliaceae Disease Research Fields Aglaia elliptifolia Cancer	NF-κB HSP Eukaryotic Initiation Factor (eIF)
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia ^[1] .

Species:	Human (84) Rhesus Macaque (7) Mouse (29) Rat (6) Bovine (1) Cynomolgus (5) Canine (2)
Tag:	SUMO (3) His (85) Tag Free (31) Strep (1) Avi (3) Myc (3) GST (6) Fc (14) Flag (1)
Source:	HEK293 (62) CHO (2) P. pastoris (6) Sf9 insect cells (5) E. coli (57)

Cat. No.	Compare	Product Name	Species	Source

HY-P70644

	IL-4 Protein, Mouse Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; Lymphocyte stimulatory factor 1; IL-4; BSF-1	Mouse	E. coli
	IL-4 Protein, Mouse is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression.

HY-P72282

	*Nucleolar transcription factor 1/UBTF Protein, Human (His-SUMO)* NOR 90; UBF1; Upstream binding factor 1; Upstream-binding factor 1	Human	E. coli
	The nucleolar transcription factor 1/UBTF protein critically activates RNA polymerase I-mediated transcription by binding to the ribosomal RNA gene promoter and cooperating with the SL1/TIF-IB complex. Nucleolar transcription factor 1/UBTF Protein, Human (His-SUMO) is the recombinant human-derived Nucleolar transcription factor 1/UBTF protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of Nucleolar transcription factor 1/UBTF Protein, Human (His-SUMO) is 670 a.a., with molecular weight of ~95.0 kDa.

HY-P700514

	USF1 Protein, Human (His) USF1; upstream transcription factor 1; UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11; OTTHUMP00000029691; OTTHUMP00000029693; USF; Major late transcription factor 1; upstream stimulatory factor 1	Human	E. coli
	The USF1 protein is a transcription factor that binds symmetric E-box DNA (5'-CACGTG-3') in viral and cellular promoters. Efficient DNA binding requires dimerization, typically using bHLH proteins. USF1 Protein, Human (His) is the recombinant human-derived USF1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of USF1 Protein, Human (His) is 308 a.a., with molecular weight of 37.3 kDa.

HY-P71859

	IL-4 Protein, Rhesus macaque IL4Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1	Rhesus Macaque	E. coli
	IL-4 protein actively engages in B-cell activation, serving as a costimulator for DNA synthesis, inducing class II MHC molecule expression, and enhancing IgE and IgG1 secretion. It regulates CD23 expression on lymphocytes and monocytes, positively influences IL31RA expression in macrophages, and induces autophagy in dendritic cells through mTORC1 signaling interference and RUFY4 induction. IL-4 Protein, Rhesus macaque is the recombinant Rhesus Macaque-derived IL-4 protein, expressed by E. coli , with tag free. The total length of IL-4 Protein, Rhesus macaque is 129 a.a., with molecular weight of ~14.9 kDa.

HY-P70653A

	IL-4 Protein, Mouse (HEK293, C-His) Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; Lymphocyte stimulatory factor 1; IL-4; BSF-1	Mouse	HEK293
	Interleukin 4 (IL-4) Protein is a pleiotropic cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. IL-4 participates in STAT6 signaling and regulates the expression of MHC II, IgE, IgG1 amd CD23. IL-4 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived IL-4 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of IL-4 Protein, Mouse (HEK293, C-His) is 120 a.a., with molecular weight of ~18 kDa.

HY-P70445

	IL-4 Protein, Human Maximum Cited Publications 11 Publications Verification Interleukin-4; IL-4; B-Cell Stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory factor 1; Pitrakinra; IL4	Human	E. coli
	IL-4 Protein, Human is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells.

HY-P70653

	IL-4 Protein, Mouse (HEK293, His) 4 Publications Verification Interleukin-4; IL-4; IL4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Lymphocyte stimulatory factor 1	Mouse	HEK293
	IL-4 Protein, Mouse (HEK293, His) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 Protein, Mouse (HEK293, His) is a recombinant mouse interleukin-4 (rhIL-4) expressed in HEK 293 cells with a His tag.

HY-P71794

	IL-4 Protein, Cynomolgus (P.pastoris, His) IL4Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1	Cynomolgus	P. pastoris
	IL-4 protein has an important effect on B cell activation, acting as a costimulator for DNA synthesis and promoting the expression of class II MHC molecules on resting B cells. It enhances IgE and IgG1 secretion and cell surface expression while also regulating CD23 expression on lymphocytes and monocytes. IL-4 Protein, Cynomolgus (P.pastoris, His) is the recombinant cynomolgus-derived IL-4 protein, expressed by P. pastoris , with N-His labeled tag. The total length of IL-4 Protein, Cynomolgus (P.pastoris, His) is 129 a.a., with molecular weight of ~16.9 kDa.

HY-P72089

	ARF1 Protein, Human (His-GST, Myc) ADP Ribosylation factor 1; ADP-ribosylation factor 1; ARF 1; ARF1; ARF1_HUMAN	Human	E. coli
	ARF1 is a small GTPase responsible for coordinating protein transport within the Golgi complex. In its GTP-bound state, ARF1 critically regulates Golgi vesicle budding and uncoating by recruiting coat proteins. ARF1 Protein, Human (His-GST, Myc) is the recombinant human-derived ARF1 protein, expressed by E. coli , with N-10*His, C-Myc, GST labeled tag. The total length of ARF1 Protein, Human (His-GST, Myc) is 180 a.a., with molecular weight of ~55 kDa.

HY-P78549

	GMP IL-4 Protein, Human 3 Publications Verification Interleukin-4; IL-4; B-Cell Stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory factor 1; Pitrakinra; IL4	Human	E. coli
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. GMP IL-4 Protein, Human is the recombinant human-derived IL-4 protein, expressed by E. coli , with tag free. The total length of GMP IL-4 Protein, Human is 129 a.a., with molecular weight of ~15.6 kDa.

HY-P70750

	IL-4 Protein, Human (HEK293) Interleukin-4; IL-4; B-Cell Stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory factor 1; Pitrakinra; IL4	Human	HEK293
	IL-4 Protein, Human (HEK293) is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells. IL-4 Protein, Human (HEK293) is a recombinant human interleukin-4 (rhIL-4) expressed in HEK 293 cells.

HY-P70764

	IL-4 Protein, Human (HEK293, His) Interleukin-4; IL-4; B-Cell Stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory factor 1; Pitrakinra; IL4	Human	HEK293
	IL-4 Protein, Human (HEK293, His) is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells. IL-4 Protein, Human (HEK293, His) is a recombinant human interleukin-4 (rhIL-4) expressed in HEK 293 cells with a His tag.

HY-P70750G

	GMP IL-4 Protein, Human (HEK293) Interleukin-4; IL-4; B-Cell Stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory factor 1; Pitrakinra; IL4	Human	HEK293
	GMP IL-4 Protein, Human (HEK293) is a recombinant GMP-grade protein produced by HEK293 cells with C-His tag. IL-4 is an anti-inflammatory cytokine acting as a pleiotropic regulator of numerous immune and inflammatory processes.

HY-P700130AF

	Animal-Free IL-4 Protein, Human (His) Interleukin-4; IL-4; B-Cell Stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory factor 1; Pitrakinra; IL4	Human	E. coli
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. Animal-Free IL-4 Protein, Human (His) is the recombinant human-derived animal-FreeIL-4 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-4 Protein, Human (His) is 129 a.a., with molecular weight of ~15.9 kDa.

HY-P70209

	EDF1/MBF1 Protein, Human (His) rHuEndothelial differentiation-related factor 1/EDF1, His; Endothelial Differentiation-Related factor 1; EDF-1; Multiprotein-Bridging factor 1; MBF1; EDF1	Human	E. coli
	The EDF1/MBF1 protein is a transcriptional coactivator that stimulates NR5A1, NR1H3/LXRA, and PPARG transcriptional activity. It enhances ATF1, ATF2, CREB1 and NR5A1 DNA binding. EDF1/MBF1 Protein, Human (His) is the recombinant human-derived EDF1/MBF1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of EDF1/MBF1 Protein, Human (His) is 147 a.a., with molecular weight of 16 & 40 kDa, respectively.

HY-P700502

	APAF1 Protein, Human (P. pastoris, His) APAF 1; Apaf-1; APAF_HUMAN; Apaf1; Apoptotic peptidase activating factor 1; Apoptotic protease activating factor 1; Apoptotic protease activating factor; Apoptotic protease-activating factor 1; CED 4; CED4; KIAA0413	Human	P. pastoris
	APAF1 Protein, a pivotal apoptosome component, orchestrates cytochrome c-dependent activation of pro-caspase-9, initiating caspase-3 activation and apoptosis. Forming an apoptosome ring with cytochrome c and dATP, APAF1 interacts with pro-caspase-9, releasing mature caspase-9. Pro-caspase-3 joins the complex, activating caspase-3. Notably, APAF1 isoform 6 is less effective in inducing apoptosis. APAF1 interacts with APIP, NAIP/BIRC1, and CIAO2A, contributing to its multifaceted role in apoptotic regulation. APAF1 Protein, Human (P. pastoris, His) is the recombinant human-derived APAF1 protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of APAF1 Protein, Human (P. pastoris, His) is 312 a.a., with molecular weight of 37.4 kDa.

HY-P70438

	FGF-1 Protein, Mouse/Rat Fibroblast Growth factor 1; FGF-1; Acidic Fibroblast Growth factor; aFGF; Heparin-Binding Growth factor 1; HBGF-1; Fgf1; Fgf-1; Fgfa	Rat;Mouse	E. coli
	The FGF-1 protein plays a key role in regulating a variety of cellular processes, serving as a potent mitogen and ligand for FGFR1 and integrins. In the presence of heparin, FGF-1 binds to FGFR1, initiating dimerization and autophosphorylation, resulting in multiple signaling cascades. FGF-1 Protein, Mouse/Rat is the recombinant rat, mouse-derived FGF-1 protein, expressed by E. coli , with tag free. The total length of FGF-1 Protein, Mouse/Rat is 140 a.a., with molecular weight of ~16.0 kDa.

HY-P7488A

	AIF1 Protein, Human (N-His) AIF-1; Allograft inflammatory factor 1	Human	E. coli
	The AIF1 protein is an actin-binding promoter that enhances membrane ruffling, activates RAC, and amplifies the actin-bundling activity of LCP1. This calcium-binding protein has a critical impact on RAC signaling, phagocytosis, and may contribute to macrophage function. AIF1 Protein, Human (N-His) is the recombinant human-derived AIF1 protein, expressed by E. coli , with N-His labeled tag. The total length of AIF1 Protein, Human (N-His) is 147 a.a., with molecular weight of ~19 kDa.

