Search Result

Results for "

glutamate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	EAAT (10) iGluR (75) mGluR (91) ADC Linker (1) Adenylate Cyclase (1) Akt (1) Amino Acid Derivatives (13) Antibiotic (4) Apoptosis (39) Autophagy (9) Bacterial (11) Bcl-2 Family (1) Biochemical Assay Reagents (5) Calcium Channel (23) Calmodulin (3) Cannabinoid Receptor (1) Carboxypeptidase (4) Caspase (1) CaSR (1) Chloride Channel (4) Cholinesterase (ChE) (3) CXCR (4) Cytochrome P450 (2) Drug-Linker Conjugates for ADC (2) Endogenous Metabolite (93) ERK (1) Ferroptosis (17) FKBP (1) Fungal (1) GABA Receptor (10) Glutaminase (1) GlyT (1) GPR35 (4) HDAC (1) HIF/HIF Prolyl-Hydroxylase (3) HIV (3) HSP (1) Isotope-Labeled Compounds (32) Keap1-Nrf2 (1) Ligands for Target Protein for PROTAC (1) Liposome (1) Lipoxygenase (1) LPL Receptor (1) MDM-2/p53 (3) Mitochondrial Metabolism (3) Monoamine Oxidase (3) Na+/H+ Exchanger (NHE) (1) nAChR (1) NF-κB (1) Nucleoside Antimetabolite/Analog (11) Opioid Receptor (2) Oxidative Phosphorylation (1) P-glycoprotein (2) Parasite (6) PARP (1) PERK (1) Phosphodiesterase (PDE) (2) PKC (2) Potassium Channel (7) Reactive Oxygen Species (7) Small Interfering RNA (siRNA) (1) Sodium Channel (10) Src (1) Tau Protein (1) Trk Receptor (1) VEGFR (1)
By Research Areas:	Cancer (40) Cardiovascular Disease (9) Endocrinology (5) Infection (17) Inflammation/Immunology (24) Metabolic Disease (36) Neurological Disease (225)
Click Chemistry:	Alkynes (2)

372

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: mGluR iGluR EAAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2911

Glutamate dehydrogenase (NAD(P)) GLDH	Mitochondrial Metabolism	Others
Glutamate dehydrogenase NAD(P) (GLDH) can be found in hepatocytes, renal tissue, brain, muscle, and intestinal cells. Glutamate dehydrogenase NAD(P) is often used in biochemical studies. Glutamate dehydrogenase is a mitochondrial enzyme, it catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG) as part of the urea cycle .

HY-E70003

Glutamate dehydrogenase	Biochemical Assay Reagents	Endocrinology
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .

HY-144382

Glutamate-5-kinase-IN-2	Bacterial	Infection
Glutamate-5-kinase-IN-2 (compound 54) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC (minimum inhibitory concentration) of 4.2 µM. Glutamate-5-kinase-IN-2 shows G5K inhibition by promotes conformational changes at the L-glutamate binding site. Glutamate-5-kinase-IN-2 has the potential for the research of anti-TB agents .

HY-144381

Glutamate-5-kinase-IN-1	Bacterial	Infection
Glutamate-5-kinase-IN-1 (compound 50) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC (minimum inhibitory concentration) of 4.1 µM. Glutamate-5-kinase-IN-1 shows G5K inhibition by alters the ATP binding site architecture for enzyme recognition. Glutamate-5-kinase-IN-1 has the potential for the research of anti-TB agents .

HY-W037817

Dimethyl L-glutamate Dimethyl glutamate	Potassium Channel Bacterial	Infection Metabolic Disease
Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the K_ATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism .

HY-N0455B

*L-Arginine (L-glutamate)* 5+ Cited Publications (S)-(+)-Arginine (L-glutamate)
L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research .

HY-130313

Sodium lauroyl glutamate	Amino Acid Derivatives	Inflammation/Immunology
Sodium lauroyl glutamate is an anionic amino acid surfactant. Sodium lauroyl glutamate has the irritant contact dermatitis potential, and possible anti-irritating potential in a surfactant mixture on human skin .

HY-131885

*RuBi-Glutamate* hexafluorophosphate sodium**	Others	Neurological Disease
RuBi-Glutamate hexafluorophosphate sodium is a novel cage glutamate compound based on ruthenium photochemistry. RuBi-Glutamate hexafluorophosphate sodium can be excited at visible wavelengths and release glutamate after single or two-photon excitation. It has high quantum efficiency and can be used at low concentrations, partially avoiding the blocking of GABA energy transmission by other cage compounds. Two-photon release of RuBi-Glutamate hexafluorophosphate sodium has high spatial resolution and produces a physiodynamic excitatory response in a single dendritic spine .

HY-W010785

Dibenzyl L-glutamate tosylate

Amino Acid Derivatives Others

Dibenzyl L-glutamate tosylate is a glutamic acid derivative .

*Dibenzyl L-glutamate* tosylate**	Amino Acid Derivatives	Others
Dibenzyl L-glutamate tosylate is a glutamic acid derivative .

HY-131039

MDNI-caged-L-glutamate MDNI-glu	Amino Acid Derivatives	Others
MDNI-caged-L-glutamate (MDNI-glu) is a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate. MDNI-caged-L-glutamate makes more efficient use of incident light .

HY-30232

L-Glutamate-γ-benzyl ester

Amino Acid Derivatives Others

L-Glutamate-γ-benzyl ester is a glutamic acid derivative .
HY-W745139

5-Octyl D-Glutamate

Amino Acid Derivatives Others

5-Octyl D-Glutamate is aamino acids and their derivatives.

*L-Glutamate-γ-benzyl ester*	Amino Acid Derivatives	Others
L-Glutamate-γ-benzyl ester is a glutamic acid derivative .

5-Octyl D-Glutamate	Amino Acid Derivatives	Others
5-Octyl D-Glutamate is aamino acids and their derivatives.

HY-W250122

Glutamic acid sodium salt Monosodium glutamate	Biochemical Assay Reagents	Others
Monosodium glutamate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-107520A

MNI-caged-L-glutamate TFA

Others

MNI-caged-L-glutamate TFA is a reagent capable of rapidly and efficiently releasing neuroactive amino acids .
HY-Y0749A

Dimethyl D-glutamate hydrochloride

Glutamic acid, dimethyl ester, hydrochloride, D-
Amino Acid Derivatives Others

Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .
HY-149448

Poly-γ-benzyl-L-glutamate (MW 150000-350000)

Amino Acid Derivatives Others

Poly-γ-benzyl-L-glutamate (MW 150000-350000) is aamino acid polymer.
HY-W025811

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride

Amino Acid Derivatives Others

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative .

*MNI-caged-L-glutamate* TFA**	Others
MNI-caged-L-glutamate TFA is a reagent capable of rapidly and efficiently releasing neuroactive amino acids .

*Dimethyl D-glutamate* hydrochloride** Glutamic acid, dimethyl ester, hydrochloride, D-	Amino Acid Derivatives	Others
Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .

*Poly-γ-benzyl-L-glutamate* (MW 150000-350000)**	Amino Acid Derivatives	Others
Poly-γ-benzyl-L-glutamate (MW 150000-350000) is aamino acid polymer.

*1-(tert-Butyl) 5-methyl L-glutamate* hydrochloride**	Amino Acid Derivatives	Others
1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative .

HY-100616

cis-ACBD cis-1-Aminocyclobutane-1,3-dicarboxylic acid	Others	Neurological Disease
cis-ACBD is a potent and selective inhibitor of the high-affinity, Na ⁺-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate .

HY-W276106

KM02894	Others	Cancer
KM02894 is an inhibitor of glutamate release. Cancer cells release high levels of glutamate, which disrupts normal bone turnover and may lead to cancer-induced bone pain. KM02894 can be used for cancer related research .

HY-150220

1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate	Liposome	Others
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate can be used for the synthesis of phospholipid vesicle and improve the encapsulation efficiency of proteins .

HY-W022255

Fmoc-D-Glu-OH

D-Fmoc-glutamic acid
Amino Acid Derivatives Others

Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .

Fmoc-D-Glu-OH D-Fmoc-glutamic acid	Amino Acid Derivatives	Others
Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .

HY-N10272

Avenaciolide	Fungal Bacterial	Infection
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .

HY-N2553

4-Deoxypyridoxine 5'-phosphate	LPL Receptor	Metabolic Disease
4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a K_i of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (K_i of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase .

HY-131289

LY3020371	mGluR	Neurological Disease
LY3020371 is a potent and selective antagonist of glutamate (mGlu) 2/3 receptor, with K_is of 5.26 and 2.50 nM for hmGluR2 and hmGluR3, respectively. LY3020371 can be used for the research of depression .

HY-131481

Mnm5s2U

Others Others

Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA .

Mnm5s2U	Others	Others
Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA .

HY-161042

Neuroprotective agent 2	Others	Neurological Disease
Neuroprotective agent 2 (Compd 28) is a potent neuroprotective agent which has a protective effect in both salsolinol and glutamate-induced neurodegeneration models. Neuroprotective agent 2 reduces oxidative stress and caspase-3/7 activity in the glutamate model .

HY-W017500

N-Methyl-DL-aspartic acid	iGluR	Neurological Disease
N-Methyl-DL-aspartic acid is a glutamate analogue and a NMDA receptor agonist and can be used for neurological diseases research .

HY-131091

Boc-Glu(OBzl)-OSu

Amino Acid Derivatives Others

Boc-Glu(OBzl)-OSu can be used for the solid-phase peptide synthesis containing glutamate benzyl ester residues.

Boc-Glu(OBzl)-OSu	Amino Acid Derivatives	Others
Boc-Glu(OBzl)-OSu can be used for the solid-phase peptide synthesis containing glutamate benzyl ester residues.

HY-153691

BTB01303	Others	Others
BTB01303 is a (glutamate release) inhibitor. Cancer cells release high levels of (glutamate), which disrupts normal bone turnover and may lead to cancer-induced bone pain. BTB01303 has the potential to improve cancer-induced bone pain .

HY-122487

Troriluzole BHV-4157	Others	Neurological Disease
Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active *glutamate* modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD) .

HY-141536

PSMA-ALB-56

Drug-Linker Conjugates for ADC Cancer

PSMA-ALB-56 is a PSMA-targeting radioligand designed by combining the glutamate-urea PSMA-binding entity and an albumin binder .

PSMA-ALB-56	Drug-Linker Conjugates for ADC	Cancer
PSMA-ALB-56 is a PSMA-targeting radioligand designed by combining the glutamate-urea PSMA-binding entity and an albumin binder .

HY-13058

ADX-47273 1 Publications Verification	mGluR	Neurological Disease
ADX-47273 is a potent, selective and brain-penetrant mGluR5 positive allosteric modulator (PAM), with an EC₅₀ of 0.17 μM for potentiation of glutamate (50 nM) response. ADX-47273 has antipsychotic and procognitive activities .

HY-139692

EAAT2 activator 1	EAAT	Neurological Disease
EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently .

HY-N5110

Marmesinin (-)-Marmesinin; Ammijin	Others	Neurological Disease
Marmesinin ((-)-Marmesinin), a natural coumarin, is a biosynthetic precursor of psoralen and linear furanocoumarins. Marmesinin exhibits significant neuroprotective activities against glutamate-induced toxicity .

HY-N8115

S-(4-Hydroxybenzyl)glutathione	Others	Neurological Disease
S-(4-Hydroxybenzyl)glutathione is a glutathione derivative. S-(4-Hydroxybenzyl)glutathione inhibits the in vitro binding of kainic acid to brain glutamate receptors, with an IC₅₀ of 2 μM .

HY-107521

TFB-TBOA CF3-Bza-TBOA	EAAT	Neurological Disease
TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC₅₀ values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs .

HY-N11930

5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone	Others	Neurological Disease
Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent . Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cell .

HY-103232

IEM-1925 bromide	mGluR	Neurological Disease
IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy .

HY-103568

YM-298198 hydrochloride	mGluR	Neurological Disease
YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of *metabotropic glutamate* receptor type 1 (mGluR1)**. YM-298198 hydrochloride can be used for the research of neurological disorders .

HY-114481

Imidazole ketone erastin 20+ Cited Publications IKE	Ferroptosis	Cancer
Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system x_c ^- and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity .

HY-107522

DL-TBOA	EAAT	Neurological Disease
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [ ¹⁴C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with K_i values of 4.4 μM and 3.2 μM, respectively .

HY-P3016

Aspartate aminotransferase, Genetically engineered bacteria EC 2.6.1.1; GOT; AST	Endogenous Metabolite	Others
Aspartate aminotransferase, Genetically engineered bacteria (EC 2.6.1.1) (AST) is a transaminase enzyme, is often used in biochemical studies. Aspartate aminotransferase catalyzes aspartate and alpha-ketoglutarate converts to oxaloacetate and glutamate. Aspartate aminotransferase can be found in cerebrospinal fluid, exudates, and transudates .

HY-B0649

Propofol 5+ Cited Publications 2,6-Diisopropylphenol	GABA Receptor Endogenous Metabolite	Neurological Disease Cancer
Propofol potently and directly activates GABA_A receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic .

HY-110278

ADX71743	mGluR	Neurological Disease
ADX71743 is a highly selective, noncompetitive and brain-penetrant *metabotropic glutamate* receptor 7 negative allosteric modulator (mGlu7 NAM**). ADX71743 has anxiolytic-like activity .

HY-107522B

DL-TBOA ammonium	EAAT	Neurological Disease
DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [ ¹⁴C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA ammonium blocks EAAT4 and EAAT5 in a competitive manner with K_i values of 4.4 μM and 3.2 μM, respectively .

HY-108546

L-AP3 3-Phosphono-L-alanine	mGluR	Neurological Disease
L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC₅₀s of 368 μM and 2087 μM, respectively .

HY-149094

Neuroprotective agent 1	Others	Cardiovascular Disease
Neuroprotective agent 1 (2), a promising neuroprotective agent for the study of ischemic stroke, shows promising neuroprotective activity with the EC₅₀ value of 16.07 μM in the model of glutamate-induced excitotoxicity and 19.30 μM in the model of H₂O₂-induced oxidative damage .

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .

HY-103345

2-MPPA GPI-5693	Carboxypeptidase	Neurological Disease Cancer
2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC₅₀ of 90 nM .

HY-100815D

(RS)-AMPA monohydrate (±)-AMPA monohydrate	iGluR	Neurological Disease
(RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors .

Cat. No.	Product Name	Type

HY-P2911

Glutamate dehydrogenase (NAD(P)) GLDH	Biochemical Assay Reagents
Glutamate dehydrogenase NAD(P) (GLDH) can be found in hepatocytes, renal tissue, brain, muscle, and intestinal cells. Glutamate dehydrogenase NAD(P) is often used in biochemical studies. Glutamate dehydrogenase is a mitochondrial enzyme, it catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG) as part of the urea cycle .

HY-E70003

Glutamate dehydrogenase	Biochemical Assay Reagents
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .

HY-W250122

Glutamic acid sodium salt Monosodium glutamate	Biochemical Assay Reagents
Monosodium glutamate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P3263

Glutamate oxidase L-glutamate oxidase	Biochemical Assay Reagents
Glutamate oxidase (L-Glutamate oxidase) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2912

Glutamate dehydrogenase (NADP)	Biochemical Assay Reagents
Glutamate dehydrogenase (NADP) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-149448

Poly-γ-benzyl-L-glutamate (MW 150000-350000)

Biochemical Assay Reagents

Poly-γ-benzyl-L-glutamate (MW 150000-350000) is aamino acid polymer.

HY-150220

1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate	Drug Delivery
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate can be used for the synthesis of phospholipid vesicle and improve the encapsulation efficiency of proteins .

HY-134136

Octanoyl Coenzyme A	Biochemical Assay Reagents
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-134136A

Octanoyl coenzyme A lithium	Biochemical Assay Reagents
Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-B1102

Evans Blue

5+ Cited Publications

Direct Blue 53; T-1824; C.I. 23860

Cell Assay Reagents

Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .

HY-131384

8,11,14-Eicosatriynoic acid

8,11,14-Icosatriynoic acid

Biochemical Assay Reagents

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Target	Research Area

HY-W010785

Dibenzyl L-glutamate tosylate

Amino Acid Derivatives Others

Dibenzyl L-glutamate tosylate is a glutamic acid derivative .
HY-30232

L-Glutamate-γ-benzyl ester

Amino Acid Derivatives Others

L-Glutamate-γ-benzyl ester is a glutamic acid derivative .

HY-P3263

Glutamate oxidase L-glutamate oxidase	Peptides	Others
Glutamate oxidase (L-Glutamate oxidase) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2912

Glutamate dehydrogenase (NADP)	Peptides	Others
Glutamate dehydrogenase (NADP) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W037817

Dimethyl L-glutamate Dimethyl glutamate	Potassium Channel Bacterial	Infection Metabolic Disease
Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the K_ATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism .

HY-W745139

5-Octyl D-Glutamate

Amino Acid Derivatives Others

5-Octyl D-Glutamate is aamino acids and their derivatives.
HY-Y0749A

Dimethyl D-glutamate hydrochloride

Glutamic acid, dimethyl ester, hydrochloride, D-
Amino Acid Derivatives Others

Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .
HY-W025811

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride

Amino Acid Derivatives Others

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative .
HY-100801A

DL-threo-3-Hydroxyaspartic acid

Peptides Others

DL-threo-3-Hydroxyaspartic acid is a glutamate uptake inhibitor that can block glutamate transport in cannulated sprague dawley rat .

HY-134141

5-Octyl hydrogen L-glutamate	Peptides	Metabolic Disease
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate) .

HY-W022255

Fmoc-D-Glu-OH

D-Fmoc-glutamic acid
Amino Acid Derivatives Others

Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .

HY-P3089

Dendrotoxin K	Potassium Channel	Others
Dendrotoxin K is a Kv1.1 channel blocker. Dendrotoxin K determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-P1077

CALP1	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity .

HY-P1077A

CALP1 TFA 1 Publications Verification	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity .

HY-P3089A

Dendrotoxin K TFA	Potassium Channel	Others
Dendrotoxin K TFA is a Kv1.1 channel blocker. Dendrotoxin K TFA determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-P1080

ω-Agatoxin IVA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA is a potent, selective P/Q type Ca ²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca ²⁺ channels, respectively. ω-Agatoxin IVA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels .

HY-P1080A

ω-Agatoxin IVA TFA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca ²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca ²⁺ channels, respectively. ω-Agatoxin IVA TFA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels .

HY-126169

L-Glutamine amide

Endogenous Metabolite Infection

L-Glutamine amide is a metabolite involved in glutamate metabolism.
HY-P1232

HAE

Peptides Metabolic Disease

HAE is a 3-amino acid peptide which consists of histidine, alanine and glutamate.
HY-W008326

Z-Glu(OtBu)-OH

Amino Acid Derivatives Others

Z-Glu(OtBu)-OH is a derivative of glutamate, can be used for molecule, agent, compounds synthesis .

HY-16757

Trofinetide 1 Publications Verification NNZ-2566	Peptides	Neurological Disease
Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.

HY-139468

Ala-Glu-OH

Peptides Others

Ala-Glu-OH is an agent of the dipeptide .
HY-20167

H-Glu(OtBu)-OtBu

Amino Acid Derivatives Others

H-Glu(OtBu)-OtBu is a glutamic acid derivative .

HY-P0188A

ω-Conotoxin MVIIC TFA	Calcium Channel	Neurological Disease
ω-Conotoxin MVIIC TFA is a N- and P/Q-type Ca ²⁺ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release .

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Derivatives	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-P5911

GluN1(359-378)	Peptides	Inflammation/Immunology
GluN1 (359-378) is an anti-N-methyl-D-aspartate receptor (NMDAR) antibody. GluN1 (359-378) can cross the blood-brain barrier. GluN1 (359-378) can be used to study anti-NMDAR encephalitis therapy targeting the immune system .

HY-P2210A

BigLEN(mouse) TFA	Peptides
BigLEN(mouse) TFA is a GPR171 agonist. BigLEN(mouse) TFA is a proSAAS-derived neuropeptide. BigLEN(mouse) TFA regulates food intake in mice. BigLEN(mouse) inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

HY-P5305A

GAD65(247-266) epitope TFA	GABA Receptor	Metabolic Disease
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A ^g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .

HY-117483

Gly-Pro-Glu	Peptides	Neurological Disease
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC₅₀ value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .

HY-P1399

Pep2m, myristoylated Myr-Pep2m	PKC	Neurological Disease
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, *N-ethylmaleimide-sensitive factor/glutamate* receptor subunit 2 (NSF/GluR2) interactions**. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-P1399A

Pep2m, myristoylated TFA Myr-Pep2m TFA	PKC	Neurological Disease
Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, *N-ethylmaleimide-sensitive factor/glutamate* receptor subunit 2 (NSF/GluR2) interactions**. PKMζ is an autonomously active isozyme of protein kinase C (PKC) .

