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fern

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Keap1-Nrf2 (1) NO Synthase (1) Tyrosinase (1)
By Research Areas:	Cancer (2) Infection (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9304

Fern-7-en-19α-ol

19a-Hydroxyferna-7,9(11)-diene
Others Others

Fern-7-en-19α-ol (9a-Hydroxyferna-7,9(11)-diene) is a triterpenoid compound isolated from Adiantum caudatum .
HY-134041

Phloroglucide

Others Others

Phloroglucide is a natural product that can be isolated from ferns .
HY-N2141

Pseudoaspidin

Others Infection

Pseudoaspidin is isolated from the ferns of the class Pterophyta or Filicinae .
HY-N10748

2',3'-Dihydro-2'-hydroxyprotoapigenone

Others Cancer

2',3'-Dihydro-2'-hydroxyprotoapigenone is a natural protoflavonoid found in ferns impair .
HY-122946

Pterisolic acid B

Keap1-Nrf2 Others

Pterisolic acid B (Compound 2) is an ent-Kaurane diterpenoid. Pterisolic acid B can be isolated from fern Pteris semipinnata (Pteridaceae) .

Fern-7-en-19α-ol 19a-Hydroxyferna-7,9(11)-diene	Others	Others
Fern-7-en-19α-ol (9a-Hydroxyferna-7,9(11)-diene) is a triterpenoid compound isolated from Adiantum caudatum .

Phloroglucide	Others	Others
Phloroglucide is a natural product that can be isolated from ferns .

Pseudoaspidin	Others	Infection
Pseudoaspidin is isolated from the ferns of the class Pterophyta or Filicinae .

2',3'-Dihydro-2'-hydroxyprotoapigenone	Others	Cancer
2',3'-Dihydro-2'-hydroxyprotoapigenone is a natural protoflavonoid found in ferns impair .

Pterisolic acid B	Keap1-Nrf2	Others
Pterisolic acid B (Compound 2) is an ent-Kaurane diterpenoid. Pterisolic acid B can be isolated from fern Pteris semipinnata (Pteridaceae) .

HY-N1558

Pterisolic acid A
Pterisolic acid A is a ent-kaurane diterpenoid, and also is a derivates of ent-15-oxokauran-19-oic acid. Pterisolic acid A can be isolated from the fern Pteris semipinnata (Pteridaceae) .

HY-N1562

Pterisolic acid F
Pterisolic acid F is a ent-kaurane diterpenoid, and also is a derivates of ent-15-oxokauran-19-oic acid. Pterisolic acid F can be isolated from the fern Pteris semipinnata (Pteridaceae) .

HY-N1570

Pterosin B
Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 .

HY-N12317

Multiflorin B	NO Synthase	Others
Multiflorin B (compound 5) is a kind of kaempferol glycoside. Multiflorin B can be isolated from the root of the fern Neocheiropteris palmatopedata. Multiflorin B inhibits nitric oxide production at a concentration of 20 μg/ml with an inhibition of 52% .

HY-N11901

Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside	Others	Others
Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside can be isolated from the aerial parts of the fern Ophioglossum vulgatum L and has wound healing activity .

HY-134008

Protoapigenone	Others	Cancer
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .

HY-N1644

2,16,19-Kauranetriol 2-O-β-D-allopyranoside	Others	Others
2,16,19-Kauranetriol 2-O-β-D-allopyranoside is an ent-kaurane glycoside, which can be isolated from the fronds of Pteris cretica .

HY-N3810

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Tyrosinase	Others
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

Phloroglucide	Structural Classification Dryopteridaceae Source classification Phenols Polyphenols Dryopteris formosana (Christ) C. Chr. Plants	Others
Phloroglucide is a natural product that can be isolated from ferns .

Pseudoaspidin	Infection Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Plants Disease Research Fields	Others
Pseudoaspidin is isolated from the ferns of the class Pterophyta or Filicinae .

2',3'-Dihydro-2'-hydroxyprotoapigenone	Structural Classification Flavonoids Flavones Source classification Equisetum fluviatile L. Plants Equisetaceae	Others
2',3'-Dihydro-2'-hydroxyprotoapigenone is a natural protoflavonoid found in ferns impair .

Pterisolic acid B	Structural Classification Terpenoids Source classification Pteridaceae Diterpenoids Plants Pteris semipinnata L. Sp.	Keap1-Nrf2
Pterisolic acid B (Compound 2) is an ent-Kaurane diterpenoid. Pterisolic acid B can be isolated from fern Pteris semipinnata (Pteridaceae) .

Multiflorin B	Structural Classification Lepisorus palmatopedatus (Baker) C. F. Zhao, R. Wei & X. C. Zhang Flavonoids Flavones Source classification Polypodiaceae Plants	NO Synthase
Multiflorin B (compound 5) is a kind of kaempferol glycoside. Multiflorin B can be isolated from the root of the fern Neocheiropteris palmatopedata. Multiflorin B inhibits nitric oxide production at a concentration of 20 μg/ml with an inhibition of 52% .

Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside	Structural Classification Ophioglossum vulgatum L. Source classification Ophioglossaceae Phenols Polyphenols Plants	Others
Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside can be isolated from the aerial parts of the fern Ophioglossum vulgatum L and has wound healing activity .

Protoapigenone	Structural Classification Flavonoids Flavones Source classification Plants Macrothelypteris torresiana (Gaud.) Ching Thelypteridaceae	Others
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .

2,16,19-Kauranetriol 2-O-β-D-allopyranoside	Classification of Application Fields Terpenoids Source classification Pteridaceae Other Diseases Diterpenoids Plants Disease Research Fields Archidendron jiringa	Others
2,16,19-Kauranetriol 2-O-β-D-allopyranoside is an ent-kaurane glycoside, which can be isolated from the fronds of Pteris cretica .

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Structural Classification Terpenoids Source classification Pteridaceae Diterpenoids Plants Pteris semipinnata L. Sp.	Tyrosinase
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

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fern

Inhibitors & Agonists

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