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gpx4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Bcl-2 Family (2) CDK (1) COX (2) Ferroptosis (27) Glutathione Peroxidase (22) JNK (1) Keap1-Nrf2 (1) MDM-2/p53 (2) Microtubule/Tubulin (1) p62 (1) Prostaglandin Receptor (1) PROTACs (3) Reactive Oxygen Species (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (29) Endocrinology (1) Inflammation/Immunology (3) Neurological Disease (1)
Click Chemistry:	Alkynes (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141809

GPX4-IN-3 1 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM .

HY-138556

GPX4-IN-2

Glutathione Peroxidase Cancer

GPX4-IN-2 is a potent GPX4 inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer .

GPX4-IN-2	Glutathione Peroxidase	Cancer
GPX4-IN-2 is a potent *GPX4* inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer .

HY-RS05767

GPX4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX4 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX4 Human Pre-designed siRNA Set A GPX4 Human Pre-designed siRNA Set A

HY-163272

GPX4/CDK-IN-1	Glutathione Peroxidase CDK	Cancer
GPX4/CDK-IN-1 (Compound B9) is a dual inhibitor of *GPX4* and CDK, with IC₅₀ values of 542.5 nM, 191.2 nM and 68.1 nM for GPX4, CDK4 and CDK6, reapectively. GPX4/CDK-IN-1 shows strong cancer cell growth inhibition in vivo .

HY-156286

GPX4-IN-7	Ferroptosis	Cancer
GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC₅₀ value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis .

HY-149923

GPX4-IN-4

Glutathione Peroxidase Cancer

GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer .
HY-149455

GPX4-IN-8

Glutathione Peroxidase Cancer

GPX4-IN-8 (compound A80) is a potent GPX4 inhibitor. GPX4-IN-8 shows antiproliferative activity .

GPX4-IN-4	Glutathione Peroxidase	Cancer
GPX4-IN-4 (Compound 24) is a potent *GPX4* inhibitor. GPX4-IN-4 can be used for the research of cancer .

GPX4-IN-8	Glutathione Peroxidase	Cancer
GPX4-IN-8 (compound A80) is a potent *GPX4* inhibitor. GPX4-IN-8 shows antiproliferative activity .

HY-157762

GPX4-IN-9	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets *GPX4* under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research .

HY-115627

PKUMDL-LC-101-D04 1 Publications Verification gpx4-Activator-1d4	Glutathione Peroxidase	Inflammation/Immunology
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 *(GPX4)* allosteric activator (pEC₅₀=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts .

HY-155663

GPX4-IN-5	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-5 (Compound C18) is a *GPX4* covalent inhibitor with an IC₅₀ value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

HY-155664

GPX4-IN-6	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-6 (Compound C25) is a *GPX4* covalent inhibitor with an IC₅₀ value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

HY-149236

PROTAC GPX4 degrader-1

PROTACs Glutathione Peroxidase Ferroptosis Cancer

PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC₅₀ of 0.03 μM in HT1080 cells .

*PROTAC GPX4* degrader-1**	PROTACs Glutathione Peroxidase Ferroptosis	Cancer
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based *GPX4* degrader, with a DC₅₀ of 0.03 μM in HT1080 cells .

HY-162106

*PROTAC GPX4* degrader-2**	Ferroptosis PROTACs Glutathione Peroxidase	Cancer
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC_{50, 48h} value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect .

HY-103087

FIN56 5+ Cited Publications	Ferroptosis	Others
FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

HY-100002

ML162 3 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

HY-139001

JKE-1716	Glutathione Peroxidase Ferroptosis	Others
JKE-1716 is a potent and selective nitrolic acid-containing *GPX4* inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent *GPX4* inhibition .

HY-129457

FINO2 1 Publications Verification	Ferroptosis	Cancer
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation .

HY-100003

ML-210 5+ Cited Publications
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity .

HY-155075

NC-R17	Glutathione Peroxidase Ferroptosis	Cancer
NC-R17 is a RSL3-based noncovalent *GPX4* degrader, involving in Ferroptosis. NC-R17 exhibits anti-tumor activity, used for noncovalent GPX4 PROTACs design .

HY-162065

N6F11	Ferroptosis	Cancer
N6F11 is a ferroptosis inducer, and can trigger the degradation of glutathione peroxidase 4 (GPX4) specifically in cancer cells. N6F11 can be used for ferroptosis study .

HY-157068

icFSP1	Ferroptosis	Cancer
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. icFSP1 does not competitively inhibit FSP1 enzyme activity, but instead triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation before ferroptosis induction, in synergism with GPX4 inhibition .

HY-155852

Lepadin H	Ferroptosis	Others
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-155851

Lepadin E	Ferroptosis MDM-2/p53 Glutathione Peroxidase	Cancer
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-N0070

Solasonine 2 Publications Verification	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-100218A

RSL3 Maximum Cited Publications 180 Publications Verification (1S,3R)-RSL3	p62 Glutathione Peroxidase Ferroptosis	Cancer
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-138153

JKE-1674	Glutathione Peroxidase Ferroptosis	Cancer
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of *GPX4* inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors .

HY-153748

ML162-yne	Glutathione Peroxidase	Cancer
ML162-yne is a potent GPX4-inhibitor affinity probe . ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151212

BCP-T.A	Ferroptosis Glutathione Peroxidase	Cancer
BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to *GPX4* . BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151428

Antitumor agent-78	Ferroptosis Apoptosis Bcl-2 Family COX	Cancer
Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .

HY-151429

Antitumor agent-77	Apoptosis Ferroptosis Bcl-2 Family COX	Cancer
Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .

HY-120912

Gingerenone A	Keap1-Nrf2 Glutathione Peroxidase	Inflammation/Immunology
Gingerenone A is a *Nrf2-Gpx4* activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale .

HY-136057

iFSP1 5+ Cited Publications	Ferroptosis	Cancer
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

HY-B0774

Seratrodast 4 Publications Verification AA 2414	Ferroptosis JNK MDM-2/p53 Prostaglandin Receptor Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity .

HY-157788

ZX703	PROTACs Reactive Oxygen Species Ferroptosis Glutathione Peroxidase	Cancer
ZX703 (compound 5I) is a PROTAC that significantly degrades *GPX4* in a dose- and time-dependent manner through the ubiquitin-proteasome and autophagy-lysosome pathways (DC₅₀=0.315 µM). ZX703 induces ferroptosis by inducing Reactive Oxygen Species (ROS) accumulation in cells. ZX703 can be used for cancer research .

HY-155203

Anticancer agent 154	Apoptosis Reactive Oxygen Species Ferroptosis	Cancer
Anticancer agent 154 (Compound 8h) increases the levels of reactive oxygen species and leads to mitochondrial damage. Anticancer agent 154 induces cell apoptosis and DNA damage. Anticancer agent 154 also induces ferroptosis by reducing the GSH level and GPX4 expression and increasing the lipid peroxidation level. Anticancer agent 154 inhibits cancer cell (HT29, H1975, A549, and MCF-7) proliferation with IC₅₀s of 1.0-1.9 μM .

HY-161075

Microtubule inhibitor 8	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 8 (MP-HJ-1b) is a potent inhibitor of microtubule. Microtubule inhibitor 8 triggers cell death through ferroptosis. Microtubule inhibitor 8 has anti-tumor effect .

Solasonine 2 Publications Verification	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Solanum nigrum Linn. Plants Solanaceae Disease Research Fields Cancer	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase
Gingerenone A is a *Nrf2-Gpx4* activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale .

Lepadin H	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

Lepadin E	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis MDM-2/p53 Glutathione Peroxidase
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .


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Glutathione Peroxidase 4 Antibody Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHgpx; EC 1.11.1.12; Glutathione peroxidase 4; gpx-4; GSHPx-4	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
Glutathione Peroxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 22 kDa, targeting to Glutathione Peroxidase 4. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

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