2. Search Result
Search Result
Results for "

gankyrin

" in MedChemExpress (MCE) Product Catalog:

1

Inhibitors & Agonists

1

Recombinant Proteins

Cat. No. Compare Product Name Species Source
  • HY-P70213
    Gankyrin/PSMD10 Protein, Human

    rHu26S proteasome non-ATPase regulatory subunit 10/PSMD10; 26S Proteasome Non-ATPase Regulatory Subunit 10; 26S Proteasome Regulatory Subunit p28; gankyrin; p28(GANK); PSMD10

    		 Human E. coli
    Gankyrin/PSMD10 protein is a critical chaperone in 26S proteasome assembly, contributing to PA700/19S regulatory complex (RC) formation. In base subcomplex assembly, it engages with PSMD10, PSMC4, PSMC5, and PAAF1, likely connecting with PSMD5, PSMC2, PSMC1, and PSMD2. Independently, Gankyrin regulates EGF-induced AKT activation by inhibiting the RHOA/ROCK/PTEN pathway. It plays a key role in RAS-induced tumorigenesis, acting as a proto-oncoprotein by negatively regulating RB1 and p53/TP53. Gankyrin overexpression leads to RB1 phosphorylation and degradation, while also competing with CDKN2A for CDK4 binding. Additionally, Gankyrin facilitates MDM2-p53/TP53 binding and promotes p53/TP53 ubiquitination by MDM2, influencing the TP53:MDM2 complex's targeting to the 26S proteasome. Involved in p53-independent apoptosis, Gankyrin regulates NF-kappa-B by retaining RELA in the cytoplasm and facilitating its XPO1/CRM1-mediated nuclear export. Gankyrin/PSMD10 Protein, Human is the recombinant human-derived Gankyrin/PSMD10 protein, expressed by E. coli, with tag free. The total length of Gankyrin/PSMD10 Protein, Human is 226 a.a., with molecular weight of ~26.0 kDa.

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: