Search Result

Results for "

hormone

" in MCE Product Catalog:

By Targets:	GHSR (22) GnRH Receptor (42) MCHR1 (GPR24) (16) PTHR (1) Thyroid Hormone Receptor (55) TSH Receptor (3) 5-HT Receptor (1) Adenylate Cyclase (5) Adrenergic Receptor (5) Akt (2) Amylin Receptor (4) Androgen Receptor (10) Antibiotic (1) Apoptosis (21) Arrestin (2) Autophagy (20) Bacterial (7) Biochemical Assay Reagents (2) Bradykinin Receptor (1) Calcium Channel (1) Cannabinoid Receptor (8) Caspase (1) CaSR (8) CGRP Receptor (4) Cholecystokinin Receptor (3) COX (2) CRFR (8) Cytochrome P450 (8) DNA/RNA Synthesis (6) Dopamine Receptor (1) Drug Metabolite (2) EBV (1) Endogenous Metabolite (109) Endothelin Receptor (2) Estrogen Receptor/ERR (38) FAAH (1) Fungal (1) FXR (1) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (1) GCGR (19) GLP Receptor (2) Glucocorticoid Receptor (11) Histamine Receptor (1) Histone Methyltransferase (1) IGF-1R (3) Insulin Receptor (8) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (12) Kisspeptin Receptor (3) LXR (1) MAGL (1) Melanocortin Receptor (29) Melatonin Receptor (5) mGluR (2) Mineralocorticoid Receptor (2) Mitophagy (4) Molecular Glues (3) Monocarboxylate Transporter (1) Neurokinin Receptor (2) Neuropeptide Y Receptor (5) NF-κB (4) Oxytocin Receptor (3) Parasite (1) PI3K (2) PKA (1) PKC (2) Potassium Channel (1) PPAR (1) Progesterone Receptor (25) Prostaglandin Receptor (7) Proton Pump (1) Reactive Oxygen Species (1) Secretin Receptor (2) Small Interfering RNA (siRNA) (2) Sodium Channel (1) Somatostatin Receptor (5) Src (1) TRP Channel (8) Tyrosinase (1) Vasopressin Receptor (6) VD/VDR (9)
By Research Areas:	Cancer (132) Cardiovascular Disease (39) Endocrinology (254) Infection (10) Inflammation/Immunology (54) Metabolic Disease (172) Neurological Disease (86)

By Targets:

GHSR (22)

GnRH Receptor (42)

MCHR1 (GPR24) (16)

PTHR (1)

Thyroid Hormone Receptor (55)

TSH Receptor (3)

5-HT Receptor (1)

Adenylate Cyclase (5)

Adrenergic Receptor (5)

Akt (2)

Amylin Receptor (4)

Androgen Receptor (10)

Antibiotic (1)

Apoptosis (21)

Arrestin (2)

Autophagy (20)

Bacterial (7)

Biochemical Assay Reagents (2)

Bradykinin Receptor (1)

Calcium Channel (1)

Cannabinoid Receptor (8)

Caspase (1)

CaSR (8)

CGRP Receptor (4)

Cholecystokinin Receptor (3)

COX (2)

CRFR (8)

Cytochrome P450 (8)

DNA/RNA Synthesis (6)

Dopamine Receptor (1)

Drug Metabolite (2)

EBV (1)

Endogenous Metabolite (109)

Endothelin Receptor (2)

Estrogen Receptor/ERR (38)

FAAH (1)

Fungal (1)

FXR (1)

G Protein-coupled Receptor Kinase (GRK) (1)

GABA Receptor (1)

GCGR (19)

GLP Receptor (2)

Glucocorticoid Receptor (11)

Histamine Receptor (1)

Histone Methyltransferase (1)

IGF-1R (3)

Insulin Receptor (8)

Integrin (1)

Interleukin Related (1)

Isotope-Labeled Compounds (12)

Kisspeptin Receptor (3)

LXR (1)

MAGL (1)

Melanocortin Receptor (29)

Melatonin Receptor (5)

mGluR (2)

Mineralocorticoid Receptor (2)

Mitophagy (4)

Molecular Glues (3)

Monocarboxylate Transporter (1)

Neurokinin Receptor (2)

Neuropeptide Y Receptor (5)

NF-κB (4)

Oxytocin Receptor (3)

Parasite (1)

PI3K (2)

PKA (1)

PKC (2)

Potassium Channel (1)

PPAR (1)

Progesterone Receptor (25)

Prostaglandin Receptor (7)

Proton Pump (1)

Reactive Oxygen Species (1)

Secretin Receptor (2)

Small Interfering RNA (siRNA) (2)

Sodium Channel (1)

Somatostatin Receptor (5)

Src (1)

TRP Channel (8)

Tyrosinase (1)

Vasopressin Receptor (6)

VD/VDR (9)

By Research Areas:

Cancer (132)

Cardiovascular Disease (39)

Endocrinology (254)

Infection (10)

Inflammation/Immunology (54)

Metabolic Disease (172)

Neurological Disease (86)

513

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

262

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Thyroid Hormone Receptor PTHR GHSR TSH Receptor GnRH Receptor MCHR1 (GPR24)

Cat. No.	Product Name	Target	Research Areas

HY-106373

Adrenocorticotropic hormone ACTH; Adrenocorticotrophic hormone	Androgen Receptor	Endocrinology
Adrenocorticotropic hormone (ACTH) is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone regulates cortisol and androgen production.

HY-106373A

*Adrenocorticotropic hormone* TFA** ACTH TFA; Adrenocorticotrophic hormone TFA	Androgen Receptor	Metabolic Disease
Adrenocorticotropic hormone (ACTH) TFA is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone regulates cortisol and androgen production.

HY-P0089

*Human growth hormone-releasing factor* Growth hormone Releasing Factor human	GHSR	Endocrinology
Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.

HY-P0089A

*Human growth hormone-releasing factor TFA* Growth hormone Releasing Factor human TFA	GHSR	Endocrinology
Human growth hormone-releasing factor TFA (Growth Hormone Releasing Factor human TFA) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.

HY-P2279A

*Parathyroid hormone* (1-34) (rat) acetate**	Thyroid Hormone Receptor	Endocrinology Metabolic Disease
Parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis.

HY-P2279

*Parathyroid hormone* (1-34) (rat)**	Thyroid Hormone Receptor	Endocrinology Metabolic Disease
Parathyroid hormone (1-34) (rat) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis.

HY-P0059A

Teriparatide acetate hydrate Human parathyroid hormone-(1-34) (acetate hydrate); hPTH (1-34) (acetate hydrate)	Others	Others
Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) is a PHT agonist. Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) can be used for osteoporosis research.

HY-P0252

α-MSH α-Melanocyte-Stimulating hormone	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease
α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

HY-134400

Follicle-stimulating hormone	Others	Endocrinology
Follicle-stimulating hormone is a heterodimer glycoprotein expressed by gonadotropin in the anterior pituitary gland. Follicle-stimulating hormone affects the fertility and reproductive efficiency of animals.

HY-P2510

*Parathyroid Hormone* (1-34), human, biotinylated**	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), human, biotinylated is a probe for the parathyroid hormone receptor, can be used for analyzing the interaction between parathyroid hormone and parathyroid hormone receptors in living cells and for purifying hormone-receptor complexes with affinity columns.

HY-108787

Parathyroid hormone PTH; Parathyroidin; Parathyrin	Endogenous Metabolite	Endocrinology
Parathyroid hormone (PTH) is a circulating hormone comprised of 84 amino acids. Parathyroid hormone is produced in the parathyroid glands and acts primarily on bone and kidney to maintain extracellular calcium levels within normal limits. Parathyroid hormone can be used for osteoporosis research.

HY-P1252

*Parathyroid Hormone* (1-34), bovine**	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), bovine is a potent *parathyroid hormone* (PTH) receptor** agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.

HY-N7240S

Juvenile Hormone III-d3
Isotope-Labeled Compounds Others

Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III[1].

*Juvenile Hormone* III-d3**	Isotope-Labeled Compounds	Others
Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III[1].

HY-P0002A

Protirelin acetate Thyrotropin-releasing-hormone acetate; TRH acetate	Thyroid Hormone Receptor	Endocrinology Inflammation/Immunology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P0002

Protirelin Thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P1252A

*Parathyroid Hormone* (1-34), bovine TFA**	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), bovine TFA is a potent *parathyroid hormone* (PTH) receptor** agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.

HY-P1628

Ganirelix	GnRH Receptor	Metabolic Disease
Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea.

HY-P1478

Adrenocorticotropic Hormone (ACTH) (4-10), human
Melanocortin Receptor Metabolic Disease

Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

*Adrenocorticotropic Hormone* (ACTH) (4-10), human**	Melanocortin Receptor	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

HY-P1525

*Melanin Concentrating Hormone, salmon* MCH (salmon)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P3572

*Adipokinetic hormone* I (Locusta migratoria)** Lom-AKH-I	Endogenous Metabolite	Endocrinology
Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs).

HY-P3570

*Adipokinetic hormone* II (Locusta migratoria)** Lom-AKH-II	Endogenous Metabolite	Metabolic Disease
Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs).

HY-P1531

*γ-1-Melanocyte Stimulating Hormone* (MSH), amide**	Melanocortin Receptor	Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-P3683

a-Helical Corticotropin Releasing Factor (12-41)	CRFR	Endocrinology
a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect.

HY-P1525A

*Melanin Concentrating Hormone, salmon TFA* MCH (salmon) (TFA)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P3684

[DPro5] Corticotropin Releasing Factor, human, rat	CRFR	Endocrinology
[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat.

HY-137178

20α,22R-Dihydroxycholesterol	Endogenous Metabolite	Metabolic Disease
20α,22R-Dihydroxycholesterol is an endogenous metabolic intermediate. 20α,22R-Dihydroxycholesterol involved in the biosynthesis of cholesterol to steroid hormones.

HY-P1211A

*Adrenocorticotropic Hormone* (ACTH) (1-39), human(TFA)** 1-39-Corticotropin (human)(TFA)	Melanocortin Receptor	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) is a melanocortin receptor agonist.

HY-P1477

*Adrenocorticotropic Hormone* (ACTH) (1-39), rat** ACTH (1-39) (mouse, rat)	Melanocortin Receptor	Metabolic Disease Endocrinology
Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist.

HY-P1558

ACTH (11-24) Adrenocorticotropic hormone (11-24)	Melanocortin Receptor	Neurological Disease
ACTH (11-24) is an *adrenocorticotropic hormone* (ACTH) receptor** antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.

HY-P3595

GHRF, porcine
GHSR Endocrinology

GHRF, porcine is a growth hormone releasing factor (GHRF) peptide (porcine). GHRF binds to GHSR and induces the release of growth hormone.

GHRF, porcine	GHSR	Endocrinology
GHRF, porcine is a growth hormone releasing factor (GHRF) peptide (porcine). GHRF binds to GHSR and induces the release of growth hormone.

HY-P1174

GnRH Associated Peptide (GAP) (1-13), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-13), human is an amino acid peptide fragment derived from GnRH. GAP can increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in rat anterior pituitary cells. GAP also inhibit the secretion of prolactin.

HY-A0070B

Liothyronine sodium hydrate Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate	Thyroid Hormone Receptor Endogenous Metabolite	Cancer Endocrinology
Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-A0070

Liothyronine sodium Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium	Thyroid Hormone Receptor Endogenous Metabolite	Cancer Endocrinology
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-A0070C

Liothyronine hydrochloride Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochloride	Thyroid Hormone Receptor Endogenous Metabolite	Cancer Endocrinology
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-A0070A

Liothyronine Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor Endogenous Metabolite	Cancer Endocrinology
Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-B1161

Methoprene ZR-515	Others	Others
Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist.

HY-P1477A

*Adrenocorticotropic Hormone* (ACTH) (1-39), rat TFA** ACTH (1-39) (mouse, rat) TFA	Melanocortin Receptor	Metabolic Disease Endocrinology
Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 (MC2) receptor agonist.

HY-P1558A

ACTH (11-24) (acetate) Adrenocorticotropic hormone (11-24) (acetate)	Melanocortin Receptor	Neurological Disease
ACTH (11-24) (acetate) is an *adrenocorticotropic hormone* (ACTH) receptor** antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.

HY-125572

Gibberellin A7 GA7	Others	Others
Gibberellin A7 (GA7) is a plant hormone. Gibberellin A7 is the metabolite of Gibberella fujikuroi. Gibberellin A7 promotes the plant growth and elongation of cells.

HY-P3582A

sGnRH-A acetate	GnRH Receptor	Endocrinology
sGnRH-A acetate is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A acetate stimulates growth hormone secretion. sGnRH-A acetate also can be used as an inducer of ovulation by artificial insemination.

HY-P3582

sGnRH-A	GnRH Receptor	Endocrinology
sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A stimulates growth hormone secretion. sGnRH-A also can be used as an inducer of ovulation by artificial insemination.

HY-105184

YM511	Cytochrome P450	Endocrinology
YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones.

HY-N2549

(±)-Abscisic acid (±)-ABA	Others	Metabolic Disease
(±)-Abscisic acid is an orally active plant hormone that is present also in animals. (±)-Abscisic acid (ABA) contributes to the regulation of glycemia in mammals.

HY-P0252A

α-MSH TFA α-Melanocyte-Stimulating hormone TFA	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease
α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC).

HY-P1504

*β-Melanocyte Stimulating Hormone* (MSH), human** Beta-MSH (1-22) (human)	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-111973

Phaseic acid	Others	Metabolic Disease
Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission.

HY-N9441

Ascr#7	Others	Others
Ascr#7, an ascaroside, is a hormone of nematodes. Ascr#7 is expressed during nematode development. Ascarosides can induce formation of long-lived and highly stress resistant dauer larvae.

HY-106608

Glutaurine Litoralon	Thyroid Hormone Receptor	Neurological Disease
Glutaurine containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine, as a hormone, is isolated from parathyroid gland oxyphil cells. Glutaurine can be used for the research of antiepileptic and anti-amnesia.

HY-129974

3,3'-Diiodo-L-thyronine 3,3'-T2	Endogenous Metabolite COX	Metabolic Disease
3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity.

HY-P1226

HAEGTFTSD	GCGR	Metabolic Disease
HAEGTFTSD is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide (HY-P0054A). GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretionin a glucose-dependant manner

HY-P0252B

α-MSH free acid α-Melanocyte-Stimulating hormone free acid	Melanocortin Receptor	Neurological Disease
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC₅₀s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R.

HY-P3685

[Met(O)21] Corticotropin Releasing Factor, ovine	CRFR	Endocrinology
[Met(O)21] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor isolated from ovine hypothalamic extracts. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH).

HY-B0234

Estrone E1; Oestrone	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells.

HY-P3964

TRH Precursor Peptide	Endogenous Metabolite	Endocrinology
TRH Precursor Peptide is a precursor peptide of thyrotropin-releasing hormone (TRH). TRH Precursor Peptide formation of TRH in rat brain and pituitary is zinc-dependent.

HY-P2416

Gastrin I, rat
Rat Gastrin-17
Cholecystokinin Receptor Endocrinology

Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently.
HY-128030

Makisterone A
Others Endocrinology

Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera.

HY-P0276

GIP, human Gastric Inhibitory Peptide (GIP), human	Insulin Receptor	Metabolic Disease
GIP, human, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion.

HY-P1504A

*β-Melanocyte Stimulating Hormone* (MSH), human TFA** Beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-P0276A

GIP, human TFA Gastric Inhibitory Peptide (GIP), human TFA	Insulin Receptor	Metabolic Disease
GIP, human TFA, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human TFA acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion.

HY-142441

THR-β agonist 1	Others	Endocrinology
THRβ Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THRβ Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2).

HY-P3969

Prepro-TRH-(160-169)	Thyroid Hormone Receptor	Endocrinology Neurological Disease
Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release.

HY-P3567

(p-Iodo-Phe7)-ACTH (4-10)	Melanocortin Receptor	Neurological Disease
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.

HY-16168A

Degarelix	GnRH Receptor Apoptosis	Cancer Endocrinology
Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist. Degarelix can be used for prostate cancer research.

HY-16168B

Degarelix acetate hydrate	GnRH Receptor Apoptosis	Cancer Endocrinology
Degarelix acetate hydrate is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist. Degarelix acetate hydrate can be used for prostate cancer research.

HY-P3604

LH-RH II (chicken)	Androgen Receptor	Endocrinology
LH-RH II (chicken) is one of the two forms of luteinizing hormone-releasing hormone (LHRH) the hypothalamus of the domestic hen, which are structural variants of mammalian LHRH. LH-RH II (chicken) enhances gonadotrophin release in the domestic chicken.

HY-107916

Thyrotropin TSH; Pretiron	Others	Endocrinology Metabolic Disease
Thyrotropin (TSH) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid.

HY-148147

Metamizol Methamizole	Others	Cardiovascular Disease
Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.

HY-136152

MCHR1 antagonist 3	MCHR1 (GPR24)	Endocrinology Metabolic Disease
MCHR1 antagonist 3 is a potent the *melanin-concentrating hormone* receptor-1 (MCHR1)** antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism.

HY-107917

Desoxycorticosterone pivalate DOCP	Mineralocorticoid Receptor	Endocrinology
Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism.

HY-P3606

GnRH Associated Peptide (1-24), human GAP (1-24), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.

HY-P3621

Biotinyl-Glucagon (1-29), human, bovine, porcine	GCGR	Metabolic Disease
Biotinyl-Glucagon (1-29), human, bovine, porcine is a biotinylated glucagon. Glucagon is a peptide hormone, produced by α-cells of the pancreas, can increase concentration of glucose and fatty acids in the bloodstream.

HY-A0070AS2

Liothyronine-13C6-1 Triiodothyronine-13C6-1; 3,3',5-Triiodo-L-thyronine-13C6-1; T3-13C6-1	Thyroid Hormone Receptor	Cancer Endocrinology
Liothyronine-13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-100321

MCHR1 antagonist 2	MCHR1 (GPR24) Potassium Channel	Metabolic Disease Endocrinology
MCHR1 antagonist 2 is an antagonist of *melanin concentrating hormone* receptor 1, with an IC₅₀ of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC₅₀** of 4.0 nM in IMR-32 cells.

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes.

HY-10003A

1α-Hydroxy-3-epi-vitamin D3	Thyroid Hormone Receptor	Metabolic Disease
1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion.

HY-W008452

H-Tyr(3-I)-OH	Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite.

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

HY-P3605

GnRH Associated Peptide (25-53), human GAP (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.

HY-111975

7'-Hydroxy ABA 7'-OH ABA	Others	Metabolic Disease
7'-Hydroxy ABA (7'-OH ABA) is a metabolite of Abscisic acid (Abscisic acid) through hydroxylation of the 7′-carbon atom of Abscisic acid. 7'-Hydroxy ABA exhibits significant hormonal activity.

HY-N7443

Gibberellin A1
Others Others

Gibberellin A1 is a kind of plant hormones. Gibberellin A1 is a growth-promoting acids isolated from immature seed of Phaseolus multiflorus.

HY-P3928

Amylin (1-37) (human) hIAPP (1-37)	Amylin Receptor	Metabolic Disease
Amylin (1-37) (human) (hIAPP (1-37)) is a peptide hormone, present in pancreatic betacell secretory granules. The C-terminus of Amylin (1-37) (human) is amidated and there is a disulfide bond between cysteine residues 2 and 7.

HY-50760

L-692585	GHSR	Endocrinology
L-692585 is a potent and nonpeptidyl *growth hormone* secretagogue receptor (GHS-R1a) agonist, with a K_i** of 0.8 nM. L-692585 acts directly on somatotropes causing GH release.

HY-B1617AS

Zuclomiphene-d4 citrate	Estrogen Receptor/ERR	Endocrinology Metabolic Disease
Zuclomiphene-d₄ (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].

HY-101402A

Cyclo(his-pro) TFA Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA	NF-κB Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

HY-13681

Methylprednisolone acetate	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone acetate, a prednisolone derivative, is a *corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo*.

HY-P1418

DPC-AJ1951	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 in ex vivo and in vivo assays of bone resorption.

HY-14820A

Macimorelin acetate EP-1572 acetate; AEZS-130 acetate	GHSR	Cancer Endocrinology Neurological Disease
Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS).

HY-14820

Macimorelin EP-1572; AEZS-130	GHSR	Cancer Endocrinology
Macimorelin (EP-1572), a GH secretagogue, is an orally active GHSR agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS).

HY-100812

2-Hydroxysaclofen	GABA Receptor	Endocrinology Neurological Disease
2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABA_B) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats.

HY-P1418A

DPC-AJ1951 TFA	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951 TFA, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 TFA in ex vivo and in vivo assays of bone resorption.

HY-P0024

Veldoreotide DG3173; PTR-3173	Somatostatin Receptor	Cancer Endocrinology
Veldoreotide (DG3173) a somatostatin analogue, that can bind to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits *growth hormone* (GH)** secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent

HY-150542

Steroid sulfatase-IN-2	Others	Cancer
Steroid sulfatase -IN-2 is an active steroid sulfatase (STS) inhibitor with an IC₅₀ value of 109.5 nM. Steroid sulfatase-IN-2 can be used for the research of hormone-dependent cancers, such as estrogen-dependent breast and endometrial cancer.

HY-119174

MK771	Others	Neurological Disease
MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome.

HY-P1777

IGF-I (24-41) Insulin-like Growth Factor I (24-41)	IGF-1R	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development.

HY-B0141

Estradiol β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Endocrinology Cancer
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.

