Search Result

Results for "

genotoxicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (1) Antibiotic (1) Apoptosis (3) Bacterial (5) Bcl-2 Family (1) Biochemical Assay Reagents (2) Cytochrome P450 (1) DNA Alkylator/Crosslinker (3) DNA/RNA Synthesis (2) Drug Metabolite (3) Endogenous Metabolite (8) Fluorescent Dye (3) Histone Acetyltransferase (1) Histone Methyltransferase (1) Isotope-Labeled Compounds (5) MDM-2/p53 (1) mTOR (1) Parasite (3) PARP (2) Reactive Oxygen Species (1) Topoisomerase (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Infection (10) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (4)

By Targets:

Aldehyde Dehydrogenase (ALDH) (1)

Antibiotic (1)

Apoptosis (3)

Bacterial (5)

Bcl-2 Family (1)

Biochemical Assay Reagents (2)

Cytochrome P450 (1)

DNA Alkylator/Crosslinker (3)

DNA/RNA Synthesis (2)

Drug Metabolite (3)

Endogenous Metabolite (8)

Fluorescent Dye (3)

Histone Acetyltransferase (1)

Histone Methyltransferase (1)

Isotope-Labeled Compounds (5)

MDM-2/p53 (1)

mTOR (1)

Parasite (3)

PARP (2)

Reactive Oxygen Species (1)

Topoisomerase (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (1)

Infection (10)

Inflammation/Immunology (2)

Metabolic Disease (2)

Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119329

Glycidamide Oxiranecarboxamide; 2,3-Epoxypropanamide	Others	Others
Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects .

HY-133647

Dibromoacetaldehyde

Others Others

Dibromoacetaldehyde, a halogenated product, is a byproduct in drinking water and has genotoxicity .
HY-133648

Bromochloroacetaldehyde

Others Others

Bromochloroacetaldehyde belongs to dihalogenated acetaldehyde and is a byproduct in drinking water. Bromochloroacetaldehyde has genotoxicity .

Dibromoacetaldehyde	Others	Others
Dibromoacetaldehyde, a halogenated product, is a byproduct in drinking water and has genotoxicity .

Bromochloroacetaldehyde	Others	Others
Bromochloroacetaldehyde belongs to dihalogenated acetaldehyde and is a byproduct in drinking water. Bromochloroacetaldehyde has genotoxicity .

HY-133649

Dibromochloroacetaldehyde	Others	Others
Dibromochloroacetaldehyde belongs to trihalogenated acetaldehyde and is a byproduct in drinking water. Dibromochloroacetaldehyde has genotoxicity .

HY-121345

Homobaldrinal	Others	Neurological Disease Cancer
Homobaldrinal is a decomposition product of Valepotriate (HY-N0718). Homobaldrinal exhibits genotoxic activity in the Salmonella/microsome test .

HY-400785

Dapagliflozin impurity A	Others	Cancer
Dapagliflozin impurity A (Compound A) is a dapagliflozin peroxide, a genotoxic impurity, can cause damage to human genetic material at very low concentrations, leading to genetic mutations and possibly tumorigenesis .

HY-N8022

Lucidin primeveroside Lucidin 3-O-β-primeveroside	Biochemical Assay Reagents	Cancer
Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts .

HY-N2081

Skimmianine 1 Publications Verification	Others	Inflammation/Immunology Cancer
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-151628

MRV03-068	Others	Cancer
MRV03-068 (Compound 2) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-068 can be used in colorectal cancer research .

HY-151629

MRV03-069	Others	Cancer
MRV03-069 (Compound 3) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-069 can be used in colorectal cancer research .

HY-119635

Albicanol	Others	Cancer
Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. Albicanol shows cytotoxicity. Albicanol suppress profenofos (HY-B0832) induced genotoxicity in grass carp hepatocytes .

HY-133787

Levofloxacin N-oxide	Drug Metabolite	Infection
Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .

HY-125098

Illudin S	DNA Alkylator/Crosslinker Apoptosis	Infection Cancer
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-146121

Antitubercular agent-26	Bacterial	Infection
Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC₅₀ of 0.50 μM and an intracellular IC₅₀ of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity .

HY-W014940

Ethylene glycol dimethacrylate	Reactive Oxygen Species Apoptosis	Others
Ethylene glycol dimethacrylate is a methacrylate monomer, exhibits cytotoxic and genotoxic effects on human gingival fibroblasts (HGFs). Ethylene glycol dimethacrylate increases intracellular reactive oxygen species (ROS) production, causes DNA damage, increases apoptosis and causes cell cycle arrest in G1/G0 phase .

HY-W795264

FR900098	Parasite	Infection
FR900098 is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 has no effect on bone marrow red blood cells in NMRI mice .

HY-122817

FR900098 sodium	Antibiotic Parasite	Infection
FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .

HY-124489S1

2-Hydroxyestradiol-d5	Endogenous Metabolite	Infection
2-Hydroxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].

HY-124489S

2-Hydroxyestradiol-13C6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].

HY-121213

Erysolin

Cytochrome P450 Cancer

Erysolin is a CYP1A inhibitor with antigenic toxicity. Erysolin reduces benzo(a)pyrene-induced genotoxicity .

Erysolin	Cytochrome P450	Cancer
Erysolin is a CYP1A inhibitor with antigenic toxicity. Erysolin reduces benzo(a)pyrene-induced genotoxicity .

HY-131102

Mequindox	Bacterial DNA/RNA Synthesis	Infection
Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .

HY-W010553

2,5-Dimethyl-3(2H)-furanone

Others Others

2,5-Dimethyl-3(2H)-furanone is a flavouring substance without genotoxicity .

2,5-Dimethyl-3(2H)-furanone	Others	Others
2,5-Dimethyl-3(2H)-furanone is a flavouring substance without genotoxicity .

HY-Y0069

N-Acetylglycine Aceturic acid; Acetamidoacetic acid	Endogenous Metabolite	Others
N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.

HY-N4183

Licoflavone C

Others Cancer

Licoflavone C is a prenyl-flavone extracted from Genista ephedroides, reduces the genotoxicity of cancer agents in human peripheral lymphocytes .
HY-136375

Cyanazine

Others Others

Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic .

Licoflavone C	Others	Cancer
Licoflavone C is a prenyl-flavone extracted from Genista ephedroides, reduces the genotoxicity of cancer agents in human peripheral lymphocytes .

Cyanazine	Others	Others
Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic .

HY-122099

Riddelline	DNA/RNA Synthesis	Others
Riddelline, a pyrrolizidine alkaloid, is a potent genotoxic agent. Riddelline induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver .

HY-118948

MSN-50	Bcl-2 Family	Neurological Disease
MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection .

HY-116108

Musk tibetene Musk tibetine	Others	Cancer
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line .

HY-124489

2-Hydroxyestradiol	Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-136375S

Cyanazine-d5	Isotope-Labeled Compounds	Others
Cyanazine-d₅ is deuterium labeled Cyanazine. Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic[1].

HY-154958

mTOR inhibitor-12	mTOR	Neurological Disease
mTOR inhibitor-12 (Compound 11) is a selective brain penetrant mTOR inhibitor without genotoxicity risk. mTOR inhibitor-12 can be used for the research of CNS diseases .

HY-Y0069S

N-Acetylglycine-d5 Aceturic acid-d₅; Acetamidoacetic acid-d₅	Isotope-Labeled Compounds Endogenous Metabolite
N-Acetylglycine-d₅ is the deuterium labeled N-Acetylglycine. N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.

HY-125815

Reactive Blue 4 1 Publications Verification	Fluorescent Dye	Others
Reactive Blue 4 is an anthraquinone dye, as a single colorimetric chemosensor for sequential determination of multiple analytes with different optical responses in aqueous media. Reactive Blue 4 is phytotoxic, cytotoxic and genotoxic. Reactive Blue 4 .

HY-151626

MRV03-037	Bacterial	Infection
MRV03-037 is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-037 prevents gut bacterial genotoxin production .

HY-W612269S

Isonicotinoyl chloride-d4	Isotope-Labeled Compounds	Others
Isonicotinoyl chloride-d₄ is the deuterated labeled Isonicotinoyl chloride (HY-W612269). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .

HY-N2627

Isorhamnetin 3-O-robinobioside	Others	Cancer
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H₂O₂. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .

HY-N1094

Verminoside	PARP MDM-2/p53	Inflammation/Immunology
Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins .

HY-139149

NiCur	Histone Acetyltransferase	Cancer
NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC₅₀ value of 0.35 μΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies without affecting the expression of target proteins .

HY-B0928

Homosalate 1 Publications Verification Homomenthyl salicylate	Biochemical Assay Reagents	Others
Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity .

HY-D0249

Sunset Yellow FCF 1 Publications Verification Orange Yellow S; Food Yellow 3; CI 15985	Fluorescent Dye	Others
Sunset Yellow FCF (Orange Yellow S) is an orange azo dye with a maximum absorption wavelength of 480 nm. Sunset Yellow FCF can be used in food, cosmetics and pharmaceuticals .

HY-136440

Hydroxymetronidazole Metronidazole-OH	Bacterial Parasite	Infection
Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle .

HY-Y0069S1

N-Acetylglycine-d2 Aceturic acid-d₂; Acetamidoacetic acid-d₂	Isotope-Labeled Compounds Endogenous Metabolite	Others
N-Acetylglycine-d₂ (Aceturic acid-d₂; Acetamidoacetic acid-d₂) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .

HY-152187

Topoisomerase IIα-IN-5	Topoisomerase Apoptosis	Others
Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629) .

HY-152775

RK-701	Histone Methyltransferase	Cancer
RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC₅₀ value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A .

HY-W001189

1,3-Dithiane	Bacterial Endogenous Metabolite	Infection
1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon . 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward S. typhimurium TA98 and TA100 .

HY-D0342

Disperse Red 1

Fluorescent Dye Others

Disperse Red 1, an azobenzene derivative, is an azo textile dye extensively used for dyeing polyester fabrics in textile industry .

Disperse Red 1	Fluorescent Dye	Others
Disperse Red 1, an azobenzene derivative, is an azo textile dye extensively used for dyeing polyester fabrics in textile industry .

HY-113466

4-Hydroxynonenal 5 Publications Verification 4-HNE	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Cardiovascular Disease Neurological Disease Cancer
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-W006566

5-AIQ 5-Aminoisoquinolin-1-one	PARP	Cancer
5-AIQ (5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver .

HY-137316

Phosphoramide mustard	DNA Alkylator/Crosslinker Drug Metabolite	Cancer
Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage .

HY-137316A

Phosphoramide mustard cyclohexanamine 1 Publications Verification	DNA Alkylator/Crosslinker Drug Metabolite	Cancer
Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage .

Cat. No.	Product Name	Category	Target	Chemical Structure