HY-P701854

	PMF1 Protein, Human PMF1; Polyamine-modulated factor 1; PMF-1	Human	E. coli
	The PMF1 protein is part of the MIS12 complex and ensures the correct alignment, segregation and kinetochore formation of chromosomes in mitosis. It also acts as a co-transcriptional partner of NFE2L2, regulating polyamine-induced SSAT transcription. PMF1 Protein, Human is the recombinant human-derived PMF1 protein, expressed by E. coli , with tag free. The total length of PMF1 Protein, Human is 205 a.a., .

HY-P74463

	WIF-1 Protein, Mouse (HEK293, His) Wnt inhibitory factor 1; WIF-1	Mouse	HEK293
	WIF-1 Protein crucially binds to WNT proteins, inhibiting their activities and regulating WNT signaling pathways. Beyond inhibition, WIF-1 may contribute to mesoderm segmentation, hinting at roles in embryonic development. Interactions with MYOC suggest potential involvement in additional cellular processes or signaling cascades. The multifaceted interactions of WIF-1 underscore its importance in modulating WNT-mediated activities and potential roles in broader developmental and cellular events. WIF-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived WIF-1 protein, expressed by HEK293, with C-His labeled tag. The total length of WIF-1 Protein, Mouse (HEK293, His) is 379 a.a., with molecular weight of ~44 kDa.

HY-P701855

	PMF1 Protein, Human (His, Strep) PMF1; Polyamine-modulated factor 1; PMF-1	Human	E. coli
	The PMF1 protein is part of the MIS12 complex and ensures the correct alignment, segregation and kinetochore formation of chromosomes in mitosis. It also acts as a co-transcriptional partner of NFE2L2, regulating polyamine-induced SSAT transcription. PMF1 Protein, Human (His, Strep) is the recombinant human-derived PMF1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of PMF1 Protein, Human (His, Strep) is 205 a.a., .

HY-P7488

	AIF1 Protein, Human (C-His) rHuAllograft inflammatory factor 1, His; AIF-1; Allograft inflammatory factor 1	Human	E. coli
	AIF1 Protein, Human (C-His), the recombinant human allograft inflammatory factor 1, has a His tag at the C-terminus. Allograft inflammatory factor-1 (AIF1) is an inflammatory cytokine produced mainly by macrophages within human white adipose tissue.

HY-P700289

	FGF-1 Protein, Human (154a.a) 1 Publications Verification Fibroblast Growth factor 1; FGF-1; Acidic Fibroblast Growth factor; aFGF; Endothelial Cell Growth factor; ECGF; Heparin-Binding Growth factor 1; HBGF-1; FGF1; FGFA	Human	E. coli
	FGF-1 Protein intricately regulates cell survival, division, angiogenesis, differentiation, and migration. Acting as a potent mitogen, it serves as a ligand for FGFR1 and integrins. Binding to FGFR1, especially with heparin, leads to dimerization and activation, initiating signaling cascades. Additionally, FGF-1 Protein binds to integrin ITGAV:ITGB3, forming a ternary complex crucial for FGF1 signaling. Inducing phosphorylation of key proteins, it plays a multifaceted role in diverse cellular processes, emphasizing its significance in cell physiology. FGF-1 Protein, Human (154a.a) is the recombinant human-derived FGF-1 protein, expressed by E. coli, with His, tag free. The total length of FGF-1 Protein, Human (154a.a) is 154 a.a., with molecular weight of 18.54 kDa.

HY-P7042

	IL-4 Protein, Human (CHO) 2 Publications Verification rHuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	Human	CHO
	IL-4 Protein, Human (CHO) is a CHO cell derived, potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells.

HY-P7080

	IL-4 Protein, Mouse (CHO) 5+ Cited Publications rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	Mouse	CHO
	IL-4 Protein, Mouse (CHO) is a species-specific cytokine which promotes the proliferation, differentiation and cell-surface protein modulation of B lymphocytes.

HY-P70982

	WIF-1 Protein, Human (HEK293, His) 2 Publications Verification Wnt Inhibitory factor 1; WIF-1; WIF1	Human	HEK293
	WIF-1 protein critically binds to WNT protein, inhibits its activity and regulates the WNT signaling pathway. In addition to its inhibitory role, WIF-1 may also contribute to mesoderm segmentation, implicating its role in embryonic development. WIF-1 Protein, Human (HEK293, His) is the recombinant human-derived WIF-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of WIF-1 Protein, Human (HEK293, His) is 351 a.a., with molecular weight of ~45.0 kDa.

HY-P79001

	Crlf1 Protein, Mouse (HEK293, His, solution) Cytokine receptor-like factor 1; CRLM-3	Mouse	HEK293
	Crlf1 protein combines with CLCF1 to form an important neurotrophic cytokine involved in neuronal development. It plays a crucial role in the initiation and maintenance of lactation in neonatal mice and is associated with immune system regulation. Crlf1 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived Crlf1 protein, expressed by HEK293 , with His labeled tag. The total length of Crlf1 Protein, Mouse (HEK293, His, solution) is 386 a.a., with molecular weight of ~75.0 kDa.

HY-P73214

	IL-4 Protein, Canine 1 Publications Verification Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1	Canine	E. coli
	The IL-4 protein actively participates in the B cell activation process, acting as a costimulator for DNA synthesis. It induces the expression of class II MHC molecules on resting B cells, enhances IgE and IgG1 secretion and cell surface expression, and modulates CD23 expression on lymphocytes and monocytes. IL-4 Protein, Canine is the recombinant canine-derived IL-4 protein, expressed by E. coli , with N-Met labeled tag. The total length of IL-4 Protein, Canine is 108 a.a., with molecular weight of 12-14 kDa.

HY-P77510

	IL-4 Protein, Human (Biotinylated) Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1	Human	E. coli
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. IL-4 Protein, Human (Biotinylated) is the recombinant human-derived IL-4 protein, expressed by E. coli , with tag free. The total length of IL-4 Protein, Human (Biotinylated) is 129 a.a., with molecular weight of ~.

HY-P701093

	IL-4 Protein, Mouse (HEK293) rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	Mouse	HEK293
	IL-4 Protein, Mouse (HEK293) is a species-specific cytokine which promotes the proliferation, differentiation and cell-surface protein modulation of B lymphocytes.

HY-P70553

	M-CSF Protein, Mouse (HEK293) 1 Publications Verification Macrophage colony-stimulating factor 1; CSF-1; MCSF; Csf1; Csfm	Mouse	HEK293
	M-CSF Protein, Mouse (HEK293) is a pro-inflammatory cytokine which binds to its receptor CSF1R, and is involved in the development and proliferation of cells of the monocyte/macrophage lineage and participates in the induction of osteoclasts.

HY-P73827

	M-CSF Protein, Human (HEK293, His) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; Lanimostim	Human	HEK293
	The M-CSF protein is an important cytokine that modulates hematopoietic precursor cells, especially mononuclear phagocytes, affecting innate immunity and inflammation through the release of proinflammatory chemokines. It is essential for osteoclast proliferation and regulates bone resorption, bone development and fertility. M-CSF Protein, Human (HEK293, His) is the recombinant human-derived M-CSF protein, expressed by HEK293 , with C-His labeled tag. The total length of M-CSF Protein, Human (HEK293, His) is 158 a.a., with molecular weight of 27-32 kDa.

HY-P73829

	M-CSF Protein, Human (HEK293, Fc) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; Lanimostim	Human	HEK293
	The M-CSF protein is an important cytokine that modulates hematopoietic precursor cells, especially mononuclear phagocytes, affecting innate immunity and inflammation through the release of proinflammatory chemokines. It is essential for osteoclast proliferation and regulates bone resorption, bone development and fertility. M-CSF Protein, Human (HEK293, Fc) is the recombinant human-derived M-CSF protein, expressed by HEK293 , with C-hFc labeled tag. The total length of M-CSF Protein, Human (HEK293, Fc) is 223 a.a., with molecular weight of ~51.9 kDa.

HY-P77516

	M-CSF Protein, Human (Biotinylated, HEK293) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; Lanimostim	Human	HEK293
	The M-CSF protein is an important cytokine that modulates hematopoietic precursor cells, especially mononuclear phagocytes, affecting innate immunity and inflammation through the release of proinflammatory chemokines. It is essential for osteoclast proliferation and regulates bone resorption, bone development and fertility. M-CSF Protein, Human (Biotinylated, HEK293) is the recombinant human-derived M-CSF protein, expressed by HEK293 , with tag free. The total length of M-CSF Protein, Human (Biotinylated, HEK293) is 158 a.a., with molecular weight of ~18.4 KDa.

HY-P700214AF

	Animal-Free IL-4 Protein, Mouse (His) rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	Mouse	E. coli
	Interleukin 4 (IL-4) Protein is a pleiotropic cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. IL-4 participates in STAT6 signaling and regulates the expression of MHC II, IgE, IgG1 amd CD23. Animal-Free IL-4 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-4 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-4 Protein, Mouse (His) is 120 a.a., with molecular weight of ~14.5 kDa.

HY-P70493

	M-CSF Protein, Rat (HEK293) Macrophage colony-stimulating factor 1; CSF-1; M-CSF; MCSF; CSF1	Rat	HEK293
	The M-CSF protein regulates hematopoietic precursor cells, promoting their survival, proliferation, and differentiation. M-CSF Protein, Rat (HEK293) is the recombinant rat-derived M-CSF protein, expressed by HEK293 , with tag free. The total length of M-CSF Protein, Rat (HEK293) is 222 a.a., with molecular weight of ~46.0 kDa.

HY-P70511

	TFF1 Protein, Mouse (HEK293, His) Trefoil factor 1; Protein pS2; Tff1; Bcei; Ps2	Mouse	HEK293
	TFF1 protein functions as a mucous gel stabilizer, vital for fortifying the gastrointestinal mucosa against noxious agents. It contributes to the mucous layer's integrity, providing a crucial physical barrier for the gastrointestinal tract, safeguarding it from potential harm. TFF1's stabilizing role emphasizes its significance in preserving the mucosal barrier, essential for overall gastrointestinal health and protection. TFF1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TFF1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TFF1 Protein, Mouse (HEK293, His) is 66 a.a., with molecular weight of ~15.0 kDa.

HY-P73287

	M-CSF Protein, Human (Biotinylated, HEK293, His) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; Lanimostim	Human	HEK293
	The M-CSF protein is an important cytokine that modulates hematopoietic precursor cells, especially mononuclear phagocytes, affecting innate immunity and inflammation through the release of proinflammatory chemokines. It is essential for osteoclast proliferation and regulates bone resorption, bone development and fertility. M-CSF Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived M-CSF protein, expressed by HEK293 , with C-His labeled tag. The total length of M-CSF Protein, Human (Biotinylated, HEK293, His) is 158 a.a., with molecular weight of 27-32 kDa.

