Search Result

Results for "

hematopoietic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	15-PGDH (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (4) Arrestin (2) Aryl Hydrocarbon Receptor (2) Autophagy (1) Bcl-2 Family (1) Bcr-Abl (1) Btk (1) Caspase (1) CD3 (1) CXCR (7) DNA/RNA Synthesis (2) Drug Metabolite (2) Endogenous Metabolite (1) ERK (1) FLT3 (1) Formyl Peptide Receptor (FPR) (1) HIV (2) Integrin (3) Isotope-Labeled Compounds (1) JAK (1) Ligands for Target Protein for PROTAC (1) LPL Receptor (1) MAP4K (26) NAMPT (1) Nucleoside Antimetabolite/Analog (2) PARP (1) PGE synthase (6) Phosphatase (3) PI3K (1) Prostaglandin Receptor (5) PROTACs (1) Reactive Oxygen Species (1) RET (1) SARS-CoV (1) Src (2) STAT (1) Syk (1) TNF Receptor (1)
By Research Areas:	Cancer (45) Cardiovascular Disease (4) Endocrinology (5) Infection (5) Inflammation/Immunology (40) Metabolic Disease (1) Neurological Disease (2)

By Targets:

15-PGDH (1)

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (4)

Arrestin (2)

Aryl Hydrocarbon Receptor (2)

Autophagy (1)

Bcl-2 Family (1)

Bcr-Abl (1)

Btk (1)

Caspase (1)

CD3 (1)

CXCR (7)

DNA/RNA Synthesis (2)

Drug Metabolite (2)

Endogenous Metabolite (1)

ERK (1)

FLT3 (1)

Formyl Peptide Receptor (FPR) (1)

HIV (2)

Integrin (3)

Isotope-Labeled Compounds (1)

JAK (1)

Ligands for Target Protein for PROTAC (1)

LPL Receptor (1)

MAP4K (26)

NAMPT (1)

Nucleoside Antimetabolite/Analog (2)

PARP (1)

PGE synthase (6)

Phosphatase (3)

PI3K (1)

Prostaglandin Receptor (5)

PROTACs (1)

Reactive Oxygen Species (1)

RET (1)

SARS-CoV (1)

Src (2)

STAT (1)

Syk (1)

TNF Receptor (1)

By Research Areas:

Cancer (45)

Cardiovascular Disease (4)

Endocrinology (5)

Infection (5)

Inflammation/Immunology (40)

Metabolic Disease (1)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145107

HPK1-IN-19

MAP4K Inflammation/Immunology Cancer

HPK1-IN-19 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor extracted from patent WO2018102366A1 compound I-47 .
HY-145109

HPK1-IN-20

MAP4K Inflammation/Immunology Cancer

HPK1-IN-19 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor extracted from patent WO2020235902A1 compound 106 .
HY-127178

ML120 analog 1

Phosphatase Cancer

ML120 analog 1 (compound 1) is a competitive inhibitor with a K_i of 0.69 μM for Hematopoietic protein tyrosine phosphatase (HePTP) .

HPK1-IN-19	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-19 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor extracted from patent WO2018102366A1 compound I-47 .

HPK1-IN-20	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-19 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor extracted from patent WO2020235902A1 compound 106 .

ML120 analog 1	Phosphatase	Cancer
ML120 analog 1 (compound 1) is a competitive inhibitor with a K_i of 0.69 μM for Hematopoietic protein tyrosine phosphatase (HePTP) .

HY-145041

HPK1-IN-15	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-15 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2018049200A1, compound 50) .

HY-145042

HPK1-IN-16	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-16 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-16 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019051199A1, compound 39) .

HY-145044

HPK1-IN-17	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-17 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-17 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 73) .

HY-145045

HPK1-IN-18	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-18 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-18 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 1) .

HY-144091

HPK1-IN-24

MAP4K Cancer

HPK1-IN-24 (example 51) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with a K_i of 100 nM. HPK1-IN-24 has the potential for cancer research .

HPK1-IN-24	MAP4K	Cancer
HPK1-IN-24 (example 51) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with a K_i of 100 nM. HPK1-IN-24 has the potential for cancer research .

