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Results for "

fibrinogen

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Autophagy (2) Bacterial (2) Complement System (1) Estrogen Receptor/ERR (1) Factor Xa (2) Fluorescent Dye (4) Integrin (8) Interleukin Related (1) NF-κB (1) Thrombin (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (23) Infection (1) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125864

Fibrinogen (Bovine)	Interleukin Related NF-κB	Inflammation/Immunology
Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

HY-P0074A

GPRP acetate 1 Publications Verification Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate	Integrin	Cardiovascular Disease
GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-P3537

AGDV

Others Cardiovascular Disease

AGDV is the γ chain of fibrinogen. AGDV is critical for platelet aggregation .
HY-117824

L-703014

Others Others

L-703014 is a fibrinogen receptor antagonist, with the IC₅₀ of 94 nM, that acts as a novel parenteral and potential oral antithrombotic agent .

AGDV	Others	Cardiovascular Disease
AGDV is the γ chain of fibrinogen. AGDV is critical for platelet aggregation .

L-703014	Others	Others
L-703014 is a fibrinogen receptor antagonist, with the IC₅₀ of 94 nM, that acts as a novel parenteral and potential oral antithrombotic agent .

HY-P0074

GPRP Gly-Pro-Arg-Pro; Pefa 6003	Integrin	Cardiovascular Disease
GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-10315

Elarofiban RWJ-53308	Integrin	Cardiovascular Disease
Elarofiban (RWJ-53308) is a nonpeptide, orally active fibrinogen receptor antagonist. Elarofiban has the potential for platelet mediated thrombotic disorders research .

HY-149833

ERRγ inverse agonist 2	Estrogen Receptor/ERR	Infection Metabolic Disease
ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a K_d value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities .

HY-P3726

Lys-Gln-Ala-Gly-Asp-Val	Integrin	Inflammation/Immunology Cancer
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α_2bβ₃ integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .

HY-123275A

H-D-Phe-Pip-Arg-pNA hydrochloride S-2238 hydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform .

HY-123275

H-D-Phe-Pip-Arg-pNA S-2238	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform .

HY-123275C

H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) dihydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA dihydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA dihydrochloride is sensitive, accurate, and easy to perform .

HY-123275B

H-D-Phe-Pip-Arg-pNA acetate S-2238 acetate	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) acetate, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA acetate is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA acetate is sensitive, accurate, and easy to perform .

HY-19163

SC-52012

Others Cardiovascular Disease

HY-19163 is an orally active fibrinogen receptor antagonist, with antiplatelet activities.

SC-52012	Others	Cardiovascular Disease
HY-19163 is an orally active fibrinogen receptor antagonist, with antiplatelet activities.

HY-E70231

Defibrase, deinagkistrodonacutus	Others	Cardiovascular Disease
Defibrase, deinagkistrodonacutus is a proteolytic enzyme extraction of Agkistrodon halys venom. Defibrase can be used for degradation of fibrinogen. Defibrase can exacerbate myosin-induced EAM (experimental autoimmune myositis). Defibrase can be used for degradation of fibrinogen. Defibrase is commonly used for research of acute ischemic cerebrovascular disease, thromboangiitis obliterans, deep phlebitis and sudden deafness .

HY-N1400

(20R)-Ginsenoside Rh1

(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .

(20R)-Ginsenoside Rh1
(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .

HY-142123

Fluocortolone	Others	Inflammation/Immunology
Fluocortolone is an orally active anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adjuvanted joint inflammation (3-12 mg/kg) .

HY-114164A

Human α-Thrombin EC 3.4.21.5; Human Alpha Thrombin	Thrombin	Cardiovascular Disease
Human α-thrombin is a multifunctional serine protease that plays a pivotal role in the coagulation pathway. Human α-thrombin cleaves fibrinogen and converts it into fibrin. Human α-thrombin can stimulate platelet activation and stabilize fibrin polymers .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-17369

Tirofiban hydrochloride monohydrate 1 Publications Verification L700462 hydrochloride monohydrate; MK383 hydrochloride monohydrate	Integrin	Cardiovascular Disease
Tirofiban (L700462) hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits *fibrinogen* binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride monohydrate induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .

HY-17369B

Tirofiban 1 Publications Verification L700462; MK383	Integrin	Cardiovascular Disease
Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits *fibrinogen* binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .

HY-17369A

Tirofiban hydrochloride L700462 hydrochloride; MK383 hydrochloride	Integrin	Cardiovascular Disease
Tirofiban (L700462) hydrochloride is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits *fibrinogen* binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .

HY-117983

RU-505	Amyloid-β	Neurological Disease
RU-505 is an effective β-amyloid (Aβ)-fibrinogen interaction inhibitor with IC₅₀s of 5.00 and 2.72 μM in fluorescence polarization (FP) and AlphaLISA assays, respectively. RU-505 is highly permeable to the BBB. RU-505 reduces cerebral amyloid angiopathy (CAA). RU-505 can be used for the research of Alzheimer’s disease (AD) .

HY-15701

Leukadherin-1 2 Publications Verification	Integrin Complement System	Inflammation/Immunology
Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC₅₀ of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling .

Cat. No.	Product Name

HY-L136

Coagulation and Anti-coagulation Compound Library	965 compounds
Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation. Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process. MCE supplies a unique collection of 965 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Coagulation and Anti-coagulation Compound Library

965 compounds

Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation.

Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process.

MCE supplies a unique collection of 965 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Cat. No.	Product Name	Type

HY-125864

Fibrinogen (Bovine)	Native Proteins
Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

Fibrinogen (Bovine)

Native Proteins

Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Cell Assay Reagents
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Cell Assay Reagents
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

Cat. No.	Product Name	Target	Research Area

HY-P1741

Fibrinogen-Binding Peptide 1 Publications Verification	Peptides	Cardiovascular Disease
Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin .

HY-P1741A

Fibrinogen-Binding Peptide TFA 1 Publications Verification	Peptides	Cardiovascular Disease
Fibrinogen-Binding Peptide TFA (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide TFA binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin .

HY-P1507

Fibrinogen Binding Inhibitor Peptide	Peptides	Cardiovascular Disease
Fibrinogen Binding Inhibitor Peptide is a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411). Fibrinogen Binding Inhibitor Peptide is a specific binding site of the ligand for activated glycoprotein (GP) IIb/IIIa.

HY-P3531

Fibrinogen γ-chain (397-411)	Peptides	Others
Fibrinogen γ-chain (397-411), a esidues 397-411 of the γ chain of fibrinogen, is a site recognizing the platelet receptor, which is distinct from the site(s) involved in polymerization of fibrin monomers .

HY-P5121

*γ-Fibrinogen* 377-395**	Peptides	Cardiovascular Disease
γ-Fibrinogen377-395 is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation .

HY-P5121A

*γ-Fibrinogen* 377-395 TFA**	Peptides	Cardiovascular Disease
γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation .

HY-P5991

K-Casein (106-116),bovine	Peptides	Cardiovascular Disease
K-Casein (106-116),bovine is a peptide that inhibits platelet aggregation and fibrinogen binding, plays an important role in atherosclerosis .

HY-P0074

GPRP Gly-Pro-Arg-Pro; Pefa 6003	Integrin	Cardiovascular Disease
GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-P0074A

GPRP acetate 1 Publications Verification Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate	Integrin	Cardiovascular Disease
GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-P3726

Lys-Gln-Ala-Gly-Asp-Val	Integrin	Inflammation/Immunology Cancer
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α_2bβ₃ integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .

HY-123275A

H-D-Phe-Pip-Arg-pNA hydrochloride S-2238 hydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform .

HY-123275

H-D-Phe-Pip-Arg-pNA S-2238	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform .

HY-123275C

H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) dihydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA dihydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA dihydrochloride is sensitive, accurate, and easy to perform .

HY-123275B

H-D-Phe-Pip-Arg-pNA acetate S-2238 acetate	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) acetate, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA acetate is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA acetate is sensitive, accurate, and easy to perform .