HY-P1777A

IGF-I (24-41) (TFA) Insulin-like Growth Factor I (24-41) (TFA)	IGF-1R	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) TFA is amino acids 24 to 41 fragment of IGF-I. IGF-I TFA, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I TFA is partly responsible for systemic growth hormone (GH) activities. IGF-I TFA has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) TFA regulates somatic growth and behavioral development.

HY-19884

Relamorelin RM-131; BIM-28131	GHSR	Metabolic Disease
Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective *ghrelin/growth hormone* secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a** receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.

HY-19884A

Relamorelin acetate RM-131 acetate; BIM-28131 acetate	GHSR	Metabolic Disease
Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective *ghrelin/growth hormone* secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a** receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.

HY-P3343A

hFSH-β-(33-53) (TFA)	Estrogen Receptor/ERR	Cancer
hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells.

HY-P0082A

Glucagon (1-29), bovine, human, porcine hydrochloride Porcine glucagon hydrochloride	GCGR	Metabolic Disease
Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation.

HY-P0082

Glucagon (1-29), bovine, human, porcine Porcine glucagon	GCGR	Metabolic Disease
Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation.

HY-P3169

a-Helical Corticotropin Releasing Factor (9-41)	CRFR	Inflammation/Immunology
α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo.

HY-B0141C

Estradiol hemihydrate β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Cancer Neurological Disease
Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.

HY-19884B

Relamorelin TFA RM-131 TFA; BIM-28131 TFA	GHSR	Metabolic Disease
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective *ghrelin/growth hormone* secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a** receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.

HY-B1617A

Zuclomiphene citrate	Estrogen Receptor/ERR	Endocrinology Metabolic Disease
Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent.

HY-A0245

Dihydrotachysterol	VD/VDR	Metabolic Disease
Dihydrotachysterol is a synthetic analog of vitamin D. Dihydrotachysterol can be used to for the research of hypocalcemia (lack of calcium in the blood) and hypoparathyroidism (lack of parathyroid hormone in the body) .

HY-17613

Evocalcet KHK7580	CaSR	Metabolic Disease
Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism.

HY-A0158

Diflorasone	Others	Inflammation/Immunology
Diflorasone act as a *corticosteroid hormone* receptor** agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis.

HY-N8393

Ascr#18	Bacterial Fungal	Infection
Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 is expressed during nematode development. Ascr#18 increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections.

HY-108905

Mecasermin Human IGF-I; FK 780	IGF-1R	Metabolic Disease
Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies.

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Endocrinology Neurological Disease
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.

HY-113313

Aldosterone	Endogenous Metabolite	Cardiovascular Disease
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.

HY-12956

Dinoprost Prostaglandin F2α; PGF2α	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis	Endocrinology
Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.

HY-18572A

2,4-D sodium salt Sodium 2,4-dichlorophenoxyacetate; 2,4-Dichlorophenoxyacetic acid sodium salt	DNA/RNA Synthesis	Others
2,4-D sodium salt (Sodium 2,4-dichlorophenoxyacetate) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D sodium salt acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D sodium salt inhibits DNA and protein synthesis and thereby prevents normal plant growth and development.

HY-18572

2,4-D 2,4-Dichlorophenoxyacetic acid	DNA/RNA Synthesis	Others
2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development.

HY-P3607

GHRF, bovine bGRF(1-44)-NH2	GHSR	Endocrinology
GHRF, bovine (bGRF(1-44)-NH2) is the bovine growth hormone (GH)-releasing factor (GHRF). GHRF, bovine increases the release of bovine GH, and shows a synergistic effect with Hydrocortisone (HY-N0583).

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.

HY-P3662

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Tyrosinase	Cancer
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model.

HY-N0160

Kinetin 6-Furfuryladenine; N6-Furfuryladenine	Others	Neurological Disease
Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects.

HY-P1070

Amylin, amide, human DAP amide, human	Amylin Receptor	Metabolic Disease
Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.

HY-P0262A

Galantide TFA	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease
Galantide TFA is a reversible and non-specific galanin (GAL) receptor antagonist. Galantide TFA dose-dependently shows antagonism to galanin-induced K⁺ conductance with an IC₅₀ value of 4 nM. Galantide TFA can be used for the research of neurological disease and hormone metabolism research.

HY-12956A

Dinoprost tromethamine salt Prostaglandin F2α tromethamine salt; PGF2α THAM; Prostaglandin F2α THAM	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis	Endocrinology
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.

HY-B0390

Mestranol	Estrogen Receptor/ERR	Cancer Endocrinology
Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a?progestin in vivo?and can be used for?the research of menopausal hormone or?menstrual disorders.

HY-113890

Halofenozide RH-0345	Others	Others
Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone.

HY-P2090

Angiopeptin	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research.

HY-13673

Goserelin ICI 118630	GnRH Receptor Apoptosis	Cancer Endocrinology
Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.

HY-P1070A

Amylin, amide, human TFA DAP amide, human TFA	Amylin Receptor	Metabolic Disease
Amylin, amide, human TFA, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human TFA inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.

HY-13673A

Goserelin acetate ICI-118630 acetate	GnRH Receptor Apoptosis	Endocrinology Cancer
Goserelin acetate (ICI-118630 acetate), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin acetate can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.

HY-P2090A

Angiopeptin TFA	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.

HY-P3102

GLP-1(32-36)amide	GCGR	Metabolic Disease
GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.

HY-P1210

Lys-γ3-MSH(human)	Melanocortin Receptor	Endocrinology
Lys-γ3-MSH(human) is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) is a potent stimulator of lipolysis with an apparent EC₅₀ of 3.56 nM. Lys-γ3-MSH(human) can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis.

HY-P3102A

GLP-1(32-36)amide TFA	GCGR	Metabolic Disease
GLP-1(32-36)amide TFA, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide TFA could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.

HY-148350

DS69910557	Thyroid Hormone Receptor	Cancer
DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC₅₀ value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.

HY-P1210A

Lys-γ3-MSH(human) TFA	Melanocortin Receptor	Endocrinology
Lys-γ3-MSH(human) TFA is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) TFA potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) TFA is a potent stimulator of lipolysis with an apparent EC₅₀ of 3.56 nM. Lys-γ3-MSH(human) TFA can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis.

HY-109106A

Upacicalcet sodium	CaSR	Endocrinology
Upacicalcet sodium is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT).

HY-109106

Upacicalcet	CaSR	Endocrinology
Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT).

HY-16785

Veledimex INXN-1001; RG-115932	Interleukin Related	Cancer Inflammation/Immunology
Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys.

HY-17462

Adrenosterone (+)-Adrenosterone	Androgen Receptor Endogenous Metabolite	Cancer Endocrinology
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.

HY-N6979

Crustecdysone 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).

HY-109106B

(Rac)-Upacicalcet	CaSR	Endocrinology
(Rac)-Upacicalcet is the racemate of Upacicalcet.Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT).

HY-107953

Chorionic gonadotrophin hCG; Chorionic gonadotropic hormone	Endogenous Metabolite	Endocrinology
Chorionic gonadotrophin (hCG) is a gonadotropin that can be isolated from the anterior pituitary gland. Chorionic gonadotrophin has potential applications in ovarian and follicular development.

HY-17571A

Oxytocin acetate α-Hypophamine acetate; Oxytocic hormone acetate	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.

HY-110161

sst2 Receptor agonist-1	Somatostatin Receptor	Endocrinology Cardiovascular Disease
sst2 Receptor agonist-1 is a potent somatostatin receptor subtype 2 (sst₂) agonist with a K_i value of 0.025 nM and a cAMP IC₅₀ value of 4.8 nM. sst2 Receptor agonist-1 can inhibit rat growth hormone (GH) secretion and ocular neovascular lesion formation. Antiangiogenic effect.

HY-111614

Melengestrol acetate	Progesterone Receptor	Cancer Metabolic Disease
Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.

HY-122940

Precocene II
Others Others

Precocene II is the insect antijuvenile hormone.

HY-P3960

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.

HY-14495

BMS-604992 EX-1314	GHSR	Metabolic Disease
BMS-604992 (EX-1314) is a selective, orally active small-molecule *growth hormone* secretagogue receptor (GHSR) agonist. BMS-604992 demonstrates high-affinity binding (K_i=2.3 nM) and potent functional activity (EC₅₀**=0.4 nM). BMS-604992 can stimulate food intake in rodents.

HY-14495B

BMS-604992 dihydrochloride EX-1314 dihydrochloride	GHSR	Metabolic Disease
BMS-604992 (EX-1314) dihydrochloride is a selective, orally active small-molecule *growth hormone* secretagogue receptor (GHSR) agonist. BMS-604992 dihydrochloride demonstrates high-affinity binding (k_i=2.3 nM) and potent functional activity (EC₅₀**=0.4 nM). BMS-604992 dihydrochloride can stimulate food intake in rodents.

HY-10955

TTA-P1	Calcium Channel	Neurological Disease
TTA-P1 is a potent state-independent compound inhibiting human T-type calcium channel. T-type calcium channels play a role in diverse physiological responses including neuronal burst firing, hormone secretion, and cell growth. TTA-P1 has the potential for the research of absence epilepsy.

HY-B1033

Metergoline	5-HT Receptor Dopamine Receptor Sodium Channel	Neurological Disease
Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pK_is of 8.64, 8.75 and 8.75 for 5-HT_2A, 5-HT_2B and 5-HT_2C, respectively. Metergoline is a high-affinity ligand for the h5-HT₇ receptor, with a K_i of 16 nM. Metergoline is also a reversible neural Na⁺ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.

HY-P3622

(Ser8)-GLP-1 (7-36) amide, human	GCGR	Metabolic Disease
(Ser8)-GLP-1 (7-36) amide, human is a glucagon-like peptide 1 amide derived from glucagonogen, a cleavage product of the GLP-1 (1-36) amide peptide. (Ser8)-GLP-1 (7-36) amide, human is an entero-insulinotropic hormone that causes glucose-dependent release of insulin from pancreatic β-cells and affects gastrointestinal motility and secretion.

HY-149218

THR-β agonist 6	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 6 is an orally active, selective *thyroid hormone* receptor β (THR-β) agonist with EC₅₀**s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research.

HY-14495A

BMS-604992 free base EX-1314 free base	GHSR	Metabolic Disease
BMS-604992 (EX-1314) free base is a selective, orally active small-molecule *growth hormone* secretagogue receptor (GHSR) agonist. BMS-604992 free base demonstrates high-affinity binding (k_i=2.3 nM) and potent functional activity (EC₅₀**=0.4 nM). BMS-604992 free base can stimulate food intake in rodents.

HY-P4564

(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

HY-P4568

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

HY-P4577

(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

HY-P1582

ACTH (1-14)
Adrenocorticotropic hormone Fragment 1-14
Adrenergic Receptor Cancer

ACTH (1-14) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.

HY-N0179

Ecdysone α-Ecdysone	Endogenous Metabolite Apoptosis	Metabolic Disease
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979).

HY-P4572

(D-Trp6)-LHRH free acid
GnRH Receptor Cancer

(D-Trp6)-LHRH free acid is a luteinizing hormone-releasing hormone (LHRH) agonist.

HY-P0093

Sincalide Cholecystokinin octapeptide; CCK-8; SQ19844	Cholecystokinin Receptor Apoptosis PI3K Akt	Cancer Infection
Sincalide (Cholecystokinin octapeptide, CCK‐8) is a rapid-acting *amino acid polypeptide hormone* analogue** of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. CCK‐8 can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK.

HY-P0093A

Sincalide ammonium Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium	Cholecystokinin Receptor Apoptosis PI3K Akt	Cancer Infection
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting *amino acid polypeptide hormone* analogue** of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK.

HY-100209

Sufugolix TAK-013	Others	Endocrinology
Sufugolix (TAK-013) is a highly potent and orally available luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC₅₀ of 0.1 nM.

HY-B0672

Estradiol valerianate β-Estradiol 17-valerate	Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-50844

Ibutamoren Mesylate MK-677; MK-0677	GHSR	Endocrinology
Ibutamoren Mesylate (MK-677) is a potent, non-peptide *Growth hormone* secretagogue receptor (GHSR)** agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.

HY-P1869

Neuropeptide EI, rat	MCHR1 (GPR24) Melanocortin Receptor	Neurological Disease Endocrinology
Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.

HY-P1582A

ACTH (1-14) (TFA) Adrenocorticotropic hormone Fragment 1-14 TFA	Adrenergic Receptor	Others
ACTH (1-14) (TFA) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.

HY-B0983

Hydrocortisone 17-butyrate Cortisol 17-butyrate; Hydrocortisone butyrate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Hydrocortisone 17-butyrate is an adrenocortico hormone

HY-101406

Thyroxine sulfate
T4 Sulfate
Thyroid Hormone Receptor Drug Metabolite Endogenous Metabolite Metabolic Disease Endocrinology

Thyroxine sulfate is a thyroid hormone metabolite.
HY-107533

T-98475
Others Endocrinology

T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC₅₀ of 0.2 nM.

HY-I0352

Epiandrosterone 3β-Androsterone; trans-Androsterone; iso-Androsterone	Androgen Receptor Endogenous Metabolite	Endocrinology
Epiandrosterone is a steroid hormone with weak androgenic activity.

HY-18341B

L-Thyroxine sodium Levothyroxine sodium; T4 sodium	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-100271

Org41841	TSH Receptor	Endocrinology
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC₅₀s of 0.2 and 7.7 μM, respectively.

HY-U00353

MCHR1 antagonist 1	MCHR1 (GPR24)	Metabolic Disease Endocrinology
MCHR1 antagonist 1 is a selective antagonist of *melanin concentrating hormone-1 (MCH1) receptor, with a K_b* of 1 nM and a K_i of 4 nM at human MCH1, and may be used to reduce the body mass.

HY-P3668

[D-Lys6]-LH-RH
GnRH Receptor Cancer Endocrinology

[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist.

HY-109551

Lutropin	Others	Endocrinology
Lutropin is a heterodimeric glycoprotein, a hormone produced by gonadotropic cells in the anterior pituitary gland, also known as luteinizing hormone and lutrophin. Lutropin stimulates follicular development, and can be used for researching infertility.

HY-P3672

[D-Ala6]-LH-RH
GnRH Receptor Endocrinology

[D-Ala6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Ala6]-LH-RH acts as a GnRH receptor agonist.
HY-P0035

Insulin (human)
Insulin Receptor Metabolic Disease Endocrinology

Insulin (human) is a polypeptide hormone that regulates the level of glucose.

HY-W010696

Reverse T3 3′,5′,3-Triiodothyronine	Thyroid Hormone Receptor	Cardiovascular Disease
Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.

HY-P0009

Cetrorelix SB-75	GnRH Receptor	Endocrinology
Cetrorelix is a potent *gonadotrophin-releasing hormone* (GnRH)** antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice.

HY-18341

L-Thyroxine Levothyroxine; T4	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology
L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-P3675

LH-RH (4-10)	GnRH Receptor	Endocrinology
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes.

HY-18341A

L-Thyroxine sodium salt pentahydrate Sodium levothyroxine pentahydrate	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-153637

THR-β modulator-1	Thyroid Hormone Receptor	Endocrinology
THR-β modulator-1 (compound 1a) is a potent *thyroid hormone* receptor β** modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders.

HY-77839

Cortodoxone 11-Deoxycortisol; cortexolone; Reichstein's substance S	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone).

HY-B1710

Norethindrone acetate 19-Norethindrone acetate	Progesterone Receptor	Endocrinology Inflammation/Immunology Cardiovascular Disease
Norethindrone acetate is a female hormone used for the research of endometriosis.

HY-N0437

Progesterone Pregn-4-ene-3,20-dione	Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-P0056

Histrelin	GnRH Receptor	Cancer
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis.

HY-B0672S1

Estradiol valerianate-d4 β-Estradiol 17-valerate-d₄	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerianate-d₄ is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-B0672S

Estradiol valerianate-d9	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol valerianate-d₉ is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-P3919

Adrenotensin (human) Pro-ADM-153-185 (human)	CGRP Receptor	Cardiovascular Disease
Adrenotensin (human) (Pro-ADM-153-185 (human)) is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones.

HY-B1161S

Methoprene-d7 ZR-515-d₇	Isotope-Labeled Compounds	Others
Methoprene-d₇ is the deuterium labeled Methoprene[1]. Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist[2][3].

HY-B0110

Gestodene
SHB 331; WL 70
Progesterone Receptor Endocrinology

Gestodene(SHB 331;WL 70) is a progestogen hormonal contraceptive.
HY-152856

Merigolix
GnRH Receptor Endocrinology

Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist.
HY-B0257

Levonorgestrel
D-Norgestrel
Progesterone Receptor Endocrinology

Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.
HY-N9418

Gibberellin A5
Others Others

Gibberellin A5 is a plant hormone that promotes floral development .

HY-N6022

Byakangelicin	Others	Metabolic Disease
Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of agent-agent interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones.

HY-P4456

(Des-His6)-ACTH (1-24) (human, bovine, rat)	Adrenergic Receptor	Endocrinology
(Des-His6)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production.

HY-P4413

(Des-Glu5)-ACTH (1-24) (human, bovine, rat)	Androgen Receptor	Endocrinology
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production.

HY-N0583

Hydrocortisone Cortisol	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.

HY-130248

BAY-899	GnRH Receptor	Endocrinology
BAY-899 is an orally active and selective *luteinizing hormone* receptor (LH-R) antagonist with IC₅₀*s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone* levels.

HY-50713

Calcium-Sensing Receptor Antagonists I
CaSR Others

Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors.
HY-U00334

LH secretion antagonist 1
Others Neurological Disease

LH secretion antagonist 1 is an antagonist of luteinising hormone secretion, and may be used as an analgesic.

HY-B0648

Medroxyprogesterone 17α-Hydroxy-6α-methylprogesterone; U8840	Progesterone Receptor	Endocrinology
Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

HY-141513

NH-3	Thyroid Hormone Receptor	Neurological Disease
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC₅₀ of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.

HY-146997

TRβ agonist 1	Thyroid Hormone Receptor	Metabolic Disease
TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC₅₀ value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH).

HY-Y1091

D-Lysine	Endogenous Metabolite	Others
D-Lysine is a useful raw material employed as an analog of lutenizing-hormone-releasing hormone and as a agent carrier in the form of polylysine. D-Lysine decreases renal uptake of radioactivity during scintigraphy and PRRT with low toxicity. D-Lysine not interferes with the natural amino acid metabolic balance.

HY-P4605

(Ile8)-Oxytocin
Mesotocin
Endogenous Metabolite Metabolic Disease

(Ile8)-Oxytocin is a neurohypophysial hormone mesotocin produced in marsupials.
HY-100305

Substituted piperidines-1
Others Endocrinology

Substituted piperidines-1 is a compound that can promote the release of growth hormone in humans and animals.

HY-P0054A

GLP-1(7-36), amide Glucagon-like peptide-1 (GLP-1)(7-36), amide; Human GLP-1 (7-36), amide	GCGR	Metabolic Disease
GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretion.

HY-113414

Deoxycorticosterone	Endogenous Metabolite	Others
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.

HY-U00289

Opigolix ASP-1707	GnRH Receptor	Inflammation/Immunology Endocrinology
Opigolix is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis.

HY-U00257

AZD1979
MCHR1 (GPR24) Metabolic Disease Endocrinology

AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC₅₀ of ~12 nM.

HY-P3594

[His1,Nle27] GHRF (1-32), amide, human	GHSR	Endocrinology
[His1,Nle27] GHRF (1-32), amide, human is a Growth hormone releasing hormone (GHRH) analog. [His1,Nle27] GHRF (1-32), amide, human has great receptor affinity for GHRHR.

HY-P4144

Onvitrelin ucalontide Phor18-LHRH (338613)	GnRH Receptor	Cancer Endocrinology
Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is an analogue of luteinizing hormone releasing hormone (LHRH) with antineoplastic activity. Onvitrelin ucalontide is a peptide with sequences of KFAKFAKKFAKFAKKFAKQHWSYGLRPG. Onvitrelin ucalontide effectively inhibits breast cancer, ovarian cancer and prostate cancer xenografts in mouse model.

HY-18341S1

Thyroxine hydrochloride-13C6 Levothyroxine-¹³C₆; T4-¹³C₆	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology
Thyroxine hydrochloride-¹³C₆ is the ¹³C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].

HY-153485

Cimdelirsen ISIS 766720; IONIS-GHR-LRx	Small Interfering RNA (siRNA)	Others
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce *growth hormone* receptor (GHr)** synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

HY-126236

3,5-Diiodothyropropionic acid	Thyroid Hormone Receptor	Cardiovascular Disease Endocrinology
3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to *thyroid hormone* receptor (TR)**, with K_a of 2.40 and 4.06 M^-1 for TRα1 and TRβ1, respectively.

HY-153485A

Cimdelirsen sodium ISIS 766720 sodium; IONIS-GHR-LRx sodium	Small Interfering RNA (siRNA)	Others
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce *growth hormone* receptor (GHr)** synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

HY-114116

ML-109
TSH Receptor Metabolic Disease Endocrinology

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC₅₀ of 40 nM.

HY-142006

(-)-Jasmonoyl-L-isoleucine (-)-JA-L-Ile	Endogenous Metabolite	Others
(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile) is an inactive endogenous hormone. (-)-Jasmonoyl-L-isoleucine is an enantiomer of (+)-JA-L-Ile.

HY-B1012

Quinestrol W-3566	Estrogen Receptor/ERR	Endocrinology Cancer
Quinestrol is a synthetic estrogen, used in hormone replacement therapy, and occasionally to treat breast cancer and prostate cancer

HY-P0055

GLP-1(7-37)
GCGR Metabolic Disease

GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.