HY-P5395

TAT-GluR23A Fusion Peptide	HIV	Others
TAT-GluR23A Fusion Peptide is a biological active peptide. (This is the GluR23A sequence, a control inactive peptide used as a mutant counterpart to glutamate receptor endocytosis inhibitor (GluR23Y), connected to an 11 amino acid cell permeable HIV Trans-Activator of Transcription (TAT) protein transduction domain (PTD). GluR23A is derived from GluR23Y amino acids 869 to 877, with Ala substituted for Tyr, and thus lacking essential phosphorylation sites.Control peptide of HY-P2259)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5110

Marmesinin (-)-Marmesinin; Ammijin	Pseudognaphalium affine (D. Don) Anderberg Source classification Coumarins Phenylpropanoids Plants Umbelliferae	Others
Marmesinin ((-)-Marmesinin), a natural coumarin, is a biosynthetic precursor of psoralen and linear furanocoumarins. Marmesinin exhibits significant neuroprotective activities against glutamate-induced toxicity .

HY-N8115

S-(4-Hydroxybenzyl)glutathione	Structural Classification Monophenols Gastrodia elata Bl. Ketones, Aldehydes, Acids Orchidaceae Source classification Phenols Plants	Others
S-(4-Hydroxybenzyl)glutathione is a glutathione derivative. S-(4-Hydroxybenzyl)glutathione inhibits the in vitro binding of kainic acid to brain glutamate receptors, with an IC₅₀ of 2 μM .

HY-B0649

Propofol 5+ Cited Publications 2,6-Diisopropylphenol	Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	GABA Receptor Endogenous Metabolite
Propofol potently and directly activates GABA_A receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic .

HY-N10272

Avenaciolide	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Fungal Bacterial
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .

HY-N11930

5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone	Structural Classification Gramineae Source classification Phenols Polyphenols Plants Imperata cylindrica (L.) Beauv.	Others
Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent . Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cell .

HY-12597

Quisqualic acid L-Quisqualic acid	Structural Classification Ketones, Aldehydes, Acids Combretaceae Source classification Plants Quisqualis indica Linn.	iGluR mGluR
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .

HY-134136

Octanoyl Coenzyme A	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Others Endogenous Metabolite
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-113371

2-Methylcitric acid Methylcitric acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-N10772

Albanin A	Structural Classification Flavonoids Source classification Morus nigra Linn. Plants Moraceae Other Flavonoids	Calcium Channel Calmodulin Adenylate Cyclase
Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca ²⁺/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity .

HY-126169

L-Glutamine amide	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Glutamine amide is a metabolite involved in glutamate metabolism.

HY-113080

N-Acetylornithine 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.

HY-W014666

Xanthurenic acid 1 Publications Verification	Structural Classification Monophenols Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite	Endogenous Metabolite mGluR Apoptosis
Xanthurenic acid is a putative endogenous *Group II metabotropic glutamate* receptor** agonist, on sensory transmission in the thalamus.

HY-17551

NMDA 10+ Cited Publications N-Methyl-D-aspartic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	iGluR Endogenous Metabolite
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

HY-N2309

Kainic acid 5+ Cited Publications	Alkaloids Structural Classification other families Pyrrole Alkaloids Neurological Disease Classification of Application Fields Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	EAAT
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures .

HY-N7034

Magnolioside	Pseudognaphalium affine (D. Don) Anderberg other families Source classification Coumarins Phenylpropanoids Plants Umbelliferae	Others
Magnolioside, isolated from Angelica gigas Nakai (Umbelliferae), exhibits significant neuroprotective activities against glutamate-induced toxicity .

HY-N0391

L-Citrulline 3 Publications Verification	Classification of Application Fields Source classification Other Diseases Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-12688

Succinyl phosphonate	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species
Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

HY-12688A

Succinyl phosphonate trisodium salt 10+ Cited Publications	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Reactive Oxygen Species
Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

HY-W014666R

Xanthurenic acid (Standard)	Structural Classification Monophenols Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Endogenous metabolite	Endogenous Metabolite mGluR Apoptosis
Xanthurenic acid (Standard) is the analytical standard of Xanthurenic acid. This product is intended for research and analytical applications. Xanthurenic acid is a putative endogenous *Group II metabotropic glutamate* receptor** agonist, on sensory transmission in the thalamus.

HY-122808

(-)-Camphoric acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Cinnamomum glanduliferum (Wall.) Nees Metabolic Disease Plants Lauraceae Disease Research Fields	mGluR
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression. Camphoric acid also significantly induced the activation of NF-κB and AP-1 .

HY-B0158

Cytidine 3 Publications Verification Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms other families Animals Source classification Disease markers Nervous System Disorder Plants Endogenous metabolite	Nucleoside Antimetabolite/Analog Endogenous Metabolite
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-107512

Kynurenic acid sodium 3 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields	iGluR Apoptosis Endogenous Metabolite CXCR GPR35
Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting *NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8*.

HY-100806

Kynurenic acid 3 Publications Verification Quinurenic acid	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Quinoline Alkaloids Endogenous metabolite Disease Research Fields Endocrinology	iGluR Endogenous Metabolite Apoptosis CXCR GPR35
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting *NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8*.

HY-N12635

Levinoid C	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Levinoid C is a Cytochrome P450-modified bacterial terpenoid. Levinoid C shows moderate neuroprotective activity against glutamate-induced excitotoxicity cell model with an EC₅₀ of 21 μM .

HY-N8412

4-O-Methylbutein	Structural Classification Labiatae Source classification Phenols Polyphenols Helianthella quinquenervis (Hook.) A.Gray Plants	Others
4-O-Methylbutein is a phenolic glucoside that can be isolated from Elsholtzia ciliata.4-O-Methylbutein exhibits neuroprotective effects against glutamate-induced HT22 cell death with an EC₅₀ of 35.2 μM .

HY-B0649R

Propofol (Standard) 2,6-Diisopropylphenol (Standard)	Structural Classification Monophenols Source classification Phenols Endogenous metabolite	GABA Receptor Endogenous Metabolite
Propofol (Standard) is the analytical standard of Propofol. This product is intended for research and analytical applications. Propofol potently and directly activates GABA_A receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic .

HY-N12067

Columbianetin β-D-glucopyranoside	Structural Classification Source classification Plants Umbelliferae Seriphidium transiliense Saccharides Monosaccharides	Others
Columbianetin β-D-glucopyranoside can be isolated from Angelicae pubescentis radix and has antiplatelet aggregation, anti-inflammatory and analgesic activities. Columbianetin β-D-glucopyranoside exerts significant protective effects against glutamate-induced toxicity .

HY-W040307

Saccharopine L-Saccharopine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis .

HY-W040307B

Saccharopine hydrochloride L-Saccharopine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis .

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-N12016

Fulvotomentoside B	Triterpenes Structural Classification Caprifoliaceae Terpenoids Source classification Plants Lonicera macrantha (D. Don) Spreng. Saccharides Monosaccharides	Others
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-100806R

Kynurenic acid (Standard) Quinurenic acid (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Quinoline Alkaloids Endogenous metabolite	iGluR Endogenous Metabolite Apoptosis CXCR GPR35
Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting *NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8*.

HY-113371A

2-Methylcitric acid trisodium Methylcitric acid trisodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-100355

C18-Ceramide	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
C18-Ceramide can promote exocytosis of glutamate from damaged neurons. C18-Ceramide promotes cell death in glioma cells. Ceramides is involved in diverse cellular functions, such as differentiation, cell cycle progression, cell-cell adhesion, senescence, and apoptosis .

HY-14608

L-Glutamic acid 3 Publications Verification	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Endogenous Metabolite iGluR Ferroptosis Apoptosis
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases .

HY-112171

γ-L-Glutamyl-L-alanine 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite CaSR
γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function .

HY-W670700

2,5-Dihydroxy-4-methoxyacetophenone	Structural Classification Source classification Asclepiadaceae Phenols Polyphenols Cynanchum paniculatum (Bunge) Kitagawa Plants	Others
2,5-Dihydroxy-4-methoxyacetophenone (compounds 3) can be isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa. 2,5-Dihydroxy-4-methoxyacetophenone inhibits glutamate-induced cytotoxicity in hippocampal HT22 cell line .

HY-Y0966

Glycine 4 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite iGluR VEGFR Small Interfering RNA (siRNA)
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .

HY-N6776

Penitrem A	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Potassium Channel
Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .

HY-W017230

L-Cysteinesulfinic acid monohydrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	mGluR Endogenous Metabolite
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-B0778

Milbemycin oxime	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Antibiotic Parasite
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-14608A

L-Glutamic acid monosodium salt 3 Publications Verification	Structural Classification Microorganisms other families Animals Source classification Amino acids Plants	iGluR Apoptosis Ferroptosis Endogenous Metabolite
L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases .

HY-118482

Sauristolactam Saurolactam	Alkaloids Monophenols Aristolochia debilis Sieb. et Zucc. Source classification Phenols Plants Aristolochiaceae Indole Alkaloids	Others
Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells . Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation .

HY-15121

L-Theanine 1 Publications Verification L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Anti-aging Source classification Amino acids Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Theaceae	Apoptosis Endogenous Metabolite Reactive Oxygen Species
L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active .

HY-N9404

6-Benzoylheteratisine	Alkaloids Piperidine Alkaloids Structural Classification Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Sodium Channel
6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na ⁺]i, [Ca ²⁺]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge .

HY-Z0283

Benzamide Benzenecarboxamide; Phenylamide	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite PARP
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-17387

(-)-Huperzine A 3 Publications Verification Huperzine A	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Huperziaceae Source classification Pyridine Alkaloids Plants Alkaloids Terpenoids Sesquiterpenes Huperzia serrata Disease Research Fields	Cholinesterase (ChE) Apoptosis iGluR
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of *N-methyl-D-aspartate glutamate* (NMDA) receptor**. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-13653

(-)-Epigallocatechin Gallate Maximum Cited Publications 29 Publications Verification EGCG; Epigallocatechol Gallate	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Flavonoids other families Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-N0037

Albiflorin 2 Publications Verification	Structural Classification Other Monoterpenes Classification of Application Fields Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

HY-N0215

L-Phenylalanine Phenylalanine	Structural Classification Microorganisms Classification of Application Fields Animals Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Calcium Channel iGluR Endogenous Metabolite
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

Species:	Human (19) Mouse (6) Rat (1) E.coli (2)
Tag:	His (23) SUMO (3) Tag Free (2) GST (2) MBP (1) Flag (2) Fc (1)
Source:	HEK293 (8) E. coli Cell-free (3) Sf9 insect cells (8) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P70294

	Glutamine synthetase/GLUL Protein, Human (His) rHuGlutamine synthetase/GLUL, His; Glutamine Synthetase; GS; glutamate Decarboxylase; glutamate--Ammonia Ligase; GLUL; GLNS	Human	E. coli
	GLUL proteins catalyze the conversion of glutamate and ammonia to glutamine. Glutamine synthetase/GLUL Protein, Human (His) is the recombinant human-derived Glutamine synthetase/GLUL protein, expressed by E. coli , with C-6*His labeled tag. The total length of Glutamine synthetase/GLUL Protein, Human (His) is 372 a.a., with molecular weight of 40-50 kDa.

HY-P72213

	GRIN1 Protein, Human (His) GluN1; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor ionotropic N methyl D aspartate 1; glutamate receptor ionotropic, NMDA 1; Grin1; MRD8	Human	E. coli
	The GRIN1 protein is a component of the NMDA receptor complex that forms heterotetrameric ligand-gated ion channels with high calcium permeability. GRIN1 Protein, Human (His) is the recombinant human-derived GRIN1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GRIN1 Protein, Human (His) is 541 a.a., with molecular weight of ~64.6 kDa.

HY-P76352

	FTCD Protein, Human (sf9, His) Formimidoyltransferase-cyclodeaminase; FTCD; LCHC1; glutamate formyltransferase	Human	Sf9 insect cells
	The FTCD protein is a folate-dependent enzyme with dual functions of transferase and deaminase activities. It plays a crucial role in directing the one-carbon units from methyliminoglutamic acid into the folate pool, contributing to the regulation of folate metabolism. FTCD Protein, Human (sf9, His) is the recombinant human-derived FTCD protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FTCD Protein, Human (sf9, His) is 541 a.a., with molecular weight of ~60.4 KDa.

HY-P702436

	SLC25A18 Protein, Mouse (Cell-Free, His) Mitochondrial glutamate carrier 2; glutamate/H(+) symporter 2; Solute carrier family 25 member 18	Mouse	E. coli Cell-free
	SLC25A18 protein facilitates the symport transport of glutamate from the cytosol into the mitochondrial matrix, accompanied by the concurrent import of a proton. SLC25A18 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived SLC25A18 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SLC25A18 Protein, Mouse (Cell-Free, His) is 320 a.a., with molecular weight of 35.7 kDa.

HY-P702437

	SLC25A18 Protein, Rat (Cell-Free, His) Mitochondrial glutamate carrier 2; glutamate/H(+) symporter 2; Solute carrier family 25 member 18	Rat	E. coli Cell-free
	SLC25A18 Protein transports glutamate molecules from the cytosol into the mitochondrial matrix through a symport system that involves simultaneous proton import. SLC25A18 Protein, Rat (Cell-Free, His) is the recombinant rat-derived SLC25A18 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SLC25A18 Protein, Rat (Cell-Free, His) is 320 a.a., with molecular weight of 35.7 kDa.

HY-P701914

	GLUD1 Protein, Human GLUD1; glutamate dehydrogenase 1; mitochondrial; GDH 1	Human	E. coli
	GLUD1 protein is a mitochondrial glutamate dehydrogenase that converts L-glutamate into α-ketoglutarate, supporting glutamine anaplerosis and the tricarboxylic acid cycle. In addition to metabolism, GLUD1 plays a key role in insulin homeostasis, complexly regulating glucose metabolism. GLUD1 Protein, Human is the recombinant human-derived GLUD1 protein, expressed by E. coli , with tag free. The total length of GLUD1 Protein, Human is 505 a.a., .