HY-P0309

Arg-Gly-Glu-Ser

Peptides Cancer

Arg-Gly-Glu-Ser is a RGD-related peptide and a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets.
HY-P0314

Arg-Gly-Asp-Cys

Peptides Others

Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and can inhibit platelet aggregation and fibrinogen binding.
HY-P1493

Fibrinopeptide B, human

FPB,human
Peptides Inflammation/Immunology

Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.
HY-P0309A

Arg-Gly-Glu-Ser TFA

Peptides Others

Arg-Gly-Glu-Ser TFA is a RGD-related peptide and a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets.

Arg-Gly-Glu-Ser	Peptides	Cancer
Arg-Gly-Glu-Ser is a RGD-related peptide and a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets.

HY-P1538

Fibrinopeptide A, human Human fibrinopeptide A	Peptides	Cardiovascular Disease
Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH₂-termini of the Aα chain.

HY-P1493A

Fibrinopeptide B, human TFA FPB,human TFA	Peptides	Inflammation/Immunology
Fibrinopeptide B, human TFA (FPB,human TFA), human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin .

HY-P1538A

Fibrinopeptide A, human TFA Human fibrinopeptide A TFA	Peptides	Cardiovascular Disease
Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH₂-termini of the Aα chain .

HY-P0314A

Arg-Gly-Asp-Cys TFA	Peptides	Cardiovascular Disease
Arg-Gly-Asp-Cys TFA is the binding motif of fibronectin to cell adhesion molecules. Arg-Gly-Asp-Cys TFA can inhibit platelet aggregation and fibrinogen binding .

HY-P10045

Integrin signaling inhibitor, mP13	Peptides	Cardiovascular Disease
Integrin signaling inhibitor, mP13 is an inhibitor of integrin signaling. Integrin signaling inhibitor, mP13 inhibits inside-out and outside-in signaling, including fibrinogen binding, platelet adhesion, and clot retraction .

HY-P0308

[Glu1]-Fibrinopeptide B	Peptides	Cardiovascular Disease
[Glu1]-Fibrinopeptide B is derived from fibrinopeptide B amino acid residues 1-14. Human fibrinopeptide B (hFpB), a thrombin-derived proteolytic cleavage product of the fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts.

Species:	Human (10) Rhesus Macaque (1) Mouse (5) Rat (2) Cynomolgus (5) Staphylococcus aureus (3)
Tag:	His (16) Tag Free (3) Avi (8) GST (1) Fc (6) Flag (8)
Source:	HEK293 (17) P. pastoris (3) Sf9 insect cells (3) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72291

	Clumping factor B Protein, S. aureus (His) fibrinogen receptor B; fibrinogen-binding protein B	Staphylococcus aureus	E. coli
	Clumping factor B (ClfB) is a cell surface-associated protein implicated in virulence, playing a crucial role in bacterial pathogenicity by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen. Its significance lies in inducing the formation of bacterial clumps, a mechanism that contributes to the pathogenicity and virulence of the bacteria. Clumping factor B Protein, S. aureus (His) is the recombinant Staphylococcus aureus-derived Clumping factor B protein, expressed by E. coli , with N-His labeled tag. The total length of Clumping factor B Protein, S. aureus (His) is 498 a.a., with molecular weight of ~80 kDa.

HY-P75772

	*FGG/Fibrinogen* gamma chain Protein, Human (P.pastoris)** fibrinogen gamma chain; FGG; PRO2061	Human	P. pastoris
	FGG/fibrinogen gamma chain proteins polymerize together with FGA and FGB to form the fibrin matrix, which is essential for blood clot formation. In addition to coagulation, it aids in early wound repair, stabilizes lesions, and guides cell migration. FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) is the recombinant human-derived FGG/Fibrinogen gamma chain protein, expressed by P. pastoris , with tag free. The total length of FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) is 285 a.a., with molecular weight of ~32.2 kDa.