HY-130249

BAY-298	GnRH Receptor	Endocrinology
BAY-298 is an orally active and selective *luteinizing hormone* receptor (LH-R) antagonist with IC₅₀*s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone* levels.

HY-18341S2

L-Thyroxine-13C6	Thyroid Hormone Receptor Endogenous Metabolite
L-Thyroxine-¹³C₆ is the ¹³C labeled L-Thyroxine[1]. L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[2].

HY-A0070AS1

Liothyronine-13C9,15N Triiodothyronine-¹³C₉,¹⁵N; 3,3',5-Triiodo-L-thyronine-¹³C₉,¹⁵N; T3-¹³C₉,¹⁵N	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine-¹³C₉,¹⁵N is the ¹³C and ¹⁵N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].

HY-B1214

Prednisolone acetate Prednisolone 21-acetate	Glucocorticoid Receptor	Inflammation/Immunology
Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

HY-100308

SB-568849
MCHR1 (GPR24) Metabolic Disease Endocrinology

SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pK_i of 7.7.
HY-23524

HSL-IN-3
Others Others

HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL).
HY-100318

NGD-4715
MCHR1 (GPR24) Metabolic Disease Endocrinology

NGD-4715 is a selective and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist .

HY-B2031

Pyriproxyfen S-31183	Autophagy Parasite	Infection
Pyriproxyfen is a juvenile hormone analog, preventing larvae from developing into adulthood and thus rendering them unable to reproduce.

HY-102056

BAY 59-9435
Others Metabolic Disease

BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC₅₀ of 0.023 μM.

HY-17365

Octreotide acetate SMS 201-995 acetate	Somatostatin Receptor	Inflammation/Immunology Cardiovascular Disease Endocrinology Cancer
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

HY-111398

ALB-127158(a)
MCHR1 (GPR24) Metabolic Disease Endocrinology

ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH₁) receptor antagonist.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-N0437S

Progesterone-d9 Pregn-4-ene-3,20-dione-d₉	Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone-d₉ is the deuterium labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-B0554

Norethindrone Norethisterone	Progesterone Receptor Bacterial	Endocrinology Cancer
Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-13534

Abarelix
R3827; PPI 149
GnRH Receptor Cancer Endocrinology

Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
HY-P0055A

GLP-1(7-37) acetate
GCGR Metabolic Disease

GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.

HY-W127334

N-Palmitoyl phosphatidylethanolamine	Biochemical Assay Reagents	Others
N-Palmitoyl phosphatidylethanolamine (Tripelargonin) is endogenous lipid anorectic hormone, significantly reduces food intake in a dose-dependent manner

HY-12131

DMP 696
CRFR Endocrinology Neurological Disease

DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.

HY-P3553

Alsactide	Melanocortin Receptor	Neurological Disease
Alsactide, a heptadecapeptide analogue, is an *adrenocorticotropic hormone* (ACTH)** agonist. Alsactide can be used in research of central nervous system.

HY-125859

Peroxidase	Reactive Oxygen Species	Endocrinology Inflammation/Immunology
Peroxidase actively involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases.

HY-B1161A

S-Methoprene (+)-Methoprene; (7S)-Methoprene	Others	Others
(S)-Methoprene is a juvenile hormone analogue that prohibits the ability of the insect to change from pupae to adult and is used as an insecticide.

HY-111442

GC 14
Thyroid Hormone Receptor Metabolic Disease

GC 14 is a selective thyroid hormone receptor antagonist, with IC₅₀ values of 35 nM and 200 nM for hTRβ and hTRα, respectively.
HY-U00433

JMV 2959
GHSR Neurological Disease Endocrinology

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32 nM.

HY-16168AS

Degarelix-d7	GnRH Receptor	Cancer Endocrinology
Degarelix-d₇ is deuterium labeled Degarelix. Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.

HY-P1021

Peptide YY (PYY) (3-36), porcine	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), porcine is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

HY-113114

Tetrahydrocortisone	Endogenous Metabolite	Others
Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase.

HY-101405

Gestrinone R 2323	Estrogen Receptor/ERR	Inflammation/Immunology
Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC₅₀ of 43.67 μM.

HY-B1201

Tiratricol 3,3',5-Triiodothyroacetic acid	Thyroid Hormone Receptor	Endocrinology
Tiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects.

HY-B0257S1

Norgestrel-d6	Progesterone Receptor	Endocrinology
Norgestrel-d₆ is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.

HY-W345393

Trh-gly
TRH-glycine
Thyroid Hormone Receptor Endocrinology

Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin.
HY-U00300

Cancer-Targeting Compound 1
Others Cancer

Cancer-Targeting Compound 1 is used in the research of hormone-related cancer, extracted from patent WO 2008021331 A2.

HY-B1710S

Norethindrone acetate-D8 19-Norethindrone acetate-d₈	Progesterone Receptor	Endocrinology Inflammation/Immunology Cardiovascular Disease
Norethindrone acetate-d₈ is the deuterium labeled Norethindrone acetate. Norethindrone acetate is a female hormone used for the research of endometriosis[1].

HY-144863

BAY 1214784	GnRH Receptor	Cancer
BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids.

HY-B1089

Ethynodiol diacetate Ethynodiol acetate	Progesterone Receptor	Endocrinology
Ethynodiol diacetate (Ethynodiol acetate) is a steroidal progestin which is used as a hormonal contraceptive, it has relatively little or no potency as an androgen,has significant estrogenic effects.

HY-N0437S2

Progesterone-13C3	Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone-¹³C₃ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-N0583S1

Hydrocortisone-d7 Cortisol-d₇	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone-d₇ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

HY-P0054

GLP-1(7-36), amide acetate Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate; Human GLP-1 (7-36), amide acetate	GCGR	Metabolic Disease
GLP-1(7-36), amide acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.

HY-122974

VA-K-14 hydrochloride
TSH Receptor Endocrinology

VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC₅₀= 12.3 μM).

HY-N0384

Homovanillic acid Vanilacetic acid	Endogenous Metabolite	Metabolic Disease
Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-P0009B

Cetrorelix diacetate SB-75 diacetate	GnRH Receptor	Endocrinology Neurological Disease
Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC₅₀ of 1.21 nM.

HY-N0583S3

Hydrocortisone-d3 Cortisol-d₃	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone-d₃ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

HY-P0009A

Cetrorelix Acetate SB-75 acetate	GnRH Receptor	Neurological Disease Endocrinology
Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC₅₀ of 1.21 nM.

HY-B0110S

Gestodene-d6
SHB 331-d₆; WL 70-d₆
Progesterone Receptor Endocrinology

Gestodene-d₆is the deuterium labeled Gestodene. Gestodene(SHB 331) is a progestogen hormonal contraceptive[1][2].

HY-N0583S2

Hydrocortisone-d4 Cortisol-d₄	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone-d₄ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

HY-100856

PCO371
Thyroid Hormone Receptor Endocrinology

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.
HY-P1144

Oxyntomodulin
GCGR Metabolic Disease

Oxyntomodulin, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-77839S1

Cortodoxone-d2 11-Deoxycortisol-d₂; cortexolone-d₂; Reichstein's substance S-d₂	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone-d₂ is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone)[1].

HY-13534A

Abarelix Acetate PPI 149 Acetate; R 3827 Acetate	GnRH Receptor	Cancer Endocrinology
Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent *gonadotrophin-releasing hormone* (GnRH)** antagonist, used for prostate cancer research.

HY-N0437S1

Progesterone-13C5 Pregn-4-ene-3,20-dione-¹³C₅	Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone-¹³C₅ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-15243

Capromorelin Tartrate CP 424391-18	GHSR	Neurological Disease Endocrinology
Capromorelin Tartrate is an orally active, potent *growth hormone* secretagogue receptor (GHSR) agonist, with K_i** of 7 nM for hGHS-R1a.

HY-N0437S3

Progesterone-13C2 Pregn-4-ene-3,20-dione-¹³C₂	Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease Cancer
Progesterone-¹³C₂ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-P3155

Ac-hMCH(6-16)-NH2	MCHR1 (GPR24)	Metabolic Disease
Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC₅₀ values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R.

HY-112102

(22S,23S)-Homobrassinolide SSHB	Others	Metabolic Disease
(22S,23S)-Homobrassinolide is one of the most active brassinosteroids in inducing plant growth in various plant bioassay systems. (22S,23S)-Homobrassinolide shows Akt-dependent anabolic activity in rat skeletal muscle cells. Orally active.

HY-P3671

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH	GnRH Receptor	Endocrinology
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist.

HY-P1144A

Oxyntomodulin TFA
GCGR Metabolic Disease

Oxyntomodulin TFA, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-14789

(R)-Elagolix NBI-56418	GnRH Receptor	Cancer Endocrinology
Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).

HY-N0583S5

Hydrocortisone-d2 Cortisol-d₂	Glucocorticoid Receptor Endogenous Metabolite
Hydrocortisone-d₂ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1][2].

HY-12216

Resmetirom MGL-3196; VIA-3196	Thyroid Hormone Receptor	Cardiovascular Disease Endocrinology
Resmetirom (MGL-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC₅₀ value of 0.21 μM.

HY-B0648S

Medroxyprogesterone-d3 17α-Hydroxy-6α-methylprogesterone-d₃; U8840-d₃	Progesterone Receptor	Endocrinology
Medroxyprogesterone-d₃ is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

HY-P0090

Calcitonin (salmon) Salmon calcitonin	CGRP Receptor	Cancer
Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.

HY-P3579

Gastric Inhibitory Peptide, porcine	Insulin Receptor	Endocrinology
Gastric Inhibitory Peptide, porcine is a glucose-dependent insulinotropic polypeptide, is a 42 amino acid intestinal hormone with effects on fat and glucose metabolism.

HY-N11020

Cabenoside D	EBV	Infection Inflammation/Immunology
Cabenoside D (compound 8) is a triterpenoid glycoside, which can be isolated from the methanol extract of lichen root. Cabenoside D shows anti-inflammatory activity and inhibits inflammation induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice. Cabenoside D also inhibits TPA-induced Epstein-Barr virus (EBV) early antigen (EBV-EA) activation.

HY-114271A

T3-ATA (S-isomer)
Thyroid Hormone Receptor Endocrinology

T3-ATA S-isomer is the S-isomer of T3-ATA, which is the active form of the thyroid hormone.

HY-P1021A

Peptide YY (PYY) (3-36), porcine TFA	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), porcine TFA is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

HY-15157

Calcitetrol
1α, 24, 25-Trihydroxy VD3
VD/VDR Metabolic Disease

Calcitetrol(1α, 24, 25-Trihydroxy VD3) is the hormonally active form of vitamin D with three hydroxyl groups.

HY-B0257S

Levonorgestrel-D8 D-Norgestrel-d₈	Progesterone Receptor	Endocrinology
Levonorgestrel-d₈ is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives[1][2].

HY-N2448

Lindleyin	Estrogen Receptor/ERR	Endocrinology
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity.

HY-114272A

T4-ATA (S-isomer)
Thyroid Hormone Receptor Endocrinology

T4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.
HY-126558

GA3-AM
Others Others

GA3-AM is a cell permeable analog of the plant hormone gibberellic acid that acts as a chemical dimerizer or chemical inducer of dimerization.

HY-P1024

GLP-2(1-33)(human) GLP-2 (human); Glucagon-like peptide 2 (human)	GCGR	Metabolic Disease
GLP-2(1-33) (human) is an enteroendocrine hormone which can bind to the GLP-2 receptor and stimulate the growth of intestinal epithelium.

HY-117178

TA 0910 acid-type
Others Metabolic Disease

TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analogue of thyrotropin releasing hormone (TRH).
HY-P3962

[Phe2]-TRH
Thyroid Hormone Receptor Endocrinology

[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin.

HY-P1428

RFRP-1(human)	Neuropeptide Y Receptor	Endocrinology
RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively.

HY-P0054B

GLP-1(7-36), amide TFA Glucagon-like peptide-1 (GLP-1)(7-36), amide TFA; Human GLP-1 (7-36), amide TFA	GCGR	Metabolic Disease
GLP-1(7-36), amide TFA is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.

HY-125611

Fluorogestone acetate	GnRH Receptor	Endocrinology
Fluorogestone acetate is a progesterone compound. Fluorogestone acetate inhibits ovulation and synchronizes the estrous cycle in cattle by inhibiting the release of luteinizing hormone (LH) from the pituitary gland.

HY-P0051

Lecirelin	GnRH Receptor	Cancer Endocrinology
Lecirelin, a synthetic gonadotropin-releasing hormone (GnRH) analogue, acts as a GnRH agonist. Lecirelin is widely used for the research of bovine ovarian follicular cysts.

HY-111443

TR antagonist 1	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
TR antagonist 1 is a high-affinity *thyroid hormone* receptor (TR) antagonist with IC₅₀**s of 36 and 22 nM for TRα and TRβ, respectively.

HY-B0891

17α-Hydroxyprogesterone 17-Hydroxyprogesterone; 17-OHP	Progesterone Receptor Endogenous Metabolite	Others
17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-75041

Calcitriol Impurities A	VD/VDR	Metabolic Disease
Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-A0152

D-Thyroxine D-T4	Endogenous Metabolite	Metabolic Disease
D-Thyroxine (D-T4) is a thyroid hormone that can inhibit TSH secretion. D-Thyroxine can be used for the research of hypercholesterolemia.

HY-50919

Paricalcitol	VD/VDR	Metabolic Disease
Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.

HY-111498A

RGX-104 Abequolixron	LXR	Cancer Inflammation/Immunology
RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-N3755

Dihydroresveratrol	Estrogen Receptor/ERR	Cancer
Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations.

HY-P1514

Peptide YY (PYY), human	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease Endocrinology
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.

HY-P4715

(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)	PTHR	Endocrinology
(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) is a peptide and can be used as a parathyroid hormone (PTH) receptor ligand.

HY-W020005

2-Carboxyphenol-d4	Isotope-Labeled Compounds	Others
2-Carboxyphenol-d4 is the deuterium labeled 2-Carboxyphenol. 2-Carboxyphenol is a plant *hormone* and mediates host responses against microbial pathogens.

HY-77274

Calcitriol Impurities D	VD/VDR	Metabolic Disease
Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-B1214S

Prednisolone acetate-d8 Prednisolone 21-acetate-d₈	Isotope-Labeled Compounds Glucocorticoid Receptor	Inflammation/Immunology
Prednisolone acetate-d₈ is the deuterium labeled Prednisolone acetate. Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

HY-U00433A

JMV 2959 hydrochloride	GHSR	Neurological Disease Endocrinology
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32±3 nM in LLC-PK₁ cells.

HY-P3673

Lamprey LH-RH I	GnRH Receptor	Endocrinology
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models.

HY-113414S

Deoxycorticosterone-d8	Endogenous Metabolite	Others
Deoxycorticosterone-d₈ is the deuterium labeled Deoxycorticosterone. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor[1][2].

HY-107470

Antitumor agent-21	Others	Cancer Inflammation/Immunology
Antitumor agent-21 is an aryl-quinolin derivative, with potential anticancer, anti-inflammatory, anti-proliferative, anti-hormonal effects and inhibition of vasculogenic mimicry .

HY-139303

LUF5771	Others	Endocrinology
LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy.

HY-B0554S

Norethindrone-d6 Norethisterone-d₆	Progesterone Receptor
Norethindrone-d₆ is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-P1465

Secretin (28-54), human Human secretin	Secretin Receptor	Metabolic Disease Cancer
Secretin (28-54), human is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-15890

C-7280948
Histone Methyltransferase Cancer

C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC₅₀ value of 12.75 μM.

HY-P1214

γ1-MSH	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH is a melanocortin MC3 receptor agonist, with a K_i of 34 nM for the rat MC3 receptor. γ1-MSH displays ~40-fold selectivity over MC4 (K_i=1318 nM).

HY-P1465A

Secretin (28-54), human TFA Human secretin TFA	Secretin Receptor	Metabolic Disease Cancer
Secretin (28-54), human TFA is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-P1213

JKC363	Melanocortin Receptor	Neurological Disease
JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

HY-100940

6-Chloromelatonin	Melatonin Receptor	Endocrinology
6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [³H]-melatonin and 2-[¹²⁵I]-iodomelatonin binding to MT1 receptors (pK_i=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [³H]-melatonin binding to MT2 receptors (pK_i=9.77).

HY-P1213A

JKC363 TFA	Melanocortin Receptor	Neurological Disease
JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

HY-P1214A

γ1-MSH TFA	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH TFA is a melanocortin MC3 receptor agonist, with a K_i of 34 nM for the rat MC3 receptor. γ1-MSH TFA displays ~40-fold selectivity over MC4 (K_i=1318 nM).

HY-B0765

Dehydroepiandrosterone sulfate sodium salt Sodium prasterone sulfate	Endogenous Metabolite	Metabolic Disease
Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone.

HY-133080

BAY-784
GnRH Receptor Cancer

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC₅₀s of 21 and 24 nM for human and rat GnRH-R, respectively.

HY-113114S

Tetrahydrocortisone-d5	Endogenous Metabolite	Others
Tetrahydrocortisone-d₅ is the deuterium labeled Tetrahydrocortisone. Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase[1].

HY-130012

CO23	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
CO23 is a selective *thyroid hormone* receptor (TR) α** agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.

HY-113114S1

Tetrahydrocortisone-d6	Endogenous Metabolite	Others
Tetrahydrocortisone-d₆ is the deuterium labeled Tetrahydrocortisone. Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase[1].

HY-P2273

Calcitonin (human)	CGRP Receptor	Metabolic Disease
Calcitonin (human) is a hypocalcemic hormone. Calcitonin can lower blood calcium levels and inhibit bone resorption. Calcitonin can be used in hypercalcemia or osteoporosis research.

HY-16474

Relugolix TAK-385	GnRH Receptor	Cancer Endocrinology
Relugolix (TAK-385) is a potent, orally active, nonpeptidic *gonadotropin-releasing hormone* (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC₅₀=0.33 nM) and monkey receptor (IC₅₀*=0.32 nM) compared with TAK-013 (HY-100209). Relugolix is used for the study of sex-hormone*-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al.

HY-113313S2

Aldosterone-d4	Endogenous Metabolite	Cardiovascular Disease
Aldosterone-d₄ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by t

HY-P4800

Osteostatin (human) Human PTHrP(107-139)	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis.

HY-76585

Paricalcitol-d6	VD/VDR	Metabolic Disease
Paricalcitol-d₆ is the deuterium labeled Paricalcitol. Paricalcitol is a agent used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure[1].

HY-P1156

Insulin(cattle) Insulin from bovine pancreas	Insulin Receptor	Metabolic Disease Endocrinology
Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells.

HY-101509

HSL-IN-1	Others	Metabolic Disease
HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC₅₀=2 nM) with a significantly reduced reactive metabolite liability.

HY-14383

Vosilasarm RAD140	Androgen Receptor	Endocrinology Neurological Disease
Vosilasarm (RAD140) is a potent, orally active, nonsteroidal selective androgen receptor modulator (SARM) with a K_i of 7 nM. Vosilasarm shows good selectivity over other steroid hormone nuclear receptors.

HY-B0596

Taltirelin TA-0910	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Taltirelin (TA0910) is a superagonist at *thyrotropin-releasing hormone* receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀** of 36 nM for stimulating an increase in cytosolic Ca²⁺ concentration (Ca²⁺ release).

HY-N0384S2

Homovanillic acid-d5 Vanilacetic acid-d₅	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d₅ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-N0384S

Homovanillic acid-d3 Vanilacetic acid-d₃	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d₃ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-N0384S1

Homovanillic acid-d2 Vanilacetic acid-d₂	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d₂ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-13071

Nestoron ST-1435; Elcometrine	Progesterone Receptor	Endocrinology
Nestoron (ST-1435) is a 19-norprogesterone derivative with high affinity and selectivity for progesterone receptors. Nestoron is a highly selective and potent progestogen that can be used as a hormonal contraceptive.

HY-B0596A

Taltirelin acetate TA-0910 acetate	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Taltirelin acetate (TA-0910 acetate) is a superagonist at *thyrotropin-releasing hormone* receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀** of 36 nM for stimulating an increase in cytosolic Ca²⁺ concentration (Ca²⁺ release).

HY-B1192

Estradiol benzoate β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Estrogen Receptor/ERR	Endocrinology Cancer
Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability.

HY-P1955

Etelcalcetide AMG 416; KAI-4169	CaSR	Endocrinology
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis.

HY-P0004

Lysipressin Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-P0004A

Lysipressin acetate Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-18569

3-Indoleacetic acid Indole-3-acetic acid; 3-IAA	Molecular Glues Endogenous Metabolite	Others
3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-P1955A

Etelcalcetide hydrochloride AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis.

HY-101952

Prostaglandin E2 PGE2; Dinoprostone	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-N7523

Neoxanthin	DNA/RNA Synthesis Apoptosis	Cancer
Neoxanthin is a major xanthophyll carotenoid and a precursor of the plant hormone abscisic acid in dark green leafy vegetables. Neoxanthin is a potent antioxidant and light-harvesting pigment. Neoxanthin induces apoptosis and has anticancer actions.

HY-10957

L-692429 MK-0751	GHSR	Metabolic Disease
L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl *growth hormone* secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a K_i** of 63 nM.

HY-16498

Tigapotide PCK-3145	Apoptosis	Cancer
Tigapotide (PCK-3145) is an anti-tumour peptide that reduces the development of skeletal metastases associated with prostate cancer. Tigapotide induces apoptosis and reduces tumour *parathyroid hormone-related peptide (PTHrP)* levels.