HY-144092

HPK1-IN-25	MAP4K	Cancer
HPK1-IN-25 (example 94) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with a enzymatic activity IC₅₀ of 129 nM. HPK1-IN-25 has the potential for cancer research .

HY-151634

Syk-IN-6	Syk STAT ERK	Cancer
Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks Syk kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML) .

HY-135892

GNE-1858 1 Publications Verification	MAP4K	Inflammation/Immunology
GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC₅₀s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively .

HY-106420

16,16-Dimethyl prostaglandin E2 16,16-dimethyl PGE2	Prostaglandin Receptor	Inflammation/Immunology
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway .

HY-107589A

BIO5192 hydrate 1 Publications Verification	Integrin	Inflammation/Immunology
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (K_d<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC₅₀=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels .

HY-107589

BIO5192 1 Publications Verification	Integrin	Inflammation/Immunology
BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (K_d<10 pM). BIO5192 selectively binds to α4β1 (IC₅₀=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels .

HY-133146

DJ001	Phosphatase Apoptosis	Inflammation/Immunology
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC₅₀ of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration .

HY-117779

DBIBB	Apoptosis	Endocrinology
DBIBB is a specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2). DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation, and reduces apoptosis. DBIBB represents a agent candidate capable of mitigating acute radiation syndrome caused by high-dose γ-radiation to the hematopoietic and gastrointestinal system .

HY-P99376

Narsoplimab OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)	SARS-CoV	Infection
Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2 .

HY-145036

HPK1-IN-10	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-10 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-10 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 103) .

HY-145037

HPK1-IN-11	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-11 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-11 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 2) .

HY-145038

HPK1-IN-12	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-12 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-12 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 85) .

HY-145039

HPK1-IN-13	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-13 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-13 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 64) .

HY-145040

HPK1-IN-14	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-14 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-14 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 79) .

HY-145035

HPK1-IN-9	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-9 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-9 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 112) .

HY-110167

TFC 007	PGE synthase Ligands for Target Protein for PROTAC	Cancer
TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC₅₀ value of 83 nM). TFC-007 can be used for composing H-PGDS degradation inducer PROTAC(H-PGDS)-1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon) .

HY-N3540

Caraphenol A	Others	Inflammation/Immunology
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-12878

UM171
UM171 is a selective agonist of human hematopoietic stem cell self-renewal. UM171 binds to hematopoietic cytokines and has the ability to promote the maintenance and expansion of human primary HSCs in vitro. UM171 can be used in the study of hematopoietic derivation of human pluripotent stem cells in vitro.

HY-144347

HF51116	CXCR	Infection Cancer
HF51116 is a potent antagonist of CXCR4. HF51116 strongly antagonizes SDF-1α-induced cell migration, calcium mobilization, and CXCR4 internalization. HF51116 inhibits HIV-1 infection via CXCR4. HF51116 has the potential for the research of HIV-1 infection, hematopoietic stem cell mobilization, and cancer metastasis .

HY-N8572

3',4'-Dimethoxyflavone	PARP Reactive Oxygen Species Aryl Hydrocarbon Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

HY-126134

HPGDS inhibitor 2	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC₅₀ of 9.9 nM .

HY-132869

MEIS-IN-1

Others Others

MEIS-IN-1 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor to induce murine and human hematopoietic stem-cell expansion.

MEIS-IN-1	Others	Others
MEIS-IN-1 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor to induce murine and human hematopoietic stem-cell expansion.

HY-157577

PROTAC(H-PGDS)-8	PROTACs Prostaglandin Receptor	Cardiovascular Disease
PROTAC(H-PGDS)-8 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a IC₅₀ of 0.14 μM .

HY-139972

PROTAC(H-PGDS)-7

Prostaglandin Receptor Cardiovascular Disease

PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a DC₅₀ of 17.3 pM .

PROTAC(H-PGDS)-7	Prostaglandin Receptor	Cardiovascular Disease
PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a DC₅₀ of 17.3 pM .

HY-139171

F092	PGE synthase	Inflammation/Immunology
F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a K_D value of 0.14 nM. F092 can be used in the study of allergic and inflammatory responses .

