Search Result

Results for "

growth-inhibitory

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TGF-beta/Smad (2) Akt (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (1) Apoptosis (4) Aurora Kinase (1) Autophagy (2) Bacterial (1) Bcr-Abl (1) CCR (2) CDK (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (4) Eukaryotic Initiation Factor (eIF) (1) FAK (1) FLT3 (1) Fungal (1) Isotope-Labeled Compounds (1) Kinesin (1) mTOR (2) Notch (1) Parasite (4) PI3K (2) Proteasome (1) RAR/RXR (1) STAT (1)
By Research Areas:	Cancer (24) Cardiovascular Disease (4) Endocrinology (3) Infection (4) Inflammation/Immunology (6) Metabolic Disease (3) Neurological Disease (2)

By Targets:

TGF-beta/Smad (2)

Akt (1)

Angiotensin Receptor (2)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (1)

Apoptosis (4)

Aurora Kinase (1)

Autophagy (2)

Bacterial (1)

Bcr-Abl (1)

CCR (2)

CDK (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (4)

Eukaryotic Initiation Factor (eIF) (1)

FAK (1)

FLT3 (1)

Fungal (1)

Isotope-Labeled Compounds (1)

Kinesin (1)

mTOR (2)

Notch (1)

Parasite (4)

PI3K (2)

Proteasome (1)

RAR/RXR (1)

STAT (1)

By Research Areas:

Cancer (24)

Cardiovascular Disease (4)

Endocrinology (3)

Infection (4)

Inflammation/Immunology (6)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Macrophage migration inhibitory factor (MIF) FGFR VEGFR TGF-beta/Smad PDGFR TGF-β Receptor GHSR EGFR IGF-1R Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19356A

Didesmethylrocaglamide	Eukaryotic Initiation Factor (eIF) Apoptosis	Cancer
Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC₅₀ of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity .

HY-B0673S

Pirfenidone-d5 AMR69-d₅	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone-d₅ is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

HY-122308

Militarine

Others Metabolic Disease

Militarine, a glycosidic compound isolated from Bletilla striata, exhibits plant growth-inhibitory activity .

Militarine	Others	Metabolic Disease
Militarine, a glycosidic compound isolated from Bletilla striata, exhibits plant growth-inhibitory activity .

HY-N12636

Kagimminol A	Parasite	Infection
Kagimminols A is a cembrene-type diterpenoids and can be isolated from an Okeania sp. marine cyanobacterium. Kagimminols A shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .

HY-N12637

Kagimminol B	Parasite	Infection
Kagimminol B, a cembrene-type diterpenoid, can be isolated from an Okeania sp. marine cyanobacterium. Kagimminol B shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .

HY-P99153

Farletuzumab MORAb-003	Antibiotic	Cancer
Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .

HY-B0673

Pirfenidone Maximum Cited Publications 39 Publications Verification AMR69	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities .

HY-13334

BGT226 maleate 5 Publications Verification NVP-BGT226 maleate	PI3K mTOR Autophagy Apoptosis	Cancer
BGT226 (NVP-BGT226 maleate) is a PI3K (with IC₅₀s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells .

HY-13334A

BGT226 5 Publications Verification NVP-BGT226	PI3K mTOR Autophagy	Cancer
BGT226 (NVP-BGT226) is a PI3K (with IC₅₀s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells .

HY-13072

Cenisertib 1 Publications Verification AS-703569; R-763	Aurora Kinase Bcr-Abl Akt STAT FLT3	Cancer
Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia .

HY-12403A

Talfirastide acetate 5+ Cited Publications TXA127 acetate; Angiotensin (1-7) (acetate); Ang-(1-7) (acetate)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .

HY-12403

Talfirastide 5+ Cited Publications TXA127; Angiotensin (1-7); Ang-(1-7)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .

HY-101404

DL-Homocysteine thiolactone hydrochloride	Endogenous Metabolite	Others
DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

HY-B0984A

Fendiline

Fendiline is a STING agonist and has tumor growth inhibitory activity. Fendiline can be used for research on cancer and viral infections .

Fendiline
Fendiline is a STING agonist and has tumor growth inhibitory activity. Fendiline can be used for research on cancer and viral infections .

HY-N4114

Picrocrocin	Apoptosis	Cancer
Picrocrocin, an apocarotenoid found in Saffron. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells .

HY-101404S

DL-Homocysteine thiolactone-d4 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Others
DL-Homocysteine thiolactone-d4 hydrochloride is the deuterium labeled DL-Homocysteine thiolactone (hydrochloride). DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

HY-W047478

3-Methylcarbazole NSC 10154	Others	Cancer
3-Methylcarbazole is an carbazole alkaloid compound with anticancer effects. 3-Methylcarbazole shows growth inhibitory activity (IC₅₀ of 25 μg/mL) on human fibrosarcoma HT-1080 cells .