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	PKC	Endocrinology
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1).

HY-16474S

Relugolix-d6 TAK-385-d₆	GnRH Receptor	Cancer Endocrinology
Relugolix-d₆ is deuterium labeled Relugolix. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209)[1]. Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al[2].

HY-106765

Thymotrinan RGH-0205; TP3	Others	Inflammation/Immunology
Thymotrinan (RGH-0205) is a biologically active fragment of the naturally occurring thymus hormone thymopoietin and a immunomodulating peptide. Thymotrinan exerts similar immunomodulatory activities to TP5 and to affect humoral as well as cellular responses.

HY-100331

MCH-1 antagonist 1	MCHR1 (GPR24) Cytochrome P450	Metabolic Disease Endocrinology
MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a K_i of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC₅₀ of 10 μM.

HY-13293

Impurity C of Calcitriol	VD/VDR	Cancer
Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-13292

Impurity B of Calcitriol 1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol	VD/VDR	Cancer
Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-N0384S3

Homovanillic acid-13C6,18O	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-¹³C₆,¹⁸O is the ¹³C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-14823

Sobetirome GC-1; QRX-431	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM.

HY-150210

FSHR agonist 1	Estrogen Receptor/ERR	Endocrinology
FSHR agonist 1 is a high affinity and allosteric *follicle stimulating hormone* receptor (FSHR) agonist with a pEC₅₀** of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR.

HY-N0034

Arctiin Arctii; NSC 315527; Arctigenin-4-glucoside	Others	Cancer
Arctiin(NSC 315527), a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis.

HY-12433

BMS-819881	MCHR1 (GPR24) Cytochrome P450	Metabolic Disease Endocrinology
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a K_i of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC₅₀ of 13 μM.

HY-P1784

Secretin, canine	Src	Endocrinology
Secretin, canine is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.

HY-N0647

Silychristin	Monocarboxylate Transporter	Endocrinology
Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC₅₀ of 110 nM.

HY-N10511

GM1a Ganglioside oligosaccharide	Others	Inflammation/Immunology
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses.

HY-W016784

Indole-3-acetamide	Endogenous Metabolite	Others
Indole-3-acetamide is a biosynthesis intermediate of indole-3-acetic acid (HY-18569). Indole-3-acetic acid is the most common natural plant growth hormone of the auxin class.

HY-119332

3-Keto petromyzonol	Others	Endocrinology
3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey.

HY-B0141S

Estradiol-d3 β-Estradiol-d₃; 17β-Estradiol-d₃; 17β-Oestradiol-d₃	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-119283

MAGL-IN-5 CAY10499	MAGL FAAH	Metabolic Disease
MAGL-IN-5 (CAY10499) is a non-selective lipase inhibitor with IC₅₀ values of 144, 90, and 14 nM for human recombinant monoacylglycerol lipase(MAGL),hormone sensitive lipase(HSL), and fatty acid amide hydrolase(FAAH) respectively.

HY-11083

GW-803430 GW-3430	MCHR1 (GPR24)	Metabolic Disease
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC₅₀ of 9.3. GW-803430 is orally active in an animal model of obesity.

HY-151930

8′-Hydroxy ABA 8'-OH-ABA	Drug Metabolite	Metabolic Disease
8′-Hydroxy ABA (8'-OH-ABA) is a principal catabolite of abscisic acid (ABA). 8′-Hydroxy ABA has hormonal activity and leads to increased oil synthesis. 8′-Hydroxy ABA is a labile compound.

HY-124097

HNMPA-(AM)3	Insulin Receptor	Metabolic Disease
HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis.

HY-N0791

Tectoridin	Estrogen Receptor/ERR	Cancer
Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway.

HY-151931

JA-ACC Jasmonyl-ACC	Others	Metabolic Disease
JA-ACC (Jasmonyl-ACC) is a derivative of 1-aminocyclopropane-1-carboxylic acid (ACC). ACC is the direct precursor of the plant hormone ethylene. JA-ACC inhibits root growth in Arabidopsis and the inhibition is independent of jasmonic acid (JA) signaling.

HY-P3035

Corazonin	G Protein-coupled Receptor Kinase (GRK)	Neurological Disease
Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species.

HY-P3061

[Hyp3]-Bradykinin	Bradykinin Receptor	Endocrinology Cardiovascular Disease
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts.

HY-109532

Ganirelix acetate Ganirest	GnRH Receptor	Metabolic Disease
Ganirelix acetate (Ganirest) is an injectable competitive *gonadotropin-releasing hormone* (GnRH)** antagonist. Ganirelix acetate directly competes against the endogenous molecule for receptor binding, and causes a rapid reduction in estradiol levels. Ganirelix acetate can be used for researching ovarian hyperstimulation syndrome (OHSS).

HY-P1235A

Carperitide acetate Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

HY-110201

Estrogen receptor modulator 1	Estrogen Receptor/ERR	Cancer
Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC₅₀ of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors.

HY-13632

Exemestane FCE 24304; EXE	Cytochrome P450	Cancer Endocrinology
Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC₅₀s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research.

HY-118860

Corifollitropin alfa Org 36286; MK-8962	Estrogen Receptor/ERR	Endocrinology
Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC₅₀ of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility.

HY-N8805

Nortrachelogenin-8'-O-β-glucoside	Others	Cancer
Nortrachelogenin-8'-O-β-glucoside is a natural product that can be isolated from the dried roots of Pulsatilla koreana. Nortrachelogenin-8'-O-β-glucoside inhibits cancer cell proliferation and reduces hormone dependence.

HY-B0891S

17α-Hydroxyprogesterone-d8 17-Hydroxyprogesterone-d₈; 17-OHP-d₈	Progesterone Receptor Endogenous Metabolite	Others
17α-Hydroxyprogesterone-d₈ is the deuterium labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-103302

SUN B8155	CGRP Receptor	Endocrinology
SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis.

HY-17000

Tolvaptan OPC-41061	Vasopressin Receptor Autophagy	Cardiovascular Disease Endocrinology Cancer
Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V₂R) antagonist with an IC₅₀ of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia.

HY-13604

Cyproterone acetate	Androgen Receptor	Cancer Endocrinology
Cyproterone acetate is an anti-androgen (IC₅₀=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors.

HY-N9536

Cinnamtannin A2	GLP Receptor	Metabolic Disease
Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect.

HY-130248B

(R)-BAY-899	GnRH Receptor	Others
(R)-BAY-899 is the R-enantiomer of BAY-899. BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively.

HY-109017

Vamorolone VBP15	Glucocorticoid Receptor Mineralocorticoid Receptor NF-κB	Inflammation/Immunology
Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.

HY-18678

Bremelanotide PT-141	Melanocortin Receptor	Endocrinology
Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders.

HY-P3613

Oxyntomodulin (swine)	GLP Receptor GCGR	Metabolic Disease Neurological Disease
Oxyntomodulin (swine) is a dual agonist for GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR), a peptide hormone released from the gut in post-prandial state. Oxyntomodulin (swine) suppresses appetite and reduces food intake.

HY-B0234S1

Estrone-d2 E1-d₂; Oestrone-d₂	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone-d₂ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B0141S2

Estradiol-d5 β-Estradiol-d₅; 17β-Estradiol-d₅; 17β-Oestradiol-d₅	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0891S1

17α-Hydroxyprogesterone-13C3 17-Hydroxyprogesterone-¹³C₃; 17-OHP-¹³C₃	Progesterone Receptor Endogenous Metabolite	Others
17α-Hydroxyprogesterone-¹³C₃ is the ¹³C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-B0141S3

Estradiol-d2 β-Estradiol-d₂; 17β-Estradiol-d₂; 17β-Oestradiol-d₂	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S1

Estradiol-d4 β-Estradiol-d₄; 17β-Estradiol-d₄; 17β-Oestradiol-d₄	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0234S2

Estrone-d4 E1-d₄; Oestrone-d₄	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone-d₄ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-N0848

Epibrassinolide 24-Epibrassinolide; B1105; BP55	Apoptosis	Cancer
Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants. Epibrassinolide is a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth.

HY-B0234S4

Estrone-d2-1 E1-d₂-1; Oestrone-d₂-1	Estrogen Receptor/ERR Endogenous Metabolite
Estrone-d₂-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B1192S

Estradiol benzoate-d3 β-Estradiol 3-benzoate-d₃; 17β-Estradiol 3-benzoate-d₃	Estrogen Receptor/ERR
Estradiol benzoate-d₃ is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].

HY-113603

Tildacerfont	CRFR	Cancer
Tildacerfont is a potent and orally active corticotrophin-releasing factor type 1 (CRF1) receptort antagonis. Tildacerfont effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. Tildacerfont has favourable safety profile. Tildacerfont can be used for researching congenital adrenal hyperplasia.

HY-19464

Org 43553	Others	Endocrinology
Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC₅₀ values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine.

HY-W250978

Ovalbumins	Endogenous Metabolite	Cancer Inflammation/Immunology
Ovalbumins, the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone control of gene expression in this tissue.

HY-122304

Adrenaline sulfate	Endogenous Metabolite Adrenergic Receptor	Endocrinology Neurological Disease
Adrenaline sulfate is a orally active hormone secreted by the medulla of the adrenal glands. Adrenaline sulfate is an α-adrenergic and β-adrenergic receptor agonist. Adrenaline sulfate can be used in the research of anaphylaxis. Adrenaline sulfate has the potential for the research of cardiac arrest.

HY-B0234S

Estrone-13C3 E1-¹³C₃; Oestrone-¹³C₃	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone-¹³C₃ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B0141S6

Estradiol-d2-1 β-Estradiol-d₂-1; E2-d₂-1; 17β-Estradiol-d₂-1; 17β-Oestradiol-d₂-1	Estrogen Receptor/ERR Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].

HY-P1366

des-Gln14-Ghrelin	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-B0141S4

Estradiol-13C6 β-Estradiol-¹³C₆; E2-¹³C₆; 17β-Estradiol-¹³C₆; 17β-Oestradiol-¹³C₆	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S5

Estradiol-13C2 β-Estradiol-¹³C₂; E2-¹³C₂; 17β-Estradiol-¹³C₂; 17β-Oestradiol-¹³C₂	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol-¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0234S3

Estrone-13C2 E1-¹³C₂; Oestrone-¹³C₂	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone-¹³C₂ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B0867

2,4-D Butyl ester	Others	Others
2,4-D Butyl ester is an organic phenoxy herbicide and used to control woody broad-leaf weeds. 2,4-D butyl ester produces its herbicidal effect by mimicking natural plant growth hormones causing plants to grow too rapidly to survive.

HY-113906

GSK1614343	GHSR	Metabolic Disease
GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC₅₀ value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models.

HY-P1366A

des-Gln14-Ghrelin TFA	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-13632S

Exemestane-d2 FCE 24304-d₂; EXE-d₂	Cytochrome P450 Isotope-Labeled Compounds	Cancer Endocrinology
Exemestane-d₂ is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

HY-13632S2

Exemestane-d3 FCE 24304-d₃; EXE-d₃	Cytochrome P450 Isotope-Labeled Compounds	Cancer Endocrinology
Exemestane-d₃ is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

HY-P3977

ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)	Melanocortin Receptor	Cancer Inflammation/Immunology Cardiovascular Disease
ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH). ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) can be used for research of a variety of diseases, including cancer, immune diseases, cardiovascular disease.

HY-103565

AMN082	mGluR	Neurological Disease
AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC₅₀ values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.

HY-103565A

AMN082 free base	mGluR	Neurological Disease
AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC₅₀ values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.

HY-W087008

7-Hydroxyflavanone	Cytochrome P450	Cancer Endocrinology
7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC₅₀ of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula

HY-18569S4

3-Indoleacetic acid-13C6 Indole-3-acetic acid-¹³C₆; 3-IAA-¹³C₆	Endogenous Metabolite Molecular Glues	Others
3-Indoleacetic acid-¹³C₆ is the ¹³C labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-P2080B

GIP (1-30) amide,human acetate	Insulin Receptor	Metabolic Disease
GIP (1-30) amide,human acetate is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide,human acetate dose-dependently promotes insulin secretion over the range 10^-9-10^-6 M.

HY-108742

Abaloparatide BA 058; BIM 44058	Thyroid Hormone Receptor Arrestin	Metabolic Disease
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis.

HY-N2098

Obtusifolin	NF-κB	Cancer
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.

HY-15106

SB-423557	CaSR	Metabolic Disease Inflammation/Immunology
SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC₅₀=520 nM), precursor of SB-423562 (IC₅₀=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation.

HY-12753A

Debutyldronedarone hydrochloride SR35021 hydrochloride	Thyroid Hormone Receptor	Cardiovascular Disease
Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective *thyroid hormone* receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁** by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.

HY-B1805

Triclocarban 3,4,4′-Trichlorocarbanilide	Bacterial	Infection
Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes.

HY-18569S3

3-Indoleacetic acid-d7 Indole-3-acetic acid-d₇; 3-IAA-d₇	Endogenous Metabolite Molecular Glues	Others
3-Indoleacetic acid-d₇ is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-B0390S

Mestranol-d2	Isotope-Labeled Compounds Estrogen Receptor/ERR	Cancer
Mestranol-d₂ is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a?progestin in vivo?and can be used for?the research of menopausal hormone or?menstrual disorders[1][2][3].

HY-P1235

Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.

HY-P2080

GIP (1-30) amide,human	Insulin Receptor	Metabolic Disease
GIP (1-30) amide,human is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide,human dose-dependently promotes insulin secretion over the range 10^-9-10^-6 M.

HY-13632S1

Exemestane-13C3	Cytochrome P450 Isotope-Labeled Compounds	Cancer Endocrinology
Exemestane-¹³C₃ is the ¹³C-labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

HY-10473

Eprotirome KB2115	Thyroid Hormone Receptor	Endocrinology Metabolic Disease
Eprotirome (KB2115) is a liver-selective *thyroid hormone* receptor (TR) agonist. KB2115 has modestly higher affinity for TRβ than for TRα**. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research.

HY-B0390S1

Mestranol-d4	Isotope-Labeled Compounds Estrogen Receptor/ERR
Mestranol-d₄ is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a?progestin in vivo?and can be used for?the research of menopausal hormone or?menstrual disorders[1][2][3].

HY-101952G

Prostaglandin E2 PGE2; Dinoprostone	Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2 (GMP) is Prostaglandin E2 (HY-101952) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Prostaglandin E2, an inflammatory mediator, is a endogenous hormone-like substance that participate in a wide range of body functions.

HY-12956S

Dinoprost-d4 Prostaglandin F2a-d₄; PGF2α-d₄	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis	Endocrinology
Dinoprost-d₄ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

HY-P3217

[Asp5]-Oxytocin	Oxytocin Receptor	Endocrinology
[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin causes uterine contractions in vitro, enhanced by Mg²⁺. [Asp5]-Oxytocin has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic.

HY-B0075S

Melatonin-d4 N-Acetyl-5-methoxytryptamine-d₄	Melatonin Receptor Autophagy Mitophagy Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Melatonin-d₄ is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

HY-12956S1

Dinoprost-d9 Prostaglandin F2a-d₉; PGF2α-d₉	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis	Endocrinology
Dinoprost-d₉ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

HY-W008859

Tetrac Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid	Integrin Endogenous Metabolite	Cancer
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities.

HY-P3217A

[Asp5]-Oxytocin acetate	Oxytocin Receptor	Endocrinology
[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg²⁺. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic.

HY-101952S1

Prostaglandin E2-d9 PGE2-d₉; Dinoprostone-d₉	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-18569S2

3-Indoleacetic acid-2,2-d2 Indole-3-acetic acid-2,2-d₂; 3-IAA-2,2-d₂	Endogenous Metabolite	Others
3-Indoleacetic acid-2,2-d₂ is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-101952S

Prostaglandin E2-d4 PGE2-d₄; Dinoprostone-d₄	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2-d₄ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-A0070AG

Liothyronine Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor	Cancer Endocrinology
Liothyronine (Triiodothyronine) (GMP) is Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-113313S1

Aldosterone-d7	Endogenous Metabolite	Cardiovascular Disease
Aldosterone-d₇ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

HY-B1617AS1

Zuclomiphene-d5 citrate	Estrogen Receptor/ERR
Zuclomiphene-d₅ (citrate) is the deuterium labeled Zuclomiphene citrate[1]. Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[2][3][4][5].

HY-P2501

Amylin (8-37), human	Amylin Receptor	Metabolic Disease
Amylin (8-37), human is a fragment of human Amylin. Amylin (8-37), human has direct vasodilator effects in the isolated mesenteric resistance artery of the rat. Human Amylin is a small hormone secreted by pancreatic β-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus.

HY-129974S

3,3'-Diiodo-L-thyronine-13C6 3,3'-T2-¹³C₆	COX Endogenous Metabolite	Metabolic Disease
3,3'-Diiodo-L-thyronine-¹³C₆ is the ¹³C labeled 3,3'-Diiodo-L-thyronine[1]. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[2][3].

HY-15103

AH3960	Androgen Receptor Thyroid Hormone Receptor	Cancer
AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC₅₀ value of 0.82 μM. AH3960 also serves as an agonist of *parathyroid hormone* receptor-1 (PTHR1)**.

HY-P3862

[MePhe7]-Neurokinin B	Neurokinin Receptor	Endocrinology Neurological Disease
[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC₅₀ value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).

HY-107624

ATC0175	MCHR1 (GPR24)	Neurological Disease
ATC0175 is a potent, selective and orally active *melanin-concentrating hormone* 1 recepter antagonist with IC₅₀**s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.

HY-A0182A

Felypressin acetate PLV-2 acetate	Vasopressin Receptor	Cardiovascular Disease
Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin acetate is widely used in dental procedures.

HY-A0182

Felypressin PLV-2	Vasopressin Receptor	Cardiovascular Disease
Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures.

HY-P2426

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)	Thyroid Hormone Receptor	Metabolic Disease
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of *parathyroid hormone* (PTH), with a K_i** of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.

HY-P2336

CCZ01048	Melanocortin Receptor	Cancer
CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.

HY-108742A

Abaloparatide TFA BA 058 TFA; BIM 44058 TFA	Thyroid Hormone Receptor Arrestin	Metabolic Disease Endocrinology
Abaloparatide TFA (BA 058 TFA) is a *parathyroid hormone* receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin** recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis.

HY-P4823

pTH (1-37) (human)	Thyroid Hormone Receptor	Metabolic Disease
pTH (1-37) (human) is a fragment of parathyroid hormone (PTH). pTH (1-37) (human) induces the cAMP formation and increases alkaline phosphatase activity. pTH (1-37) (human) increases growth, bone calcium content, and bone mineral density (BMD) in uremic animals. pTH (1-37) (human) has the potential for the research of osteoporosis.

HY-E70077

Penicillinase (from calf stomach)	Endogenous Metabolite	Infection Metabolic Disease
Penicillinase (from calf stomach) is an enzyme that degrades penicillin by hydrolyzing the cyclic amide bonds in the lactam ring of penicillin, which can inactivate penicillin. Penicillinase (from calf stomach) can be isolated from penicillin resistant strains. Penicillinase (from calf stomach) has potential application as a marker for steroid hormone enzyme linked immunosorbent assay.

HY-W127758

Alginic acid	Histamine Receptor Apoptosis Autophagy Endogenous Metabolite	Endocrinology Inflammation/Immunology
Alginic acid is a natural polysaccharide, which has been widely concerned and applied due to its excellent water solubility, film formation, biodegradability and biocompatibility. Alginic acid induces oxidative stress-mediated hormone secretion disorder, apoptosis and autophagy in mouse granulosa cells and ovaries. Alginic acid has an inhibitory effect on histamine release. Anti-anaphylactic and anti-inflammatory properties.

HY-108468

KL001	Others	Metabolic Disease
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis.

HY-145709

Ar-V7-IN-1	Androgen Receptor	Cancer
Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer (extracted from patent WO2018114781A1, compound 43).

HY-103377

Antalarmin hydrochloride	CRFR	Endocrinology Inflammation/Immunology
Antalarmin (hydrochloride) is a non-peptide *corticotropin-releasing hormone* receptor 1 (CRHR1) antagonist with a K_i** of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.

HY-W016784S

Indole-3-acetamide-d5	Endogenous Metabolite	Others
Indole-3-acetamide-d₅ is the deuterium labeled Indole-3-acetamide[1]. Indole-3-acetamide is a biosynthesis intermediate of indole-3-acetic acid (HY-18569). Indole-3-acetic acid is the most common natural plant growth hormone of the auxin class[2].

HY-125209

TH5427	Others	Cancer
TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells.

HY-B1805S

Triclocarban-d4 3,4,4′-Trichlorocarbanilide-d₄	Bacterial	Infection
Triclocarban-d₄ is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes[1][2][3].

HY-111614S

Melengestrol acetate-d6	Progesterone Receptor	Cancer Metabolic Disease
Melengestrol acetate-d₆ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-111614S2

Melengestrol acetate-d3	Progesterone Receptor	Cancer Metabolic Disease
Melengestrol acetate-d₃ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-111614S1

Melengestrol acetate-d2	Progesterone Receptor	Cancer Metabolic Disease
Melengestrol acetate-d₂ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-144035

GLP-1R agonist 4	GCGR	Cancer
GLP-1R agonist 4 is a potent agonist of GLP-1R. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 4 has the potential for the research of diabetes (extracted from patent WO2019239319A1, compound 96).

HY-W008452S

H-Tyr(3-I)-OH-13C6	Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH-¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

HY-N2466A

Melanotan I acetate MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate	Melanocortin Receptor	Cancer
Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research.

