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Targets Recommended: Free Fatty Acid Receptor
Results for "

free radicals

" in MCE Product Catalog:

80

Inhibitors & Agonists

1

Screening Libraries

2

Dye Reagents

3

Biochemical Assay Reagents

1

Peptides

42

Natural
Products

9

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas
  • HY-106408
    Nelonemdaz

    Salfaprodil free base; Neu2000

    iGluR Neurological Disease
    Nelonemdaz (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz is also a free radical scavenger. Nelonemdaz has excellent neuroprotection against NMDA- and free radical-induced cell death.
  • HY-106408A
    Nelonemdaz potassium

    Salfaprodil; Neu2000 potassium

    iGluR Neurological Disease
    Nelonemdaz (Salfaprodil) potassium is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz potassium is also a free radical scavenger. Nelonemdaz potassium has excellent neuroprotection against NMDA- and free radical-induced cell death.
  • HY-114713
    POBN

    4-POBN

    Others Others
    POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts.
  • HY-N7518
    Eulophiol

    Others Inflammation/Immunology
    Eulophiol shows the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity with an EC50 of 27.7μM. Antioxidant activity.
  • HY-N1859
    3'-O-Methylorobol

    Others Metabolic Disease Inflammation/Immunology
    3'-O-Methylorobol, an antioxidant flavonoid, exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay.
  • HY-W015913
    Sodium 2-oxopropanoate

    Sodium pyruvate

    Reactive Oxygen Species Endogenous Metabolite Metabolic Disease
    Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.
  • HY-125568
    Pyridoxatin

    Others Others
    Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E.
  • HY-N10176
    D-Isofloridoside

    Reactive Oxygen Species MMP Cardiovascular Disease
    D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9.
  • HY-N10294
    Epicoccone B

    HIV Infection Inflammation/Immunology
    Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC50 value of 10.8 μM, and has potent α-glucosidase inhibition with IC50 value of 27.3 μM. Anti-HIV activity.
  • HY-N3220
    Myricetin 3-O-galactoside

    Xanthine Oxidase Metabolic Disease
    Myricetin 3-O-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical. Myricetin 3-O-galactoside inhibits lipid peroxidation with an IC50 of 160 μg/mL. Antioxidant activity.
  • HY-W273690
    Pentifylline

    1-Hexyltheobromine; Hexyltheobromine

    Others Cardiovascular Disease
    Pentifylline is a vasodilator. Pentifylline inhibits platelet aggregation and thromboxane A2 synthesis, decrease the release of free radicals. Pentifylline has the potential for the research of acute ischaemic stroke.
  • HY-150585
    BuChE-IN-5

    Amyloid-β Cholinesterase (ChE) Tau Protein Neurological Disease
    BuChE-IN-5 (compound 25b) is a potent BuChE inhibitor with an IC50 value of 1.94 μM. BuChE-IN-5 efficiently inhibits aggregation and tau protein in Escherichia coli. BuChE-IN-5 also has free radical scavenging capacity and antioxidant activity. BuChE-IN-5 can be used for researching Alzheimer’s disease.
  • HY-N10295
    Flavipin

    Aryl Hydrocarbon Receptor Inflammation/Immunology
    Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 + T cells and CD11b + macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA. Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM.
  • HY-B1777
    Spermine

    NSC 268508; Neuridine

    Endogenous Metabolite Influenza Virus Infection Metabolic Disease
    Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.
  • HY-N0026
    2'-Acetylacteoside

    2'-AA

    Others Others
    2'-Acetylacteoside is a phenylethanoid glycoside isolated from Brandisia hancei, inhibits free radical-induced hemolysis of red blood cells and exhibits free radical scavenging activity.
  • HY-N1449
    Neonuezhenide

    Others Others
    Neonuezhenide exhibits strong antioxidant effect against hemolysis of red blood cells induced by free radicals.
  • HY-W076778
    Monoethyl itaconate

    Others Others
    Monoethyl itaconate is a free radical can be used for polymerization.
  • HY-N2628
    Erigeroside

    Others Metabolic Disease
    Erigeroside is as a derivatives of -glucose extracted from Satureja khuzistanica Jamzad. Erigeroside has good ability of anti-oxidation and scavenging oxidation free radical.
  • HY-N0091
    Hypoxanthine