HY-P73288

	M-CSF Protein, Mouse (HEK293, Tag Free) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; Lanimostim	Mouse	HEK293
	The M-CSF protein is a key orchestrator in regulating the survival, proliferation, and differentiation of hematopoietic precursor cells, particularly mononuclear phagocytes, including macrophages and monocytes. It actively promotes the release of pro-inflammatory chemokines, thereby playing a key role in innate immunity and inflammatory processes. M-CSF Protein, Mouse (HEK293, Tag Free) is the recombinant mouse-derived M-CSF protein, expressed by HEK293 , with tag free. The total length of M-CSF Protein, Mouse (HEK293, Tag Free) is 230 a.a., with molecular weight of ~45 kDa.

HY-P74569

	SDF-1 Protein, Canine Stromal Cell-Derived factor 1; SDF-1; IRH; hIRH; PBSF; CXCL12; SDF1	Canine	E. coli
	SDF-1 (stromal cell-derived factor-1) is a homeostatic chemokine that binds CXCR4 and CXCR7 receptors and physiologically functions in hematopoiesis, leucocyte trafficking, cardiogenesis, and neurogenesis. SDF-1 is constitutively expressed in several organs including lung, liver, skeletal muscle, brain, kidney, heart, skin, and bone marrow. SDF-1 has an essential role in neural and vascular development, hematopoiesis, cancer and in immunity. SDF-1 Protein, Canine is produced in E. coli, and consists of 72 amino acids (K22-M93).

HY-P701251

	M-CSF Protein, Human (Tag free, HEK293) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; Lanimostim	Human	HEK293
	The M-CSF protein is an important cytokine that modulates hematopoietic precursor cells, especially mononuclear phagocytes, affecting innate immunity and inflammation through the release of proinflammatory chemokines. It is essential for osteoclast proliferation and regulates bone resorption, bone development and fertility. M-CSF Protein, Human (Tag free, HEK293) is the recombinant human-derived M-CSF protein, expressed by HEK293 , with tag free. The total length of M-CSF Protein, Human (Tag free, HEK293) is 158 a.a., with molecular weight (glycosylation form) of 23-28 kDa.

HY-P73830

	M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, His) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; Lanimostim	Rhesus Macaque;Cynomolgus	HEK293
	The M-CSF protein regulates hematopoietic precursor cells, promoting their survival, proliferation, and differentiation. M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque, cynomolgus-derived M-CSF protein, expressed by HEK293 , with C-His labeled tag. The total length of M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is 190 a.a., with molecular weight of ~19.8 kDa.

HY-P73831

	M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; Lanimostim	Rhesus Macaque;Cynomolgus	HEK293
	The M-CSF protein regulates hematopoietic precursor cells, promoting their survival, proliferation, and differentiation. M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque, cynomolgus-derived M-CSF protein, expressed by HEK293 , with C-hFc labeled tag. The total length of M-CSF Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 190 a.a., with molecular weight of ~45.1 kDa.

HY-P74493

	TRF1 Protein, Human (sf9, His) Telomeric repeat-binding factor 1; TERF1; PIN2; TRBF1; TRF	Human	Sf9 insect cells
	CHST1 protein is a protein involved in the sulfation process of glycosaminoglycans. It plays a crucial role in regulating cellular functions such as cell adhesion and signaling. TRF1 Protein, Human (sf9, His) is the recombinant human-derived TRF1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TRF1 Protein, Human (sf9, His) is 419 a.a., with molecular weight of ~60 kDa.

HY-P76314

	EEF1E1 Protein, Human (His) Eukaryotic translation elongation factor 1 epsilon-1; AIMP3; P18	Human	E. coli
	The EEF1E1 protein is an important component of a multi-subunit complex that actively regulates the ATM response to DNA damage. It coordinates tRNA ligases of various amino acids and interacts with both MARS1 and EPRS1 in a core complex with AIMP2. EEF1E1 Protein, Human (His) is the recombinant human-derived EEF1E1 protein, expressed by E. coli , with N-His labeled tag. The total length of EEF1E1 Protein, Human (His) is 174 a.a., with molecular weight of 19-24 KDa.

HY-P700137AF

	Animal-Free M-CSF Protein, Human (His) Macrophage Colony-Stimulating factor 1; CSF-1; M-CSF; MCSF; Lanimostim; CSF1	Human	E. coli
	The M-CSF protein regulates macrophage production, differentiation, and function. It exists as an active disulfide-linked homodimer outside of cells, generated through proteolytic cleavage. It may also play a role in placental development. Alternative splicing produces multiple transcript variants. M-CSF is widely expressed in tissues such as placenta, spleen, and 25 other tissues. Animal-Free M-CSF Protein, Human (His) is the recombinant human-derived animal-FreeM-CSF protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free M-CSF Protein, Human (His) is 232 a.a., with molecular weight of ~13.34 kDa.

HY-P76455

	INSL6 Protein, Human (HEK293, His) Insulin-like peptide INSL6; Relaxin/insulin-like factor 1; INSL6; RIF1	Human	HEK293
	The INSL6 protein plays a crucial role in sperm development and fertilization, highlighting its importance in male reproductive biology. Its potential function in promoting sperm development and successful fertilization emphasizes its importance in reproductive physiology. INSL6 Protein, Human (HEK293, His) is the recombinant human-derived INSL6 protein, expressed by HEK293 , with C-His labeled tag. The total length of INSL6 Protein, Human (HEK293, His) is 178 a.a., with molecular weight of ~22.1 KDa.

HY-P71345

	SUMF1 Protein, Human (HEK293, His) Sulfatase-Modifying factor 1; C-Alpha-Formylglycine-Generating Enzyme 1; SUMF1; FGE	Human	HEK293
	The SUMF1 protein plays an important role as an oxidase that converts cysteine to 3-oxoalanine on specific target proteins such as GALNS, ARSA, STS, and ARSE. This enzymatic activity is essential for the maturation of arylsulfatase and alkaline phosphatase, leading to the formation of 3-oxoalanine (fGly). SUMF1 Protein, Human (HEK293, His) is the recombinant human-derived SUMF1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SUMF1 Protein, Human (HEK293, His) is 341 a.a., with molecular weight of 38-42 kDa.

HY-P72606

	IGF-I R Protein, Human (HEK293, His) Insulin-like growth factor 1 receptor; IGF-I receptor; IGF1R; CD221	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IGF-I R Protein, Human (HEK293, His) is 902 a.a., with molecular weight of 100-130 & 54 kDa, respectively.

HY-P75942

	NNT1/CLC Protein, Human (HEK293, Fc) Cardiotrophin-like cytokine factor 1; BSF-3; CLCF1; BSF3; CLC; NNT1	Human	HEK293
	NNT1/CLC protein binds to CRLF1 to form an important neurotropic cytokine related to neuronal development. In addition, it stimulates B cells and upon binding activates the ILST/gp130 receptor. NNT1/CLC Protein, Human (HEK293, Fc) is the recombinant human-derived NNT1/CLC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NNT1/CLC Protein, Human (HEK293, Fc) is 198 a.a., with molecular weight of ~53 kDa.

Cat. No.	Product Name	Chemical Structure

HY-16560S

Camptothecin-d5

Camptothecin-d₅ is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].

HY-10984S1

Pomalidomide-d3
Pomalidomide-d₃ is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors[1][2].

HY-15494S1

Picropodophyllin-d6
Picropodophyllin-d₆ (AXL1717-d₆) is deuterium labeled Picropodophyllin. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

HY-B0239S2

Threo-Chloramphenicol-d6

Threo-Chloramphenicol-d₆ is the deuterium labeled Chloramphenicol[1]. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research[2][3][4].

HY-112499S

Menaquinone-7-d7

Menaquinone-7-d₇ is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

HY-112499S1

Menaquinone-7-13C6

Menaquinone-7- ¹³C₆ is the ¹³C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

HY-10917S

GW2580-d6
GW2580-d6 is the deuterium labeled GW2580. GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling ^[1].

Cat. No.	Product Name	Application	Reactivity

HY-P81736

APAF1 Antibody (YA1481) APAF; APAF-1; APAF1; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; Apoptotic protease-activating factor 1; CED4; DKFZp781B1145; KIAA0413	WB, IHC-P, ICC/IF	Human, Mouse

HY-P82552

*Thyroid Transcription Factor 1* Antibody (YA2297)** NKX2-1; NKX2A; TITF1; TTF1; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1	WB, ICC/IF	Human, Hamster

HY-P80722

IL-4 Antibody (YA343) IL4; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	WB	Transfected
IL-4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 17 kDa, targeting to IL-4. It can be used for WB assays with tag free, in the background of Transfected.

HY-P83210

GRSF1 Antibody (YA2955)

G-rich sequence factor 1
WB, ICC/IF Human

HY-P80769

Nrf1 Antibody alpha pal; alpha palindromic binding protein; Alpha palindromic-binding protein; Alpha-pal; locus control region factor 1; NFE2 related factor 1; NRF-1; Nrf1; NRF1_HUMAN; Nuclear respiratory factor 1; transcription factor 11.	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
Nrf1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to Nrf1. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82919

WIF1 Antibody (YA2664)

WNT inhibitory factor 1; WIF-1
WB, IP Human, Mouse, Rat
HY-P83420

PMF 1 Antibody (YA3165)

Polyamine-modulated factor 1
WB, IP Human, Mouse, Rat
HY-P83373

IRF1 Antibody (YA3118)

IRF1; Interferon regulatory factor 1; IRF-1
WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

HY-P81685

FGF1 Antibody (YA1430) FGF1; FGFA; Fibroblast growth factor 1; FGF-1; Acidic fibroblast growth factor; aFGF; Endothelial cell growth factor; ECGF; Heparin-binding growth factor 1; HBGF-1	WB, IHC-P	Human, Mouse, Rat

HY-P80750

M-CSF Antibody CSF1; Macrophage colony-stimulating factor 1; CSF-1; M-CSF; MCSF; Lanimostim	WB, IHC-F, IHC-P, ICC/IF	Human
M-CSF Antibody is a non-conjugated and Rabbit origined monoclonal antibody, targeting to M-CSF. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P82555

XLF Antibody (YA2300)

Cernunno; Nhej1; Non homologous end joining factor 1; Protein cernunnos; XLF; XRCC4 like factor
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P82259

Elongation factor 1 gamma Antibody (YA2004)

EEF1G; EF1G; Elongation factor 1-gamma; EF-1-gamma; eEF-1B gamma
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P83419

LEF1 Antibody (YA3164)

LEF1; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha
WB, ICC/IF Human

HY-P82028

PTN Antibody (YA1773) PTN; HBNF1; NEGF1; Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1; OSF-1	WB, IP	Human, Rat

HY-P80534

AIF Antibody (YA835) AIFM1; AIF; PDCD8; Apoptosis-inducing factor 1; mitochondrial; Programmed cell death protein 8	WB, ICC/IF	Human
AIF Antibody (YA835) is a non-conjugated and Mouse origined monoclonal antibody about 67 kDa, targeting to AIF (8H1). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P81438

Nampt Antibody (YA1183)

Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin
IHC-P Human

HY-P81235

IL-4 Antibody Interleukin-4; IL4; IL 4; B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s Cell Growth factor; IA Inducing factor; IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_MOUSE; B-cell stimulatory factor 1; BSF-1.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat
IL-4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 14 kDa, targeting to IL-4. It can be used for WB、ELISA、IHC-P、IHC-F、IF assays with tag free, in the background of Transfected.

HY-P80717

IGF1 Receptor Antibody IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P	Human
IGF1 Receptor Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 155 kDa, targeting to IGF1 Receptor. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81481

DMRT1 Antibody (YA1226)

DMT1; DMRT1; DM domain expressed in testis protein 1; Doublesex- and mab-3-related transcription factor 1
IHC-P Human
HY-P83391

ATF1 Antibody (YA3136)

Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1 Protein TREB36; ATF1
WB, ICC/IF, IP Human

HY-P80825

Phospho-IGF1 Receptor (Tyr1166) Antibody IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IP	Human, Mouse, Rat
Phospho-IGF1 Receptor (Tyr1166) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 155 kDa, targeting to Phospho-IGF1 Receptor (Tyr1166). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81052

HSF1 Antibody (YA896) HSF1; HSTF1; Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1; HSTF 1	WB, IHC-P, ICC/IF, IP, FC	Human
HSF1 Antibody (YA896) is an unconjugated, approximately 57-80 kDa, rabbit-derived, anti-HSF1 (YA896) monoclonal antibody. HSF1 Antibody (YA896) can be used for: WB, IHC-P, ICC/IF, IP, FC expriments in human background without labeling.

HY-P83536

NeuroD1 Antibody (YA3281)

NEUROD1; BHLHA3; NEUROD; Neurogenic differentiation factor 1; NeuroD; NeuroD1; Class A basic helix-loop-helix protein 3; bHLHa3
WB, IP Human, Mouse, Rat
HY-P81842

GATA1 Antibody (YA1587)

GATA1; ERYF1; GF1; Erythroid transcription factor; Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
WB, ICC/IF, IP, ChIP Human
HY-P82467

BOB1 Antibody (YA2212)

BOB 1; BOB-1; OBF 1; OBF1; OCA B; OCA-B; OCAB; OCT binding factor 1; Pou2af1
WB, IHC-P, ICC/IF, FC Human

HY-P81112

IGF 1 Antibody IBP1; IGF 1; IGF I; IGF-1; IGF IA; IGF IB; IGF1; IGFI; IGFIA; Insulin like growth factor 1 (somatomedin C); Full=Insulin-like growth factor I; Insulin Like Growth factor 1; Insulin like growth factor IA; Insulin like growth factor IB; Mechano growth factor; MGF; Mechano growth factor; MGF; Somatomedia C; Somatomedin C; IGF1_HUMAN. IGF-I;	WB; ELISA; IP; IHC-P; IHC-F; IF	Human, Mouse, Rat, Dog(predicted: Pig, Cow, Rabbit, Sheep)
IGF 1 Antibody is an unconjugated, approximately 7.7/21 kDa, rabbit-derived, anti-IGF 1 polyclonal antibody. IGF 1 Antibody can be used for: WB, ELISA, IP, IHC-P, IHC-F, IF expriments in human, mouse, rat, dog, and predicted: pig, cow, rabbit, sheep background without labeling.

HY-P80669

FEN1 Antibody (YA765) FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1	WB, IP	Human, Mouse, Rat
FEN1 Antibody (YA765) is a non-conjugated and Mouse origined monoclonal antibody about 43 kDa, targeting to FEN1 (1E7). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80822

Phospho-HSF1 (Ser303/Ser307) Antibody HSF1; HSTF1; Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1; HSTF 1	WB, IHC-P	Human
Phospho-HSF1 (Ser303/Ser307) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 57 kDa, targeting to Phospho-HSF1 (Ser303/Ser307). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81050

Phospho-HSF1 (Ser326) Antibody(YA894) HSF1; HSTF1; Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1; HSTF 1	WB, IF-Cell, IHC-P, IP, FC	Human
Phospho-HSF1 (Ser326) Antibody(YA894) is an unconjugated, approximately 57 kDa, rabbit-derived, anti-HSF1 (Ser326)(YA894) monoclonal antibody. Phospho-HSF1 (Ser326) Antibody(YA894) can be used for: WB, IF-Cell, IHC-P, IP, FC expriments in human background without labeling.

