Search Result

Results for "

helicase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (3) Bacterial (2) DNA/RNA Synthesis (43) Eukaryotic Initiation Factor (eIF) (4) Filovirus (1) G-quadruplex (1) GLUT (2) HCV (3) HSV (4) SARS-CoV (6) TMV (1) Topoisomerase (1)
By Research Areas:	Cancer (46) Infection (18) Inflammation/Immunology (1) Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148740

*Werner syndrome RecQ helicase-IN-3*	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-3 is a potent and orally active *werner syndrome recQ helicase* (WRN) inhibitor with an IC₅₀** value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity .

HY-148741

*Werner syndrome RecQ helicase-IN-4*	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-4 is a potent and orally active *werner syndrome recQ helicase* (WRN) inhibitor with an IC₅₀** value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity .

HY-148699

*Werner syndrome RecQ helicase-IN-1*	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-1 (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-148700

*Werner syndrome RecQ helicase-IN-2*	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-128712

NCGC00029283	DNA/RNA Synthesis	Cancer
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC₅₀s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .

HY-146987

FWM-3

SARS-CoV Infection

FWM-3 is a potent SARS-CoV-2 NSP13 helicase inhibitor .

FWM-3	SARS-CoV	Infection
FWM-3 is a potent SARS-CoV-2 NSP13 helicase inhibitor .

HY-137820

Brr2-IN-3	DNA/RNA Synthesis	Others
Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC₅₀ value of 1.3 μM .

HY-161151

*RecQ helicase-IN-1*	DNA/RNA Synthesis Apoptosis	Cancer
Frangulin B (Compd 11g), a potent anticancer agent, is a potential pan RecQ helicase inhibitor . Frangulin B (Compd 11g) induces apoptosis in both HCT-116 and MDA-MB-231 cell lines, but also causes an G2/M phase cell cycle arrest in HCT-116 cells .

HY-150279

PolQi2

DNA/RNA Synthesis Others

PolQi2 inhibits the helicase activity of Polθ. PolQi2 improves the precision of gene editing at various loci and in different cell lines .
HY-157611

DHX9-IN-17

DNA/RNA Synthesis Cancer

DHX9-IN-17 (186) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.161 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157612

DHX9-IN-16

DNA/RNA Synthesis Cancer

DHX9-IN-16 (208) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.125 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157605

DHX9-IN-11

DNA/RNA Synthesis Cancer

DHX9-IN-11 (469) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.0838 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157606

DHX9-IN-13

DNA/RNA Synthesis Cancer

DHX9-IN-13 (389) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157607

DHX9-IN-15

DNA/RNA Synthesis Cancer

DHX9-IN-15 (287) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.232 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157604

DHX9-IN-9

DNA/RNA Synthesis Cancer

DHX9-IN-9 (509) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.0177 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157610

DHX9-IN-14

DNA/RNA Synthesis Cancer

DHX9-IN-14 (161) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157609

DHX9-IN-12

DNA/RNA Synthesis Cancer

DHX9-IN-12 (83) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.917 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157608

DHX9-IN-10

DNA/RNA Synthesis Cancer

DHX9-IN-10 (49) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 9.04 μM in DHX9 cellular target engagement. Used in cancer research .
HY-157603

DHX9-IN-7

DNA/RNA Synthesis Cancer

DHX9-IN-7 (550) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.105 μM in DHX9 cellular target engagement. Used in cancer research .

PolQi2	DNA/RNA Synthesis	Others
PolQi2 inhibits the helicase activity of Polθ. PolQi2 improves the precision of gene editing at various loci and in different cell lines .