    Purin-6-ol; Sarcine

    Endogenous Metabolite Others
    Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
  • HY-113248
    3-Nitro-L-tyrosine

    Endogenous Metabolite Metabolic Disease
    3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.
  • HY-N9370
    Isobellidifolin

    Fungal Infection
    Isobellidifolin, a xanthone, is a free radical scavenger and antioxidant compound. Isobellidifolin has potent antifungal effect.
  • HY-D0187
    L-Glutathione reduced

    GSH; γ-L-Glutamyl-L-cysteinyl-glycine

    Endogenous Metabolite Reactive Oxygen Species Ferroptosis Cancer Inflammation/Immunology Neurological Disease Cardiovascular Disease
    L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
  • HY-100297
    MK-447

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins.
  • HY-B1001A
    Todralazine hydrochloride

    Ecarazine hydrochloride

    Adrenergic Receptor Cardiovascular Disease Endocrinology
    Todralazine hydrochloride (Ecarazine hydrochloride) is an anti-hypertensive agent, acts as a β2AR blocker, with antioxidant and free radical scavenging activity.
  • HY-B0871
    Quinclorac

    Others Others
    Quinclorac, an herbicide widely applied in agriculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system.
  • HY-B1001
    Todralazine

    Ecarazine

    Adrenergic Receptor Cardiovascular Disease Endocrinology
    Todralazine (Ecarazine) is an anti-hypertensive agent, acts as a β2AR blocker, with antioxidant and free radical scavenging activity.
  • HY-N1430
    Oxyresveratrol

    trans-Oxyresveratrol

    Tyrosinase HSV Autophagy Others
    Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.
  • HY-N1579
    Pyrogallol

    Endogenous Metabolite Fungal Apoptosis Infection
    Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.
  • HY-B0099
    Edaravone

    MCI-186

    MMP Apoptosis Neurological Disease
    Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
  • HY-N4246
    Bacopaside I

    Others Neurological Disease
    Bacopaside I, a saponin isolated from Bacopa monniera, exbibits antioxidant properties and free radical scavenging capacity and exerts antidepressant-like effect.
  • HY-100768
    HTHQ

    1-O-hexyl-2,3,5-trimethylhydroquinone; HX-1171; BTT-105

    Reactive Oxygen Species Cancer
    HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) is a potent lipophilic phenolic antioxidant. HTHQ has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS) and scavenging ROS to form more stable free radicals.
  • HY-N7774
    Echinatine N-oxide

    Others Others
    Echinatine N-oxide is a pyrrolizidine alkaloid found in R. graeca.
  • HY-N8169
    10-O-Trans-p-methoxycinnamoylcatalpol

    Others Others
    10-O-Trans-p-methoxycinnamoylcatalpol has antioxidant activity with the IC50 value of 0.37 μM/mL in DPPH free radical scavenging assay.
  • HY-N7692
    Polyporusterone A

    Others Others
    Polyporusterone A is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone A has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis).
  • HY-135849
    Catalase

    Reactive Oxygen Species Cancer
    Catalase is a key enzyme in the metabolism of H2O2 and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors. Free oxygen radical scavenger.
  • HY-B1978
    Iprodione

    Fungal Reactive Oxygen Species Infection
    Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective.
  • HY-41121S1
    Boc-L-Ala-OH-3-13C

    Endogenous Metabolite Others
    Boc-L-Ala-OH-3-13C is a 13C-labeled Hypoxanthine. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
  • HY-N7693
    Polyporusterone B

    Others Others
    Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis).
  • HY-13244
    Disufenton sodium

    NXY-059

    Reactive Oxygen Species Neurological Disease
    Disufenton sodium (NXY-059) is the disulfonyl derivative of the neuroprotective spin trap phenylbutynitrone(PBN), both NXY-059, its parent PBN and their hydrolysis/oxidation product MNT are very powerful scavengers of free radicals.
  • HY-135152
    CYPMPO

    Others Cancer
    CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity.
  • HY-W012855S
    3-Mercapto-3-methylbutan-1-ol-d6

    Others Others
    3-Mercapto-3-methylbutan-1-ol-d6 is the deuterium labeled Hypoxanthine. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
  • HY-112053
    DPPH

    2,2-Diphenyl-1-picrylhydrazyl

    Others Metabolic Disease
    DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants.
  • HY-B0099S
    Edaravone-d5

