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ganglioside

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (1) Apoptosis (1) Biochemical Assay Reagents (2) Endogenous Metabolite (4) Influenza Virus (1) Isotope-Labeled Compounds (2) Parasite (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114456

Ganglioside GM3	Others	Metabolic Disease
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-N10546

Ganglioside GM1	Others	Neurological Disease
Ganglioside GM1 is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 is a functional tissue receptor for the Cholera Toxin1 .

HY-148385

Ganglioside GM2

Others Cancer

Ganglioside GM2 is a human tumor antigen (OFA-I-1). Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease .

Ganglioside GM2	Others	Cancer
Ganglioside GM2 is a human tumor antigen (OFA-I-1). Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease .

HY-114456AS

Ganglioside GM3-d5 Bovine Milk ammonium salt	Isotope-Labeled Compounds	Others
Ganglioside GM3-d₅ (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).

HY-E70043

Ganglioside sialidase (AuSialidase S) Sialidase isoenzyme S; AuSialidase S	Endogenous Metabolite	Metabolic Disease
Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .

HY-131139

Ganglioside GD3 disodium salt

Others Cancer

Ganglioside GD3 disodium salt is a melanoma-associated antigen and has been used as a target for the immune therapy of melanomas .

Ganglioside GD3 disodium salt	Others	Cancer
Ganglioside GD3 disodium salt is a melanoma-associated antigen and has been used as a target for the immune therapy of melanomas .

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents	Others
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

HY-W127324

Ganglioside GM3 (phyto-type) NeuAcα(2-3)Galβ(1-4)Glc-ceramide (phyto-type)	Biochemical Assay Reagents	Others
Ganglioside GM3 (phyto-type) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N10511

*GM1a Ganglioside* oligosaccharide**	Others	Inflammation/Immunology
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-157343

GD3 Ganglioside	Apoptosis	Neurological Disease Cancer
GD3 Ganglioside is a prominent ganglioside of human melanoma. GD3 Ganglioside is an inducer of mitochondrial permeability. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. GD3 ganglioside is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis .

HY-146876S

C18:0 GM1 Ganglioside-d5 ammonium

Isotope-Labeled Compounds Others

C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

*C18:0 GM1 Ganglioside-d5 ammonium*	Isotope-Labeled Compounds	Others
C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

HY-P1446

Cholera toxin 5+ Cited Publications Choleragen	Adenylate Cyclase	Inflammation/Immunology
Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER) . Choleragen activates adenylate cyclase by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein .

HY-I0400

N-Acetylneuraminic acid 2 Publications Verification NANA; Lactaminic acid	Influenza Virus Endogenous Metabolite	Cardiovascular Disease
N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells.

HY-N7575

Lacto-N-fucopentaose II LNFP II	Endogenous Metabolite	Metabolic Disease
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-N10526

Isoglobotriaose Gala-3Galb-4Glc	Others	Others
Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .

HY-N7390

Cholesterol glucuronide

Endogenous Metabolite Metabolic Disease

Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase .

Cholesterol glucuronide	Endogenous Metabolite	Metabolic Disease
Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase .

HY-N10534

Lewis X trisaccharide Lewis X	Parasite	Infection Inflammation/Immunology Cancer
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

Cat. No.	Product Name	Type

HY-E70043

Ganglioside sialidase (AuSialidase S) Sialidase isoenzyme S; AuSialidase S	Biochemical Assay Reagents
Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .

HY-E70073

Ganglioside sialidase (AuSialidase M2) Sialidase isoenzyme M2; AuSialidase M2	Biochemical Assay Reagents
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

Ganglioside GM2, Asialo

Gangliotriosylceramide

Biochemical Assay Reagents

Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

HY-W127324

Ganglioside GM3 (phyto-type) NeuAcα(2-3)Galβ(1-4)Glc-ceramide (phyto-type)	Biochemical Assay Reagents
Ganglioside GM3 (phyto-type) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-E70049

beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) GM2/GD2 synthase	Biochemical Assay Reagents
beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides .

HY-E70147

ST3 β-Gal α-2,3-Sialyltransferase 6 EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase	Enzyme Substrates
ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

ST3 β-Gal α-2,3-Sialyltransferase 6

EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase

Enzyme Substrates

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

Racotumomab 1E10	Inhibitory Antibodies	Inflammation/Immunology Cancer
Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is an anti-idiotype monoclonal antibody (MAb). Racotumomab reacts to Neu-glycolyl (NeuGc)-containing gangliosides, sulfatides, and other antigens expressed in tumors. Racotumomab is an active anticancer agent for lung cancer .

Mitumomab	Inhibitory Antibodies	Cancer
Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma .

Ecromeximab KM 871; KW 2871	Inhibitory Antibodies	Others
Ecromeximab (KM 871; KW 2871) is a mouse-derived IgG-κ chimeric antibody targeting ganglioside GD3. Ecromeximab is expressed by YB2/0 rat hybridoma cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-I0400

N-Acetylneuraminic acid 2 Publications Verification NANA; Lactaminic acid	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides	Influenza Virus Endogenous Metabolite
N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells.

HY-N7575

Lacto-N-fucopentaose II LNFP II	Structural Classification Polysaccharides Classification of Application Fields Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Cancer	Endogenous Metabolite
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-N10546

Ganglioside GM1	Structural Classification Natural Products Animals	Others
Ganglioside GM1 is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 is a functional tissue receptor for the Cholera Toxin1 .

HY-N10511

*GM1a Ganglioside* oligosaccharide**	Structural Classification Natural Products Polysaccharides Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Others
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-N10526

Isoglobotriaose Gala-3Galb-4Glc	Structural Classification Natural Products Microorganisms	Others
Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .

HY-N7390

Cholesterol glucuronide	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase .

HY-N10534

Lewis X trisaccharide Lewis X	Infection Structural Classification Natural Products Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Cancer	Parasite
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

Species:	Human (3)
Tag:	His (3)
Source:	HEK293 (2) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70954

	GM2A Protein, Human (HEK293, His) ganglioside GM2 activator; Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3; SAP-3	Human	HEK293
	Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. GM2A catalyzes the degradation of the ganglioside GM2 as well as affects lipid storage and neuromuscular process controlling balance. GM2A Protein, Human (HEK293, His) is the recombinant human-derived GM2A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GM2A Protein, Human (HEK293, His) is 162 a.a., with molecular weight of 19-22 kDa.

HY-P75160

	GM2A Protein, Human (sf9, His) ganglioside GM2 activator; GM2-AP; Sphingolipid activator protein 3; SAP-3	Human	Sf9 insect cells
	GM2A Protein is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. And it is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. GM2A Protein, Human (sf9, His) is the recombinant human-derived GM2A protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of GM2A Protein, Human (sf9, His) is 170 a.a., with molecular weight of ~25 kDa.

HY-P71334

	ST8SIA1 Protein, Human (HEK293, His) Alpha-N-Acetylneuraminide Alpha-2; 8-Sialyltransferase; Alpha-2; 8-Sialyltransferase 8A; ganglioside GD3 Synthase; ganglioside GT3 Synthase; Sialyltransferase 8A; SIAT8-A; Sialytransferase St8Sia I; ST8SiaI; ST8SIA1; SIAT8; SIAT8A	Human	HEK293
	The ST8SIA1 protein links sialic acid to ganglioside GM3 via an α 2,8-bond to form ganglioside GD3. ST8SIA1 Protein, Human (HEK293, His) is the recombinant human-derived ST8SIA1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ST8SIA1 Protein, Human (HEK293, His) is 308 a.a., with molecular weight of ~48.0 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-114456AS

Ganglioside GM3-d5 Bovine Milk ammonium salt

Ganglioside GM3-d₅ (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).
HY-146876S

C18:0 GM1 Ganglioside-d5 ammonium

C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

Ganglioside GM3-d5 Bovine Milk ammonium salt
Ganglioside GM3-d₅ (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).

*C18:0 GM1 Ganglioside-d5 ammonium*
C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

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ganglioside

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
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