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furin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Furin (5) Bacterial (4) SARS-CoV (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Infection (7) Inflammation/Immunology (2)

11

Inhibitors & Agonists

7

Peptides

2

Recombinant Proteins

1

Antibodies

Targets Recommended: Furin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Hexa-D-arginine 3 Publications Verification furin Inhibitor II	Bacterial	Infection
Hexa-D-arginine (Furin Inhibitor II) is a stable *furin* inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for *furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin* A and anthrax toxins toxicity in vitro and in vivo .

SSM3 tetraTFA hydrate	Furin	Infection
SSM3 tetraTFA hydrate is a potent synthetic *furin* inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .

Hexa-D-arginine TFA furin Inhibitor II TFA	Bacterial	Infection
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable *furin* inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for *furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin* A and anthrax toxins toxicity in vitro and in vivo .

HY-P3797

Furin Substrate

Furin Cancer

Furin Substrate is an peptide. Furin Substrate can be used for the research of various biochemical .

FURIN Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FURIN Human Pre-designed siRNA Set A contains three designed siRNAs for FURIN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FURIN Human Pre-designed siRNA Set A FURIN Human Pre-designed siRNA Set A

SSM3 tetraTFA	Furin	Infection
SSM3 tetraTFA is a potent synthetic *furin* inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .

MI-1851	SARS-CoV	Infection
MI-1851 is a potent *furin* inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity .

BOS-318	Furin	Inflammation/Immunology
BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable *furin* inhibitor with IC₅₀ value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease .

Histatin-3 TFA	Bacterial	Inflammation/Immunology
Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant K_i of 1.98 μM .

Boc-Arg-Val-Arg-Arg-AMC hydrochloride Boc-RVRR-AMC	Furin	Others
Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .

IN-2-LF	Bacterial	Infection
IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC₅₀ of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R .

Cat. No.	Product Name	Target	Research Area

Hexa-D-arginine 3 Publications Verification furin Inhibitor II	Bacterial	Infection
Hexa-D-arginine (Furin Inhibitor II) is a stable *furin* inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for *furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin* A and anthrax toxins toxicity in vitro and in vivo .

Histatin-3 TFA	Bacterial	Inflammation/Immunology
Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant K_i of 1.98 μM .

Boc-Arg-Val-Arg-Arg-AMC hydrochloride Boc-RVRR-AMC	Furin	Others
Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .

Hexa-D-arginine TFA furin Inhibitor II TFA	Bacterial	Infection
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable *furin* inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for *furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin* A and anthrax toxins toxicity in vitro and in vivo .

HY-P3797

Furin Substrate

Furin Cancer

Furin Substrate is an peptide. Furin Substrate can be used for the research of various biochemical .

DEC-RVRK-CMK Decanoyl-Arg-Val-Arg-Lys-chloromethylketone	Peptides	Infection
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a small, synthetic, irreversible, cell-permeable competitive furin inhibitor against Zika virus (ZIKV), Japanese encephalitis virus (JEV) has strong antiviral activity .

IN-2-LF	Bacterial	Infection
IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC₅₀ of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

	Furin/PCSK3 Protein, Human (HEK293, His) furin; FUR; PACE; PCSK3; SPC1	Human	HEK293
	Furin/PCSK3 protein is a ubiquitous endoprotease in the constitutive secretory pathway that efficiently cleaves the RX(K/R)R consensus motif. Its versatility is evident in processing TGFB1 (essential for TGF-β-1 activation) and converting the brain natriuretic factor prohormone into active BNP(1-32). Furin/PCSK3 Protein, Human (HEK293, His) is the recombinant human-derived Furin/PCSK3 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of Furin/PCSK3 Protein, Human (HEK293, His) is 548 a.a., with molecular weight of 60-75 kDa.

	Furin/PCSK3 Protein, Mouse (HEK293, His) furin; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE; Prohormone convertase 3; Fur; Pcsk3	Mouse	HEK293
	Furin/PCSK3 protein is an endoprotease with RX(K/R)R cleavage activity and is widely expressed in the constitutive secretory pathway. It plays a crucial role in processing various substrates, including TGFB1, and activating TGF-β-1. Furin/PCSK3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Furin/PCSK3 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Furin/PCSK3 Protein, Mouse (HEK293, His) is 690 a.a., with molecular weight of 75-91 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81696

Furin Antibody (YA1441)

FUR; furin; PACE; PCSK3; SPC1
WB, IHC-P, ICC/IF Human, Mouse, Rat

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