    MCI-186-d5

    MMP Apoptosis Neurological Disease
    Edaravone D5 is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
  • HY-N1521
    Rehmannic acid

    Lantadene A

    Others Inflammation/Immunology
    Rehmannic acid (lantadene A) is a compound isolated from Lantana camara. Rehmannic acid shows considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner. Rehmannic acid is a promising candidate for use as an antioxidant and hepatoprotective agent.
  • HY-113248S
    3-Nitro-L-tyrosine-d3

    Endogenous Metabolite Metabolic Disease
    3-Nitro-L-tyrosine-d3 is the deuterium labeled 3-Nitro-L-tyrosine. 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.
  • HY-141898
    Biotin-4-aminophenol

    Others Others
    Biotin-4-aminophenol is a biotin-phenol analog. Biotin-4-aminophenol generates free radicals and conjugates to tyrosine residues in proteins more efficiently and selectively than the previously reported BP1.
  • HY-N1417
    Sesamol

    Apoptosis Cancer
    Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities. Anticancer activities.
  • HY-P1934A
    Cyclo(L-Phe-L-Pro)

    Fungal IFNAR Reactive Oxygen Species Cancer Inflammation/Immunology Infection
    Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay.
  • HY-N0523
    Gallic acid

    3,4,5-Trihydroxybenzoic acid

    COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite Cancer Metabolic Disease
    Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities.
  • HY-N0523A
    Gallic acid hydrate

    3,4,5-Trihydroxybenzoic acid hydrate

    COX Reactive Oxygen Species Apoptosis Ferroptosis Endogenous Metabolite Cancer Inflammation/Immunology
    Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities.
  • HY-W008016S
    Fmoc-Tyr(tBu)-OH-13C9,15N

    Endogenous Metabolite Others
    Fmoc-Tyr(tBu)-OH-13C9,15N is a 15N-labeled and 13C-labled Hypoxanthine. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
  • HY-N0513
    Loganic acid

    Others Inflammation/Immunology Cardiovascular Disease
    Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity.
  • HY-136476B
    Cu(II) protoporphyrin IX

    Others Cancer Inflammation/Immunology
    Cu (II) Protoporphyrin IX is used as a negative control for Zn (II) Protoporphyrin (an inihibitor of heme oxygenase). Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair.
  • HY-N3138
    Ombuoside

    Bacterial Infection
    Ombuoside is a glycoside ombuoside isolated from Gynostemma pentaphyllum.Ombuoside has antimicrobial activity against several strains of gram-positive and gram-negative bacteria and the yeast Candida albicans. Ombuoside has antioxidant effects by scavenging free radicals and ROS.
  • HY-N0136
    Taxifolin

    (+)-Dihydroquercetin; (+)-Taxifolin

    Autophagy Tyrosinase Inflammation/Immunology
    Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
  • HY-W009300S1
    4-Hydroxyestrone-13C6

    4-OHE1-13C6

    Endogenous Metabolite Others
    4-Hydroxyestrone-13C6 (4-OHE1-13C6) is a 13C-labeled Hypoxanthine. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
  • HY-W004520
    Phenazine methylsulfate

    5-Methylphenazinium methylsulfate

    Bacterial Antibiotic Apoptosis Others
    Phenazine methylsulfate is a free radical generator. Phenazine methylsulfate has been used as an electron transfer reactant in cell viability assays. Phenazine methylsulfate induces ssDNA break formation in the presence of the reducing agent NADPH. Phenazine methylsulfate induces oxidative DNA damage in an alkaline comet assay and apoptosis.
  • HY-N3847
    Eriodictyol-7-O-glucoside

    Eriodictyol 7-O-β-D-glucoside

    Keap1-Nrf2 Metabolic Disease
    Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is a potent free radical scavenger. Eriodictyol-7-O-glucoside is also an Nrf2 activator, confers protection against Cisplatin-induced toxicity.
  • HY-N0136A
    (±)-Taxifolin

    (±)-Dihydroquercetin

    Autophagy Tyrosinase Inflammation/Immunology
    (±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
  • HY-N0136B
    (-)-Taxifolin

    (-)-Dihydroquercetin

    Tyrosinase Inflammation/Immunology
    (-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
  • HY-N7648
    Atherosperminine

    Atherospermine

    Parasite Infection
    Atherosperminine(Atherospermine)is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC50 of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC50 of 29.56 µg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis.
  • HY-W017330
    Methacrylic anhydride

