heterogeneous

By Targets:	Apoptosis (1) c-Myc (2) Cholinesterase (ChE) (1)
By Research Areas:	Cancer (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124811

IRES-C11	c-Myc	Cancer
IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes .

HY-135691

hnRNPK-IN-1	c-Myc Apoptosis	Cancer
hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with K_d values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities .

HY-131768

2'-O-Succinyl-cAMP	Cholinesterase (ChE)	Others
2'-O-Succinyl-cAMP is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Succinyl-cAMP conjugate has been used as tracers in a classical heterogeneous competitive enzyme immunoassay allowing the determination of cAMP .

Cat. No.	Product Name

HY-L074

Anti-Breast Cancer Compound Library	1953 compounds
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC). Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer. MCE supplies a unique collection of 1953 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Anti-Breast Cancer Compound Library

1953 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 1953 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Species:	Human (7) Mouse (1)
Tag:	His (7) SUMO (3) Myc (1) GST (2) B2M (1)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P72229

	HNRNPA1 Protein, Human (His) HNRNPA 1; Helix destabilizing protein; Helix-destabilizing protein; heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP core protein A1; HNRNPA1; HNRPA1	Human	E. coli
	The HNRNPA1 protein is complexly involved in multiple RNA processing functions, packaging pre-mRNA into hnRNP particles, promoting Poly(A) mRNA transport, and regulating splice site selection. Crucially, it binds inhibitoryly to sequences flanking PKM exon 9, favoring the inclusion of exon 10 in pyruvate kinase PKM splicing, thereby generating the PKM M2 isoform. HNRNPA1 Protein, Human (His) is the recombinant human-derived HNRNPA1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HNRNPA1 Protein, Human (His) is 353 a.a., with molecular weight of ~40.9 kDa.

HY-P72233

	HNRNPH1 Protein, Human (His-SUMO) DKFZp686A15170; heterogeneous nuclear ribonucleoprotein H; heterogeneous nuclear ribonucleoprotein H1 H; ; heterogeneous nuclear ribonucleoprotein H1; HNRH1_HUMAN; hnRNP H; hnRNPH; Hnrnph1; HNRPH 1; HNRPH; HNRPH1 protein; N-terminally processed	Human	E. coli
	The HNRNPH1 protein is an important component of the hnRNP complex and plays a key role in pre-mRNA processing events leading to mRNA conversion in the cytoplasm. Functionally, it cooperates with CUGBP1 to regulate alternative splicing of pre-mRNA, specifically inhibiting the inclusion of insulin receptor (IR) pre-mRNA exon 11 in myoblasts. HNRNPH1 Protein, Human (His-SUMO) is the recombinant human-derived HNRNPH1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HNRNPH1 Protein, Human (His-SUMO) is 448 a.a., with molecular weight of ~65.1 kDa.

HY-P73920

	hnRNP-R Protein, Human (sf9, His-GST) heterogeneous nuclear ribonucleoprotein R; hnRNP R; HNRNPR	Human	Sf9 insect cells
	hnRNP-R Protein, a constituent of ribonucleosomes, participates in precursor mRNA processing within the nucleus. It's part of the spliceosome C complex and involved in IGF2BP1-dependent mRNP granule complexes containing untranslated mRNAs. Additionally, hnRNP-R interacts with GTPBP1. hnRNP-R Protein, Human (sf9, His-GST) is the recombinant human-derived hnRNP-R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of hnRNP-R Protein, Human (sf9, His-GST) is 635 a.a., with molecular weight of ~114 kDa.

HY-P72231

	HNRNPA2B1 Protein, Human (GST) Hnrnpa2b1; Hnrpa2b1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Human	E. coli
	Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (GST) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-GST labeled tag. The total length of HNRNPA2B1 Protein, Human (GST) is 249 a.a., with molecular weight of ~55.4 kDa.