HY-P75178

	GAD2/GAD65 Protein, Mouse (sf9) glutamate decarboxylase 2; GAD-65; GAD2	Mouse	Sf9 insect cells
	GAD2/GAD65 Protein is a key enzyme in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). Meanwhile, GAD2 also has glutamate binding activity, glutamate decarboxylase activity, and pyridoxal phosphate binding activity. GAD2 is expressed in several structures, including the genitourinary system, the gastrointestinal nervous system, and sensory organs. It can be used to study epilepsy and type 1 diabetes. GAD2/GAD65 Protein, Mouse (sf9) is the recombinant mouse-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with tag free. The total length of GAD2/GAD65 Protein, Mouse (sf9) is 585 a.a., with molecular weight of ~58 kDa.

HY-P701915

	GLUD1 Protein, Human (His) GLUD1; glutamate dehydrogenase 1; mitochondrial; GDH 1	Human	E. coli
	GLUD1 protein is a mitochondrial glutamate dehydrogenase that converts L-glutamate into α-ketoglutarate, supporting glutamine anaplerosis and the tricarboxylic acid cycle. In addition to metabolism, GLUD1 plays a key role in insulin homeostasis, complexly regulating glucose metabolism. GLUD1 Protein, Human (His) is the recombinant human-derived GLUD1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GLUD1 Protein, Human (His) is 505 a.a., .

HY-P7611

	GOT1 Protein, Human (His) rHuGOT1, His; glutamate Oxaloacetate Transaminase 1; Transaminase A; GOT1	Human	E. coli
	GOT1 Protein, Human (His), a recombinant human GOT1 produced in E. coli, has a His tag. Calcitonin has an effect on decreasing osteoclast activity and has the potential for hypercalcemia research. Reduction in glutamate concentration in blood is induced through the activity of the blood-resident enzyme glutamate oxaloacetate transaminase 1 (GOT1), which catalyzes the reversible transformation of oxaloacetate and glutamate to aspartate and α-ketoglutarate.

HY-P75179

	GAD2/GAD65 Protein, Human (sf9, GST) glutamate decarboxylase 2; GAD-65; GAD2	Human	Sf9 insect cells
	GAD2/GAD65 proteins are key enzymes in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). GABA is an important inhibitory neurotransmitter in the central nervous system, playing a key role in regulating neuronal excitability and maintaining the balance between excitation and inhibition in the brain. GAD2/GAD65 Protein, Human (sf9, GST) is the recombinant human-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of GAD2/GAD65 Protein, Human (sf9, GST) is 585 a.a., with molecular weight of ~92.6 kDa.

HY-P702045

	SLC1A2 Protein, Human (Sf9, His, MBP, FLAG) SLC1A2; Excitatory amino acid transporter 2; glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2	Human	Sf9 insect cells
	The SLC1A2 protein is a sodium-dependent high-affinity amino acid transporter that greatly promotes the uptake of L-glutamic acid, L-aspartate, and D-aspartate. As an symporter, it co-transports an amino acid molecule with two or three Na(+) ions and a proton, while counter-transporting a K(+) ion. SLC1A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC1A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC1A2 Protein, Human (Sf9, His, MBP, FLAG) is 574 a.a., .

HY-P75177

GAD2/GAD65 Protein, Mouse (sf9, His-GST)

glutamate decarboxylase 2; GAD-65; GAD2
Mouse Sf9 insect cells

HY-P75180

	GAD1/GAD67 Protein, Human (sf9, His) glutamate decarboxylase 1; GAD-67; GAD1; GAD	Human	Sf9 insect cells
	The GAD1/GAD67 protein utilizes pyridoxal 5'-phosphate as a cofactor and acts as a catalyst in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). GAD1 plays a key role in the conversion of glutamate to GABA, a key neurotransmitter involved in regulating neuronal excitability. GAD1/GAD67 Protein, Human (sf9, His) is the recombinant human-derived GAD1/GAD67 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of GAD1/GAD67 Protein, Human (sf9, His) is 594 a.a., with molecular weight of ~64 kDa.

HY-P75156

	GRIK2 Protein, Human (HEK293, hFc) glutamate receptor ionotropic, kainate 2; GluK2; EAA4; GluR6	Human	HEK293
	GRIK2 is an ionotropic glutamate receptor that plays an important role in central nervous system synapses, responding to L-glutamate as an excitatory neurotransmitter. Upon binding of L-glutamate, GRIK2 undergoes a conformational change that opens cation channels that convert chemical signals into electrical impulses. GRIK2 Protein, Human (HEK293, hFc) is the recombinant human-derived GRIK2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GRIK2 Protein, Human (HEK293, hFc) is 530 a.a., with molecular weight of ~100-115 kDa.

HY-P70548

	PSMA Protein, Human (HEK293, His) glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1	Human	HEK293
	PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA Protein, Human (HEK293, His) is the recombinant human-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PSMA Protein, Human (HEK293, His) is 707 a.a., with molecular weight of 90-120 kDa.

HY-P71240

	PSMA Protein, Mouse (HEK293, His) glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1	Mouse	HEK293
	PSMA Protein, a multifunctional enzyme, acts as a folate hydrolase and NAALADase with a preference for tri-alpha-glutamate peptides. In the intestine, it aids folate uptake for metabolic processes. In the brain, PSMA modulates neurotransmission by hydrolyzing NAAG, releasing glutamate. It also shows dipeptidyl-peptidase IV type activity and effectively cleaves Gly-Pro-AMC, highlighting its versatile enzymatic functions. PSMA Protein, Mouse (HEK293, His) is the recombinant mouse-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PSMA Protein, Mouse (HEK293, His) is 709 a.a., with molecular weight of 100-120 kDa.

HY-P76703

	PSMA Protein, Human (Biotinylated, HEK293, His) glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1	Human	HEK293
	PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PSMA Protein, Human (Biotinylated, HEK293, His) is 707 a.a., with molecular weight of ~81.7 kDa.

HY-P70548A

	PSMA Protein, Human (HEK293, N-His) glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1	Human	HEK293
	PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA Protein, Human (HEK293, N-His) is the recombinant human-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PSMA Protein, Human (HEK293, N-His) is 707 a.a., with molecular weight of 80-120 kDa.

HY-P70103

	CNDP2 Protein, Mouse (HEK293, His) rMuCytosolic non-specific dipeptidase/CNDP2, His; CNDP2; CNDP dipeptidase 2; Cytosolic non-specific dipeptidase; glutamate carboxypeptidase-like protein 1; Cn2	Mouse	HEK293
	CNDP2 Protein, an enzyme, plays a vital role in the metabolism of carnosine and homocarnosine. Dysregulation of CNDP2 Protein has been linked to diabetic nephropathy and neurodegenerative disorders. Targeting CNDP2 Protein may offer potential therapeutic strategies by regulating carnosine metabolism, improving renal function, and potentially treating these conditions. CNDP2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CNDP2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CNDP2 Protein, Mouse (HEK293, His) is 475 a.a., with molecular weight of 56-60 kDa.

HY-P7740

	Carnosine Dipeptidase 1/CNDP1 Protein, Human (HEK293, His) rHuCarnosine Dipeptidase 1, His; Beta-Ala-His Dipeptidase; CNDP Dipeptidase 1; Carnosine Dipeptidase 1; glutamate Carboxypeptidase-Like Protein 2; Serum Carnosinase; CNDP1; CN1; CPGL2	Human	HEK293
	Carnosine Dipeptidase 1 Protein, Human (HEK293, His) is a human carnosine dipeptidase 1 protein with a his-flag, expressed in HEK293 cells. Carnosine Dipeptidase 1 is a member of the M20 metalloprotease family, encoded by the CNDP1 gene.