HY-P702579

FGG/Fibrinogen gamma chain Protein, Mouse (P.pastoris, Tag Free)

fibrinogen gamma chain; FGG; PRO2061
Mouse P. pastoris

HY-P71829

	Clumping factor A Protein, S. aureus (P.pastoris, His) clfA; fibrinogen receptor A; fibrinogen-binding protein A	Staphylococcus aureus	P. pastoris
	Clumping factor A protein facilitates bacterial attachment to human fibrinogen gamma-chain, promoting the formation of bacterial clumps. It is a cell surface-associated protein and plays a role in bacterial virulence. Clumping factor A Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Clumping factor A protein, expressed by P. pastoris , with N-His labeled tag. The total length of Clumping factor A Protein, S. aureus (P.pastoris, His) is 331 a.a., with molecular weight of ~38.5 kDa.

HY-P71581

	Clumping factor A Protein, S. aureus clfA; SAS0752; Clumping factor A; fibrinogen receptor A; fibrinogen-binding protein A	Staphylococcus aureus	E. coli
	Clustering factor A (ClfA) is a virulence-related cell surface-associated protein that plays a key role in bacterial pathogenicity. It promotes bacterial attachment exclusively to the gamma chain of human fibrinogen, demonstrating the specificity of its interaction with host proteins. Clumping factor A Protein, S. aureus is the recombinant Staphylococcus aureus-derived Clumping factor A protein, expressed by E. coli , with tag free. The total length of Clumping factor A Protein, S. aureus is 331 a.a., with molecular weight of ~36.1 kDa.

HY-P701078

	FGL2 Protein, Human (HEK293, hFc-Flag) Fibroleukin; pT49; FGL2; fibrinogen-like 2	Human	HEK293
	FGL2 protein is involved in immune responses specific to mucosal tissues, regulating physiologic lymphocyte functions. It forms disulfide-linked homotetramers, indicating its quaternary structure. Studying how FGL2 influences lymphocyte functions and its homotetrameric organization can provide insights into its role in mucosal immunity and immune system regulation. FGL2 Protein, Human (HEK293, hFc-Flag) is the recombinant human-derived FGL2 protein, expressed by HEK293 , with N-hFc, N-Flag labeled tag. The total length of FGL2 Protein, Human (HEK293, hFc-Flag) is 235 a.a., with molecular weight of 60-70 kDa.

HY-P700721

	FGL2 Protein, Human (HEK293, His-Avi, Flag) Fibroleukin; pT49; FGL2; fibrinogen-like 2	Human	HEK293
	FGL2 protein is involved in immune responses specific to mucosal tissues, regulating physiologic lymphocyte functions. It forms disulfide-linked homotetramers, indicating its quaternary structure. Studying how FGL2 influences lymphocyte functions and its homotetrameric organization can provide insights into its role in mucosal immunity and immune system regulation. FGL2 Protein, Human (HEK293, His-Avi, Flag) is the recombinant human-derived FGL2 protein, expressed by HEK293, with C-Avi, N-His, N-Flag labeled tag. The total length of FGL2 Protein, Human (HEK293, His-Avi, Flag) is 235 a.a., with molecular weight of 40-50 kDa.

HY-P700990

	FGL2 Protein, Mouse (HEK293, His-Avi, Flag) 1 Publications Verification Fibroleukin; pT49; FGL2; fibrinogen-like 2	Mouse	HEK293
	FGL2 is a key enzyme in the coagulation cascade and plays a key role in the conversion of prothrombin to thrombin, reflecting its important contribution to hemostasis and coagulation processes. Structurally, FGL2 forms homotetramers characterized by disulfide bonds that contribute to its functional integrity and catalytic activity in the complex process of thrombin generation. FGL2 Protein, Mouse (HEK293, His-Avi, Flag) is the recombinant mouse-derived FGL2 protein, expressed by HEK293 , with C-Avi, N-His, N-Flag labeled tag. The total length of FGL2 Protein, Mouse (HEK293, His-Avi, Flag) is 236 a.a., with molecular weight of 40-50 kDa.