HY-100791

NSC23005 sodium 1 Publications Verification	Others	Cancer
NSC23005 sodium is a novel and effective p18 inhibitor (ED₅₀=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.

HY-109134

Pizuglanstat TAS-205 free base	Prostaglandin Receptor	Metabolic Disease
Pizuglanstat (compound 3) is a prostaglandin D synthase inhibitor with an IC₅₀ of 76 nM for human hematopoietic prostaglandin D synthases (H-PGDS). Pizuglanstat can be used for myodegenerative disease research, such as muscular dystrophy .

HY-162350

TDI-11055	Endogenous Metabolite	Cancer
TDI-11055 is an inhibitor of the epigenetic reader protein 11-19 leukemia (ENL) YEATS, which drives the oncogenic transcriptional program of acute myeloid leukemia (AML), the hematopoietic malignancy AML .

HY-134259

MEISi-2	Others	Cancer
MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer .

HY-P99199

Foralumab NI-0401	CD3	Inflammation/Immunology
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .

HY-15001A

Stemregenin 1 hydrochloride SR1 hydrochloride	Aryl Hydrocarbon Receptor	Others
Stemregenin 1 hydrochloride is a purine derivative that antagonizes aryl hydrocarbon receptor signaling in CD34+ cells. IC₅₀ The value is 127 nM. Stemregenin 1 hydrochloride can be used to expand the pluripotency of hematopoietic stem cells (HSC) in stem cell studies .

HY-144088

ZYF0033 HPK1-IN-22	MAP4K	Inflammation/Immunology Cancer
ZYF0033 is effective in inhibiting hematopoietic progenitor cells HPK1, basically inhibiting MBP protein oxidation IC₅₀ 10 nM . ZYF0033 promotes anti-cancer immune response, lowers SLP76 (acid 376) oxidation. ZYF0033 Suppression 4T-1 Small mouse model with the same underlying cause, medium bulge growth length expansion DC, NK 细细和 CD107a ^{+ CD8 ⁺ T Cells, PD-1 ⁺CD8 ⁺ T Cells, TIM-3 ⁺CD8 ⁺ T Cells LAG3< sup>+}CD8 ⁺ T Cellular immersion decreases.

HY-136241

OT-82	NAMPT Caspase	Cancer
OT-82 is a potent, selective and orally active inhibitor of NAMPT. OT-82 is selectively toxic to cells of hematopoietic origin and induces cell death in a NAD ⁺ dependent manner. OT-82 is a promising antineoplastic agent for the study of hematological malignancies .

HY-152257

HPK1-IN-31	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC₅₀ value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunoresearch .

HY-10046

Plerixafor Maximum Cited Publications 60 Publications Verification AMD 3100; JM3100; SID791	CXCR HIV	Infection Inflammation/Immunology Endocrinology Cancer
Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM .

HY-P0266B

N-Acetyl-Ser-Asp-Lys-Pro acetate Ac-SDKP acetate	Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .

HY-109038

Mocravimod KRP-203 free base	LPL Receptor	Cancer
Mocravimod is an oral activity amphematoshenol-1-1-phosphate receptor (S1PR) regulator, which can block the required signal from lymph organs to prevent the migration of effect cells from migrating to non-lymph hematopoietic tissue. Mocravimod can be used for cancer research .

HY-153362

HPK1-IN-34	MAP4K	Cancer
HPK1-IN-34 (Compound 143) is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC₅₀ of <100 nM . HPK1-IN-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10439

HPGDS inhibitor 1	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC₅₀s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .

HY-138568

HPK1-IN-3	MAP4K	Inflammation/Immunology
HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC₅₀ of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC₅₀ of 108 nM in human peripheral blood mononuclear cells (PBMCs) .

HY-149206

HPK1-IN-33	MAP4K	Cancer
HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a K_i value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC₅₀s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively .

HY-108259

HQL-79	PGE synthase	Inflammation/Immunology
HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD₂, and acts as an anti-allergic agent, with a K_d of 0.8 μM and an IC₅₀ of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS .

Cat. No.	Product Name

HY-L171

Anti-Hematopathy Compound Library

2706 Compounds compounds

Hematopathy, also known as hematopoietic system diseases, are a class of diseases that hematopoietic system has abnormal changes. Common hematopathy include: aplastic anemia, myeloproliferative diseases, thalassemia, leukemia, lymphoma, myeloma and hemophilia, etc. In recent years, treatments for hematopathy have been developed. In particular, the treatment of malignant hematopathy developed from chemotherapy, radiotherapy, bone marrow development to immunotherapy, induced differentiation therapy, cell therapy, gene therapy and hematopoietic stem cell transplantation. Although these therapies have greatly improved the survival rate of patients, there are still problems such as low cure rate and easy recurrence in the treatment of hematopathy. Therefore, it is of great significance to actively search for new hematopathy therapeutic drugs.

MCE designs a unique collection of 2706 anti-hematopathy small molecules, which is an effective tool for development and research of anti-hematopathy compounds.

HY-L174

Macrophage Related Compound Library

153 compounds

Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance.

MCE designs a unique collection of 153 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P0266B

N-Acetyl-Ser-Asp-Lys-Pro acetate Ac-SDKP acetate	Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .

HY-P1122

Cyclosporin H 1 Publications Verification	Formyl Peptide Receptor (FPR)	Infection Inflammation/Immunology
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

HY-P1682A

Balixafortide TFA 1 Publications Verification POL6326 TFA	CXCR Arrestin	Cancer
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-P0172A

ATI-2341 TFA 2 Publications Verification	CXCR	Inflammation/Immunology Endocrinology Cancer
ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .

HY-P1682

Balixafortide POL6326	CXCR Arrestin	Cancer
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-P0172

ATI-2341	CXCR	Inflammation/Immunology Endocrinology Cancer
ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3540

Caraphenol A	Leguminosae Phenols Polyphenols Plants Caragana sinica (Buchoz) Rehd.	Others
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-N8572

3',4'-Dimethoxyflavone	Flavonoids other families Flavones Coniogramme japonica (Thunb.) Diels Plants	PARP Reactive Oxygen Species Aryl Hydrocarbon Receptor
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

HY-N0307

Ciwujianoside B	Triterpenes Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Bcl-2 Family
Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory . Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of Bax/Bcl-2 in bone marrow cells exposed to radiation .

Species:	Human (20) Rhesus Macaque (1) Mouse (9) Rat (3) Canine (1)
Tag:	His (20) Tag Free (10) Myc (1) Fc (4)
Source:	HEK293 (14) Sf9 insect cells (1) CHO (1) P. pastoris (3) Sf9 insect cells (4) E. coli (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P7216

	IL-3 Protein, Canine rCaIL-3; Mast cell growth factor; MCGF; hematopoietic growth factor	Canine	E. coli
	IL-3 Protein, Canine is a hemopoietic growth factor involved in the survival, proliferation and differentiation of multipotent hemopoietic cells.

HY-P7064

	SCF Protein, Mouse (P.pastoris) rMuSCF; hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Mouse	P. pastoris
	SCF Protein, Mouse (P.pastoris) is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.

HY-P7056

	SCF Protein, Human (P.pastoris) rHuSCF; hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Human	P. pastoris
	SCF Protein, Human (P.pastoris), the c-kit ligand, is a two disulfide bridge-containing cytokine in the regulation of the development and function of hematopoietic cell lineages and other cells such as mast cells, germ cells, and melanocytes.

HY-P7107

	SCF Protein, Rat (P.pastoris) rRtSCF; hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Rat	P. pastoris
	SCF Protein, Rat (P.pastoris) is a hematopoietic cytokine, triggered by binding to its ligand c-kit, and plays an important role in hematopoiesis, spermatogenesis, and melanogenesis.

HY-P70289

	HCLS1 Protein, Human (HEK293, His) rHuhematopoietic lineage cell-specific protein/HCLS1, His; hematopoietic lineage cell-specific protein; hematopoietic cell-specific LYN substrate 1; LckBP1; p75	Human	HEK293
	HCLS1, a substrate of antigen receptor-coupled tyrosine kinase, is pivotal in lymphoid cell antigen receptor signaling, influencing clonal expansion and deletion. Beyond signaling, it may regulate gene expression. HCLS1 forms associations with LCK, LYN, and ANKRD54, exhibiting intricate involvement in signaling networks. Interactions with FES/FPS and FGR add to its functional complexity, emphasizing its role in diverse cellular processes. HCLS1 Protein, Human (HEK293, His) is the recombinant human-derived HCLS1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HCLS1 Protein, Human (HEK293, His) is 486 a.a., with molecular weight of 55-110 kDa.

HY-P7107A

	SCF Protein, Rat (HEK293) rRtSCF; hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Rat	HEK293
	SCF Protein, Rat (HEK293) is a hematopoietic cytokine, triggered by binding to its ligand c-kit, and plays an important role in hematopoiesis, spermatogenesis, and melanogenesis.

HY-P72734

	CD34 Protein, Human (HEK293, His) hematopoietic progenitor cell antigen CD34; CD34	Human	HEK293
	CD34 protein, a potential adhesion molecule, is vital in early hematopoiesis, aiding stem cell attachment to the bone marrow's extracellular matrix or stromal cells. It potentially serves as a scaffold for lineage-specific glycans, facilitating interaction with lectins on stromal cells. CD34 also presents carbohydrate ligands to selectins, enhancing its role in cell adhesion processes. CD34 Protein, Human (HEK293, His) is the recombinant human-derived CD34 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD34 Protein, Human (HEK293, His) is 259 a.a., with molecular weight of 60-90 kDa.

HY-P73410

	SCF Protein, Human (sf9, His) SCF; hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Human	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. SCF Protein, Human (sf9, His) is the recombinant human-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SCF Protein, Human (sf9, His) is 164 a.a., with molecular weight of ~22 kDa.

HY-P73662

	SCF Protein, Mouse (sf9, His) SCF; hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Mouse	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. SCF Protein, Mouse (sf9, His) is the recombinant mouse-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SCF Protein, Mouse (sf9, His) is 189 a.a., with molecular weight of ~23 kDa.

HY-P77524

	CD34 Protein, Human (Biotinylated, HEK293, His) hematopoietic progenitor cell antigen CD34; CD34	Human	HEK293
	CD34 protein, a potential adhesion molecule, is vital in early hematopoiesis, aiding stem cell attachment to the bone marrow's extracellular matrix or stromal cells. It potentially serves as a scaffold for lineage-specific glycans, facilitating interaction with lectins on stromal cells. CD34 also presents carbohydrate ligands to selectins, enhancing its role in cell adhesion processes. CD34 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived CD34 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD34 Protein, Human (Biotinylated, HEK293, His) is 290 a.a., with molecular weight of ~29 KDa.

HY-P77525

	CD34 Protein, Human (Biotinylated, HEK293, Fc) hematopoietic progenitor cell antigen CD34; CD34	Human	HEK293
	CD34 protein, a potential adhesion molecule, is vital in early hematopoiesis, aiding stem cell attachment to the bone marrow's extracellular matrix or stromal cells. It potentially serves as a scaffold for lineage-specific glycans, facilitating interaction with lectins on stromal cells. CD34 also presents carbohydrate ligands to selectins, enhancing its role in cell adhesion processes. CD34 Protein, Human (Biotinylated, HEK293, Fc) is the recombinant human-derived CD34 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD34 Protein, Human (Biotinylated, HEK293, Fc) is 290 a.a., with molecular weight of ~54 KDa.

HY-P74304

	CD34 Protein, Rat (HEK293, Fc) hematopoietic progenitor cell antigen CD34; CD34; HPCA1	Rat	HEK293
	CD34 Protein is a transmembrane phosphoglycoprotein that exists on the surface of human and various animal cells. CD34 Protein is used as a cellular marker for hematopoietic stem cell sorting and as an islet endocrine cell marker. CD34 Protein plays an important role in cell adhesion, inflammatory cell chemotaxis, cell proliferation and differentiation, and enhancement of inflammatory response. CD34 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD34 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD34 Protein, Rat (HEK293, Fc) is 255 a.a., with molecular weight of 95-130 kDa.

HY-P74306

	CD34 Protein, Human (HEK293, Fc) hematopoietic progenitor cell antigen CD34; CD34; HPCA1	Human	HEK293
	CD34 protein, a potential adhesion molecule, is vital in early hematopoiesis, aiding stem cell attachment to the bone marrow's extracellular matrix or stromal cells. It potentially serves as a scaffold for lineage-specific glycans, facilitating interaction with lectins on stromal cells. CD34 also presents carbohydrate ligands to selectins, enhancing its role in cell adhesion processes. CD34 Protein, Human (HEK293, Fc) is the recombinant human-derived CD34 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD34 Protein, Human (HEK293, Fc) is 290 a.a., with molecular weight of ~116 & 96 kDa, respectively.

HY-P77529

	SCF Protein, Mouse (Biotinylated, sf9, His) SCF; hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Mouse	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. SCF Protein, Mouse (Biotinylated, sf9, His) is the recombinant mouse-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SCF Protein, Mouse (Biotinylated, sf9, His) is 189 a.a., with molecular weight of ~19.7 KDa.

HY-P75310

	DAP10 Protein, Human (HEK293, mFc) hematopoietic cell signal transducer; HCST; DAP10; KAP10; PIK3AP	Human	HEK293
	DAP10 is a transmembrane adapter protein that forms the activating receptor KLRK1-HCST, which is critical for cytotoxicity in target cells expressing stress-inducing ligands. It is activated by ULBP, triggering calcium mobilization and activating PI3K, MAP2K/ERK and JAK2/STAT5 signaling pathways. DAP10 Protein, Human (HEK293, mFc) is the recombinant human-derived DAP10 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of DAP10 Protein, Human (HEK293, mFc) is 30 a.a., with molecular weight of ~33-45 kDa.

HY-P70528

	SCF Protein, Mouse Kit ligand; hematopoietic growth factor KL; Mast cell growth factor; MGF; Steel factor; Stem cell factor; SCF	Mouse	E. coli
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. SCF Protein, Mouse is the recombinant mouse-derived SCF protein, expressed by E. coli , with tag free. The total length of SCF Protein, Mouse is 164 a.a., with molecular weight of ~16.0 kDa.

HY-P74305

	CD34 Protein, Mouse (287a.a, HEK293, His) hematopoietic progenitor cell antigen CD34; CD34; HPCA1	Mouse	HEK293
	CD34 protein functions as a potential adhesion molecule, aiding early hematopoiesis by facilitating stem cell attachment to the bone marrow extracellular matrix or stromal cells. It acts as a scaffold for lineage-specific glycans, enabling stem cells to bind to lectins on stromal cells or other marrow components. Moreover, CD34 may present carbohydrate ligands to selectins, contributing to cell adhesion processes. CD34 Protein, Mouse (287a.a, HEK293, His) is the recombinant mouse-derived CD34 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD34 Protein, Mouse (287a.a, HEK293, His) is 287 a.a., with molecular weight of 50-60 kDa.

HY-P71200

	PGCP Protein, Mouse (HEK293, His) PGCP; Carboxypeptidase Q; hematopoietic lineage switch 2; Plasma glutamate carboxypeptidase; Cpq; Hls2	Mouse	HEK293
	PGCP is a carboxypeptidase with a potentially critical role in the hydrolysis of circulating peptides. It catalyzes the cleavage of terminally unsubstituted dipeptides, releasing amino acids. PGCP Protein, Mouse (HEK293, His) is the recombinant mouse-derived PGCP protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PGCP Protein, Mouse (HEK293, His) is 452 a.a., with molecular weight of ~60.0 kDa.

HY-P76059

Serglycin/SRGN Protein, Human (HEK293, His)

hematopoietic proteoglycan core protein; Platelet proteoglycan core protein; P.PG; SRGN; PRG; PRG1
Human HEK293

HY-P7040

	IL-3 Protein, Human rHuIL-3; hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Human	E. coli
	IL-3 Protein, Human is a multilineage hematopoietic cytokine with promising effects on platelet and neutrophil counts and special usefulness in patients with secondary hematopoietic failure.

HY-P7062

	IL-3 Protein, Mouse rMuIL-3; hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Mouse	E. coli
	IL-3 Protein, Mouse is a pleiotropic cytokine containing 135 amino acids, which functions via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines.

HY-P76058

	Serglycin/SRGN Protein, Human (HEK293, His-Myc) hematopoietic proteoglycan core protein; Platelet proteoglycan core protein; P.PG; SRGN; PRG; PRG1	Human	HEK293
	Serine (SRGN) is essential for the formation of mast cell secretory granules and the storage of various compounds. It plays a crucial role in the storage of proteases in mast cells, including granzyme B in T lymphocytes, and contributes to the localization of neutrophil elastase. Serglycin/SRGN Protein, Human (HEK293, His-Myc) is the recombinant human-derived Serglycin/SRGN protein, expressed by HEK293 , with C-His, C-Myc labeled tag. The total length of Serglycin/SRGN Protein, Human (HEK293, His-Myc) is 158 a.a., with molecular weight of ~27 kDa.

HY-P7040A

	IL-3 Protein, Human (CHO) 1 Publications Verification rHuIL-3; hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Human	CHO
	IL-3 Protein, Human (CHO) is a multilineage hematopoietic cytokine with promising effects on platelet and neutrophil counts and special usefulness in patients with secondary hematopoietic failure.

HY-P70576AF

	Animal-Free IL-3 Protein, Human (His) rHuIL-3; hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Human	E. coli

HY-P700205AF

	Animal-Free IL-3 Protein, Mouse (His) rMuIL-3; hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Mouse	E. coli
	IL-3 protein is secreted by T lymphocytes, mast cells and osteoblasts. It plays an important regulatory role in hematopoietic progenitor cells and stimulates mature basophils, eosinophils and monocytes. In addition to hematopoiesis, it supports neuronal cell proliferation, survival, and bone homeostasis by inhibiting osteoclast differentiation. Animal-Free IL-3 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-3 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-3 Protein, Mouse (His) is 134 a.a., with molecular weight of ~16.04 kDa.

HY-P70576

	IL-3 Protein, Human (His) 1 Publications Verification Interleukin-3; IL-3; hematopoietic Growth Factor; Mast Cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-Cell-Stimulating Factor; IL3	Human	E. coli
	IL-3 protein is mainly secreted by T lymphocytes, mast cells and osteoblasts and is critical for the generation and differentiation of hematopoietic progenitor cells. It stimulates mature basophils, eosinophils and monocytes, promoting functional activation. IL-3 Protein, Human (His) is the recombinant human-derived IL-3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-3 Protein, Human (His) is 133 a.a., with molecular weight of 13-16 kDa.

HY-P70576G

	GMP IL-3 Protein, Human (His) Interleukin-3; IL-3; hematopoietic Growth Factor; Mast Cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-Cell-Stimulating Factor; IL3	Human	E. coli
	IL-3 protein is mainly secreted by T lymphocytes, mast cells and osteoblasts and is critical for the generation and differentiation of hematopoietic progenitor cells. It stimulates mature basophils, eosinophils and monocytes, promoting functional activation. GMP IL-3 Protein, Human (His) is the recombinant human-derived IL-3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GMP IL-3 Protein, Human (His) is 133 a.a., with molecular weight of 13-16 kDa.

HY-P71858A

	IL-3 Protein, Rhesus macaque (His) IL3; Interleukin-3; IL-3; hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor	Rhesus Macaque	E. coli
	IL-3 protein, a hematopoietic cytokine, regulates hematopoiesis by influencing the production, differentiation, and function of various white blood cell populations. It acts as a colony-stimulating factor, promoting the development and maturation of these cell types and maintaining a functional immune system. IL-3 Protein, Rhesus macaque (His) is the recombinant Rhesus Macaque-derived IL-3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-3 Protein, Rhesus macaque (His) is 124 a.a., with molecular weight of approximately 17 kDa.

HY-P701691

	HCK Protein, Human (Sf9) HCK; Tyrosine-protein kinase HCK; hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck	Human	Sf9 insect cells
	The HCK protein is a hematopoietic cell-dominated non-receptor tyrosine protein kinase that is critical for innate immune responses in neutrophils, monocytes, macrophages, and mast cells. HCK Protein, Human (Sf9) is the recombinant human-derived HCK protein, expressed by Sf9 insect cells , with tag free. The total length of HCK Protein, Human (Sf9) is 446 a.a., .

HY-P70765

	IL-3 Protein, Human (HEK293, His) 1 Publications Verification Interleukin-3; IL-3; hematopoietic Growth Factor; Mast Cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-Cell-Stimulating Factor; IL3	Human	HEK293
	IL-3 Protein, Human (HEK293, His) is a multipotent hematopoietic growth factor that can control blood formation. IL-3 Protein, Human (HEK293, His) is a recombinant human interleukin-3 (rhIL-3) expressed in HEK 293 cells with a His tag. rhIL-3 is also a weak inflammatory mediator. rhIL-3 can be used to improve states of hematopoietic failure.

HY-P701692

	HCK Protein, Human (Sf9, His) HCK; Tyrosine-protein kinase HCK; hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck	Human	Sf9 insect cells
	The HCK protein is a hematopoietic cell-dominated non-receptor tyrosine protein kinase that is critical for innate immune responses in neutrophils, monocytes, macrophages, and mast cells. HCK Protein, Human (Sf9, His) is the recombinant human-derived HCK protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of HCK Protein, Human (Sf9, His) is 446 a.a., .

HY-P70685

	IL-3 Protein, Mouse (HEK293, His) Interleukin-3; IL-3; hematopoietic growth factor; Multipotential colony-stimulating factor; P-cell-stimulating factor; Il3; Il-3; Mast cell growth factor; MCGF	Mouse	HEK293
	IL-3 Protein, Mouse (HEK293, His) is a multilineage hematopoietic cytokine with promising effects on platelet and neutrophil counts and special usefulness in patients with secondary hematopoietic failure.

HY-P71141

	SHP-1 Protein, Human (His) Tyrosine-Protein Phosphatase Non-Receptor Type 6; hematopoietic Cell Protein-Tyrosine Phosphatase; Protein-Tyrosine Phosphatase 1C; PTP-1C; Protein-Tyrosine Phosphatase SHP-1; SH-PTP1; PTPN6; HCP; PTP1C	Human	E. coli
	SHP-1 Protein modulates signaling from tyrosine-phosphorylated cell surface receptors, including KIT and EGFR. It enhances the inhibition of mast cell activation via the Lilrb4a receptor. The SH2 regions interact with cellular components to regulate its phosphatase activity. In collaboration with MTUS1, it induces UBE2V2 expression upon angiotensin II stimulation. SHP-1 plays a crucial role in hematopoiesis. SHP-1 Protein, Human (His) is the recombinant human-derived SHP-1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of SHP-1 Protein, Human (His) is 299 a.a., with molecular weight of ~33.0 kDa.

HY-P71930A

	TMSB4X Protein, Human (His) Fx; hematopoietic system regulatory peptide; Prothymosin beta 4; PTMB 4; PTMB4; Seraspenide; T beta 4; T beta-4; TB4X; THYB 4; Thyb4; Thymosin beta 4; Thymosin beta 4 X chromosome; Thymosin beta 4 X linked; TMSB 4; TMSB4; Tmsb4x; TYB4_HUMAN	Human	E. coli
	TMSB4X proteins play a critical role in cytoskeletal organization, influencing actin dynamics by binding and sequestering actin monomers. As a potent inhibitor of actin polymerization, it affects the cytoskeleton. TMSB4X Protein, Human (His) is the recombinant human-derived TMSB4X protein, expressed by E. coli , with N-6*His labeled tag. The total length of TMSB4X Protein, Human (His) is 43 a.a., with molecular weight of ~13 kDa.

Cat. No.	Product Name	Chemical Structure

HY-10046S

Plerixafor-d4
Plerixafor-d₄ is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM[1][2][3][4][7].

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