DHX9-IN-17	DNA/RNA Synthesis	Cancer
DHX9-IN-17 (186) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.161 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-16	DNA/RNA Synthesis	Cancer
DHX9-IN-16 (208) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.125 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-11	DNA/RNA Synthesis	Cancer
DHX9-IN-11 (469) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.0838 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-13	DNA/RNA Synthesis	Cancer
DHX9-IN-13 (389) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-15	DNA/RNA Synthesis	Cancer
DHX9-IN-15 (287) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.232 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-9	DNA/RNA Synthesis	Cancer
DHX9-IN-9 (509) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.0177 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-14	DNA/RNA Synthesis	Cancer
DHX9-IN-14 (161) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-12	DNA/RNA Synthesis	Cancer
DHX9-IN-12 (83) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.917 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-10	DNA/RNA Synthesis	Cancer
DHX9-IN-10 (49) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 9.04 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-7	DNA/RNA Synthesis	Cancer
DHX9-IN-7 (550) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.105 μM in DHX9 cellular target engagement. Used in cancer research .

HY-110185

NSC 617145	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-157602

DHX9-IN-8

DNA/RNA Synthesis Cancer

DHX9-IN-8 (Compound 6) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .

DHX9-IN-8	DNA/RNA Synthesis	Cancer
DHX9-IN-8 (Compound 6) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 3.4 μM in DHX9 cellular target engagement. Used in cancer research .

HY-152259

TMV-IN-4	TMV	Infection
TMV-IN-4 (compound 3) is a tobacco mosaic virus (TMV) inhibitor that effectively induces resistance and enhances plant tolerance to TMV infection by interacting with TMV helicase. TMV-IN-4 enhances peroxidase and superoxide dismutase activity, thereby increasing resistance to TMV in tobacco .

HY-156579

WRN inhibitor 3	DNA/RNA Synthesis	Cancer
WRN inhibitor 3 (example 110), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 3 can be used for the research of cancer .

HY-156580

WRN inhibitor 4	DNA/RNA Synthesis	Cancer
WRN inhibitor 4 (example 107), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 4 can be used for the research of cancer .

HY-156581

WRN inhibitor 5	DNA/RNA Synthesis	Cancer
WRN inhibitor 5 (example 157), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 5 can be used for the research of cancer .

HY-156418

KY386	DNA/RNA Synthesis	Cancer
KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC₅₀ of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC₅₀ of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability .

HY-15303

Pritelivir 3 Publications Verification AIC316; BAY 57-1293	HSV	Infection
Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-15303B

Pritelivir mesylate hydrate 3 Publications Verification AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate	HSV	Infection
Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-15303A

Pritelivir mesylate 3 Publications Verification AIC316 mesylate; BAY 57-1293 mesylate	HSV	Infection
Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-12342

ML216 5 Publications Verification CID-49852229	DNA/RNA Synthesis	Cancer
ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC₅₀s of 2.98 μM and 0.97 μM for BLM ^full-length and BLM ^636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a K_i of 1.76 µM. Antitumor avtivity .

HY-100455

RK-33

1 Publications Verification

RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity.
HY-162146

NS3-IN-1

Filovirus DNA/RNA Synthesis Infection

NS3-IN-1 (compound 302) is a potent helicase (NS3) inhibitor. NS3-IN-1 shows an potent inhibitor for yellow fever helicase .

RK-33 1 Publications Verification
RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity.

NS3-IN-1	Filovirus DNA/RNA Synthesis	Infection
NS3-IN-1 (compound 302) is a potent helicase (NS3) inhibitor. NS3-IN-1 shows an potent inhibitor for yellow fever helicase .

HY-153692

WRN inhibitor 1	DNA/RNA Synthesis	Cancer
WRN inhibitor 1 (example 7) is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor that inhibits WRN helicase domain activity. WRN inhibitor 1 has the potential to study cancer .

HY-144798

FWM-5	SARS-CoV	Infection
FWM-5 is a potent NSP13 helicase inhibitor. SARS-COV-2 NSP13 helicase enzyme plays crucial role in the virus life cycle. FWM-5 has the potential for the research of infection diseases .

HY-123611

Supinoxin RX-5902	DNA/RNA Synthesis Apoptosis	Cancer
Supinoxin (RX-5902) is an orally active inhibitor of *phosphorylated-p68 RNA helicase* (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin. Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC₅₀**s ranging from 10 nM to 20 nM .