HY-P701059

	FGL2 Protein, Cynomolgus (HEK293, His-Avi, Flag) Fibroleukin; pT49; FGL2; fibrinogen-like 2	Cynomolgus	HEK293
	FGL2 is a key enzyme in the coagulation cascade and plays a key role in the conversion of prothrombin to thrombin, reflecting its important contribution to hemostasis and coagulation processes. Structurally, FGL2 forms homotetramers characterized by disulfide bonds that contribute to its functional integrity and catalytic activity in the complex process of thrombin generation. FGL2 Protein, Cynomolgus (HEK293, His-Avi, Flag) is the recombinant cynomolgus-derived FGL2 protein, expressed by HEK293 , with C-Avi, N-His, N-Flag labeled tag. The total length of FGL2 Protein, Cynomolgus (HEK293, His-Avi, Flag) is 235 a.a., with molecular weight of 40-50 kDa.

HY-P700987

	FGL2 Protein, Human (Biotinylated, HEK293, His-Avi, Flag) Fibroleukin; pT49; FGL2; fibrinogen-like 2	Human	HEK293
	FGL2 protein is involved in immune responses specific to mucosal tissues, regulating physiologic lymphocyte functions. It forms disulfide-linked homotetramers, indicating its quaternary structure. Studying how FGL2 influences lymphocyte functions and its homotetrameric organization can provide insights into its role in mucosal immunity and immune system regulation. FGL2 Protein, Human (Biotinylated, HEK293, His-Avi, Flag) is the recombinant human-derived FGL2 protein, expressed by HEK293 , with C-Avi, N-His, N-Flag labeled tag. The total length of FGL2 Protein, Human (Biotinylated, HEK293, His-Avi, Flag) is 235 a.a., with molecular weight of 40-55 kDa.

HY-P700988

	FGL2 Protein, Mouse (Biotinylated, HEK293, His-Avi, Flag) Fibroleukin; pT49; FGL2; fibrinogen-like 2	Mouse	HEK293
	FGL2 is a key enzyme in the coagulation cascade and plays a key role in the conversion of prothrombin to thrombin, reflecting its important contribution to hemostasis and coagulation processes. Structurally, FGL2 forms homotetramers characterized by disulfide bonds that contribute to its functional integrity and catalytic activity in the complex process of thrombin generation. FGL2 Protein, Mouse (Biotinylated, HEK293, His-Avi, Flag) is the recombinant mouse-derived FGL2 protein, expressed by HEK293 , with C-Avi, N-His, N-Flag labeled tag. The total length of FGL2 Protein, Mouse (Biotinylated, HEK293, His-Avi, Flag) is 236 a.a., with molecular weight of 40-50 kDa.

HY-P700989

	FGL2 Protein, Rat (Biotinylated, HEK293, His-Avi, Flag) Fibroleukin; pT49; FGL2; fibrinogen-like 2	Rat	HEK293
	FGL2 is a key enzyme in the coagulation cascade and plays a key role in the conversion of prothrombin to thrombin, reflecting its important contribution to hemostasis and coagulation processes. Structurally, FGL2 forms homotetramers characterized by disulfide bonds that contribute to its functional integrity and catalytic activity in the complex process of thrombin generation. FGL2 Protein, Rat (Biotinylated, HEK293, His-Avi, Flag) is the recombinant rat-derived FGL2 protein, expressed by HEK293 , with C-Avi, N-His, N-Flag labeled tag. The total length of FGL2 Protein, Rat (Biotinylated, HEK293, His-Avi, Flag) is 235 a.a., with molecular weight of 45-55 kDa.

HY-P701058

	FGL2 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi, Flag) Fibroleukin; pT49; FGL2; fibrinogen-like 2	Cynomolgus	HEK293
	FGL2 is a key enzyme in the coagulation cascade and plays a key role in the conversion of prothrombin to thrombin, reflecting its important contribution to hemostasis and coagulation processes. Structurally, FGL2 forms homotetramers characterized by disulfide bonds that contribute to its functional integrity and catalytic activity in the complex process of thrombin generation. FGL2 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi, Flag) is the recombinant cynomolgus-derived FGL2 protein, expressed by HEK293 , with C-Avi, N-His, N-Flag labeled tag. The total length of FGL2 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi, Flag) is 235 a.a., with molecular weight of 40-50 kDa.