HY-P4816

Pseudin-2	Bacterial Fungal	Infection Inflammation/Immunology
Pseudin-2, an AMP thast could be isolated from the skin of the South American paradoxical frog Pseudis paradoxa, exert a potent growth inhibitory effect against Gram-negative bacteria .

HY-N12430

Marsdenoside A	Others	Cancer
Marsdenoside A (compound 7) is a Marsdenoside isolated from Alocasia genus. Marsdenoside A has a weak growth inhibitory effect on two tumor cell lines, MGC-803 and HT-29, with IC₅₀ >50 μg/mL.

HY-10949

SMER3	E1/E2/E3 Enzyme	Cancer
SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF) ^Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCF ^Met30 .

HY-N12200

Mollicellin I	Others	Cancer
Mollicellin I (compound 1) is a depsidone. The growth inhibitory activity of Mollicellin I on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines is not significant, with GI₅₀s >10 μg/mL .

HY-N7623

Ursonic acid methyl ester	Others	Cancer
Ursonic acid methyl ester is an esterified derivative of Ursolic acid (HY-N0140). Ursonic acid methyl ester shows growth inhibitory activity against four tumor cell lines, HL-60, BGC, Bel-7402 and Hela with ED₅₀ values of >100 µg/ml .

HY-108530

MM11253	RAR/RXR	Cancer
MM11253 is a potent and selective RARγ antagonist with an IC₅₀ of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .

HY-111934

Cymarin	Others Parasite	Others Cancer
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM) . Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer . Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

HY-162105

Aromatase-IN-3	Cytochrome P450	Endocrinology Cancer
Aromatase-IN-3 (compound 7d) is an aromatase inhibitor with an IC₅₀ of 54 nM. Through suppressing the conversion of androstenedione to oestrogen caused by aromatase, Aromatase-IN-3 exerts an appreciable tumor growth inhibitory activities against breast cancer cell lines, suggesting its usage for ER+ cancer research .

HY-N3023

3,4-Dihydroxybenzylamine hydrobromide 1 Publications Verification NSC 263475 hydrobromide	DNA/RNA Synthesis	Cancer
3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells . 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity .

HY-N11128

Solidagonic acid	Kinesin	Cancer
Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam .

HY-N10335

Harringtonolide 1 Publications Verification	FAK	Inflammation/Immunology Cancer
Harringtonolide is a potent RACK1 inhibitor (IC₅₀=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities .

HY-N3014

Bruceine D 3 Publications Verification	Notch Apoptosis Parasite	Infection Cancer
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity . Bruceine D has strong anthelmintic activity against D. intermedius with an EC₅₀ value of 0.57 mg/L .

HY-107412

*Proteasome inhibitor* IX** PS-IX; AM114	Proteasome	Cancer
Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC₅₀ value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53 ^+/+ cells growth inhibitory activity with an IC₅₀ value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity .

HY-146335

CLK1/4-IN-1	CDK	Cancer
CLK1/4-IN-1 (compound 31) is a potent and selective Clk1 and Clk4 inhibitor with an IC₅₀ value of 9.7 nM and 6.6 nM, respectively. CLK1/4-IN-1 has growth inhibitory activities against T24 cancer cells with GI₅₀ of 1.1 μM. CLK1/4-IN-1 can be used for researching anticancer .

HY-N0970

(4Z)-Lachnophyllum lactone	Others	Others
(4Z)-Lachnophyllum lactone is a enyne derivative. (4Z)-Lachnophyllum lactone shows growth inhibitory activity against Lemna paucicostata (IC₅₀=104 μM), which is a problematic and invasive weed . (4Z)-Lachnophyllum lactone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N12198

Mollicellin H	Others	Cancer
Mollicellin H is a secondary metabolite of the fungus C. brasiliense and has a wide range of biological activities, including immunomodulation, cytotoxicity and anti-tumor effects. The growth inhibitory effects (GI₅₀s) of Mollicellin H on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines are 5.1 μg/mL, 6.5 μg/mL and 2.5 μg/mL respectively .

HY-138098

Sartorypyrone B	Others	Cancer
Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI₅₀s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases .

Cat. No.	Product Name	Target	Research Area

HY-12403A

Talfirastide acetate Maximum Cited Publications 9 Publications Verification TXA127 acetate; Angiotensin (1-7) (acetate); Ang-(1-7) (acetate)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .

HY-12403

Talfirastide Maximum Cited Publications 9 Publications Verification TXA127; Angiotensin (1-7); Ang-(1-7)	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Endocrinology
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .

HY-P1237

C-Type Natriuretic Peptide (CNP) (1-22), human 1 Publications Verification	Peptides	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P1237A

C-Type Natriuretic Peptide (CNP) (1-22), human TFA 1 Publications Verification	Peptides	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P4816

Pseudin-2	Bacterial Fungal	Infection Inflammation/Immunology
Pseudin-2, an AMP thast could be isolated from the skin of the South American paradoxical frog Pseudis paradoxa, exert a potent growth inhibitory effect against Gram-negative bacteria .