HY-P71559

	NAALADL2 Protein, Human (His-SUMO) glutamate carboxypeptidase II type non peptidase homologue; Inactive N acetylated alpha linked acidic dipeptidase like protein 2; Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2; N acetylated alpha linked acidic dipeptidase like 2; NAALADase L2; NAALADL 2; NAALADL2	Human	E. coli
	The NAALADL2 protein was identified as catalytically inactive, suggesting a role beyond enzymatic activity. The name implies that non-enzymatic functions contribute to different cellular processes. NAALADL2 Protein, Human (His-SUMO) is the recombinant human-derived NAALADL2 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of NAALADL2 Protein, Human (His-SUMO) is 653 a.a., with molecular weight of ~88.6 kDa.

HY-P702494

	GPT1 Protein, Human (His) AAT1; Alanine aminotransferase 1; Alanine aminotransferase; ALAT1_HUMAN; ALT1; glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvate transaminase (alanine aminotransferase); Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; gpt; GPT1	Human	E. coli
	The GPT1 protein is a key player that catalyzes the reversible cleavage of L-arginine succinate, which is critical in the urea cycle, aids in hepatic nitrogen detoxification and promotes de novo L-arginine synthesis. GPT1 regulates intracellular and extracellular L-arginine pools, which are critical for nitrogen homeostasis. GPT1 Protein, Human (His) is the recombinant human-derived GPT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GPT1 Protein, Human (His) is 495 a.a., with molecular weight of 58.5 kDa.

HY-P701627

	GRM5 Protein, Human (His) GRM5; Metabotropic glutamate receptor 5; mGluR5	Human	Sf9 insect cells
	The GRM5 protein is a G protein-coupled glutamate receptor that undergoes ligand-induced conformational changes and activates signaling cascades through G proteins, affecting downstream effectors. This cascade includes the phosphatidylinositol-calcium second messenger system and induces calcium-activated chloride currents. GRM5 Protein, Human (His) is the recombinant human-derived GRM5 protein, expressed by Sf9 insect cells , with C-10*His labeled tag. ,

HY-P71460

	GltI/YbeJ Protein, E.coli (His-SUMO) gltI; ybeJ; yzzK; b0655; JW5092glutamate/aspartate import solute-binding protein	E.coli	E. coli
	The GltI/YbeJ protein is a key component of the ABC transporter complex GltIJKL and is essential for active transport of glutamate and aspartate. As the solute-binding protein in the complex, GltI binds glutamate and aspartate. GltI/YbeJ Protein, E.coli (His-SUMO) is the recombinant E. coli-derived GltI/YbeJ protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of GltI/YbeJ Protein, E.coli (His-SUMO) is 280 a.a., with molecular weight of ~47.2 kDa.

HY-P71200

	PGCP Protein, Mouse (HEK293, His) PGCP; Carboxypeptidase Q; Hematopoietic lineage switch 2; Plasma glutamate carboxypeptidase; Cpq; Hls2	Mouse	HEK293
	PGCP is a carboxypeptidase with a potentially critical role in the hydrolysis of circulating peptides. It catalyzes the cleavage of terminally unsubstituted dipeptides, releasing amino acids. PGCP Protein, Mouse (HEK293, His) is the recombinant mouse-derived PGCP protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PGCP Protein, Mouse (HEK293, His) is 452 a.a., with molecular weight of ~60.0 kDa.

HY-P701838

	P371 Protein, Human (Sf9, FLAG) GGCX; Vitamin K-dependent gamma-carboxylase; Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase	Human	Sf9 insect cells
	The P371 protein is critical in cellular processes and mediates vitamin K-dependent carboxylation of glutamate residues to form calcium-binding γ-carboxyglutamic acid (Gla) residues. At the same time, it converts the reduced hydroquinone form of vitamin K into vitamin K epoxide. P371 Protein, Human (Sf9, FLAG) is the recombinant human-derived P371 protein, expressed by Sf9 insect cells , with C-Flag labeled tag. The total length of P371 Protein, Human (Sf9, FLAG) is 758 a.a., .

HY-P71511

	Gamma-GCS Protein, E.coli (His-SUMO) gshA; gsh-I; b2688; JW2663glutamate--cysteine ligase; EC 6.3.2.2; Gamma-ECS; GCS; Gamma-glutamylcysteine synthetase	E.coli	E. coli
	Gamma-GCS protein is a key enzyme in sulfur metabolism and initiates glutathione synthesis by catalyzing the incorporation of L-cysteine and L-glutamic acid. This important molecule critical for cellular antioxidant defense is synthesized through a critical 1/2 step facilitated by γ-GCS. Gamma-GCS Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Gamma-GCS protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of Gamma-GCS Protein, E.coli (His-SUMO) is 518 a.a., with molecular weight of ~74.3 kDa.

HY-P702444

	SLC7A11 Protein, Human (Cell-Free, His) Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT	Human	E. coli Cell-free
	The SLC7A11 protein forms a heterodimer with SLC3A2 and acts as an antiporter to exchange extracellular L-cystine for intracellular L-glutamate across the plasma membrane. This sodium-independent electroneutral transport, with a 1:1 stoichiometry, relies on high intracellular levels of L-glutamate and intracellular reduction of L-cystine. SLC7A11 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC7A11 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SLC7A11 Protein, Human (Cell-Free, His) is 501 a.a., with molecular weight of 58.2 kDa.

Cat. No.	Product Name	Chemical Structure

HY-113371S

2-Methylcitric acid-d3

2-Methylcitric acid-d₃ is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

HY-113080S

N-Acetylornithine-d2
N-Acetylornithine-d₂ is the deuterium labeled Melengestrol. N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.

HY-B0649S1

Propofol-d18
Propofol-d₁₈ is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission[1].

HY-Y0367S

Maleic Acid-d2

Maleic Acid-d₂ is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].

HY-B0158S4

Cytidine-d1
Cytidine-d is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol

HY-W014666S

Xanthurenic acid-d4
Xanthurenic acid-d₄ is the deuterium labeled Xanthurenic acid[1]. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus[2].

HY-B0649S

Propofol-d17
Propofol-d₁₇ is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties[1].

HY-N0391S2

L-Citrulline-d6
L-Citrulline-d₆ is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-N0391S4

L-Citrulline-d4
L-Citrulline-d₄ is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-N0391S5

L-Citrulline-d7
L-Citrulline-d₇ is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-N0391S3

L-Citrulline-13C
L-Citrulline- ¹³C is the ¹³C-labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

HY-Y0966S1

Glycine-d2
Glycine-d₂ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S8

Glycine-d5
Glycine-d₅ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S10

Glycine-d3
Glycine-d₃ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-B0158S1

Cytidine-13C
Cytidine- ¹³C is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine

HY-B0158S3

Cytidine-d2-1
Cytidine-d₂-1 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catech

HY-Y0966S3

Glycine-13C2
Glycine- ¹³C₂ is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S

Glycine-15N
Glycine- ¹⁵N is the ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].