HY-P72642

	FGL1 Protein, Cynomolgus (HEK293, His) fibrinogen like 1; FGL1	Cynomolgus	HEK293
	Fibrinogen like 1 (FGL1) is a proliferation- and metabolism-related protein secreted by the liver. FGL1 is also upregulated in tumor tissues. FGL1 is a checkpoint ligand of lymphocyte activation gene 3 (LAG3). When binding to LAG3, FGL1 can inhibit T cell activation and proliferation. FGL1 can be used for research of immune checkpoint therapy. FGL1 plays a role in proliferation, metabolism, apoptosis, epithelial-to-mesenchymal transition, and immune infiltration. FGL1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGL1 Protein, Cynomolgus (HEK293, His) is 290 a.a., with molecular weight of ~35 kDa.

HY-P70737

	FGL1 Protein, Human (HEK293, His) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein, a major ligand for LAG3, suppresses antigen-specific T-cell activation, mediating LAG3's inhibitory function independently of MHC-II binding. Secreted by hepatocytes, FGL1 contributes to their growth. Existing as a homodimer, FGL1 interacts with LAG3 through its Fibrinogen C-terminal domain, specifically binding to LAG3's Ig-like domains 1 and 2. This interaction underscores FGL1's significance in modulating immune responses and hepatocyte growth, positioning it as a key regulator of T-cell activation and hepatic functions. FGL1 Protein, Human (HEK293, His) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGL1 Protein, Human (HEK293, His) is 290 a.a., with molecular weight of ~35.0 kDa.

HY-P70740

	FGL1 Protein, Human (HEK293, mFc) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, mFc) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGL1 Protein, Human (HEK293, mFc) is 290 a.a., with molecular weight of 60-65 kDa.

HY-P75188

	FGL1 Protein, Mouse (sf9, His) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Mouse	Sf9 insect cells
	FGL1 Protein, a potent immune suppressive molecule, inhibits antigen-specific T-cell activation as a major ligand for LAG3. It crucially contributes to LAG3-mediated T-cell inhibitory functions, independently of MHC class II. Secreted by hepatocytes, FGL1 also promotes their growth. The homodimeric form of the protein interacts with LAG3, specifically engaging with its Ig-like domains 1 and 2 through the Fibrinogen C-terminal domain. FGL1 Protein, Mouse (sf9, His) is the recombinant mouse-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FGL1 Protein, Mouse (sf9, His) is 314 a.a., with molecular weight of ~35.5 kDa.

HY-P75189

	FGL1 Protein, Mouse (HEK293, hFc) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Mouse	HEK293
	The FGL1 protein has signaling receptor binding activity and negatively regulates T cell activation and immune response. It is involved in adipose tissue development, cholesterol metabolism, and response to stilbenoid. FGL1 is located in the extracellular region and is orthologous to the human FGL1 gene. It is primarily expressed in the liver at the E18 stage. FGL1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived FGL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGL1 Protein, Mouse (HEK293, hFc) is 292 a.a., with molecular weight of ~60.08 kDa.

HY-P75771

	FGL1 Protein, Rat (sf9, His) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Rat	Sf9 insect cells
	The FGL1 protein is a key immunosuppressant that acts as the primary ligand of LAG3 to inhibit antigen-specific T cell activation. FGL1 is essential for the T cell suppressor function of LAG3, which is independent of MHC class II (MHC-II) binding. FGL1 is secreted by hepatocytes and actively promotes their growth. FGL1 Protein, Rat (sf9, His) is the recombinant rat-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FGL1 Protein, Rat (sf9, His) is 314 a.a., with molecular weight of ~35.48 kDa.