Farletuzumab MORAb-003	Antibiotic	Cancer
Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122308

Militarine	Bletilla striata (Thunb. ex Murray) Rchb. f. Classification of Application Fields Orchidaceae Source classification Phenols Metabolic Disease Plants Disease Research Fields	Others
Militarine, a glycosidic compound isolated from Bletilla striata, exhibits plant growth-inhibitory activity .

HY-12403A

Talfirastide acetate Maximum Cited Publications 9 Publications Verification TXA127 acetate; Angiotensin (1-7) (acetate); Ang-(1-7) (acetate)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .

HY-12403

Talfirastide Maximum Cited Publications 9 Publications Verification TXA127; Angiotensin (1-7); Ang-(1-7)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .

HY-N12636

Kagimminol A	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Parasite
Kagimminols A is a cembrene-type diterpenoids and can be isolated from an Okeania sp. marine cyanobacterium. Kagimminols A shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .

HY-N12637

Kagimminol B	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Parasite
Kagimminol B, a cembrene-type diterpenoid, can be isolated from an Okeania sp. marine cyanobacterium. Kagimminol B shows selective growth-inhibitory activity against the causative agent of human African trypanosomiasis .

HY-101404

DL-Homocysteine thiolactone hydrochloride	Structural Classification Classification of Application Fields Source classification Other Diseases Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

HY-N4114

Picrocrocin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Lridaceae Plants Crocus sativus L. Disease Research Fields Cancer	Apoptosis
Picrocrocin, an apocarotenoid found in Saffron. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells .

HY-W047478

3-Methylcarbazole NSC 10154	Alkaloids other families Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Others
3-Methylcarbazole is an carbazole alkaloid compound with anticancer effects. 3-Methylcarbazole shows growth inhibitory activity (IC₅₀ of 25 μg/mL) on human fibrosarcoma HT-1080 cells .

HY-N12430

Marsdenoside A	Structural Classification Araceae Cardiacglycosides Source classification Plants Alocasia cucullata (Lour.) Schott Steroids	Others
Marsdenoside A (compound 7) is a Marsdenoside isolated from Alocasia genus. Marsdenoside A has a weak growth inhibitory effect on two tumor cell lines, MGC-803 and HT-29, with IC₅₀ >50 μg/mL.

HY-N12200

Mollicellin I	Structural Classification Natural Products Microorganisms Source classification	Others
Mollicellin I (compound 1) is a depsidone. The growth inhibitory activity of Mollicellin I on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines is not significant, with GI₅₀s >10 μg/mL .

HY-111934

Cymarin	Apocynaceae Structural Classification Classification of Application Fields Cardiacglycosides Source classification Other Diseases Plants Disease Research Fields Apocynum Steroids	Others Parasite
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM) . Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer . Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

HY-N11128

Solidagonic acid	Structural Classification Terpenoids Source classification Diterpenoids Solidago altissima Linnaeus Plants Compositae	Kinesin
Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam .

HY-N10335

Harringtonolide 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Cephalotaxus harringtonia Plants Cephalotaxaceae Inflammation/Immunology Disease Research Fields Cancer	FAK
Harringtonolide is a potent RACK1 inhibitor (IC₅₀=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities .

HY-N3014

Bruceine D 3 Publications Verification	Infection Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr.	Notch Apoptosis Parasite
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity . Bruceine D has strong anthelmintic activity against D. intermedius with an EC₅₀ value of 0.57 mg/L .

HY-N0970

(4Z)-Lachnophyllum lactone	Source classification Erigeron canadensis L. Plants Compositae	Others
(4Z)-Lachnophyllum lactone is a enyne derivative. (4Z)-Lachnophyllum lactone shows growth inhibitory activity against Lemna paucicostata (IC₅₀=104 μM), which is a problematic and invasive weed . (4Z)-Lachnophyllum lactone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N12198

Mollicellin H	Structural Classification Natural Products Microorganisms Source classification	Others
Mollicellin H is a secondary metabolite of the fungus C. brasiliense and has a wide range of biological activities, including immunomodulation, cytotoxicity and anti-tumor effects. The growth inhibitory effects (GI₅₀s) of Mollicellin H on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines are 5.1 μg/mL, 6.5 μg/mL and 2.5 μg/mL respectively .

HY-138098

Sartorypyrone B	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields Cancer	Others
Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI₅₀s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0673S

Pirfenidone-d5
Pirfenidone-d₅ is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

HY-101404S

DL-Homocysteine thiolactone-d4 hydrochloride
DL-Homocysteine thiolactone-d4 hydrochloride is the deuterium labeled DL-Homocysteine thiolactone (hydrochloride). DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

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growth-inhibitory

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