HY-144800

FWM-1	SARS-CoV	Infection
FWM-1 is a potent *SARS-COV-2 NSP13 helicase* enzyme** inhibitor with binding free energy equals -328.6 kcal/mol. FWM-1 effectively disrupts the binding of ATP to the SARS-COV2 helicase enzyme .

HY-145115

Adeninobananin

Others Infection

Adeninobananin, a negative control tool, does not show any inhibitory activity of the SARS Coronavirus helicase.

Adeninobananin	Others	Infection
Adeninobananin, a negative control tool, does not show any inhibitory activity of the SARS Coronavirus helicase.

HY-158116

VVD-214 RO7589831; VVD-133214	DNA/RNA Synthesis	Cancer
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers.

HY-14809

Amenamevir

ASP2151
HSV Infection

Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC₅₀ of 14 ng/mL.
HY-144799

FWM-4

SARS-CoV Infection

FWM-4 is a potent SARS-COV-2 NSP13 helicase enzyme inhibitor .
HY-160009

DHX9-IN-5

DNA/RNA Synthesis Cancer

DHX9-IN-5 (compound 277) is a RNA helicase DHX9 inhibitor with an IC₅₀ of 4.3 nM .

Amenamevir ASP2151	HSV	Infection
Amenamevir is a *helicase-primase* inhibitor which has potent antiviral activity against HSVs with an EC₅₀ of 14 ng/mL.

FWM-4	SARS-CoV	Infection
FWM-4 is a potent *SARS-COV-2 NSP13 helicase* enzyme** inhibitor .

DHX9-IN-5	DNA/RNA Synthesis	Cancer
DHX9-IN-5 (compound 277) is a *RNA helicase* DHX9 inhibitor with an IC₅₀** of 4.3 nM .

HY-149887

H3B-968	DNA/RNA Synthesis	Cancer
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC₅₀=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP .

HY-D0306

Tris(4-aminophenyl)methane

Leucopararosaniline
HCV Infection

Tris(4-aminophenyl)methane is a triphenylmethane dye. Tris(4-aminophenyl)methane is a weak HCV helicase inhibitor.
HY-153973

WRN inhibitor 2

DNA/RNA Synthesis Cancer

WRN inhibitor 2 (example 118) is a WRN (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC₅₀ ≥ 7.0 .
HY-160007

DHX9-IN-3

DNA/RNA Synthesis Cancer

DHX9-IN-3 (Compound 621) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .
HY-160008

DHX9-IN-4

DNA/RNA Synthesis Cancer

DHX9-IN-4 (Compound 609) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .
HY-160010

DHX9-IN-6

DNA/RNA Synthesis Cancer

DHX9-IN-6 (Compound 620) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .
HY-156782

DHX9-IN-1

DNA/RNA Synthesis Cancer

DHX9-IN-1 (example 160) is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC₅₀ of 9.45 nM that has antitumor activity .
HY-156784

DHX9-IN-2

DNA/RNA Synthesis Cancer

DHX9-IN-2 (example 31) is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC₅₀ of 0.0698 nM that has antitumor activity .
HY-15594

Phen-DC3

DNA/RNA Synthesis Cancer

Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

Tris(4-aminophenyl)methane Leucopararosaniline	HCV	Infection
Tris(4-aminophenyl)methane is a triphenylmethane dye. Tris(4-aminophenyl)methane is a weak HCV helicase inhibitor.

WRN inhibitor 2	DNA/RNA Synthesis	Cancer
WRN inhibitor 2 (example 118) is a WRN (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC₅₀ ≥ 7.0 .

DHX9-IN-3	DNA/RNA Synthesis	Cancer
DHX9-IN-3 (Compound 621) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .

DHX9-IN-4	DNA/RNA Synthesis	Cancer
DHX9-IN-4 (Compound 609) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .

Species:	Human (15) Virus (2) Mouse (1) E.coli (4)
Tag:	His (14) SUMO (4) Tag Free (3) Strep (3) Myc (2) GST (3) Flag (3)
Source:	HEK293 (2) P. pastoris (1) E. coli (19)

Cat. No.	Compare	Product Name	Species	Source

HY-P71641

	IFIH1 Protein, Human (His) CADM-140 autoantigen; Clinically amyopathic dermatomyositis autoantigen 140kDa; DEAD/H (Asp Glu Ala Asp/His) box polypeptide; DEAD/H box polypeptide; Helicard; helicase with 2 CARD domains; Hlcd; MDA-5	Human	E. coli
	The IFIH1 protein is an innate immune receptor that detects viral nucleic acids and triggers an antiviral response. IFIH1 is critical for type I interferon induction and recognizes ligands such as mRNA lacking 2'-O-methylation and long double-stranded RNA. IFIH1 Protein, Human (His) is the recombinant human-derived IFIH1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IFIH1 Protein, Human (His) is 326 a.a., with molecular weight of ~41.5 kDa.

HY-P72296

	*DNA helicase* II/uvrD Protein, E.coli** pdeB; DNA helicase II	E.coli	E. coli
	DNA helicase II/uvrD protein, a DNA-dependent ATPase, efficiently unwinds DNA duplexes with 3' to 5' polarity, especially from nicked substrates. It actively participates in post-incision stages of nucleotide excision repair and methyl-directed mismatch repair, contributing to genomic integrity by facilitating DNA unwinding in various repair mechanisms. DNA helicase II/uvrD Protein, E.coli is the recombinant E. coli-derived DNA helicase II/uvrD protein, expressed by E. coli, with tag free. The total length of DNA helicase II/uvrD Protein, E.coli is 720 a.a., with molecular weight of ~82.0 kDa.

HY-P701528

	HLTF Protein, Human HLTF; helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human is the recombinant human-derived HLTF protein, expressed by E. coli , with tag free. The total length of HLTF Protein, Human is 117 a.a., .

HY-P701529

	HLTF Protein, Human (His) HLTF; helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human (His) is the recombinant human-derived HLTF protein, expressed by E. coli , with N-6*His labeled tag. The total length of HLTF Protein, Human (His) is 117 a.a., .

HY-P71651

	DDX19A Protein, Human (His-SUMO) ATP dependent RNA helicase DDX19A; ATP-dependent RNA helicase DDX19A; DDX19 like protein; DEAD box protein 19A	Human	E. coli
	The DDX19A protein is an ATP-dependent RNA helicase that plays a crucial role in unwinding single- and double-stranded DNA in the 3'-5' direction. It is actively involved in DNA replication and repair by recruiting DNA2 to aid in 5' end resection during double-strand break repair. DDX19A Protein, Human (His-SUMO) is the recombinant human-derived DDX19A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of DDX19A Protein, Human (His-SUMO) is 478 a.a., with molecular weight of ~70.0 kDa.

HY-P7894

	SARS-CoV-2 PP1ab Protein (His-MBP) rReplicase polyprotein 1ab/2019-nCoV helicase, His-MBP; SARS-CoV 2 helicase; SARS-CoV 2 nsp13	Virus	E. coli
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. SARS-CoV-2 PP1ab Protein (His-MBP) is the recombinant Virus-derived SARS-CoV-2 PP1ab protein, expressed by E. coli , with C-6*His labeled tag. The total length of SARS-CoV-2 PP1ab Protein (His-MBP) is 601 a.a., with molecular weight of ~120.0 kDa.

HY-P71784

	SMARCA4 Protein, Human (P.pastoris, His) ATP dependent helicase SMARCA4; ATP-dependent helicase SMARCA4; Brahma protein like 1; BRG1; BRG1 protein; BRG1-associated factor 190A; MRD16	Human	P. pastoris
	The SMARCA4 protein is a multifaceted regulator of chromatin remodeling that dynamically alters DNA nucleosome topology through ATP-dependent enzymatic activity. As part of the SWI/SNF complex and the CREST-BRG1 complex, it regulates transcriptional processes, coordinating the release and activating recruitment of calcium-dependent repressor complexes. SMARCA4 Protein, Human (P.pastoris, His) is the recombinant human-derived SMARCA4 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of SMARCA4 Protein, Human (P.pastoris, His) is 547 a.a., with molecular weight of ~64.8 kDa.