HY-P77366

	FGL1 Protein, Cynomolgus (HEK293, Fc) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Cynomolgus	HEK293
	FGL1 is a specific hepatocyte mitogen, regulates the expression of proliferative factors, promoting liver regeneration and repairing liver injury. FGL1 inhibits T-cell activation by binding to LAG3. FGL1 promotes cell proliferation by activating the ERK/p-ERK pathway. FGL1 inhibits apoptosis of non-small cell lung cancer (NSCLC) cells by inhibiting PARP1/caspase 3 pathway. FGL1 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGL1 Protein, Cynomolgus (HEK293, Fc) is 312 a.a., with molecular weight of ~56.94 KDa.

HY-P77367

	FGL1 Protein, Cynomolgus (sf9, His) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Cynomolgus	Sf9 insect cells
	FGL1 is a specific hepatocyte mitogen, regulates the expression of proliferative factors, promoting liver regeneration and repairing liver injury. FGL1 inhibits T-cell activation by binding to LAG3. FGL1 promotes cell proliferation by activating the ERK/p-ERK pathway. FGL1 inhibits apoptosis of non-small cell lung cancer (NSCLC) cells by inhibiting PARP1/caspase 3 pathway. FGL1 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FGL1 Protein, Cynomolgus (sf9, His) is 312 a.a., with molecular weight of ~35.40 KDa.

HY-P70740A

	FGL1 Protein, Human (HEK293, mFc, solution) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, mFc, solution) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGL1 Protein, Human (HEK293, mFc, solution) is 290 a.a., with molecular weight of 60-65 kDa.

HY-P72369

	FGL1 Protein, Human (Biotinylated, 290a.a, HEK293, Avi-His) fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, 290a.a, HEK293, Avi-His) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of FGL1 Protein, Human (Biotinylated, 290a.a, HEK293, Avi-His) is 290 a.a., with molecular weight of ~35 kDa.

HY-P76930

	Ficolin-1 Protein, Human (HEK293, His) Ficolin-1; Collagen/fibrinogen domain-containing protein 1; Ficolin-A; FCNM	Human	HEK293
	IFN-β protein is a recombinant protein that does not use any animal-derived components in its production. It is used in biomedical research and drug manufacturing as a therapeutic agent for a variety of diseases, including multiple sclerosis. Ficolin-1 Protein, Human (HEK293, His) is the recombinant human-derived Ficolin-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ficolin-1 Protein, Human (HEK293, His) is 297 a.a., with molecular weight of 33-38 kDa.

HY-P77368

	Ficolin-1 Protein, Rhesus Macaque (HEK293, Fc) Collagen/fibrinogen domain-containing protein 1; Ficolin-A; M-ficolin; FCN1; FCNM	Rhesus Macaque	HEK293
	Ficolin-1 functions locally after inflammatory lesions in monocyte, macrophage, and granulocyte secretion, and is also present in serum, suggesting that it may play a role in systemic immunity. Ficolins recognize and bind to pathogens, leading to neutralization and conditioning, which subsequently activates the complement lectin pathway. Ficolin-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Ficolin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ficolin-1 Protein, Rhesus Macaque (HEK293, Fc) is 297 a.a., with molecular weight of ~59.1 KDa.

HY-P700562

	ANGPTL4/Angiopoietin-related 4 Protein, Human (GST) Angiopoietin-like protein 4Hepatic fibrinogen/angiopoietin-related protein ; HFARP	Human	E. coli
	ANGPTL4 protein mediates lipoprotein lipase (LPL) inactivation, regulating triglyceride clearance and lipid metabolism. It also affects glucose homeostasis, insulin sensitivity, endothelial cell function, and angiogenesis. Cleaved ANGPTL4 is more active in LPL inactivation, highlighting its multifaceted role in metabolic and vascular regulation. ANGPTL4/Angiopoietin-related 4 Protein, Human (GST) is the recombinant human-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by E. coli, with N-GST labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Human (GST) is 376 a.a., with molecular weight of 69.6 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P82151

Fibrinogen gamma Chain Antibody (YA1896)

FGG; fibrinogen gamma chain
WB, FC Human
HY-P82324

Fibrinogen alpha Chain Antibody (YA2069)

Fba5e; FGA; Fib; Fib2; Fibrinopeptide A
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

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