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hops

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Apoptosis (4) Bacterial (1) BCRP (1) Caspase (1) CDK (1) CMV (1) COX (1) Glucosidase (2) Histone Demethylase (1) HSV (2) Influenza Virus (1) mGluR (1) Microtubule/Tubulin (1) Parasite (2)
By Research Areas:	Cancer (10) Infection (6) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)

20

Inhibitors & Agonists

15

Natural
Products

3

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N11769

Xanthohumol C

Others Others

Xanthohumol C is a prenylchalcone, that can be isolated from the hops of Humulus lupulus .

Isoxanthohumol 1 Publications Verification	HSV	Infection Cancer
Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) .

HY-N9140

Hulupinic acid

Others Others

Hulupinic acid is a prominent oxidation product of hop acids .

Tetrasul	Parasite	Infection
Tetrasul is an acaricide. Tetrasul inhibits Tetranychus urticae and aphids on hops. Tetrasul has also been used in research of erythematous (type one) rosacea .

*3-Oxo-hop-22(29)-ene*	Glucosidase	Infection Inflammation/Immunology
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory .

HY-N3951

Glochidone

Others Cancer

Glochidone is an anti-cancer agent with IC₅₀s of 5.52 μM and 7.84 μM against HOP-62 and EPLC-272H cells, respectively .

*3β-Hydroxy-hop-22(29)-ene*	Parasite	Infection
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-N2584

(2S)-Isoxanthohumol

Others Cancer

(2S)-Isoxanthohumol is a microbial biotransformed metabolite of the hop prenylflavanone Isoxanthohumol .

KDM1/CDK1-IN-1	Histone Demethylase CDK Apoptosis Caspase	Cancer
KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC₅₀ values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC₅₀ values of 16.34, 3.45 and 7.79 μM, respectively .

*3β-Acetoxy-hop-22(29)-ene*	Glucosidase	Inflammation/Immunology
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

HY-N10867

β-Acids colupulone

Others Others

β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops .

Lupulone	Bacterial	Infection Cancer
Lupulone is a beta-acid from the hop plant H. lupulus with diverse biological activities including antibacterial, antioxidant, and anticarcinogenic properties .

Desmethylxanthohumol 1 Publications Verification	Apoptosis	Cancer
Desmethylxanthohumol is a prenylated hydroxychalcone isolated from hop cones (Humulus lupulus L.). Desmethylxanthohumol is a powerful apoptosis inducing agent. Desmethylxanthohumol has antiplasmodial, antiproliferative, and antioxidant bioactivities .

HY-N10668

2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid

Others Others

2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid (compound 29) is a natural polyphenol compound found in hop bract .

Xanthohumol D 1 Publications Verification
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC₅₀ value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro .

Anticancer agent 139	Microtubule/Tubulin	Cancer
Anticancer agent 139 (Compound 6h) has potent anticancer activity. Anticancer agent 139 displayed a π–cationic interaction with the residue Lys352 of Tublin. Anticancer agent 139 has good anticancer activity against SNB-19, OVCAR-8, and NCI-H40 with PGIs of 86.61, 85.26, and 75.99, respectively. Anticancer agent 139 also has moderate anticancer activity against HOP-62, SNB-75, ACHN, NCI/ADR-RES, 786-O, A549/ATCC, HCT-116, and MDA-MB-231 with PGIs of 67.55, 65.46, 59.09, 59.02, 57.88, 56.88, 56.53, 56.4, and 51.88 respectively .

Xanthohumol Maximum Cited Publications 8 Publications Verification	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

8-Prenylnaringenin 1 Publications Verification	Apoptosis	Cancer
8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus, with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice .

6,8-Diprenylnaringenin Lonchocarpol A; Senegalensin	BCRP	Metabolic Disease Cancer
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and ³H-Methotrexate transport (IC₅₀=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin .

mGluR2 modulator 1	mGluR	Neurological Disease
mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC₅₀ of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research .

Species:	Mouse (3)
Tag:	His (2) Fc (1)
Source:	HEK293 (3)

Cat. No.	Compare	Product Name	Species	Source

	Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, His) Alkaline phosphatase; AP-TNAP; TNSALP; ALPL	Mouse	HEK293
	Alkaline Phosphatase/ALPL Protein is a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. ALPL is also a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. Mice that lack ALPL show symptoms of osteomalacia, softening of the bones. Moreover, ALPL stimulates mineralization mainly through modulation of the balance between inorganic phosphate (Pi) and inorganic pyrophosphate (PPi) and also has a role in cardiovascular remodelling. Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, His) is the recombinant mouse-derived Alkaline Phosphatase/ALPL protein, expressed by HEK293 , with C-His, C-8*His labeled tag. The total length of Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, His) is 502 a.a., with molecular weight of ~55 kDa.

	Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, C-His) IAP; Akp2; ALPL; APTNAP; AP-TNAP; FLJ40094; FLJ93059; hops; MGC161443; TNAP; TNSALP	Mouse	HEK293
	Alkaline Phosphatase/ALPL Protein, vital with phosphatase, metal ion binding, and homodimerization activities, influences BMP stimulus response. Strategically located externally on the plasma membrane, its predicted activity emphasizes cellular functions. Prominent expression in the intestine and testis, especially in duodenum adult (RPKM 2234.3) and small intestine adult (RPKM 1574.5), underscores specific roles in these contexts. Its human orthologs, implicated in inflammatory bowel disease, highlight clinical relevance. Evolutionarily conserved, Alkaline Phosphatase/ALPL shares orthologous counterparts like ALPI in several human genes. Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived Alkaline Phosphatase/ALPL protein, expressed by HEK293 , with C-His labeled tag. The total length of Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, C-His) is 481 a.a., with molecular weight of 60-70 kDa.

	Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, Fc) Alkaline phosphatase; AP-TNAP; TNSALP; ALPL	Mouse	HEK293
	Alkaline Phosphatase/ALPL Protein is a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. ALPL is also a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. Mice that lack ALPL show symptoms of osteomalacia, softening of the bones. Moreover, ALPL stimulates mineralization mainly through modulation of the balance between inorganic phosphate (Pi) and inorganic pyrophosphate (PPi) and also has a role in cardiovascular remodelling. Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Alkaline Phosphatase/ALPL protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, Fc) is 502 a.a., with molecular weight of ~80.3 kDa.

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