HY-P72105

	BLM Protein, Mouse (His-Myc) BlmBloom syndrome protein homolog; mBLM; EC 3.6.4.12; RecQ helicase homolog	Mouse	E. coli
	BLM is an ATP-dependent DNA helicase that can unwind single- and double-stranded DNA in the 3'-5' direction and actively participates in the DNA replication and repair process. Notably, BLM plays a critical role in 5' end resection during double-strand break repair, recruiting DNA2 to cleave 5'-ssDNA. BLM Protein, Mouse (His-Myc) is the recombinant mouse-derived BLM protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of BLM Protein, Mouse (His-Myc) is 176 a.a., with molecular weight of ~24.7 kDa.

HY-P702583

DDX5 Protein, Human (His, Myc)

ATP dependent RNA helicase DDX5; DDX 5; Ddx5
Human E. coli

HY-P701998

	LGP2 Protein, Human (HEK293, FLAG) CGAS; Probable ATP-dependent RNA helicase DHX58; Probable ATP-dependent helicase LGP2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RLR-3; RIG-I-like receptor LGP2; RLR	Human	HEK293
	LGP2 protein is a key regulator of RIGI- and IFIH1/MDA5-mediated antiviral signaling and has dual negative and positive functions affected by factors such as infected viruses and target cells. LGP2 lacks a CARD domain for independent initiation of antiviral signaling and therefore inhibits RIG-I through multiple mechanisms, including competition for RNA binding and obstruction of interaction with MAVS/IPS1. LGP2 Protein, Human (HEK293, FLAG) is the recombinant human-derived LGP2 protein, expressed by HEK293 , with C-Flag labeled tag. The total length of LGP2 Protein, Human (HEK293, FLAG) is 678 a.a., .

HY-P701999

	LGP2 Protein, Human (HEK293, His, Strep, FLAG) DHX58; Probable ATP-dependent RNA helicase DHX58; ATP-dependent helicase LGP2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RLR-3; RIG-I-like receptor LGP2; RLR	Human	HEK293
	LGP2 protein is a key regulator of RIGI- and IFIH1/MDA5-mediated antiviral signaling and has dual negative and positive functions affected by factors such as infected viruses and target cells. LGP2 lacks a CARD domain for independent initiation of antiviral signaling and therefore inhibits RIG-I through multiple mechanisms, including competition for RNA binding and obstruction of interaction with MAVS/IPS1. LGP2 Protein, Human (HEK293, His, Strep, FLAG) is the recombinant human-derived LGP2 protein, expressed by HEK293 , with N-Strep, C-Flag, N-8*His labeled tag. The total length of LGP2 Protein, Human (HEK293, His, Strep, FLAG) is 678 a.a., .

HY-P74898

	NS3 protease Protein, HCV (GST) Hepatitis C virus (HCV-1a) NS3 protease / helicase immunodominant region Protein ( GST)	Virus	E. coli
	NS3 protease Protein is a zinc-dependent serine protease. NS3 needs to bind to the viral protein NS4A to enable additional conformation changes that enhance activity and appropriate intracellular localization. NS3 protein induces Caspase-8-mediated apoptosis independently of its protease or helicase activity. NS3 protease Protein, HCV (GST) is the recombinant Virus-derived NS3 protease protein, expressed by E. coli , with N-GST labeled tag. The total length of NS3 protease Protein, HCV (GST) is 104 a.a., with molecular weight of ~37.9 kDa.

HY-P71588

	CHD1L Protein, Human (His-SUMO) ALC1; Amplified in liver cancer 1; Amplified in liver cancer protein 1; chd1l; CHD1L_HUMAN; CHDL; Chromodomain helicase DNA binding protein 1 like; Chromodomain-helicase-DNA-binding protein 1-like; FLJ22530	Human	E. coli
	CHD1L protein is the ATP-binding subunit of the mitochondrial potassium channel and cooperates with CCDC51/MITOK to form a complex to promote ATP-dependent potassium current across the inner membrane (mitoK(ATP) channel). ABCB8 is essential for mitochondrial iron transport, affects cardiac function, and regulates the maturation of cytosolic iron-sulfur-containing enzymes. CHD1L Protein, Human (His-SUMO) is the recombinant human-derived CHD1L protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of CHD1L Protein, Human (His-SUMO) is 194 a.a., with molecular weight of ~37.3 kDa.

HY-P71491

	RuvA Protein, E.coli (His-SUMO) ruvA; b1861; JW1850; Holliday junction ATP-dependent DNA helicase RuvA; EC 3.6.4.12	E.coli	E. coli
	RuvA protein is a core component of the RuvA-RuvB-RuvC complex and plays a key role in gene recombination and DNA repair, especially in the processing of Holliday junction (HJ) DNA. RuvA cooperates with RuvB to promote HJ branch migration, binds to HJ cruciform DNA and imparts an open structure. RuvA Protein, E.coli (His-SUMO) is the recombinant E. coli-derived RuvA protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of RuvA Protein, E.coli (His-SUMO) is 203 a.a., with molecular weight of ~38.1 kDa.

HY-P71513

	RuvB Protein, E.coli (His-SUMO) ruvB; b1860; JW1849; Holliday junction ATP-dependent DNA helicase RuvB; EC 3.6.4.12	E.coli	E. coli
	RuvB protein is an important component of the RuvABC complex and plays a key role in recombinant DNA repair, especially for UV-induced damage. It helps rescue stalled DNA replication forks through replication fork reversal (RFR). RuvB Protein, E.coli (His-SUMO) is the recombinant E. coli-derived RuvB protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of RuvB Protein, E.coli (His-SUMO) is 336 a.a., with molecular weight of ~53.2 kDa.

HY-P702184

	DDX41 Protein, Human (FLAG) DDX41; Probable ATP-dependent RNA helicase DDX41; DEAD box protein 41; DEAD box protein abstrakt homolog	Human	E. coli
	DDX41 protein, a probable ATP-dependent RNA helicase, plays a crucial role in post-transcriptional gene expression, suggesting involvement in pre-mRNA splicing. As an ATP-dependent RNA helicase, DDX41 likely contributes to dynamic RNA unwinding, facilitating various aspects of RNA metabolism. Its multifunctional role underscores its significance in the intricate machinery governing gene expression and RNA processing within the cell. DDX41 Protein, Human (FLAG) is the recombinant human-derived DDX41 protein, expressed by E. coli , with C-Flag labeled tag. The total length of DDX41 Protein, Human (FLAG) is 622 a.a., .

HY-P71705

	Transcription termination factor Rho Protein, E.coli (His) rho; nitA; psuA; rnsC; sbaA; tsu; b3783; JW3756; Transcription termination factor Rho; ATP-dependent helicase Rho	E.coli	E. coli
	The transcription terminator Rho protein plays a key role in promoting transcription termination through a mechanism that binds to nascent RNA, activates Rho's RNA-dependent ATPase activity, and subsequently releases mRNA from the DNA template. As an RNA-dependent NTPase, Rho utilizes all four ribonucleoside triphosphates as substrates, highlighting its versatility in nucleotide interactions during termination. Transcription termination factor Rho Protein, E.coli (His) is the recombinant E. coli-derived Transcription termination factor Rho protein, expressed by E. coli , with N-6*His labeled tag. The total length of Transcription termination factor Rho Protein, E.coli (His) is 419 a.a., with molecular weight of ~51.0 kDa.

HY-P702185

	DDX41 Protein, Human (His, Strep) DDX41; Probable ATP-dependent RNA helicase DDX41; DEAD box protein 41; DEAD box protein abstrakt homolog	Human	E. coli
	DDX41 protein, a probable ATP-dependent RNA helicase, plays a crucial role in post-transcriptional gene expression, suggesting involvement in pre-mRNA splicing. As an ATP-dependent RNA helicase, DDX41 likely contributes to dynamic RNA unwinding, facilitating various aspects of RNA metabolism. Its multifunctional role underscores its significance in the intricate machinery governing gene expression and RNA processing within the cell. DDX41 Protein, Human (His, Strep) is the recombinant human-derived DDX41 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of DDX41 Protein, Human (His, Strep) is 622 a.a., .

HY-P701605

	EIF4A1 Protein, Human EIF4A1; Eukaryotic initiation factor 4A-I; eIF-4A-I; eIF4A-I; ATP-dependent RNA helicase eIF4A-1	Human	E. coli
	The EIF4A1 protein is an ATP-dependent RNA helicase and an important subunit of the eIF4F complex, which is essential for cap recognition and promoting the binding of mRNA to ribosomes. In the translation initiation model, EIF4A1 helps unravel RNA secondary structure in the mRNA 5'-UTR. EIF4A1 Protein, Human is the recombinant human-derived EIF4A1 protein, expressed by E. coli , with tag free. The total length of EIF4A1 Protein, Human is 406 a.a., .

HY-P701606

	EIF4A1 Protein, Human (His, Strep) EIF4A1; Eukaryotic initiation factor 4A-I; eIF-4A-I; eIF4A-I; ATP-dependent RNA helicase eIF4A-1	Human	E. coli
	The EIF4A1 protein is an ATP-dependent RNA helicase and an important subunit of the eIF4F complex, which is essential for cap recognition and promoting the binding of mRNA to ribosomes. In the translation initiation model, EIF4A1 helps unravel RNA secondary structure in the mRNA 5'-UTR. EIF4A1 Protein, Human (His, Strep) is the recombinant human-derived EIF4A1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of EIF4A1 Protein, Human (His, Strep) is 406 a.a., .

HY-P71534

	DDX39B Protein, Human (GST) 0610030D10Rik; 4F2-LC6; 56kDa U2AF65-associated protein; AI428441; ATP-dependent RNA helicase p47; B(0,+)-type amino acid transporter 1; BAT1; Bat1a; D17H6S81E; D17H6S81E-1; D6S81E; D6S81Eh; DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; DX39B_HUMAN; EC 3.6.1.-; Glycoprotein-associated amino acid transporter b0,+AT1; HLA-B-associated transcript 1 protein; HLA-B-associated transcript 1A; HLA-B-associated transcript-1; MGC127051; MGC19235; MGC38799; nuclear RNA helicase (DEAD family); OTTHUMP00000029229; OTTHUMP00000165889; OTTHUMP00000165890; p47; Solute carrier family 7 member 9; Spliceosome RNA helicase BAT1; Spliceosome RNA helicase DDX39B; U2AF65-associayed protein; 56-KD; UAP56	Human	E. coli
	The DDX39B protein intricately coordinates nuclear mRNA export and is specifically associated with spliced mRNA as a key component of the TREX complex. This coupling of mRNA transcription, processing, and export involves rounds of ATP-dependent hydrolysis, recruiting components such as ALYREF/THOC and CHTOP. DDX39B Protein, Human (GST) is the recombinant human-derived DDX39B protein, expressed by E. coli , with N-GST labeled tag. The total length of DDX39B Protein, Human (GST) is 250 a.a., with molecular weight of ~55.2 kDa.

HY-P700526

	EIF4A2 Protein, Human (GST) eukaryotic translation initiation factor 4A2; EIF4F, eukaryotic translation initiation factor 4A, isoform 2; eukaryotic initiation factor 4A-II; BM 010; DDX2B; EIF4A; ATP-dependent RNA helicase eIF4A-2; eukaryotic translation initiation factor 4A, isoform 2; EIF4F; BM-010; eIF4A-II; eIF-4A-II	Human	E. coli
	EIF4A2, an ATP-dependent RNA helicase, is a vital subunit of the eIF4F complex, pivotal in cap recognition and mRNA binding to ribosomes. In translation initiation, EIF4A2 crucially unwinds RNA secondary structures in mRNA 5'-UTRs. This activity facilitates small ribosomal subunit binding and efficient scanning for the initiator codon, orchestrating translation initiation. EIF4A2 Protein, Human (GST) is the recombinant human-derived EIF4A2 protein, expressed by E. coli, with N-GST labeled tag. The total length of EIF4A2 Protein, Human (GST) is 407 a.a., with molecular weight of 73.4 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81264

CHD3 Antibody (YA944) CHD3; Chromodomain-helicase-DNA-binding protein 3; CHD-3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH	WB, ICC/IF, IP	Human, Mouse, Rat

HY-P81264A

CHD3 Antibody (YA945) CHD3; Chromodomain-helicase-DNA-binding protein 3; CHD-3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P82125

RNA Helicase A Antibody (YA1870)

LKP; RHA; DDX9; NDH2; NDHII
WB Rat
HY-P82921

DDX5 Antibody (YA2666)

DDX5; G17P1; HELR; HLR1; Probable ATP-dependent RNA helicase DDX5; DEAD box protein 5; RNA helicase p68
WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P81265

CHD4 Antibody (YA946)

CHD4; Chromodomain-helicase-DNA-binding protein 4; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
WB, IP Human
HY-P81265A

CHD4 Antibody (YA947)

CHD4; Chromodomain-helicase-DNA-binding protein 4; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
WB, ICC/IF, FC Human
HY-P82276

WRN Antibody (YA2021)

Exonuclease WRN; RecQ3; RECQL2; RECQL3; Werner syndrome helicase; WRN
WB Human

HY-P80736

Ku70 Antibody (YA319) XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-	WB, IHC-F, IHC-P, ICC/IF	Human
Ku70 Antibody (YA319) is a non-conjugated and Rabbit origined monoclonal antibody about 70 kDa, targeting to Ku70. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80737

Ku80 Antibody (YA714) XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair pr	WB, ICC/IF, IP, ChIP	Human, Monkey
Ku80 Antibody (YA714) is a non-conjugated and Mouse origined monoclonal antibody about 83 kDa, targeting to Ku80 (8H1). It can be used for WB,ICC/IF,IP,ChIP assays with tag free, in the background of Human, Monkey.

HY-P81374

FUBP1 Antibody (YA1119)

DNA helicase V; FBP; FUBP; Fubp1; Fubp4; FUSE-binding protein 1; HDH V
IHC-P Human

HY-P80650

eIF4A1 Antibody (YA774) Eukaryotic initiation factor 4A-I; eIF-4A-I; eIF4A-I; ATP-dependent RNA helicase eIF4A-1	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
eIF4A1 Antibody (YA774) is a non-conjugated and Mouse origined monoclonal antibody about 46 kDa, targeting to eIF4A1 (6D7). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P82654

MDA5 Antibody (YA2399)

Helicard; Hlcd; IDDM19; IFIH1; MDA-5; RH116; RIG I like receptor 2; RLR 2; RNA helicase DEAD box protein 116
WB, ICC/IF Human

HY-P82113

RENT1 Antibody (YA1858) UPF1; KIAA0221; RENT1; Regulator of nonsense transcripts 1; ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog; hUpf1	WB, IHC-F, IHC-P, ICC/IF, IP	Human

HY-P82472

PIAS1 Antibody (YA2217) PIAS1; DDXBP1; E3 SUMO-protein ligase PIAS1; DEAD/H box-binding protein 1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P82687

G3BP Antibody (YA2432) G3BP1; G3BP; Ras GTPase-activating protein-binding protein 1; G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; GAP SH3 domain-binding protein 1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

HY-P80575

BRG1 Antibody (YA817) SMARCA4; BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/S	WB, ICC/IF, IP	Human, Mouse
BRG1 Antibody (YA817) is a non-conjugated and Mouse origined monoclonal antibody about 185 kDa, targeting to BRG1 (6D7). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse.

HY-P83496

SMARCA2 Antibody (YA3241) SMARCA2; BAF190B; BRM; SNF2A; SNF2L2; Probable global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; BRG1-associated factor 190B; BAF190B; Protein brahma homolog; hBRM; SNF2-alpha; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	WB, IHC-F, IHC-P, ICC/IF	Human

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