HY-Y0966S2

Glycine-2-13C
Glycine-2- ¹³C is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S4

Glycine-1-13C
Glycine-1- ¹³C is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-B0158S2

Cytidine-13C-1
Cytidine- ¹³C-1 is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami

HY-16973S

Fluralaner-13C2,15N,d3
Fluralaner- ¹³C₂, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

HY-Y0966S6

Glycine-13C2,15N
Glycine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S9

Glycine-15N,d2
Glycine- ¹⁵N,d₂ is the deuterium and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-B0158S

Cytidine-d2
Cytidine-d₂ is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[1][2][3].

HY-Y0966S5

Glycine-1-13C,15N
Glycine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S7

Glycine-2-13C,15N
Glycine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-14608S

L-Glutamic acid-13C
L-Glutamic acid- ¹³C is the ¹³C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-14608S7

L-Glutamic acid-d5
L-Glutamic acid-d₅ is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-14608S8

L-Glutamic acid-d3
L-Glutamic acid-d₃ is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-100806S

Kynurenic acid-d5
Kynurenic acid-d₅ is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting *NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].*

HY-14608S5

L-Glutamic acid-13C5
L-Glutamic acid- ¹³C₅ is the ¹³C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-14608S2

L-Glutamic acid-15N
L-Glutamic acid- ¹⁵N is the ¹⁵N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals[1].

HY-B0158S6

Cytidine-15N3
Cytidine- ¹⁵N₃ is the ¹⁵N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].

HY-14608S1

L-Glutamic acid-1-13C
L-Glutamic acid-1- ¹³C is the ¹³C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-14608S6

L-Glutamic acid-5-13C
L-Glutamic acid-5- ¹³C is the ¹³C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-14608S3

L-Glutamic acid-13C5,15N
L-Glutamic acid- ¹³C₅, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-14608S9

L-Glutamic acid-15N,d5
L-Glutamic acid- ¹⁵N,d₅ is the deuterium and ¹⁵N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-14608S10

L-Glutamic acid-13C2
L-Glutamic acid- ¹³C₂ is the ¹³C labeled L-Glutamic acid[1]. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals[2].

HY-Y0966S11

Glycine-13C2,15N,d2
Glycine- ¹³C₂, ¹⁵N,d₂ is the deuterium, ¹³C and ¹⁵N labeled Glycine[1]. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[2].

HY-B0158S5

Cytidine-13C9,15N3
Cytidine- ¹³C₉, ¹⁵N₃ is the ¹³C and ¹⁵N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].

HY-14608S4

L-Glutamic acid-13C5,15N,d5
L-Glutamic acid- ¹³C₅, ¹⁵N,d₅ is the deuterium, ¹³C-, and 15-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-B0495S4

Lamotrigine-13C3
Lamotrigine- ¹³C₃ is the ¹³C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-B0495S5

Lamotrigine-d3
Lamotrigine-d3 is the deuterium labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].

HY-B0495S1

Lamotrigine-13C,d3
Lamotrigine- ¹³C,d₃ is the ¹³C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-B0495S

Lamotrigine-13C3,d3
Lamotrigine- ¹³C₃,d₃ is the ¹³C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-15121S

L-Theanine-d5

L-Theanine-d₅ is the deuterium labeled L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake[1][2][3].

HY-B0495S3

Lamotrigine-13C2,15N
Lamotrigine-13C2,15N is the 13C and 15N labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].

HY-B0158S8

Cytidine-d13
Cytidine-d13 (Cytosine β-D-riboside-d13; Cytosine-1-β-D-ribofuranoside-d13) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .

HY-100808S

D-Serine-d3

D-Serine-d₃ ((R)-Serine-d₃) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

Cat. No.	Product Name	Application	Reactivity

HY-P80407

Glutamate receptor 1 Antibody	WB, IHC-P, IP	Mouse, Rat
Glutamate receptor 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 102 kDa, targeting to Glutamate receptor 1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Mouse, Rat.

HY-P81398

*Ionotropic Glutamate* Receptor 2 Antibody (YA1143)** GRIA2; GLUR2; glutamate receptor 2; GluR-2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; glutamate receptor ionotropic; AMPA 2; GluA2	IHC-P	Human

HY-P82336

*Phospho-Glutamate* Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)** GRIA1; GLUH1; GLUR1; glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; glutamate receptor ionotropic; AMPA 1; GluA1	WB	Human, Rat

HY-P81662

GCLM Antibody (YA1407) GCLM; GLCLR; glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; glutamate--cysteine ligase modifier subunit	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

HY-P83468

FTCD Antibody (YA3213)

Formimidoyltetrahydrofolate cyclodeaminase; FTCD; glutamate formiminotransferase; LCHC 1
WB, IHC-P, FC Human

HY-P82737

EAAT2 Antibody (YA2482) Excitatory amino acid transporter 2; glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2	WB, IP	Human, Mouse, Rat

HY-P82430

Aspartate Aminotransferase Antibody (YA2175)

Aspartate aminotransferase; cytoplasmic; glutamate oxaloacetate transaminase 1; Transaminase A
WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P83153

GCLC Antibody (YA2898)

GCLC; GLCL; GLCLC; glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase
WB Human, Mouse, Rat
HY-P82062

GAD67 Antibody (YA1807)

glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD 67; GAD1; GAD; GAD67
WB, IP Human
HY-P83281

Glutamate Dehydrogenase 1 Antibody (YA3026)

GDH; Gdh-X; GDH1; GLUD; Glud1; Glud1a; Glud1b; Gludl; MRG-2
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P80220

*Metabotropic glutamate* receptor 5 Antibody**	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
Metabotropic glutamate receptor 5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 132 kDa, targeting to Metabotropic glutamate receptor 5. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83473

*Metabotropic Glutamate* Receptor 2 Antibody (YA3218)** GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; MGLUR3; Metabotropic glutamate receptor 3; mGluR3	WB, IHC-P	Human, Mouse

HY-P80935

xCT Antibody (YA006) CCBR1; Cysteine/glutamate transporter; SLC7A11; solute carrier family 7; xCT	WB, IP	Human, Mouse
xCT Antibody (YA006) is a non-conjugated and Rabbit origined monoclonal antibody about 55 kDa, targeting to xCT. It can be used for WB,IP assays with tag free, in the background of Human, Mouse.

HY-P83232

Metabotropic Glutamate Receptor 3 Antibody (YA2977)

GLUR3; GPRC1C; GRM3; MGlu3; mGluR3
WB Human, Mouse, Rat
HY-P83450

mGluR1 Antibody (YA3195)

GRM1; GPRC1A; MGLUR1; Metabotropic glutamate receptor 1; mGluR1
WB Human, Mouse, Rat
HY-P81764

GRM5 Antibody (YA1509)

GPRC1E; GRM5; Metabotropic glutamate receptor 5 precursor; MGLUR5; MGR5
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P82620

EAAT3 Antibody (YA2365) SLC1A1; EAAC1; EAAT3; Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1	WB, IHC-P, ICC/IF	Human, Mouse, Rat

HY-P82734

EAAT1 Antibody (YA2479) SLC1A3; EAAT1; GLAST; GLAST1; Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3	WB, IHC-P	Human, Mouse, Rat

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