HY-P4745

hMCH-1R antagonist 1	MCHR1 (GPR24)	Metabolic Disease
hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an K_B value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC₅₀ values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research.

HY-N2466

Melanotan I MT-I; [Nle4,D-Phe7]-α-MSH	Melanocortin Receptor	Cancer
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for sunlight-induced skin cancers research.

HY-139562

BMS-986318	FXR	Metabolic Disease
BMS-986318 is a potent nonbile acid FXR agonist with EC₅₀s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis.

HY-18346

Mozavaptan OPC-31260	Vasopressin Receptor	Cancer Endocrinology Metabolic Disease
Mozavaptan (OPC-31260) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V₂ receptor antagonist with an IC₅₀ of 14 nM. Mozavaptan shows ~85-fold selectivity for V₂ receptor over V₁ receptor (IC₅₀ of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment.

HY-P0049A

Argipressin diacetate Arg8-vasopressin diacetate; AVP diacetate; ADH	Apoptosis Vasopressin Receptor	Neurological Disease
Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.

HY-100560

Abscisic acid (S)-(+)-Abscisic acid; ABA	Endogenous Metabolite Proton Pump	Metabolic Disease
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H⁺-ATPase) and leads to the plasma membrane depolarization in a Ca²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.

HY-18572S

2,4-D-13C6 2,4-Dichlorophenoxyacetic acid-¹³C₆	DNA/RNA Synthesis	Others
2,4-D-¹³C₆ is the ¹³C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[1].

HY-18572S1

2,4-D-d3	DNA/RNA Synthesis	Others
2,4-D-d₃ is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].

HY-P4542

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)	CRFR	Endocrinology
(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition.

HY-18572S2

2,4-D-d5	DNA/RNA Synthesis	Others
2,4-D-d₅ is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].

HY-123593

Mozavaptan hydrochloride OPC-31260 hydrochloride	Vasopressin Receptor	Cancer Endocrinology Metabolic Disease
Mozavaptan hydrochloride (OPC-31260 hydrochloride) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V₂ receptor antagonist with an IC₅₀ of 14 nM. Mozavaptan hydrochloride shows ~85-fold selectivity for V₂ receptor over V₁ receptor (IC₅₀ of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan hydrochloride has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment.

HY-B0075

Melatonin N-Acetyl-5-methoxytryptamine	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress.

HY-P0097A

Nonapeptide-1 acetate salt Melanostatine-5 acetate salt	Melanocortin Receptor	Cancer Endocrinology Metabolic Disease
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer.

HY-144034

GLP-1R agonist 3	GCGR	Metabolic Disease
GLP-1R agonist 3 is a potent agonist of GLP-1R. GLP-1R agonist 3 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 3 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 1).

HY-144033

GLP-1R agonist 1	GCGR	Metabolic Disease
GLP-1R agonist 1 is a potent agonist of GLP-1R. GLP-1R agonist 1 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 1 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 4).

HY-P0097

Nonapeptide-1 Melanostatine-5	Melanocortin Receptor	Cancer Endocrinology Metabolic Disease
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer.

HY-114263

NXT629	PPAR	Cancer
NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC₅₀ of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC₅₀s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models.

HY-120026

KB130015 KB015	Thyroid Hormone Receptor	Neurological Disease
KB130015 (KB015) is an orally active and potent ThRα and ThRβ (Thyroid Hormone Receptor) inhibitor, with IC₅₀ values of 4.5 and 5.1 μM, respectively. KB130015 has antiarrhythmic properties. KB130015 markedly slows the kinetics of inactivation of Na⁺ channels. KB130015 opens large-conductance Ca²⁺-activated K⁺ channels and relaxes vascular smooth muscle.

HY-B0151

Pregnenolone 3β-Hydroxy-5-pregnen-20-one	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-10002A

(1S)-Calcitriol 1α,25-Dihydroxy-3-epi-vitamin-D3	VD/VDR	Others
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D₃ (1α,25(OH)₂D₃). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion.

HY-144749

AKR1C3-IN-5	Others	Cancer
AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC₅₀) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells.

HY-118861

Enclomiphene (E)-Clomiphene; trans-Clomiphene; Enclomifene	Estrogen Receptor/ERR	Endocrinology Metabolic Disease
Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.

HY-118861B

Enclomiphene hydrochloride (E)-Clomiphene hydrochloride; trans-Clomiphene hydrochloride; Enclomifene hydrochloride	Estrogen Receptor/ERR	Endocrinology Metabolic Disease
Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.

HY-118861A

Enclomiphene citrate (E)-Clomiphene citrate; trans-Clomiphene citrate; Enclomifene citrate	Estrogen Receptor/ERR	Endocrinology Metabolic Disease
Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.

HY-110189

Pregnenolone monosulfate sodium 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-B0075S1

Melatonin-d3 N-Acetyl-5-methoxytryptamine-d₃	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Melatonin-d₃ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-N6791

KT5823	PKA PKC Bacterial Apoptosis Antibiotic	Infection Inflammation/Immunology
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an K_i value of 0.23 μM, it also inhibits PKA and PKC with K_i values of 10 μM and 4 μM, respectively. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na⁺/I^- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation.

HY-B0075S2

Melatonin-d7 N-Acetyl-5-methoxytryptamine-d₇	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Melatonin-d₇ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-P2161B

TAK-683 acetate	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-B1739

Pregnenolone monosulfate 3β-Hydroxy-5-pregnen-20-one monosulfate	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication. Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-125961

T3Inh-1	Others	Cancer
T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC₅₀=7 µM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream).

HY-B0151S1

Pregnenolone-13C2,d2 3β-Hydroxy-5-pregnen-20-one-¹³C₂,d₂	Isotope-Labeled Compounds TRP Channel Endogenous Metabolite Cannabinoid Receptor Autophagy	Neurological Disease
Pregnenolone-¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[1][2][3][4].

HY-B0151S

Pregnenolone-d4 3β-Hydroxy-5-pregnen-20-one-d₄	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

HY-B0151S2

Pregnenolone-d4-1 3β-Hydroxy-5-pregnen-20-one-d₄-1	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

HY-110189S1

Pregnenolone monosulfate-d4 sodium 3β-Hydroxy-5-pregnen-20-one monosulfate-d₄ (sodium)	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate-d₄ (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

HY-P0048

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH Surfagon	GnRH Receptor	Others
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility.

HY-110189S

Pregnenolone monosulfate sodium-13C2,d2 3β-Hydroxy-5-pregnen-20-one monosulfate (sodium)-¹³C₂,d₂	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (sodium)-¹³C₂,d₂ is the ¹³C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

HY-124187

Pinolenic acid ethyl ester Ethyl pinolenate	Biochemical Assay Reagents	Others
Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

Cat. No.	Product Name

HY-L047

Endocrinology Compound Library

813 compounds

The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function.

The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease.

MCE offers a unique collection of 813 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

HY-L131

Osteogenesis Compound Library

385 compounds

Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health.

Osteoblasts play important roles in the process of osteogenesis and prevention of osteonecrosis. Osteoblast formation and bone formation are regulated by hormones, growth factors, cytokines, etc.

MCE offers a unique collection of 385 bone formation compounds with identified and potential inducing osteogenesis activity. MCE bone formation compound library is a useful tool for the study of bone disease drugs and pharmacology.

HY-L074

Anti-Breast Cancer Compound Library

1687 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 1687 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

HY-L126

Nuclear Receptor Compound Library

568 compounds

Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes.

Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors.

MCE supplies a unique collection of 568 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

HY-L042

Glycoside Compound Library

735 compounds

Glycosides are compounds in which a sugar group is bonded through its anomeric carbon to another group via a glycosidic bond. Many biologically active compounds are glycosides. Glycosides comprise several important classes of compounds such as hormones, sweeteners, alkaloids, flavonoids, antibiotics, etc. The glycosidic residue can be crucial for their activity or can only improve pharmacokinetic parameters. Glycosides, which exhibit anti-inflammatory, anti-infection, anti-cancer and anti-oxidative properties, play numerous important roles in living organisms, such as streptomycin, as an aminoglycoside antibiotic, has anti-infection activity. Anthracyclines possess good antibacterial and anti-cancer activities.

MCE Glycoside Compound Library contains a unique collection of 735 glycoside compounds and is a useful tool to discovery glycoside drugs.

HY-L091

Lipid Metabolism Compound Library

553 compounds

Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation.

MCE offers a unique collection of 553 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

HY-L150

Membrane Receptor-targeted Compound Library

4069 Compounds compounds

Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules.

There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery.

MCE provides a unique collection of 4069 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

HY-L040

Anti-diabetic Compound Library

648 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 648 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Type

HY-E70001

Recombinant Human Luteinizing Hormone	Enzyme
Recombinant Human Luteinizing Hormone is a recombinant form of Luteinizing hormone (human) (HY-P2293). Luteinizing hormone (human), a heterodimeric glycoprotein *hormone* produced by the pituitary gland (LH), plays key roles in human reproduction.

HY-W127334

N-Palmitoyl phosphatidylethanolamine	Biochemical Assay Reagents
N-Palmitoyl phosphatidylethanolamine (Tripelargonin) is endogenous lipid anorectic hormone, significantly reduces food intake in a dose-dependent manner

HY-125859

Peroxidase
Biochemical Assay Reagents

Peroxidase actively involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases.

HY-18569

3-Indoleacetic acid Indole-3-acetic acid; 3-IAA	Biochemical Assay Reagents
3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-E70077

Penicillinase (from calf stomach)	Enzyme
Penicillinase (from calf stomach) is an enzyme that degrades penicillin by hydrolyzing the cyclic amide bonds in the lactam ring of penicillin, which can inactivate penicillin. Penicillinase (from calf stomach) can be isolated from penicillin resistant strains. Penicillinase (from calf stomach) has potential application as a marker for steroid hormone enzyme linked immunosorbent assay.

HY-CP002

Bovine Serum Albumin, Carrier Protein

Biochemical Assay Reagents

Bovine Serum Albumin (BSA) is a 583 amino acid protein consisting of three homologous full alpha structural domains. BSA is a spherical protein essential for the transport of molecules such as fatty acids, drugs and hormones from the blood. It is used in many biochemical applications as a drug carrier for biologically active compounds. For long-term storage, recombinant protein solution should be diluted further with 0.1% BSA .

HY-124187

Pinolenic acid ethyl ester

Ethyl pinolenate

Biochemical Assay Reagents

Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

Cat. No.	Product Name	Target	Research Area

HY-106373A

*Adrenocorticotropic hormone* TFA** ACTH TFA; Adrenocorticotrophic hormone TFA	Androgen Receptor	Metabolic Disease
Adrenocorticotropic hormone (ACTH) TFA is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone regulates cortisol and androgen production.

HY-P3824

Red pigment-concentrating hormone	Peptides	Others
Red pigment-concentrating hormone is a chromatophorotropic hormone and is synthesized in the eyestalk. Red pigment-concentrating hormone may plays a role as a downstream hormone of 5-HT.

HY-P0089

*Human growth hormone-releasing factor* Growth hormone Releasing Factor human	GHSR	Endocrinology
Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.

HY-P0089A

*Human growth hormone-releasing factor TFA* Growth hormone Releasing Factor human TFA	GHSR	Endocrinology
Human growth hormone-releasing factor TFA (Growth Hormone Releasing Factor human TFA) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.

HY-P2279A

*Parathyroid hormone* (1-34) (rat) acetate**	Thyroid Hormone Receptor	Endocrinology Metabolic Disease
Parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis.

HY-P2279

*Parathyroid hormone* (1-34) (rat)**	Thyroid Hormone Receptor	Endocrinology Metabolic Disease
Parathyroid hormone (1-34) (rat) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis.

HY-P0059

Teriparatide Human parathyroid hormone-(1-34); hPTH (1-34)	Peptides	Others
Teriparatide (Human parathyroid hormone-(1-34)) is a PHT agonist. Teriparatide (Human parathyroid hormone-(1-34)) can be used for osteoporosis research.

HY-P0243

*Luteinizing Hormone* Releasing Hormone (LH-RH), salmon** Salmon GnRH; Salmon gonadotropin-releasing hormone; sGnRH	Peptides	Metabolic Disease
Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

HY-P0252

α-MSH α-Melanocyte-Stimulating hormone	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease
α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

HY-P2293

*Luteinizing hormone* (human)**	Peptides	Endocrinology
Luteinizing hormone (human), a heterodimeric glycoprotein hormone produced by the pituitary gland (LH), plays key roles in human reproduction.

HY-P2510

*Parathyroid Hormone* (1-34), human, biotinylated**	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), human, biotinylated is a probe for the parathyroid hormone receptor, can be used for analyzing the interaction between parathyroid hormone and parathyroid hormone receptors in living cells and for purifying hormone-receptor complexes with affinity columns.

HY-P1252

*Parathyroid Hormone* (1-34), bovine**	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), bovine is a potent *parathyroid hormone* (PTH) receptor** agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.

HY-P4657

*Human Growth Hormone* (1-43)**	Peptides	Endocrinology
Human Growth Hormone (1-43) is an N-terminal fragment of human growth hormone with specific and pronounced insulin-like activity. Human Growth Hormone (1-43) can be used to study the function and metabolic pathways of growth hormone, a potential obesity-related factor.

HY-P0002A

Protirelin acetate Thyrotropin-releasing-hormone acetate; TRH acetate	Thyroid Hormone Receptor	Endocrinology Inflammation/Immunology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P0002

Protirelin Thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P1252A

*Parathyroid Hormone* (1-34), bovine TFA**	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), bovine TFA is a potent *parathyroid hormone* (PTH) receptor** agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.

HY-P1518

*Adrenocorticotropic Hormone* (ACTH) (1-10), human**	Peptides	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (1-10), human, an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).

HY-P3596

GHRF, mouse Mouse growth hormone-releasing factor	Peptides	Endocrinology
GHRF, mouse, a mouse growth hormone-releasing factor, is a peptide containing 44 amino acids. GHRF, mouse stimulates the release and synthesis of growth hormone.

HY-P1529

*Thyrotropin-Releasing Hormone* (TRH), Free Acid** TRH-OH	Peptides	Metabolic Disease Neurological Disease
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) is a physiological metabolite of Thyrotropin-Releasing Hormone.

HY-P3568

*Adipokinetic hormone* (Gryllus bimaculatus)** Grybi-AKH	Peptides	Metabolic Disease
Adipokinetic hormone Gryllus bimaculatus (Grybi-AKH) is an adipokinetic hormone that regulates energy homeostasis in insects by mobilizing lipid and carbohydrate from the fat body. Adipokinetic hormone Gryllus bimaculatus stimulates the locomotor activity of the two-spotted cricket. Adipokinetic hormone Gryllus bimaculatus can also be used in studies to regulate body weight, induce weight loss and alleviate glycogen storage disorders in humans.

HY-P4851

*Adipokinetic hormone* (Manduca sexta)** Manse-AKH	Peptides	Others
Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta) is a common peptide among various insects. Adipokinetic Hormone induces strong adipokinetic/hypertrehalosemic response. However Adipokinetic Hormone has no a glycogen-mobilizing function nor an adequate glycogen store in fat body for its effective utilization.

HY-P1628

Ganirelix	GnRH Receptor	Metabolic Disease
Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea.

HY-P1833

*Egg Laying Hormone, aplysia*	Peptides	Neurological Disease
Egg Laying Hormone, aplysia is a neuropeptide synthesized by the bag cell neurons, which contains 36 amino acids and can stimulate egglaying and ovulation in Aplysia via electrical discharge triggering of neurons. Egg-laying hormone of Aplysia induces a voltage-dependent slow inward current carried by Na' in an identified motoneuron.

HY-P1503

ACTH (4-11) Adrenocorticotropic hormone (4-11), human	Peptides	Metabolic Disease
ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).

HY-P1478

Adrenocorticotropic Hormone (ACTH) (4-10), human
Melanocortin Receptor Metabolic Disease

Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

HY-P3084

Human follicular gonadotropin releasing peptide hF-GRP	Peptides	Endocrinology
Human follicular gonadotropin releasing peptide (hF-GRP) is a hormone peptide. Human follicular gonadotropin releasing peptide can stimulate pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in vitro.

HY-P1525

*Melanin Concentrating Hormone, salmon* MCH (salmon)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P3572

*Adipokinetic hormone* I (Locusta migratoria)** Lom-AKH-I	Endogenous Metabolite	Endocrinology
Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs).

HY-P3570

*Adipokinetic hormone* II (Locusta migratoria)** Lom-AKH-II	Endogenous Metabolite	Metabolic Disease
Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs).

HY-P3687

[Tyr0] Corticotropin Releasing Factor, ovine	Peptides	Endocrinology
[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin.

HY-P1603

ACTH (22-39)
Adrenocorticotropic hormone (22-39)
Peptides Metabolic Disease

ACTH (22-39) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (22-39) is the 22-39 sequence of ACTH.

HY-P1456

*Adipokinetic Hormone* (AKH) (24-32), locust**	Peptides	Metabolic Disease
Adipokinetic Hormone (AKH) (24-32), locust, isolated from locust corpora cardiaca, is a neurohormone that regulates lipid utilisation during flight.

HY-P1531

*γ-1-Melanocyte Stimulating Hormone* (MSH), amide**	Melanocortin Receptor	Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-P1211

*Adrenocorticotropic Hormone* (ACTH) (1-39), human** 1-39-Corticotropin (human)	Peptides	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (1-39), human is a melanocortin receptor agonist.

HY-P1476

*Adrenocorticotropic Hormone* (ACTH) (18-39), human** CLIP (human)	Peptides	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is produced in the melanotrophs of the intermediate lobe of the pituitary.

HY-P1456A

*Adipokinetic Hormone* (AKH) (24-32), locust TFA**	Peptides	Metabolic Disease
Adipokinetic Hormone (AKH) (24-32), locust (TFA), isolated from locust corpora cardiaca, is a neurohormone that regulates lipid utilisation during flight.

HY-P3683

a-Helical Corticotropin Releasing Factor (12-41)	CRFR	Endocrinology
a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect.

HY-P1525A

*Melanin Concentrating Hormone, salmon TFA* MCH (salmon) (TFA)	MCHR1 (GPR24)	Metabolic Disease Neurological Disease Cardiovascular Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P3684

[DPro5] Corticotropin Releasing Factor, human, rat	CRFR	Endocrinology
[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat.

HY-P1211A

*Adrenocorticotropic Hormone* (ACTH) (1-39), human(TFA)** 1-39-Corticotropin (human)(TFA)	Melanocortin Receptor	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) is a melanocortin receptor agonist.

HY-P1477

*Adrenocorticotropic Hormone* (ACTH) (1-39), rat** ACTH (1-39) (mouse, rat)	Melanocortin Receptor	Metabolic Disease Endocrinology
Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist.

HY-P1558

ACTH (11-24) Adrenocorticotropic hormone (11-24)	Melanocortin Receptor	Neurological Disease
ACTH (11-24) is an *adrenocorticotropic hormone* (ACTH) receptor** antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.

HY-P1476A

*Adrenocorticotropic Hormone* (ACTH) (18-39), human TFA** CLIP (human) (TFA)	Peptides	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (18-39), human TFA is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary.

HY-P3595

GHRF, porcine
GHSR Endocrinology

GHRF, porcine is a growth hormone releasing factor (GHRF) peptide (porcine). GHRF binds to GHSR and induces the release of growth hormone.

HY-P1174

GnRH Associated Peptide (GAP) (1-13), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-13), human is an amino acid peptide fragment derived from GnRH. GAP can increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in rat anterior pituitary cells. GAP also inhibit the secretion of prolactin.

HY-P3056

GHRF, ovine	Peptides	Endocrinology
GHRF, ovine is a growth hormone-releasing factor. GHRF is a specific mediator for the effects of hypoglycemia upon the release of pituitary growth hormone (GH).

HY-P1558A

ACTH (11-24) (acetate) Adrenocorticotropic hormone (11-24) (acetate)	Melanocortin Receptor	Neurological Disease
ACTH (11-24) (acetate) is an *adrenocorticotropic hormone* (ACTH) receptor** antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.

HY-P3975

Glp-His-Pro-Gly-NH2 pGlu-His-Pro-Gly-NH2	Peptides	Endocrinology
Glp-His-Pro-Gly-NH2 (pGlu-His-Pro-Gly-NH2) is a peptide containing 4 amino acids. Glp-His-Pro-Gly-NH2 stimulates gonadotrophin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) release.

HY-P4857

pTH-Related Protein (7-34) amide (human, mouse, rat)
Peptides Endocrinology

pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent antagonist of parathyroid hormone (PTH).

HY-P3582A

sGnRH-A acetate	GnRH Receptor	Endocrinology
sGnRH-A acetate is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A acetate stimulates growth hormone secretion. sGnRH-A acetate also can be used as an inducer of ovulation by artificial insemination.

HY-P3582

sGnRH-A	GnRH Receptor	Endocrinology
sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A stimulates growth hormone secretion. sGnRH-A also can be used as an inducer of ovulation by artificial insemination.

HY-P3636

Cockroach Myoactive Peptide I Pea-CAH-I	Peptides	Neurological Disease
Cockroach Myoactive Peptide I (Pea-CAH-I) is a cockroach neuropeptide, a member of the adipokinetic hormone/red pigment-concentrating hormone family (AKH/RPCH family).

HY-P0252A

α-MSH TFA α-Melanocyte-Stimulating hormone TFA	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease
α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC).