    Others Others
    Methacrylic anhydride is a typical polymerizable 1,6-diolefin. Methacrylic anhydride can form a soluble csyclopolymer by free-radical initiation. Methacrylic anhydride can spontaneously polymerize through the vinyl group and justifies the use of 2-6-di-tert-butyl4-methylphenol as an inhibitor.
  • HY-132828
    Odatroltide

    DHDMIQK(KAP)

    Others Metabolic Disease Inflammation/Immunology Cardiovascular Disease
    Odatroltide, as a nanoscale P-selectin inhibitor, is a nano-delivery system of 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to target the thrombus.
  • HY-N0136S
    Taxifolin-d3

    (+)-Dihydroquercetin-d3; (+)-Taxifolin-d3

    Autophagy Tyrosinase Inflammation/Immunology
    Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
  • HY-124953
    7,3',4'-Trihydroxyisoflavone

    MAP3K Apoptosis Cancer
    7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities.
  • HY-D0187S
    L-Glutathione reduced-13C2,15N

    GSH-13C2,15N; γ-L-Glutamyl-L-cysteinyl-glycine-13C2,15N

    Endogenous Metabolite Reactive Oxygen Species Ferroptosis Cancer Inflammation/Immunology Neurological Disease Cardiovascular Disease
    L-Glutathione reduced-13C2,15N (GSH-13C2,15N) is the 13C- and 15N-labeled L-Glutathione reduced. L-Glutathione reduced (GSH) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
  • HY-146172
    Antioxidant agent-3

    Reactive Oxygen Species Cancer Inflammation/Immunology
    Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS + scavenging activity with IC50s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells.
  • HY-W015913S
    Sodium 2-oxopropanoate-13C3

    Sodium pyruvate-13C3

    Reactive Oxygen Species Endogenous Metabolite Metabolic Disease
    Sodium 2-oxopropanoate-13C3 (Sodium pyruvate-13C3) is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.
  • HY-N0828
    Pterostilbene

    Autophagy Cancer Inflammation/Immunology
    Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties. Pterostilbene blocks ROS production, also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide.
  • HY-N7432
    DIMBOA

    Bacterial Fungal Antibiotic Infection
    DIMBOA, an antibiotic, is a benzoxazinoid, part of the chemical defense system of graminaceous plants such as maize, wheat, and rye. DIMBOA possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae. DIMBOA exhibits a potent free-radical scavenging activity and a weaker iron (III) ions reducing activity. Antioxidant activity.
  • HY-128463
    N-tert-Butyl-α-phenylnitrone

    COX Reactive Oxygen Species Metabolic Disease Inflammation/Immunology Neurological Disease
    N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier.
  • HY-N6937
    (R,R)-Secoisolariciresinol diglucoside

    (R,R)-SDG; (R,R)-LGM2605

    Others Inflammation/Immunology
    (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells.
  • HY-N2425
    Rhodiosin

    Cholinesterase (ChE) Metabolic Disease
    Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC50 of 27.77 μM.
  • HY-N0241
    Rhodionin

    Cholinesterase (ChE) Metabolic Disease
    Rhodionin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.761 μM and a Ki of 0.769 μM. Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL. Rhodionin exhibits potent DPPH free radical scavenging activities, with an IC50 of 19.49 μM.
  • HY-W018643
    Ferulic acid methyl ester

    Methyl ferulate

    p38 MAPK Autophagy Inflammation/Immunology Neurological Disease Cancer
    Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages.
  • HY-B0639
    Amifostine

    WR2721

    MDM-2/p53 HIF/HIF Prolyl-Hydroxylase Cancer
    Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action.
  • HY-B0639A
    Amifostine trihydrate

    WR2721 trihydrate

    MDM-2/p53 HIF/HIF Prolyl-Hydroxylase Cancer
    Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action.
  • HY-100594
    EUK-134

    NF-κB Cardiovascular Disease
    EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells.
  • HY-19893
    Antroquinonol

    (+)-Antroquinonol

    Keap1-Nrf2 Cancer Inflammation/Immunology
    Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects. Antroquinonol can be used for the research of colon cancer. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice.
  • HY-19543
    Brusatol

    NSC 172924

    Keap1-Nrf2 Apoptosis Cancer
    Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent. Brusatol increases cellular apoptosis.