fluoride

By Targets:	ADC Linker (1) Amino Acid Derivatives (1) Biochemical Assay Reagents (8) Cathepsin (1) E3 Ligase Ligand-Linker Conjugates (1) Endothelin Receptor (1) Fluorescent Dye (1) Ligands for E3 Ligase (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W087383

Thalidomide 5-fluoride	Ligands for E3 Ligase	Cancer
Thalidomide 5-fluoride is Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

HY-Y0971

*Tetrabutylammonium (fluoride)* TBAF	Biochemical Assay Reagents	Others
Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.

HY-Y0415

*Tetraethylammonium (fluoride)* N,N,N-triethylethanaminium (fluoride)
Tetraethylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetraethylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it is used as a catalyst for organic reactions and as a surfactant in the production of semiconductors and microelectronics.

HY-134983

Thalidomide-Piperazine 5-fluoride	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-W145436

*Thalidomide-Piperazine 5-fluoride* hydrochloride**	Ligands for E3 Ligase	Cancer
Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis .

HY-W095635

*Tetramethylammonium fluoride* tetrahydrate**	Biochemical Assay Reagents	Others
Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

HY-W127635

*Tetraethylammonium (fluoride* trihydrofluoride)**	Biochemical Assay Reagents	Others
Tetraethylammonium fluoride trihydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127636

*Tetraethylammonium (fluoride* tetrahydrofluoride)**	Biochemical Assay Reagents	Others
Tetraethylammonium Fluoride Tetrahydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-41547

Thalidomide 4-fluoride Cereblon ligand 4; E3 ligase Ligand 4	Ligands for E3 Ligase	Cancer
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) .

HY-W145623

2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl fluoride 2,3,4,6-Tetra-O-benzyl-beta-D-glucopyranosyl fluoride	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145636

2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl fluoride 2,3,4,6-Tetra-O-benzyl-alpha-D-glucopyranosyl fluoride	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145533

2,3,4,6-Tetrakis-O-(phenylmethyl)-D-glucopyranosyl fluoride	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-benzyl-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-135859

NH2-MPAA-NODA	ADC Linker	Cancer
NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone . NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

HY-W145569

2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl fluoride (3,4,5-Triacetyloxy-6-fluorooxan-2-yl)methyl acetate	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-B0496

PMSF 60+ Cited Publications Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride	Cathepsin	Others
PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates.

HY-D0133

NBD-X acid	Fluorescent Dye	Others
NBD-X acid is a fluorescent probe for the study of fatty acids and sterols. NBD-X acid provides better yields for labelling biopolymers compared to NBD chloride and fluoride. The fluorescence spectrum of the NBD derivative is highly sensitive to the environment and the fluorescence intensity is significantly reduced in aqueous solutions .

HY-P2496

*Endothelin 1 (swine, human), Alexa Fluor* 488-labeled**	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-141464

Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH Fmoc-Asn(Ac3AcNH-beta-Glc)-OH	Amino Acid Derivatives	Cancer
Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET) .

Cat. No.	Product Name

HY-L036

Covalent Screening Library	1670 compounds
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 1670 small molecules including identified covalent inhibitors and other bioactive molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, Sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

Covalent Screening Library

1670 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE covalent inhibitor library contains 1670 small molecules including identified covalent inhibitors and other bioactive molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, Sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

HY-L036P

Covalent Screening Library Plus	2988 compounds
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 2988 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc. MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

Covalent Screening Library Plus

2988 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE covalent inhibitor library contains 2988 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

Cat. No.	Product Name	Type

HY-D0133

NBD-X acid	Fluorescent Dyes/Probes
NBD-X acid is a fluorescent probe for the study of fatty acids and sterols. NBD-X acid provides better yields for labelling biopolymers compared to NBD chloride and fluoride. The fluorescence spectrum of the NBD derivative is highly sensitive to the environment and the fluorescence intensity is significantly reduced in aqueous solutions .

Cat. No.	Product Name	Type

HY-Y0971

*Tetrabutylammonium (fluoride)* TBAF	Biochemical Assay Reagents
Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.

Tetrabutylammonium (fluoride)

TBAF

Biochemical Assay Reagents

Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.

HY-W095635

*Tetramethylammonium fluoride* tetrahydrate**	Biochemical Assay Reagents
Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

Tetramethylammonium fluoride tetrahydrate

Biochemical Assay Reagents

Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

HY-W127635

*Tetraethylammonium (fluoride* trihydrofluoride)**	Biochemical Assay Reagents
Tetraethylammonium fluoride trihydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127636

*Tetraethylammonium (fluoride* tetrahydrofluoride)**	Biochemical Assay Reagents
Tetraethylammonium Fluoride Tetrahydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145623

2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl fluoride 2,3,4,6-Tetra-O-benzyl-beta-D-glucopyranosyl fluoride	Biochemical Assay Reagents
2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145636

2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl fluoride 2,3,4,6-Tetra-O-benzyl-alpha-D-glucopyranosyl fluoride	Biochemical Assay Reagents
2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145533

2,3,4,6-Tetrakis-O-(phenylmethyl)-D-glucopyranosyl fluoride	Biochemical Assay Reagents
2,3,4,6-Tetra-O-benzyl-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145569

2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl fluoride (3,4,5-Triacetyloxy-6-fluorooxan-2-yl)methyl acetate	Biochemical Assay Reagents
2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P2496

*Endothelin 1 (swine, human), Alexa Fluor* 488-labeled**	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

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