HY-P1504

*β-Melanocyte Stimulating Hormone* (MSH), human** Beta-MSH (1-22) (human)	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-P3978

ACTH (4-9)
Peptides Neurological Disease

ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (4-9) is the 4-9 sequence fragment of ACTH.

HY-P1226

HAEGTFTSD	GCGR	Metabolic Disease
HAEGTFTSD is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide (HY-P0054A). GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretionin a glucose-dependant manner

HY-P0252B

α-MSH free acid α-Melanocyte-Stimulating hormone free acid	Melanocortin Receptor	Neurological Disease
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC₅₀s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R.

HY-P3685

[Met(O)21] Corticotropin Releasing Factor, ovine	CRFR	Endocrinology
[Met(O)21] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor isolated from ovine hypothalamic extracts. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH).

HY-P3564

(D-Ser1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)	Peptides	Others
(D-Ser1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is an adrenocorticotropic hormone (ACTH) analogue.

HY-P3964

TRH Precursor Peptide	Endogenous Metabolite	Endocrinology
TRH Precursor Peptide is a precursor peptide of thyrotropin-releasing hormone (TRH). TRH Precursor Peptide formation of TRH in rat brain and pituitary is zinc-dependent.

HY-P2416

Gastrin I, rat
Rat Gastrin-17
Cholecystokinin Receptor Endocrinology

Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently.

HY-P0276

GIP, human Gastric Inhibitory Peptide (GIP), human	Insulin Receptor	Metabolic Disease
GIP, human, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion.

HY-P1504A

*β-Melanocyte Stimulating Hormone* (MSH), human TFA** Beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Metabolic Disease Neurological Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

HY-P0276A

GIP, human TFA Gastric Inhibitory Peptide (GIP), human TFA	Insulin Receptor	Metabolic Disease
GIP, human TFA, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human TFA acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion.

HY-P3969

Prepro-TRH-(160-169)	Thyroid Hormone Receptor	Endocrinology Neurological Disease
Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release.

HY-P3567

(p-Iodo-Phe7)-ACTH (4-10)	Melanocortin Receptor	Neurological Disease
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.

HY-16168A

Degarelix	GnRH Receptor Apoptosis	Cancer Endocrinology
Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist. Degarelix can be used for prostate cancer research.

HY-16168B

Degarelix acetate hydrate	GnRH Receptor Apoptosis	Cancer Endocrinology
Degarelix acetate hydrate is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist. Degarelix acetate hydrate can be used for prostate cancer research.

HY-P3604

LH-RH II (chicken)	Androgen Receptor	Endocrinology
LH-RH II (chicken) is one of the two forms of luteinizing hormone-releasing hormone (LHRH) the hypothalamus of the domestic hen, which are structural variants of mammalian LHRH. LH-RH II (chicken) enhances gonadotrophin release in the domestic chicken.

HY-P3489

β-Corticotropin (swine)
Peptides Endocrinology

β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release.

HY-P3606

GnRH Associated Peptide (1-24), human GAP (1-24), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.

HY-P2540

Leptin (93-105), human	Peptides	Metabolic Disease
Leptin (93-105), human, is the amino acids 93 to 105 fragment of human leptin. Leptin is a 167-residue peptide hormone mainly produced by adipocytes and acts in the central nervous system to primarily coordinate the metabolic adaptations to fasting.

HY-P3304

MR 409	Peptides	Cancer Neurological Disease
MR 409 is a selected growth hormone-releasing hormone (GHRH) agonist. MR 409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis in cerebral ischemic mice. MR 409 also inhibits the in vivo growth of lung cancer.

HY-P3621

Biotinyl-Glucagon (1-29), human, bovine, porcine	GCGR	Metabolic Disease
Biotinyl-Glucagon (1-29), human, bovine, porcine is a biotinylated glucagon. Glucagon is a peptide hormone, produced by α-cells of the pancreas, can increase concentration of glucose and fatty acids in the bloodstream.

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes.

HY-P3635

Cockroach Myoactive Peptide II Pea-CAH-II	Peptides	Metabolic Disease Neurological Disease
Cockroach Myoactive Peptide II (Pea-CAH-II) is a cockroach neuropeptide. Cockroach Myoactive Peptide II is a member of the adipokinetic hormone/red pigment concentrating hormone (AKH/RPCH) family. Cockroach Myoactive Peptide II can be used for the research of metabolic functions of insect body.

HY-P3605

GnRH Associated Peptide (25-53), human GAP (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.

HY-P3216

Oxytocin free acid 9-Deamidooxytocin	Peptides	Endocrinology
Oxytocin free acid (9-Deamidooxytocin) is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior.

HY-P3216B

Oxytocin free acid TFA 9-Deamidooxytocin TFA	Peptides	Endocrinology
Oxytocin free acid (9-Deamidooxytocin) TFA is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior.

HY-P3928

Amylin (1-37) (human) hIAPP (1-37)	Amylin Receptor	Metabolic Disease
Amylin (1-37) (human) (hIAPP (1-37)) is a peptide hormone, present in pancreatic betacell secretory granules. The C-terminus of Amylin (1-37) (human) is amidated and there is a disulfide bond between cysteine residues 2 and 7.

HY-P0060

Tetracosactide Tetracosactrin; ACTH(1–24)	Peptides	Cancer
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH), Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.

HY-P1418

DPC-AJ1951	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 in ex vivo and in vivo assays of bone resorption.

HY-P1418A

DPC-AJ1951 TFA	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951 TFA, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 TFA in ex vivo and in vivo assays of bone resorption.

HY-P0024

Veldoreotide DG3173; PTR-3173	Somatostatin Receptor	Cancer Endocrinology
Veldoreotide (DG3173) a somatostatin analogue, that can bind to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits *growth hormone* (GH)** secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent

HY-P1777

IGF-I (24-41) Insulin-like Growth Factor I (24-41)	IGF-1R	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development.

HY-P1777A

IGF-I (24-41) (TFA) Insulin-like Growth Factor I (24-41) (TFA)	IGF-1R	Metabolic Disease Inflammation/Immunology
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) TFA is amino acids 24 to 41 fragment of IGF-I. IGF-I TFA, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I TFA is partly responsible for systemic growth hormone (GH) activities. IGF-I TFA has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) TFA regulates somatic growth and behavioral development.

HY-19884

Relamorelin RM-131; BIM-28131	GHSR	Metabolic Disease
Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective *ghrelin/growth hormone* secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a** receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.

HY-19884A

Relamorelin acetate RM-131 acetate; BIM-28131 acetate	GHSR	Metabolic Disease
Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective *ghrelin/growth hormone* secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a** receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.

HY-P2932

Cholecystokinin	Peptides	Metabolic Disease
Cholecystokinin is a peptide hormone. Cholecystokinin, as a hunger suppressant, inhibits food intake and stimulates the digestion of fat and protein. Cholecystokinin can be used for the research of gastrointestinal system.

HY-P3343A

hFSH-β-(33-53) (TFA)	Estrogen Receptor/ERR	Cancer
hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells.

HY-P0082A

Glucagon (1-29), bovine, human, porcine hydrochloride Porcine glucagon hydrochloride	GCGR	Metabolic Disease
Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation.

HY-P0082

Glucagon (1-29), bovine, human, porcine Porcine glucagon	GCGR	Metabolic Disease
Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation.

HY-P3169

a-Helical Corticotropin Releasing Factor (9-41)	CRFR	Inflammation/Immunology
α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo.

HY-P0211

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)	Peptides	Cardiovascular Disease
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), a growth hormone releasing factor (GRF) analogue, is a vasoactive intestinal peptide (VIP) antagonist.

HY-19884B

Relamorelin TFA RM-131 TFA; BIM-28131 TFA	GHSR	Metabolic Disease
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective *ghrelin/growth hormone* secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a** receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.

HY-108905

Mecasermin Human IGF-I; FK 780	IGF-1R	Metabolic Disease
Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies.

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Endocrinology Neurological Disease
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.

HY-P0085

Splenopentin diacetate	Peptides	Inflammation/Immunology
Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation.

HY-P3607

GHRF, bovine bGRF(1-44)-NH2	GHSR	Endocrinology
GHRF, bovine (bGRF(1-44)-NH2) is the bovine growth hormone (GH)-releasing factor (GHRF). GHRF, bovine increases the release of bovine GH, and shows a synergistic effect with Hydrocortisone (HY-N0583).

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.

HY-P3662

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Tyrosinase	Cancer
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model.

HY-P1070

Amylin, amide, human DAP amide, human	Amylin Receptor	Metabolic Disease
Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.

HY-P0262A

Galantide TFA	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease
Galantide TFA is a reversible and non-specific galanin (GAL) receptor antagonist. Galantide TFA dose-dependently shows antagonism to galanin-induced K⁺ conductance with an IC₅₀ value of 4 nM. Galantide TFA can be used for the research of neurological disease and hormone metabolism research.

HY-P2090

Angiopeptin	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research.

HY-13673

Goserelin ICI 118630	GnRH Receptor Apoptosis	Cancer Endocrinology
Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.

HY-P1070A

Amylin, amide, human TFA DAP amide, human TFA	Amylin Receptor	Metabolic Disease
Amylin, amide, human TFA, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human TFA inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.

HY-13673A

Goserelin acetate ICI-118630 acetate	GnRH Receptor Apoptosis	Endocrinology Cancer
Goserelin acetate (ICI-118630 acetate), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin acetate can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.

HY-P2090A

Angiopeptin TFA	Somatostatin Receptor Adenylate Cyclase	Cardiovascular Disease
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.

HY-P3102

GLP-1(32-36)amide	GCGR	Metabolic Disease
GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.

HY-P1210

Lys-γ3-MSH(human)	Melanocortin Receptor	Endocrinology
Lys-γ3-MSH(human) is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) is a potent stimulator of lipolysis with an apparent EC₅₀ of 3.56 nM. Lys-γ3-MSH(human) can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis.

HY-P3102A

GLP-1(32-36)amide TFA	GCGR	Metabolic Disease
GLP-1(32-36)amide TFA, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide TFA could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.

HY-109538

Secretin (swine)	Peptides	Metabolic Disease Neurological Disease
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.

HY-P1210A

Lys-γ3-MSH(human) TFA	Melanocortin Receptor	Endocrinology
Lys-γ3-MSH(human) TFA is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) TFA potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) TFA is a potent stimulator of lipolysis with an apparent EC₅₀ of 3.56 nM. Lys-γ3-MSH(human) TFA can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis.

HY-17571A

Oxytocin acetate α-Hypophamine acetate; Oxytocic hormone acetate	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.

HY-P0084

Cyclic somatostatin SRIF-14; Somatostatin-14	Peptides	Neurological Disease Cardiovascular Disease
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC₅₀ value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease.

HY-P3960

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.

HY-P1555

ACTH (1-13) Adrenocorticotropic hormone (1-13)	Peptides	Inflammation/Immunology
ACTH (1-13) is a 13-aa peptide, with cytoprotective effects in the model of ethanol induced gastric lesions in rats.

HY-P3622

(Ser8)-GLP-1 (7-36) amide, human	GCGR	Metabolic Disease
(Ser8)-GLP-1 (7-36) amide, human is a glucagon-like peptide 1 amide derived from glucagonogen, a cleavage product of the GLP-1 (1-36) amide peptide. (Ser8)-GLP-1 (7-36) amide, human is an entero-insulinotropic hormone that causes glucose-dependent release of insulin from pancreatic β-cells and affects gastrointestinal motility and secretion.

HY-P1547

Somatostatin-25
Peptides Neurological Disease

Somatostatin-25 is a endogenous neuropeptide hormone that shows inhibitory activity against secretion of growth hormone.

HY-P4564

(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

HY-P4568

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

HY-P4577

(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

HY-P1582

ACTH (1-14)
Adrenocorticotropic hormone Fragment 1-14
Adrenergic Receptor Cancer

ACTH (1-14) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.
HY-P4572

(D-Trp6)-LHRH free acid
GnRH Receptor Cancer

(D-Trp6)-LHRH free acid is a luteinizing hormone-releasing hormone (LHRH) agonist.

HY-P0093

Sincalide Cholecystokinin octapeptide; CCK-8; SQ19844	Cholecystokinin Receptor Apoptosis PI3K Akt	Cancer Infection
Sincalide (Cholecystokinin octapeptide, CCK‐8) is a rapid-acting *amino acid polypeptide hormone* analogue** of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. CCK‐8 can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK.

HY-P0093A

Sincalide ammonium Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium	Cholecystokinin Receptor Apoptosis PI3K Akt	Cancer Infection
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting *amino acid polypeptide hormone* analogue** of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK.

HY-P1373

Neuronostatin-13 (human)	Peptides	Neurological Disease
Neuronostatin-13 human is a 13-amino acid peptide hormone encoded by the somatostatin gene and plays an important role in the regulation of hormonal and cardiac function.

HY-P3666

[D-Phe2,6, Pro3]-LH-RH
Peptides Endocrinology

[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist.

HY-P1869

Neuropeptide EI, rat	MCHR1 (GPR24) Melanocortin Receptor	Neurological Disease Endocrinology
Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.

HY-P4688

(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH
Peptides Endocrinology

(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is an important peptide hormone.

HY-P1582A

ACTH (1-14) (TFA) Adrenocorticotropic hormone Fragment 1-14 TFA	Adrenergic Receptor	Others
ACTH (1-14) (TFA) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.

HY-P0238

Gastrin-Releasing Peptide, human	Peptides	Cancer
Gastrin-Releasing Peptide, human (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release.

HY-P3668

[D-Lys6]-LH-RH
GnRH Receptor Cancer Endocrinology

[D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist.

HY-P1806

Gastrin I (1-14), human	Peptides	Endocrinology Metabolic Disease
Gastrin I (1-14), human is 1-14 fragment of human gastrin I peptide. Gastrin I is an endogenous, gastrointestinal peptide hormone. Gastrin is the major hormonal regulator of gastric acid secretion.

HY-114707

Threonyl-seryl-lysine	Peptides	Endocrinology
Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5.

HY-P3672

[D-Ala6]-LH-RH
GnRH Receptor Endocrinology

[D-Ala6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Ala6]-LH-RH acts as a GnRH receptor agonist.
HY-P0035

Insulin (human)
Insulin Receptor Metabolic Disease Endocrinology

Insulin (human) is a polypeptide hormone that regulates the level of glucose.

HY-P0009

Cetrorelix SB-75	GnRH Receptor	Endocrinology
Cetrorelix is a potent *gonadotrophin-releasing hormone* (GnRH)** antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice.

HY-P1806A

Gastrin I (1-14), human TFA	Peptides	Endocrinology Metabolic Disease
Gastrin I (1-14), human TFA is 1-14 fragment of human gastrin I peptide. Gastrin I is an endogenous, gastrointestinal peptide hormone. Gastrin is the major hormonal regulator of gastric acid secretion.

HY-P3675

LH-RH (4-10)	GnRH Receptor	Endocrinology
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes.

HY-P1739

ACTH (34-39)
Peptides Neurological Disease

ACTH (34-39) is an adrenocorticotropic hormone fragment.

HY-P0056

Histrelin	GnRH Receptor	Cancer
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis.

HY-P3919

Adrenotensin (human) Pro-ADM-153-185 (human)	CGRP Receptor	Cardiovascular Disease
Adrenotensin (human) (Pro-ADM-153-185 (human)) is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones.

HY-P4456

(Des-His6)-ACTH (1-24) (human, bovine, rat)	Adrenergic Receptor	Endocrinology
(Des-His6)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production.

HY-P4413

(Des-Glu5)-ACTH (1-24) (human, bovine, rat)	Androgen Receptor	Endocrinology
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production.

HY-Y1091

D-Lysine	Endogenous Metabolite	Others
D-Lysine is a useful raw material employed as an analog of lutenizing-hormone-releasing hormone and as a agent carrier in the form of polylysine. D-Lysine decreases renal uptake of radioactivity during scintigraphy and PRRT with low toxicity. D-Lysine not interferes with the natural amino acid metabolic balance.

HY-P4605

(Ile8)-Oxytocin
Mesotocin
Endogenous Metabolite Metabolic Disease

(Ile8)-Oxytocin is a neurohypophysial hormone mesotocin produced in marsupials.

HY-P0054A

GLP-1(7-36), amide Glucagon-like peptide-1 (GLP-1)(7-36), amide; Human GLP-1 (7-36), amide	GCGR	Metabolic Disease
GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretion.

HY-P1460

His-[D-2-ME-Trp]-Ala
Peptides Others

His-[D-2-ME-Trp]-Ala is a fragment of the growth hormone hexarelin.

HY-P3594

[His1,Nle27] GHRF (1-32), amide, human	GHSR	Endocrinology
[His1,Nle27] GHRF (1-32), amide, human is a Growth hormone releasing hormone (GHRH) analog. [His1,Nle27] GHRF (1-32), amide, human has great receptor affinity for GHRHR.

HY-P4144

Onvitrelin ucalontide Phor18-LHRH (338613)	GnRH Receptor	Cancer Endocrinology
Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is an analogue of luteinizing hormone releasing hormone (LHRH) with antineoplastic activity. Onvitrelin ucalontide is a peptide with sequences of KFAKFAKKFAKFAKKFAKQHWSYGLRPG. Onvitrelin ucalontide effectively inhibits breast cancer, ovarian cancer and prostate cancer xenografts in mouse model.

HY-P0267

Melanotan (MT)-II
Peptides Neurological Disease

Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.
HY-P1760

Allatostatin IV
Peptides Neurological Disease

Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.
HY-P1786

Allatostatin II
Peptides Neurological Disease

Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.
HY-P0055

GLP-1(7-37)
GCGR Metabolic Disease

GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.

HY-P4750

Acetyl-(D-Arg2)-GRF (1-29) amide (human)	Peptides	Endocrinology
Acetyl-(D-Arg2)-GRF (1-29) amide (human) is an antagonist of growth hormone releasing factor (GRF). Acetyl-(D-Arg2)-GRF (1-29) amide (human) inhibits the release of growth hormone (GH) and can be used for endocrine research.

HY-P1574

[Arg8]-Vasotocin
Peptides Neurological Disease

[Arg8]-Vasotocin is a vertebrate neurohypophyseal peptide of the vasopressin/oxytocin hormone family.

HY-P1882

Type A Allatostatin I	Peptides	Inflammation/Immunology
Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects.

HY-17365

Octreotide acetate SMS 201-995 acetate	Somatostatin Receptor	Inflammation/Immunology Cardiovascular Disease Endocrinology Cancer
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

HY-P1463

Calcitonin, eel Thyrocalcitonin eel	Peptides	Endocrinology
Calcitonin, eel is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.

HY-P1155

GRF (1-29) amide (rat)
rGHRH(1-29)NH2
Peptides Cancer

GRF (1-29) amide (rat) is a synthetic peptide which can stimulate the growth hormone (GH) secretion.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-P1574A

[Arg8]-Vasotocin TFA
Peptides Neurological Disease

[Arg8]-Vasotocin (TFA) is a vertebrate neurohypophyseal peptide of the vasopressin/oxytocin hormone family.
HY-13534

Abarelix
R3827; PPI 149
GnRH Receptor Cancer Endocrinology

Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
HY-P0055A

GLP-1(7-37) acetate
GCGR Metabolic Disease

GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.

HY-P3553

Alsactide	Melanocortin Receptor	Neurological Disease
Alsactide, a heptadecapeptide analogue, is an *adrenocorticotropic hormone* (ACTH)** agonist. Alsactide can be used in research of central nervous system.

HY-P1021

Peptide YY (PYY) (3-36), porcine	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), porcine is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

HY-W345393

Trh-gly
TRH-glycine
Thyroid Hormone Receptor Endocrinology

Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin.

HY-P0054

GLP-1(7-36), amide acetate Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate; Human GLP-1 (7-36), amide acetate	GCGR	Metabolic Disease
GLP-1(7-36), amide acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.

HY-P0009B

Cetrorelix diacetate SB-75 diacetate	GnRH Receptor	Endocrinology Neurological Disease
Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC₅₀ of 1.21 nM.

HY-P0070

Thymus peptide C	Peptides	Inflammation/Immunology
Thymus peptide C is a hormonal agent derived from the thymus glands of young calves, which works as a substitute for the physiological functions of the thymus.

HY-P1144

Oxyntomodulin
GCGR Metabolic Disease

Oxyntomodulin, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-P1463A

Calcitonin, eel TFA Thyrocalcitonin eel TFA	Peptides	Others
Calcitonin, eel TFA is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.

HY-13534A

Abarelix Acetate PPI 149 Acetate; R 3827 Acetate	GnRH Receptor	Cancer Endocrinology
Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent *gonadotrophin-releasing hormone* (GnRH)** antagonist, used for prostate cancer research.

HY-P3155

Ac-hMCH(6-16)-NH2	MCHR1 (GPR24)	Metabolic Disease
Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC₅₀ values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R.

HY-P3671

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH	GnRH Receptor	Endocrinology
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist.

HY-P1144A

Oxyntomodulin TFA
GCGR Metabolic Disease

Oxyntomodulin TFA, a 37-amino acid peptide hormone, is a glucagon-like peptide 1 (GLP-1) receptor agonist.

HY-P0090

Calcitonin (salmon) Salmon calcitonin	CGRP Receptor	Cancer
Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.

HY-P3579

Gastric Inhibitory Peptide, porcine	Insulin Receptor	Endocrinology
Gastric Inhibitory Peptide, porcine is a glucose-dependent insulinotropic polypeptide, is a 42 amino acid intestinal hormone with effects on fat and glucose metabolism.