HY-P702591

PTBP1 Protein, Human (HEK293, His)

Polypyrimidine tract-binding protein 1; PTB; 57 kDa RNA-binding protein PPTB-1; heterogeneous nuclear ribonucleoprotein I (hnRNP I)
Human HEK293

HY-P72232

	HNRNPA2B1 Protein, Mouse (His-SUMO, Myc) Hnrnpa2b1; Hnrpa2b1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Mouse	E. coli
	The HNRNPA2B1 protein is an important heterogeneous nuclear ribonucleoprotein (hnRNP) that plays a key role in RNA processing and transport. It forms hnRNP particles that compact and stabilize transcripts to influence various cellular functions, including transcription, mRNA processing, nuclear export, localization, translation, and mRNA stability. HNRNPA2B1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived HNRNPA2B1 protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag. The total length of HNRNPA2B1 Protein, Mouse (His-SUMO) is 353 a.a., with molecular weight of ~57.4 kDa.

HY-P72230

	HNRNPA2B1 Protein, Human (His-B2M) Hnrnpa2b1; Hnrpa2b1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Human	E. coli
	Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His-B2M) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-6*His, B2M labeled tag. The total length of HNRNPA2B1 Protein, Human (His-B2M) is 249 a.a., with molecular weight of ~42.4 kDa.

HY-P72234

	HNRNPM Protein, Human (His-SUMO) CEA receptor; CEAR; heterogeneous nuclear ribonucleoprotein M; Heterogenous nuclear ribonucleoprotein M4; hnRNA binding protein M4; hnRNP M; Hnrnpm; HNRNPM4; HNRPM; HNRPM_HUMAN; HNRPM4; HTGR1; M3; M4; M4 protein; N-acetylglucosamine receptor 1; NAGR1	Human	E. coli
	The HNRNPM protein is a key pre-mRNA binding protein that exhibits strong affinity for poly(G) and poly(U) RNA homopolymers. It is central to the splicing process, complexly regulates RNA maturation, and serves as a receptor for carcinoembryonic antigen in Kupffer cells. HNRNPM Protein, Human (His-SUMO) is the recombinant human-derived HNRNPM protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HNRNPM Protein, Human (His-SUMO) is 729 a.a., with molecular weight of ~93.4 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80874

PRMT1 Antibody (YA686) ANM 1; ANM1; ANM1_HUMAN; complete cds; HCP 1; HCP1; heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2; heterogeneous nuclear ribonucleoproteins methyltransferase like 2; heterogeneous nuclear ribonucleoproteins methyltransferase like2; Hi	WB	Human
PRMT1 Antibody (YA686) is a non-conjugated and Mouse origined monoclonal antibody about 42 kDa, targeting to PRMT1 (4E9). It can be used for WB assays with tag free, in the background of Human.

HY-P81449

hnRNP K Antibody (YA1194)

HNRNPK; HNRPK; heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP
IHC-P Human
HY-P82129

hnRNP C1/C2 Antibody (YA1874)

HNRNPC; HNRPC; heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P83284

hnRNP G Antibody (YA3029)

RBMX; HNRPG; RBMXP1; RNA-binding motif protein; X chromosome; Glycoprotein p43; heterogeneous nuclear ribonucleoprotein G; hnRNP G
WB, IHC-F, IHC-P, ICC/IF Human

HY-P81279

hnRNP U Antibody (YA979) heterogeneous nuclear ribonucleoprotein U; hnRNP U protein; HNRNPU; hnRNPU protein; HNRPU; HNRPU_HUMAN; p120; p120 nuclear protein; SAF A; SAF-A; SAFA; Scaffold attachment factor A; U21.1.	WB	Human

HY-P81279A

hnRNP U Antibody (YA980) heterogeneous nuclear ribonucleoprotein U; hnRNP U protein; HNRNPU; hnRNPU protein; HNRPU; HNRPU_HUMAN; p120; p120 nuclear protein; SAF A; SAF-A; SAFA; Scaffold attachment factor A; U21.1.	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P82093

hnRNP Q Antibody (YA1838) SYNCRIP; HNRPQ; NSAP1; heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein	WB, IHC-P, ICC/IF	Human, Mouse, Rat

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