HY-P83421

Steroidogenic Factor 1 Antibody (YA3166)

AD4BP; ELP; FTZ1; FTZF1; hSF 1; NR5A1; POF7; SF1; SPGF8; SRXY3; STF1; SF-1
WB Human, Mouse, Rat

HY-P81182

PTGES2 Antibody C9orf15; FLJ14038; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF 1; GBF1; Membrane associated prostaglandin E synthase 2; MGC11289; Microsomal prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; PTGES 2; PGES2_MOUSE.	ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat(predicted: Chicken, Dog, Pig, Cow)
PTGES2 Antibody is an unconjugated, approximately 43 kDa, rabbit-derived, anti-PTGES2 polyclonal antibody. PTGES2 Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow background without labeling.

HY-P81444

CSF1R Antibody (YA1189)

CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD antigen CD115
IHC-P Human
HY-P81352

5T4 Antibody (YA1097)

TPBG,5T4,5T4 oncofetal antigen,5T4 oncofetal trophoblast glycoprotein (5T4 oncotrophoblast glycoprotein),M6P1,Wnt-activated inhibitory factor 1 (WAIF1)
IHC-P Human

HY-P80900

SREBP1 Antibody SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1	WB, ELISA	Human, Mouse, Rat
SREBP1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 122 kDa, targeting to SREBP1. It can be used for WB,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P82113

RENT1 Antibody (YA1858) UPF1; KIAA0221; RENT1; Regulator of nonsense transcripts 1; ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog; hUpf1	WB, IHC-F, IHC-P, ICC/IF, IP	Human

HY-P81089

CXCR4 Antibody C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Stromal cell-derived factor 1 receptor; SDF-1 receptor; Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; CD184 antigen; CXCR4_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat(predicted: Cow, Rabbit)
CXCR4 Antibody is an unconjugated, approximately 40 kDa, rabbit-derived, anti-CXCR4 polyclonal antibody. CXCR4 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: cow, rabbit background without labeling.

HY-P82261

CBFB Antibody (YA2006) CBFB; Core-binding factor subunit beta; CBF-beta; Polyomavirus enhancer-binding protein 2 beta subunit; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P81356

PRDM1/Blimp1 Antibody (YA1101) PRDM1; BLIMP1; PR domain zinc finger protein 1; BLIMP-1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1 (PRDI-BF1; PRDI-binding factor 1)	IHC-P	Human

HY-P83443

SDF1 Antibody (YA3188) CXCL12; SDF1; SDF1A; SDF1B; Stromal cell-derived factor 1; SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF	WB, ICC/IF	Human

HY-P81743

p150 CAF1 Antibody (YA1488) CHAF1A; CAF; CAF1P150; Chromatin assembly factor 1 subunit A; CAF-1 subunit A; Chromatin assembly factor I p150 subunit; CAF-I 150 kDa subunit; CAF-I p150; hp150	WB, IHC-F, IHC-P, ICC/IF, IP	Human

HY-P82375

APE1 Antibody (YA2120) APEX1; APE; APE1; APEX; APX; HAP1; REF1; DNA-(apurinic or apyrimidinic site) lyase; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1	WB	Human, Mouse, Rat

HY-P83061

CUG BP1 Antibody (YA2806) CELF1; BRUNOL2; CUGBP; CUGBP1; NAB50; CUGBP Elav-like family member 1; CELF-1; 50 kDa nuclear polyadenylated RNA-binding protein; Bruno-like protein 2; CUG triplet repeat RNA-binding protein 1; CUG-BP1; CUG-BP- and ETR-3-like factor 1; Dead	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

HY-P81475

TCF3 / E2A Antibody (YA1220) TCF3; BHLHB21, E2A, ITF1; Transcription factor E2-alpha; Class B basic helix-loop-helix protein 21 (bHLHb21); Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3 (TCF-3); Transcription factor ITF-1	IHC-P	Human

HY-P81173

TWIST Antibody ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS1; H-twist; OTTHUMP00000116043; SCS; Twist basic helix loop helix transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; Twist1; TWST1_HUMAN.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat,
TWIST Antibody is an unconjugated, approximately 23 kDa, rabbit-derived, anti-TWIST polyclonal antibody. TWIST Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, background without labeling.

HY-P81962

PTF1A Antibody (YA1707)

Pancreas-specific transcription factor 1a; bHLH transcription factor p48; PTF1-p48
WB, IP Human, Rat
HY-P83134

Elongation Factor 1A2 Antibody (YA2879)

HS1; STN; EF1A; STNL; MRD38; EEF1AL; EIEE33; EF-1-alpha-2
WB, IP Human, Mouse, Rat

HY-P80654

*Elongation Factor 1A1 Antibody* EEF1A1; CCS-3; CCS3; EEF-1; EEF1A; EF-Tu; EF1A; GRAF-1EF; LENG7; PTI1; eEF1A-1	WB, IHC-P, IP	Human, Mouse, Rat
Elongation Factor 1A1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 50 kDa, targeting to Elongation Factor 1A1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80705

HIF1 beta Antibody ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta	WB, IHC-P	Human, Mouse, Rat, Hamster
HIF1 beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to HIF1 beta. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P80730

KAP1 Antibody TRIM28; KAP1; RNF96; TIF1B; Transcription intermediary factor 1-beta; TIF1-beta; E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; Tripart	WB, IHC-F, IHC-P, ICC/IF	Human
KAP1 Antibody (YA719) is a non-conjugated and Mouse origined monoclonal antibody about 89 kDa, targeting to KAP1 (4E1). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P80704

HIF1 alpha Antibody HIF1A; BHLHE78; MOP1; PASD8; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS doma	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
HIF1 alpha Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 93 kDa, targeting to HIF1 alpha. It can be used for ICC/IF,WB,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks