Search Result

Results for "

hepatotoxic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adrenergic Receptor (3) Akt (1) Amyloid-β (2) Antibiotic (1) Apoptosis (7) Atg8/LC3 (1) Autophagy (3) Bacterial (2) Bcl-2 Family (1) Caspase (2) Cholinesterase (ChE) (3) COX (1) Cytochrome P450 (3) DNA/RNA Synthesis (3) Dopamine Receptor (2) Drug Metabolite (2) Endogenous Metabolite (3) Free Fatty Acid Receptor (1) Fungal (1) Histamine Receptor (2) HIV (1) HIV Protease (1) Influenza Virus (2) Interleukin Related (1) JNK (1) Necroptosis (1) NOD-like Receptor (NLR) (1) p62 (1) Parasite (1) Reactive Oxygen Species (1) Reverse Transcriptase (1) Stearoyl-CoA Desaturase (SCD) (1) TNF Receptor (2) Topoisomerase (2) Virus Protease (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Endocrinology (3) Infection (11) Inflammation/Immunology (9) Metabolic Disease (15) Neurological Disease (7)

By Targets:

5-HT Receptor (3)

Adrenergic Receptor (3)

Akt (1)

Amyloid-β (2)

Antibiotic (1)

Apoptosis (7)

Atg8/LC3 (1)

Autophagy (3)

Bacterial (2)

Bcl-2 Family (1)

Caspase (2)

Cholinesterase (ChE) (3)

COX (1)

Cytochrome P450 (3)

DNA/RNA Synthesis (3)

Dopamine Receptor (2)

Drug Metabolite (2)

Endogenous Metabolite (3)

Free Fatty Acid Receptor (1)

Fungal (1)

Histamine Receptor (2)

HIV (1)

HIV Protease (1)

Influenza Virus (2)

Interleukin Related (1)

JNK (1)

Necroptosis (1)

NOD-like Receptor (NLR) (1)

p62 (1)

Parasite (1)

Reactive Oxygen Species (1)

Reverse Transcriptase (1)

Stearoyl-CoA Desaturase (SCD) (1)

TNF Receptor (2)

Topoisomerase (2)

Virus Protease (2)

By Research Areas:

Cancer (11)

Cardiovascular Disease (2)

Endocrinology (3)

Infection (11)

Inflammation/Immunology (9)

Metabolic Disease (15)

Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0208

Methimazole 1 Publications Verification Thiamazole	Others	Endocrinology
Methimazole is an antithyroid compound widely used for the research of hyperthyroidism. Methimazole has potent hepatotoxicity .

HY-W007318

2-Iodoaniline

2-Iodophenylamine
Others Others

2-Iodoaniline (2-Iodophenylamine) is an aniline derivative, and has potential hepatotoxic and nephrotoxic activity .
HY-127011

7-Acetylintermedine

Others Metabolic Disease

7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid .
HY-N11681

Microcystin-WR

Others Others

Microcystin-WR, a microcystin, is a cyanobacterial metabolite. Microcystin-WR can produce hepatotoxicity of mice .

2-Iodoaniline 2-Iodophenylamine	Others	Others
2-Iodoaniline (2-Iodophenylamine) is an aniline derivative, and has potential hepatotoxic and nephrotoxic activity .

7-Acetylintermedine	Others	Metabolic Disease
7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid .

Microcystin-WR	Others	Others
Microcystin-WR, a microcystin, is a cyanobacterial metabolite. Microcystin-WR can produce hepatotoxicity of mice .

HY-N7905

Myricetin 3'-glucoside	Others	Inflammation/Immunology
Myricetin 3'-glucoside is a glycoside derivative of quercetin. Myricetin 3'-glucoside significantly prevents ethanol-induced hepatotoxicity by reducing hepatic transaminase activity and inflammatory response in HepG2 cells. Myricetin 3'-glucoside has a certain protective effect on alcohol-induced liver injury .

HY-133589

Fulvine	Others	Cardiovascular Disease Metabolic Disease
Fulvine is a pyrrolizidine alkaloid isolated from the seeds of Crotalaria fulva. Fulvine is *hepatotoxic* and can be used to induce hypertensive pulmonary vascular disease in vivo .

HY-111338

Tacrine	Cholinesterase (ChE)	Neurological Disease
Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC₅₀=109 nM), also acting as a CYP1A2 substrate agent. Tacrine exhibits certain hepatotoxicity in some individuals. Tacrine can be used for researching Alzheimer's disease (AD) .

HY-148147

Metamizol Methamizole	Others	Cardiovascular Disease
Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity .

HY-21065

Tienilic acid Ticrynafen; ANP 3624	Others	Metabolic Disease
Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro .

HY-N11433

Celosin L

Others Others

Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

Celosin L	Others	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-143291

AChE-IN-9	Cholinesterase (ChE)	Neurological Disease
AChE-IN-9 is a Tacrine (HY-111338) glycoconjugate tethered with acetylated β-Glucose. AChE-IN-9 is also an AChE inhibitor with an IC₅₀ value of 0.4 μM, with lower hepatotoxicity on healthy cells. Tacrine is used in Alzheimer's research .

HY-121390

Lasiocarpine	Endogenous Metabolite	Cancer
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-117082

UTL-5g GBL-5g	TNF Receptor	Inflammation/Immunology
UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors .

HY-151251

CYP2C9/CYP2C19-IN-1	Cytochrome P450 Virus Protease	Infection
CYP2C9/CYP2C19-IN-1 (compound 22d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C9/CYP2C19-IN-1 can be used in study of anti-ZIKV .

HY-W032848

Tinoridine Y-3642	COX	Inflammation/Immunology
Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. .

HY-146459

Akt1-IN-1	Akt	Cancer
Akt1-IN-1 (compound 5b) is a potent and selective Akt1 inhibitor with an IC₅₀ value of 18.79 nM in MIA Paca-2 cells. Akt1-IN-1 does not exhibit obvious teratogenicity, hepatotoxicity and cardiotoxicity (No Observed Adverse Effect Level > 100 µM). Akt1-IN-1 can be used for researching anticancer .

HY-151254

CYP2C19-IN-1	Cytochrome P450 Influenza Virus DNA/RNA Synthesis	Infection
CYP2C19-IN-1 (compound 20d) is a potent CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C19-IN-1 inhibits RNA-dependent RNA polymerase (RdRP) with a K_i value of 6.16 µM. CYP2C19-IN-1 can be used in study of anti-ZIKV .

HY-N6807

Elemicin	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial	Infection Cancer
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N1283

Seneciphyllinine	Others	Metabolic Disease
Seneciphyllinine, a pyrrolizidine alkaloid, is isolated from the roots of Gynura japonica. Pyrrolizidine alkaloids are highly hepatotoxic natural chemicals that produce irreversible chronic and acute hepatotoxic effects on human beings .

HY-N3731

Deoxycalyciphylline B

Others Metabolic Disease

Deoxycalyciphylline B is a hepatotoxic alkaloid that can be isolated from Daphniphyllum calycinum .

Deoxycalyciphylline B	Others	Metabolic Disease
Deoxycalyciphylline B is a hepatotoxic alkaloid that can be isolated from Daphniphyllum calycinum .

HY-148642

12-Hydroxynevirapine 12-hydroxy-NVP; 12-OH-NVP	Drug Metabolite	Infection
12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine .

HY-139705

Anticancer agent 12

Others Cancer

Anticancer agent 12 is unexpectedly devoids of hepatotoxicity while maintaining cytotoxic activity in malignant cells.
HY-N11812

Erucifoline N-oxide

Others Metabolic Disease

Erucifoline N-oxide, a natural compound that can be isolated from Senecio persoonia, possesses hepatotoxic activity .
HY-N1125

Triptobenzene H

Hypoglic acid
Others Others

Triptobenzene H (Hypoglic acid) significantly increases TNF-α and IL-1β mRNA levels in macrophages, causing indirect liver damage .
HY-129384

Rubratoxin B

Others Cancer

Rubratoxin B is a hepatotoxic mycotoxin that can be found in Penicillium rubrum Stoll. Rubratoxin B shows antitumor activity .

Anticancer agent 12	Others	Cancer
Anticancer agent 12 is unexpectedly devoids of hepatotoxicity while maintaining cytotoxic activity in malignant cells.

Erucifoline N-oxide	Others	Metabolic Disease
Erucifoline N-oxide, a natural compound that can be isolated from Senecio persoonia, possesses hepatotoxic activity .

Triptobenzene H Hypoglic acid	Others	Others
Triptobenzene H (Hypoglic acid) significantly increases TNF-α and IL-1β mRNA levels in macrophages, causing indirect liver damage .

Rubratoxin B	Others	Cancer
Rubratoxin B is a hepatotoxic mycotoxin that can be found in Penicillium rubrum Stoll. Rubratoxin B shows antitumor activity .

HY-N3765

Diosbulbin D	Apoptosis	Metabolic Disease
Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells .

HY-N12432

Glomeratide A	Others	Metabolic Disease
Glomeratide A is a benzophenone C-glucoside with hepatoprotective effects. Glomeratide A has a protective effect against d-galactosamine-induced hepatotoxicity in rat liver epithelial stem-like cells.

HY-N12426

Heilaohuguosu F	Others	Metabolic Disease
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-156436

Anti-inflammatory agent 62	Others	Inflammation/Immunology
Anti-inflammatory agent 62 is an anti-inflammatory agent. Anti-inflammatory agent 62 alleviate Acetaminophen-induced hepatotoxicity in HepG2 by the regulation of inflammatory and oxidative stress pathways .

HY-135627

JBP485 cyclo(L-Hyp-L-Ser)	Endogenous Metabolite	Others
JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases .

HY-B1483

Methapyrilene hydrochloride Thenylpyramine hydrochloride
Methapyrilene (Thenylpyramine) hydrochloride is an orally active H1-receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo

HY-N2867

Andrographiside	Others	Cancer
Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP) .

HY-138291

Ethoxyquin dimer	Others	Inflammation/Immunology
Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10?mg/kg shows hepatotoxicity in mice .

HY-128380

Dibenamine hydrochloride N-(2-Chloroethyl)dibenzylamine hydrochloride	Adrenergic Receptor	Metabolic Disease
Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse .

HY-N7026

Celosin I	Others	Metabolic Disease
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

HY-101063

Amthamine dihydrobromide
Amthamine is a histamine receptor (H1R-H4R) agonist. Amthamine can produce liver congestion and necrosis of liver cells. Amthamine can be used to study the induction effect of H1R-H4 agonist on hepatotoxicity .

HY-W010800

Cholesteryl hemisuccinate Cholesterol hydrogen succinate	Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis	Cancer
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .

HY-147810

5-HT7 receptor ligand 1	5-HT Receptor	Neurological Disease
5-HT7 receptor ligand 1 (Compound 5c) is a 5-HT₇ receptor ligand with a K_i of 8 nM. 5-HT7 receptor ligand 1 is not hepatotoxic and exhibit moderate potential interaction with other agents metabolized by CYP3A4 or CYP2D6 .

HY-14922

Fosalvudine tidoxil	Reverse Transcriptase HIV	Infection
Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection .

HY-P3148

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

HY-N2996

Ganodermanondiol	HIV Protease	Infection
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-N6638

Retrorsine	Others	Metabolic Disease
Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury .

HY-U00337A

Datelliptium chloride hydrochloride	DNA/RNA Synthesis	Cancer
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors .

HY-W017464

NAPQI	Drug Metabolite Endogenous Metabolite	Metabolic Disease
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-N1445

Isoquercetin 1 Publications Verification Quercetin 3-glucoside
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .

HY-151253

CYP2C1/CYP2C19-IN-2	Cytochrome P450 Virus Protease	Infection
CYP2C1/CYP2C19-IN-2 (compound 21d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C1/CYP2C19-IN-2 can be used in study of anti-ZIKV .

HY-N0373

Licochalcone B 4 Publications Verification	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

HY-150972

P163-0892

Fungal Infection

P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration .

HY-146251

BuChE-IN-6	Cholinesterase (ChE) Amyloid-β	Neurological Disease
BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC₅₀ values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively. BuChE-IN-6 also inhibits Aβ₄₂ self-aggregation .

HY-N2551

Vitamin U chloride S-Methylmethionine sulfonium chloride	Others	Inflammation/Immunology
Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration .

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