HY-P0259

Xenin
Peptides Metabolic Disease Neurological Disease

Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.

HY-P1021A

Peptide YY (PYY) (3-36), porcine TFA	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), porcine TFA is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

HY-P1024

GLP-2(1-33)(human) GLP-2 (human); Glucagon-like peptide 2 (human)	GCGR	Metabolic Disease
GLP-2(1-33) (human) is an enteroendocrine hormone which can bind to the GLP-2 receptor and stimulate the growth of intestinal epithelium.

HY-P3962

[Phe2]-TRH
Thyroid Hormone Receptor Endocrinology

[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin.

HY-P1428

RFRP-1(human)	Neuropeptide Y Receptor	Endocrinology
RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively.

HY-P2194

AtPep3	Peptides	Inflammation/Immunology
AtPep3 is a hormone-like peptide. AtPep3 can enhance salinity tolerance of plants and inhibits the salt-induced bleaching of chlorophyll in seedlings.

HY-P0054B

GLP-1(7-36), amide TFA Glucagon-like peptide-1 (GLP-1)(7-36), amide TFA; Human GLP-1 (7-36), amide TFA	GCGR	Metabolic Disease
GLP-1(7-36), amide TFA is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.

HY-P0051

Lecirelin	GnRH Receptor	Cancer Endocrinology
Lecirelin, a synthetic gonadotropin-releasing hormone (GnRH) analogue, acts as a GnRH agonist. Lecirelin is widely used for the research of bovine ovarian follicular cysts.

HY-P2677

CCK (26-31) (sulfated)	Peptides	Metabolic Disease
CCK (26-31) (sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety.

HY-P1514

Peptide YY (PYY), human	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease Endocrinology
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.

HY-107380A

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	Peptides	Endocrinology
PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole.

HY-P4715

(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)	PTHR	Endocrinology
(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) is a peptide and can be used as a parathyroid hormone (PTH) receptor ligand.

HY-P2880

PHI-27 (porcine)
Peptides Others

PHI-27 (porcine) is a 27 amino acid peptide.PHI-27 (porcine) is used to find peptide hormones and other active peptides.

HY-P3673

Lamprey LH-RH I	GnRH Receptor	Endocrinology
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models.

HY-P2194A

AtPep3 TFA	Peptides	Inflammation/Immunology
AtPep3 TFA is a hormone-like peptide. AtPep3 TFA can enhance salinity tolerance of plants and inhibits the salt-induced bleaching of chlorophyll in seedlings.

HY-P3040

PHI-27 (rat)
Peptides Others

PHI-27 (rat) is a 27 amino acid peptide.PHI-27 (rat) is used to find peptide hormones and other active peptides.

HY-P4493

(Des-Ser3)-ACTH (1-24) (human, bovine, rat)	Peptides	Others
(Des-Ser3)-ACTH (1-24) (human, bovine, rat) is a peptide analog of the adrenocorticotropic hormone (ACTH). ACTH stimulates the production of cortisol.

HY-P1465

Secretin (28-54), human Human secretin	Secretin Receptor	Metabolic Disease Cancer
Secretin (28-54), human is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-P1214

γ1-MSH	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH is a melanocortin MC3 receptor agonist, with a K_i of 34 nM for the rat MC3 receptor. γ1-MSH displays ~40-fold selectivity over MC4 (K_i=1318 nM).

HY-P1465A

Secretin (28-54), human TFA Human secretin TFA	Secretin Receptor	Metabolic Disease Cancer
Secretin (28-54), human TFA is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-P1213

JKC363	Melanocortin Receptor	Neurological Disease
JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

HY-P1213A

JKC363 TFA	Melanocortin Receptor	Neurological Disease
JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

HY-P1214A

γ1-MSH TFA	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH TFA is a melanocortin MC3 receptor agonist, with a K_i of 34 nM for the rat MC3 receptor. γ1-MSH TFA displays ~40-fold selectivity over MC4 (K_i=1318 nM).

HY-P4904

RFRP-3 (rat)	Peptides	Neurological Disease
RFRP-3 (rat) is a neuropeptide. RFRP-3 (rat) inhibits gonadotropin secretion, causing a marked increase in ghrelin mRNA and plasma growth hormone levels.

HY-P2273

Calcitonin (human)	CGRP Receptor	Metabolic Disease
Calcitonin (human) is a hypocalcemic hormone. Calcitonin can lower blood calcium levels and inhibit bone resorption. Calcitonin can be used in hypercalcemia or osteoporosis research.

HY-P4800

Osteostatin (human) Human PTHrP(107-139)	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis.

HY-P1156

Insulin(cattle) Insulin from bovine pancreas	Insulin Receptor	Metabolic Disease Endocrinology
Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells.

HY-P3903

[D-Trp8,Tyr11] Somatostatin	Peptides	Endocrinology
[D-Trp8,Tyr11] Somatostatin is an analogue of somatostatin. Somatostatin is a hormone that regulates a variety of bodily functions. DTrp8 residue can increase stability.

HY-P1955

Etelcalcetide AMG 416; KAI-4169	CaSR	Endocrinology
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis.

HY-P0004

Lysipressin Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-P0004A

Lysipressin acetate Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-P1955A

Etelcalcetide hydrochloride AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis.

HY-P4849

pTH-Related Protein (1-37) (human, mouse, rat)	Peptides	Others
pTH-Related Protein (1-37) (human, mouse, rat), the peptide analogue of pTH-Related Protein (pTHrP). pTHrP refers to parathyroid-hormone-related protein, involved in physiological regulation of bone formation.

HY-P1765

Galanin (1-19), human	Peptides	Neurological Disease
Galanin (1-19), human is the 1-19 fragment of the human galanin. Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior.

HY-16498

Tigapotide PCK-3145	Apoptosis	Cancer
Tigapotide (PCK-3145) is an anti-tumour peptide that reduces the development of skeletal metastases associated with prostate cancer. Tigapotide induces apoptosis and reduces tumour *parathyroid hormone-related peptide (PTHrP)* levels.

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	PKC	Endocrinology
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1).

HY-P1015

VIP(Guinea pig) Vasoactive Intestinal Peptide, guinea pig	Peptides	Metabolic Disease Neurological Disease
VIP Guinea pig (Vasoactive intestinal peptide), a trophic and mitogenic factor, stimulates growth in whole cultured embryos. VIP Guinea pig functions as a simple gastrointestinal hormone and suggest a possible neurotransmitter function.

HY-P4011

[1,6-Aminosuberic acid]-arginine-Vasotocin	Peptides	Neurological Disease
[1,6-Aminosuberic acid]-arginine-Vasotocin is a synthetic peptide analogue to neurohypophyseaI hormones. [1,6-Aminosuberic acid]-arginine-Vasotocin has excitatory effect on the periodically oxcillating neuron (PON) of A. fulica.

HY-P1015A

VIP(Guinea pig) TFA Vasoactive Intestinal Peptide, guinea pig TFA	Peptides	Metabolic Disease Neurological Disease
VIP Guinea pig TFA (Vasoactive intestinal peptide), a trophic and mitogenic factor, stimulates growth in whole cultured embryos. VIP Guinea pig functions as a simple gastrointestinal hormone and suggest a possible neurotransmitter function.

HY-P1784

Secretin, canine	Src	Endocrinology
Secretin, canine is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.

HY-P4798

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) Human PTHrP(107-111) amide	Peptides	Others
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) is a C-terminal parathyroid hormone-related protein fragment that can inhibit bone resorption.

HY-P3035

Corazonin	G Protein-coupled Receptor Kinase (GRK)	Neurological Disease
Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species.

HY-P3061

[Hyp3]-Bradykinin	Bradykinin Receptor	Endocrinology Cardiovascular Disease
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts.

HY-P1235A

Carperitide acetate Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

HY-P2678

CCK (26-31) (non-sulfated)	Peptides	Metabolic Disease
CCK (26-31) (non-sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety. CCK (26-31) is also less active in non-sulfated than in sulfated form.

HY-P3446A

Big Gastrin I (human) (TFA)	Peptides	Cancer Infection Inflammation/Immunology Neurological Disease Cardiovascular Disease
Big Gastrin I, human (TFA) is a gastrointestinal hormone consisting of 34 amino acids. Big Gastrin I, human (TFA) can be used as a potential substance for the study of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurological diseases or cardiovascular diseases.

HY-18678

Bremelanotide PT-141	Melanocortin Receptor	Endocrinology
Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders.

HY-P3613

Oxyntomodulin (swine)	GLP Receptor GCGR	Metabolic Disease Neurological Disease
Oxyntomodulin (swine) is a dual agonist for GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR), a peptide hormone released from the gut in post-prandial state. Oxyntomodulin (swine) suppresses appetite and reduces food intake.

HY-P3826

Chromogranin A (324-337), human	Peptides	Neurological Disease
Chromogranin A (324-337), human is a peptide fragment of chromogranin A, it can be isolated from human ileal carcinoid tumor. Chromogranin A is a soluble glycoprotein stored with hormones and neuropeptides in secretory granules of most (neuro)endocrine cells and neurons, and it is also a plasma marker of neuroendocrine tumors.

HY-P1366

des-Gln14-Ghrelin	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-P1366A

des-Gln14-Ghrelin TFA	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-P3977

ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)	Melanocortin Receptor	Cancer Inflammation/Immunology Cardiovascular Disease
ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH). ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) can be used for research of a variety of diseases, including cancer, immune diseases, cardiovascular disease.

HY-P1959

Lanreotide BIM 23014	Peptides	Cancer Endocrinology
Lanreotide (BIM 23014) is a somatostatin analogue with antineoplastic activity. Lanreotide can be used for the research of carcinoid syndrome.

HY-P1959A

Lanreotide acetate BIM 23014 acetate	Peptides	Cancer Endocrinology
Lanreotide (BIM 23014) acetate is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for the research of carcinoid syndrome.

HY-P1959B

Lanreotide diTFA BIM 23014 diTFA	Peptides	Cancer Endocrinology
Lanreotide (BIM 23014) diTFA is a somatostatin analogue with antineoplastic activity. Lanreotide diTFA can be used for the research of carcinoid syndrome.

HY-P2080B

GIP (1-30) amide,human acetate	Insulin Receptor	Metabolic Disease
GIP (1-30) amide,human acetate is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide,human acetate dose-dependently promotes insulin secretion over the range 10^-9-10^-6 M.

HY-108742

Abaloparatide BA 058; BIM 44058	Thyroid Hormone Receptor Arrestin	Metabolic Disease
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis.

HY-P1235

Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.

HY-P2080

GIP (1-30) amide,human	Insulin Receptor	Metabolic Disease
GIP (1-30) amide,human is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide,human dose-dependently promotes insulin secretion over the range 10^-9-10^-6 M.

HY-P3217

[Asp5]-Oxytocin	Oxytocin Receptor	Endocrinology
[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin causes uterine contractions in vitro, enhanced by Mg²⁺. [Asp5]-Oxytocin has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic.

HY-P4681

(Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)	Peptides	Metabolic Disease
(Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) is a fragment of the ACTH hormone. (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) can be labeled with I125 on Tyr23 to produce a radiolabeled ligand.

HY-P3217A

[Asp5]-Oxytocin acetate	Oxytocin Receptor	Endocrinology
[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg²⁺. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic.

HY-P3758

BNP (1-21), Pro (Human)	Peptides	Others
BNP (1-21), Pro (Human) is a peptide containg 21 amino acids. B-Type Natriuretic Peptide (BNP), a cardiac natriuretic hormone. BNP together with the highly homologous atrial natriuretic peptide, it forms a dual natriuretic peptide system of the heart. BNP is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life.

HY-P2501

Amylin (8-37), human	Amylin Receptor	Metabolic Disease
Amylin (8-37), human is a fragment of human Amylin. Amylin (8-37), human has direct vasodilator effects in the isolated mesenteric resistance artery of the rat. Human Amylin is a small hormone secreted by pancreatic β-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus.

HY-P3862

[MePhe7]-Neurokinin B	Neurokinin Receptor	Endocrinology Neurological Disease
[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC₅₀ value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).

HY-A0182A

Felypressin acetate PLV-2 acetate	Vasopressin Receptor	Cardiovascular Disease
Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin acetate is widely used in dental procedures.

HY-A0182

Felypressin PLV-2	Vasopressin Receptor	Cardiovascular Disease
Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures.

HY-P2426

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)	Thyroid Hormone Receptor	Metabolic Disease
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of *parathyroid hormone* (PTH), with a K_i** of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.

HY-P2336

CCZ01048	Melanocortin Receptor	Cancer
CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.

HY-108742A

Abaloparatide TFA BA 058 TFA; BIM 44058 TFA	Thyroid Hormone Receptor Arrestin	Metabolic Disease Endocrinology
Abaloparatide TFA (BA 058 TFA) is a *parathyroid hormone* receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin** recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis.

HY-P4823

pTH (1-37) (human)	Thyroid Hormone Receptor	Metabolic Disease
pTH (1-37) (human) is a fragment of parathyroid hormone (PTH). pTH (1-37) (human) induces the cAMP formation and increases alkaline phosphatase activity. pTH (1-37) (human) increases growth, bone calcium content, and bone mineral density (BMD) in uremic animals. pTH (1-37) (human) has the potential for the research of osteoporosis.

HY-P4373

Hepcidin-1 (mouse)	Peptides	Metabolic Disease
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation.

HY-N2466A

Melanotan I acetate MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate	Melanocortin Receptor	Cancer
Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research.

HY-P4745

hMCH-1R antagonist 1	MCHR1 (GPR24)	Metabolic Disease
hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an K_B value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC₅₀ values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research.

HY-N2466

Melanotan I MT-I; [Nle4,D-Phe7]-α-MSH	Melanocortin Receptor	Cancer
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for sunlight-induced skin cancers research.

HY-P0049A

Argipressin diacetate Arg8-vasopressin diacetate; AVP diacetate; ADH	Apoptosis Vasopressin Receptor	Neurological Disease
Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.

HY-P4542

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)	CRFR	Endocrinology
(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition.

HY-P0097A

Nonapeptide-1 acetate salt Melanostatine-5 acetate salt	Melanocortin Receptor	Cancer Endocrinology Metabolic Disease
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer.

HY-P0097

Nonapeptide-1 Melanostatine-5	Melanocortin Receptor	Cancer Endocrinology Metabolic Disease
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer.

HY-P2161B

TAK-683 acetate	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

HY-P0048

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH Surfagon	GnRH Receptor	Others
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility.

Cat. No.	Product Name	Target	Research Area

HY-P99951

Ripafollitropin alfa (bovine)
Inhibitory Antibodies Endocrinology

Ripafollitropin alfa (bovine) is a recombinant follicle-stimulating hormone fusion protein with chorionic gonadotropin.

HY-118860

Corifollitropin alfa Org 36286; MK-8962	Estrogen Receptor/ERR	Endocrinology
Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC₅₀ of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility.

HY-P99746

Murlentamab 3C23K; GM102	Inhibitory Antibodies	Cancer Inflammation/Immunology
Murlentamab (3C23K; GM102) is a humanized anti-AMHRII antibody. AMHRII is the anti-Müllerian hormone receptor. Murlentama significantly promotes macrophage-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Murlentama stimulates pro-inflammatory and anti-tumor internal environment, recruits and activates T cells. Murlentama suppresses tumors growth by inducing naïve macrophage orientation and promoting tumor-associated macrophage (TAM) reprogramming.

Cat. No.	Product Name	Target	Category

HY-P0002

Protirelin Thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Structural Classification Natural Products Endogenous metabolite Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-A0070A

Liothyronine Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor Endogenous Metabolite	Ketones, Aldehydes, Acids Monophenols Phenols Disease Research Fields Classification of Application Fields Endocrinology Source classification Endogenous metabolite Disease markers Endocrine diseases
Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-N2549

(±)-Abscisic acid (±)-ABA	Others	Natural Products Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants other families
(±)-Abscisic acid is an orally active plant hormone that is present also in animals. (±)-Abscisic acid (ABA) contributes to the regulation of glycemia in mammals.

HY-N9441

Ascr#7	Others	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Other Diseases Source classification Animals
Ascr#7, an ascaroside, is a hormone of nematodes. Ascr#7 is expressed during nematode development. Ascarosides can induce formation of long-lived and highly stress resistant dauer larvae.

HY-B0234

Estrone E1; Oestrone	Estrogen Receptor/ERR Endogenous Metabolite	Monophenols Phenols Steroids Disease Research Fields Cancer Classification of Application Fields Source classification Endogenous metabolite
Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells.

HY-128030

Makisterone A	Others	Steroids Classification of Application Fields Disease Research Fields Endocrinology Source classification Plants Chenopodiaceae Chenopodium quinoa Willd.
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera.

HY-W008452

H-Tyr(3-I)-OH	Endogenous Metabolite	Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Endogenous metabolite
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite.

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Natural Products Source classification Endogenous metabolite
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

HY-N7443

Gibberellin A1	Others	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Leguminosae Phaseolus vulgaris Linn.
Gibberellin A1 is a kind of plant hormones. Gibberellin A1 is a growth-promoting acids isolated from immature seed of Phaseolus multiflorus.

HY-101402A

Cyclo(his-pro) TFA Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA	NF-κB Endogenous Metabolite	Natural Products Source classification Endogenous metabolite
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

HY-B0141

Estradiol β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Monophenols Phenols Steroids Structural Classification Endocrine diseases Endogenous metabolite Disease markers Source classification Disease Research Fields Cancer Classification of Application Fields
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.

HY-N8393

Ascr#18	Bacterial Fungal	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Infection Source classification Animals
Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 is expressed during nematode development. Ascr#18 increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections.

HY-113313

Aldosterone	Endogenous Metabolite	Steroids Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Endogenous metabolite
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.

HY-12956

Dinoprost Prostaglandin F2α; PGF2α	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Endocrinology Source classification Endogenous metabolite
Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.

HY-18572

2,4-D 2,4-Dichlorophenoxyacetic acid	DNA/RNA Synthesis	Ketones, Aldehydes, Acids Biological Pesticide Research Other Diseases Disease Research Fields Agricultural Research Classification of Application Fields Source classification Endogenous metabolite
2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development.

HY-N0160

Kinetin 6-Furfuryladenine; N6-Furfuryladenine	Others	Natural Products Source classification Plants other families
Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects.

HY-17462

Adrenosterone (+)-Adrenosterone	Androgen Receptor Endogenous Metabolite	Steroids Classification of Application Fields Disease Research Fields Endocrinology Source classification Endogenous metabolite
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.

HY-N6979

Crustecdysone 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Steroids Structural Classification Compositae Serratula coronata other families Endogenous metabolite Plants Animals Source classification Disease Research Fields Classification of Application Fields Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).

HY-122940

Precocene II
Others Structural Classification Natural Products

Precocene II is the insect antijuvenile hormone.

HY-N0179

Ecdysone α-Ecdysone	Endogenous Metabolite Apoptosis	Steroids Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Animals Endogenous metabolite
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979).

HY-101406

Thyroxine sulfate T4 Sulfate	Thyroid Hormone Receptor Drug Metabolite Endogenous Metabolite	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Endocrinology Source classification Endogenous metabolite Disease markers Endocrine diseases Immune System Disorder
Thyroxine sulfate is a thyroid hormone metabolite.

HY-I0352

Epiandrosterone 3β-Androsterone; trans-Androsterone; iso-Androsterone	Androgen Receptor Endogenous Metabolite	Structural Classification Steroids Disease Research Fields Classification of Application Fields Endocrinology Source classification Endogenous metabolite
Epiandrosterone is a steroid hormone with weak androgenic activity.

HY-18341

L-Thyroxine Levothyroxine; T4	Thyroid Hormone Receptor Endogenous Metabolite	Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Endocrinology Source classification Endogenous metabolite Disease markers Endocrine diseases Nervous System Disorder Immune System Disorder
L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

HY-77839

Cortodoxone 11-Deoxycortisol; cortexolone; Reichstein's substance S	Glucocorticoid Receptor Endogenous Metabolite	Steroids Classification of Application Fields Disease Research Fields Endocrinology Source classification Endogenous metabolite
Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone).

HY-N0437

Progesterone Pregn-4-ene-3,20-dione	Progesterone Receptor Endogenous Metabolite	Steroids Disease Research Fields Cancer Classification of Application Fields Source classification Endogenous metabolite Disease markers Other disease
Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-N9418

Gibberellin A5
Others Rosa canina Gremli ex Christ Rosaceae Plants Source classification

Gibberellin A5 is a plant hormone that promotes floral development .

HY-N6022

Byakangelicin	Others	Coumarins Phenylpropanoids Structural Classification Umbelliferae Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. e Plants Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of agent-agent interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones.

HY-N0583

Hydrocortisone Cortisol	Glucocorticoid Receptor Endogenous Metabolite	Steroids Disease Research Fields Cancer Classification of Application Fields Endocrinology Source classification Endogenous metabolite
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.

HY-113414

Deoxycorticosterone	Endogenous Metabolite	Steroids Classification of Application Fields Disease Research Fields Other Diseases Source classification Endogenous metabolite Disease markers Endocrine diseases
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.

HY-113114

Tetrahydrocortisone	Endogenous Metabolite	Steroids Structural Classification Endogenous metabolite Source classification Other Diseases Disease Research Fields Classification of Application Fields
Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase.

HY-N0384

Homovanillic acid Vanilacetic acid	Endogenous Metabolite	Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Endogenous metabolite Disease markers Endocrine diseases Nervous System Disorder Immune System Disorder
Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-P0259

Xenin	Others	Natural Products Source classification Endogenous metabolite
Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.

HY-N11020

Cabenoside D	EBV	Triterpenes Structural Classification Terpenoids other families Bryonia dioica Bojer Plants Source classification Caput nigri Cucurbitaceae
Cabenoside D (compound 8) is a triterpenoid glycoside, which can be isolated from the methanol extract of lichen root. Cabenoside D shows anti-inflammatory activity and inhibits inflammation induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice. Cabenoside D also inhibits TPA-induced Epstein-Barr virus (EBV) early antigen (EBV-EA) activation.

HY-N2448

Lindleyin	Estrogen Receptor/ERR	Phenols Polyphenols Classification of Application Fields Disease Research Fields Endocrinology Source classification Plants Polygonaceae Rheum palmatum L.
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity.

HY-B0891

17α-Hydroxyprogesterone 17-Hydroxyprogesterone; 17-OHP	Progesterone Receptor Endogenous Metabolite	Steroids Other Diseases Disease Research Fields Classification of Application Fields Source classification Endogenous metabolite Disease markers Endocrine diseases Nervous System Disorder
17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-A0152

D-Thyroxine D-T4	Endogenous Metabolite	Ketones, Aldehydes, Acids Disease Research Fields Metabolic Disease Source classification Endogenous metabolite
D-Thyroxine (D-T4) is a thyroid hormone that can inhibit TSH secretion. D-Thyroxine can be used for the research of hypercholesterolemia.

HY-N3755

Dihydroresveratrol	Estrogen Receptor/ERR	Phenols Polyphenols Disease Research Fields Cancer Classification of Application Fields Source classification Plants Dioscoreaceae Dioscorea bulbifera Linn.
Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations.

HY-B0765

Dehydroepiandrosterone sulfate sodium salt Sodium prasterone sulfate	Endogenous Metabolite	Steroids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Endogenous metabolite
Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone.

HY-B1192

Estradiol benzoate β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Estrogen Receptor/ERR	Disease Research Fields Cancer Classification of Application Fields
Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability.

HY-P0004

Lysipressin Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase	Monophenols Phenols Structural Classification Animals Source classification Other Diseases Disease Research Fields Classification of Application Fields
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.

HY-18569

3-Indoleacetic acid Indole-3-acetic acid; 3-IAA	Molecular Glues Endogenous Metabolite	Indole Alkaloids Alkaloids Structural Classification Immune System Disorder Endogenous metabolite Disease markers Source classification Other Diseases Disease Research Fields Classification of Application Fields
3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-101952

Prostaglandin E2 PGE2; Dinoprostone	Prostaglandin Receptor Endogenous Metabolite	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Endocrinology Source classification Endogenous metabolite Disease markers Nervous System Disorder
Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-N7523

Neoxanthin	DNA/RNA Synthesis Apoptosis	Natural Products Classification of Application Fields Disease Research Fields Cancer Food Research Pigments Source classification Plants other families
Neoxanthin is a major xanthophyll carotenoid and a precursor of the plant hormone abscisic acid in dark green leafy vegetables. Neoxanthin is a potent antioxidant and light-harvesting pigment. Neoxanthin induces apoptosis and has anticancer actions.

HY-N0034

Arctiin Arctii; NSC 315527; Arctigenin-4-glucoside	Others	Phenylpropanoids Natural Products Lignans Disease Research Fields Cancer Anti-aging Classification of Application Fields Source classification Plants Compositae Arctium lappa L.
Arctiin(NSC 315527), a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis.

HY-N0647

Silychristin	Monocarboxylate Transporter	Phenols Flavanonols Polyphenols Structural Classification Flavonoids Compositae Cyamopsis tetragonoloba (L.) Taub. Glycine soya Plants Source classification Disease Research Fields Classification of Application Fields Endocrinology
Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC₅₀ of 110 nM.

HY-N10511

GM1a Ganglioside oligosaccharide	Others	Saccharides Polysaccharides Structural Classification Natural Products Endogenous metabolite Inflammation/Immunology Disease Research Fields Classification of Application Fields
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses.

HY-W016784

Indole-3-acetamide	Endogenous Metabolite	Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Other Diseases Source classification Endogenous metabolite
Indole-3-acetamide is a biosynthesis intermediate of indole-3-acetic acid (HY-18569). Indole-3-acetic acid is the most common natural plant growth hormone of the auxin class.

HY-119332

3-Keto petromyzonol	Others	Steroids Classification of Application Fields Disease Research Fields Endocrinology Source classification Animals
3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey.

HY-N0791

Tectoridin	Estrogen Receptor/ERR	Structural Classification Flavones Flavonoids Leguminosae Maackia amurensis Rupr. et Maxim. Plants
Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway.

HY-N8805

Nortrachelogenin-8'-O-β-glucoside	Others	Phenols Polyphenols Plants Ranunculaceae Pulsatilla cernua (Thunb.) Bercht. et Opiz.
Nortrachelogenin-8'-O-β-glucoside is a natural product that can be isolated from the dried roots of Pulsatilla koreana. Nortrachelogenin-8'-O-β-glucoside inhibits cancer cell proliferation and reduces hormone dependence.

HY-N9536

Cinnamtannin A2	GLP Receptor	Biflavones Phenols Flavanonols Polyphenols Structural Classification Flavonoids Lauraceae Plants Source classification Cinnamomum cassia Presl Metabolic Disease Disease Research Fields Classification of Application Fields
Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect.

HY-N0848

Epibrassinolide 24-Epibrassinolide; B1105; BP55	Apoptosis	Natural Products Biological Pesticide Research Disease Research Fields Cancer Agricultural Research Classification of Application Fields Source classification Plants Brassicaceae Brassica campestris L.
Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants. Epibrassinolide is a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth.

HY-W087008

7-Hydroxyflavanone	Cytochrome P450	Monophenols Phenols Papilionaceae Dalbergia cochinchinensis Plants Source classification Disease Research Fields Cancer Endocrinology
7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC₅₀ of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula

HY-N2098

Obtusifolin	NF-κB	Quinones Anthraquinones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Leguminosae seeds of Cassia tora Linn. other families
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.

HY-W008859

Tetrac Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid	Integrin Endogenous Metabolite	Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Cancer Source classification Endogenous metabolite
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities.

HY-W127758

Alginic acid	Histamine Receptor Apoptosis Autophagy Endogenous Metabolite	Saccharides Structural Classification Microorganisms Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Alginic acid is a natural polysaccharide, which has been widely concerned and applied due to its excellent water solubility, film formation, biodegradability and biocompatibility. Alginic acid induces oxidative stress-mediated hormone secretion disorder, apoptosis and autophagy in mouse granulosa cells and ovaries. Alginic acid has an inhibitory effect on histamine release. Anti-anaphylactic and anti-inflammatory properties.

HY-100560

Abscisic acid (S)-(+)-Abscisic acid; ABA	Endogenous Metabolite Proton Pump	Sesquiterpenes Terpenoids Structural Classification Microorganisms other families Endogenous metabolite Plants Animals Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H⁺-ATPase) and leads to the plasma membrane depolarization in a Ca²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.

HY-B0075

Melatonin N-Acetyl-5-methoxytryptamine	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis	Structural Classification Natural Products Other disease Endogenous metabolite Disease markers Source classification Inflammation/Immunology Neurological Disease Disease Research Fields Cancer Anti-aging Classification of Application Fields
Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress.

HY-B0151

Pregnenolone 3β-Hydroxy-5-pregnen-20-one	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Steroids Neurological Disease Disease Research Fields Anti-aging Classification of Application Fields Source classification Endogenous metabolite
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-110189

Pregnenolone monosulfate sodium 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Steroids Source classification Endogenous metabolite
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

HY-B1739

Pregnenolone monosulfate 3β-Hydroxy-5-pregnen-20-one monosulfate	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Steroids Source classification Endogenous metabolite
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication. Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

Species:	Human (29) Mouse (7) Rat (4)
Tag:	SUMO (1) His (26) Tag Free (2) Avi (1) Myc (1) GST (1) Fc (10) Flag (1)
Source:	HEK293 (28) P. pastoris (1) E. coli (9)

Cat. No.	Product Name	Species	Source

HY-P72204

*Growth Hormone* R/GHR Protein, Human (His-SUMO)** GH receptor; GH-binding protein; GHBP; GHBP, included; GHR; GHR_HUMAN; Growth hormone binding protein; Growth hormone receptor; Growth hormone receptor precursor; Growth hormone-binding protein; Growth hormone-binding protein, included; Increased responsiveness to growth hormone, included; Serum binding protein; Serum-binding protein; Somatotropin receptor	Human	E. coli

HY-P70240

Somatoliberin/GHRH Protein, Human (HEK293, Fc) rHuSomatoliberin/GHRH, Fc; Somatoliberin; Growth hormone-releasing factor; Somatocrinin; Somatorelin; Growth hormone-releasing hormone; GHRH; GHRF	Human	HEK293

HY-P700412

GH1/Somatotropin Protein, Human (HEK293, N-His, C-Myc)
GH; GH-N; GHN; hGH-N; Growth hormone; Pituitary growth hormone; growth hormone 1; GH1; IGHD1B; Somatotropin; hGH
Human HEK293
HY-P70850

Growth Hormone R/GHR Protein, Mouse (HEK293, Fc)
growth hormone binding protein; growth hormone receptor; serum binding protein; Somatotropin receptor; GHR; GH receptor; GHBP
Mouse HEK293

HY-P71244

PTH1R Protein, Human (HEK293, His) Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor; PTH1R	Human	HEK293
PTH1R Protein, Human (HEK 293, His) is a recombinant PTH1R protein with a His-Flag. PTH1R plays an important role in skeletal development and homeostasis.

HY-P73087

Growth Hormone R/GHR Protein, Mouse (HEK293, His)
Growth hormone receptor; GH receptor GHBP; Ghr
Mouse HEK293
HY-P73088

Growth Hormone R/GHR Protein, Rat (HEK293, Fc)
Growth hormone receptor; GH receptor GHBP; Ghr
Rat HEK293
HY-P73089

Growth Hormone R/GHR Protein, Rat (HEK293, His)
Growth hormone receptor; GH receptor GHBP; Ghr
Rat HEK293
HY-P73086

Growth Hormone R/GHR Protein, Mouse (HEK293, His-Fc)
Growth hormone receptor; GH receptor GHBP; Ghr
Mouse HEK293

HY-P70237

FSH Protein, Human (HEK293, Flag-His) rHuFollicle-stimulating hormone/FSH, Flag-His; Follicle-stimulating hormone; FSH; FSH alpha/beta	Human	HEK293
FSH Protein, Human (HEK293, Flag-His) is a recombinant Human Follicle-stimulating hormone (FSH) produced in HEK293 cells, with Flag-His tag. FSH is a glycoprotein polypeptide hormone.

HY-P73686

PTH Protein, Human (GST)
Parathyroid hormone; PTH; Parathormone; Parathyrin
Human E. coli

HY-P72198

FSHR Protein, Human (His) Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; Fshr; FSHR_HUMAN; FSHRO; LGR1; MGC141667; MGC141668; ODG1; ovarian dysgenesis 1	Human	E. coli

HY-P70261

GH/Somatotropin Protein, Mouse rMuSomatotropin/GH; Somatotropin; Growth hormone; Gh1; Gh	Mouse	E. coli
GH/Somatotropin Protein, Mouse is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration, which can be used for the growth disorders research.

HY-P71060

PTH Protein, Human (HEK293, His)
Parathyroid hormone; PTH; Parathormone; Parathyrin; PTH
Human HEK293
HY-P74125

GIP Protein, Human (HEK293, Fc)
Gastric inhibitory polypeptide; GIP; Incretin hormone
Human HEK293
HY-P74125A

GIP Protein, Human (HEK293, Fc, Solution)
Gastric inhibitory polypeptide; GIP; Incretin hormone
Human HEK293

HY-P70205

Progonadoliberin-2/GNRH II Protein, Human (HEK293, His) rHuProgonadoliberin-2/GnRH II, His; Progonadoliberin-2; Progonadoliberin II; Gonadoliberin-2; Gonadoliberin II; Gonadotropin-Releasing hormone II; GnRH II; Luliberin II; Luteinizing hormone-Releasing hormone II; LH-RH II; GnRH-Associated Peptide 2; GnRH-Associated Peptide II; GNRH2	Human	HEK293

HY-P72024

Growth Hormone R/GHR Protein, Human (HEK293, hFc)
Somatotropin receptor Serum-binding protein
Human HEK293
HY-P74133

FSH Protein, Human (HEK293, Fc)
Follicle-stimulating hormone; FSH; FSH alpha/beta
Human HEK293
HY-P700413

Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi)
Somatotropin receptor Serum-binding protein
Human HEK293
HY-P72077

Muellerian-inhibiting factor/AMH Protein, Mouse
Amh; Muellerian-inhibiting factor; Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS
Mouse E. coli
HY-P77147

Placental Lactogen/CSH1 Protein, Human (Biotinylated, HEK293, His)
Chorionic Somatomammotropin hormone; Placental Lactogen; PL; CSH2
Human HEK293
HY-P77146

Placental Lactogen/CSH1 Protein, Human (217a.a, HEK293, His)
Chorionic Somatomammotropin hormone; Placental Lactogen; PL; CSH1
Human HEK293
HY-P71712

Muellerian-inhibiting factor/AMH Protein, Mouse (P.pastoris, His)
Amh; Muellerian-inhibiting factor; Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS
Mouse P. pastoris
HY-P76958

GPHA2 Protein, Human (HEK293, His)
Glycoprotein hormone alpha-2; Putative secreted protein Zsig51; GPA2; ZSIG51
Human HEK293
HY-P76959

GPHA2 Protein, Human (HEK293, Fc)
Glycoprotein hormone alpha-2; Putative secreted protein Zsig51; GPA2; ZSIG51
Human HEK293

HY-P7869

CG alpha Protein, Human (92a.a, HEK293, His) rHuGlycoprotein hormones alpha chain/CGA, His; Anterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; LSH-alph	Human	HEK293

HY-P7870

CGA-CGB3 Heterodimer Protein, Human (HEK293, His) rHuGlycoprotein hormones alpha chain, C-Flag&Choriogonadotropin subunit beta 3, His; Anterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; LSH-alph	Human	HEK293

HY-P77466

PRL8A4 Protein, Rat (HEK293, His)
Prolactin-8A4; Growth hormone-related placental protein 3; PLP-H; Prlph
Rat HEK293

HY-P7871

Placental Lactogen/CSH1 Protein, Human (191a.a, HEK293, His) rHuPlacental Lactogen/CSH1, His; Chorionic Somatomammotropin hormone; Choriomammotropin; Lactogen; Placental Lactogen; PL; CSH1	Human	HEK293

HY-P70238

FSH beta Protein, Human (HEK293, His) rHuFollitropin subunit beta/FSHB, His; Follitropin Subunit Beta; Follicle-Stimulating hormone Beta Subunit; FSH-B; FSH-Beta; Follitropin Beta Chain; FSHB	Human	HEK293

HY-P71917

P4HB Protein, Human (His) Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide Isomerase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_HUMAN; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp;	Human	E. coli

HY-P70013

CRHBP Protein, Human (HEK293, His) rHuCorticotropin-releasing factor-binding protein/CRHBP, His ; Corticotropin-Releasing Factor-Binding Protein; CRF-BP; CRF-Binding Protein; Corticotropin-Releasing hormone-Binding Protein; CRH-BP; CRHBP; CRFBP	Human	HEK293

HY-P71439

ZMYND19 Protein, Human (His) Zinc Finger MYND Domain-Containing Protein 19; Melanin-Concentrating hormone Receptor 1-Interacting Zinc Finger Protein; MCH-R1-Interacting Zinc Finger Protein; ZMYND19; MIZIP	Human	E. coli

HY-P71087

P4HB Protein, Human (HEK293, His) Protein Disulfide-Isomerase; PDI; Cellular Thyroid hormone-Binding Protein; Prolyl 4-Hydroxylase Subunit Beta; p55; P4HB; ERBA2L; PDI; PDIA1; PO4DB	Human	HEK293

HY-P70977

SULT1B1 Protein, Human (His) Sulfotransferase Family Cytosolic 1B Member 1; ST1B1; Sulfotransferase 1B1; Sulfotransferase 1B2; ST1B2; Thyroid hormone Sulfotransferase; SULT1B1; ST1B2; SULT1B2	Human	E. coli

HY-P70239

GLP-1/GCG Protein, Human (HEK293, His) rHuPro-glucagon/GCG, His ; Glucagon; Glicentin; Glicentin-Related Polypeptide; GRPP; Oxyntomodulin; OXM; OXY; Glucagon; Glucagon-Like Peptide 1; GLP-1; Incretin hormone; Glucagon-like Peptide 1; GLP-1; Glucagon-Like Peptide 2; GLP-2; GCG	Human	HEK293

HY-P700159AF

Animal-Free Activin A Protein, Human/Mouse/Rat (His) Activin beta-A chain; EDF; Erythroid differentiation factor; Erythroid differentiation protein; Follicle stimulating hormone releasing protein; FRP; FSH releasing protein; INHBA; INHBA_HUMAN; Inhibin beta A chain; Inhibin beta A subunit; Inhibin, beta 1; Inhibin, beta A activin A, activin AB alpha polypeptide;	Human;Rat;Mouse	E. coli

Cat. No.	Product Name

HY-N7240S

Juvenile Hormone III-d3

Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III[1].

HY-A0070AS2

Liothyronine-13C6-1
Liothyronine-13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

HY-B1617AS

Zuclomiphene-d4 citrate
Zuclomiphene-d₄ (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].

HY-B0672S1

Estradiol valerianate-d4
Estradiol valerianate-d₄ is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-B0672S

Estradiol valerianate-d9
Estradiol valerianate-d₉ is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.

HY-B1161S

Methoprene-d7
Methoprene-d₇ is the deuterium labeled Methoprene[1]. Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist[2][3].

HY-18341S1

Thyroxine hydrochloride-13C6
Thyroxine hydrochloride-¹³C₆ is the ¹³C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].

HY-18341S2

L-Thyroxine-13C6
L-Thyroxine-¹³C₆ is the ¹³C labeled L-Thyroxine[1]. L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[2].

HY-A0070AS1

Liothyronine-13C9,15N
Liothyronine-¹³C₉,¹⁵N is the ¹³C and ¹⁵N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].

HY-N0437S

Progesterone-d9

Progesterone-d₉ is the deuterium labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
HY-16168AS

Degarelix-d7

Degarelix-d₇ is deuterium labeled Degarelix. Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
HY-B0257S1

Norgestrel-d6

Norgestrel-d₆ is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.
HY-B1710S

Norethindrone acetate-D8

Norethindrone acetate-d₈ is the deuterium labeled Norethindrone acetate. Norethindrone acetate is a female hormone used for the research of endometriosis[1].
HY-N0437S2

Progesterone-13C3

Progesterone-¹³C₃ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
HY-N0583S1

Hydrocortisone-d7

Hydrocortisone-d₇ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].
HY-N0583S3

Hydrocortisone-d3

Hydrocortisone-d₃ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].
HY-B0110S

Gestodene-d6

Gestodene-d₆is the deuterium labeled Gestodene. Gestodene(SHB 331) is a progestogen hormonal contraceptive[1][2].
HY-77839S1

Cortodoxone-d2

Cortodoxone-d₂ is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone)[1].
HY-N0437S1

Progesterone-13C5

Progesterone-¹³C₅ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
HY-N0437S3

Progesterone-13C2

Progesterone-¹³C₂ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
HY-N0583S5

Hydrocortisone-d2

Hydrocortisone-d₂ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1][2].

HY-B0648S

Medroxyprogesterone-d3
Medroxyprogesterone-d₃ is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

HY-B0257S

Levonorgestrel-D8

Levonorgestrel-d₈ is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives[1][2].

HY-B1214S

Prednisolone acetate-d8
Prednisolone acetate-d₈ is the deuterium labeled Prednisolone acetate. Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

HY-113414S

Deoxycorticosterone-d8
Deoxycorticosterone-d₈ is the deuterium labeled Deoxycorticosterone. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor[1][2].

HY-B0554S

Norethindrone-d6
Norethindrone-d₆ is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-113114S

Tetrahydrocortisone-d5
Tetrahydrocortisone-d₅ is the deuterium labeled Tetrahydrocortisone. Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase[1].

HY-113114S1

Tetrahydrocortisone-d6
Tetrahydrocortisone-d₆ is the deuterium labeled Tetrahydrocortisone. Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase[1].

HY-113313S2

Aldosterone-d4
Aldosterone-d₄ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by t

HY-76585

Paricalcitol-d6
Paricalcitol-d₆ is the deuterium labeled Paricalcitol. Paricalcitol is a agent used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure[1].

HY-N0384S2

Homovanillic acid-d5
Homovanillic acid-d₅ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-N0384S

Homovanillic acid-d3
Homovanillic acid-d₃ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-N0384S1

Homovanillic acid-d2
Homovanillic acid-d₂ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-16474S

Relugolix-d6

Relugolix-d₆ is deuterium labeled Relugolix. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209)[1]. Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al[2].

HY-N0384S3

Homovanillic acid-13C6,18O
Homovanillic acid-¹³C₆,¹⁸O is the ¹³C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-B0141S

Estradiol-d3
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-B0891S

17α-Hydroxyprogesterone-d8
17α-Hydroxyprogesterone-d₈ is the deuterium labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-B0234S1

Estrone-d2
Estrone-d₂ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B0141S2

Estradiol-d5
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0891S1

17α-Hydroxyprogesterone-13C3
17α-Hydroxyprogesterone-¹³C₃ is the ¹³C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

HY-B0141S3

Estradiol-d2
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S1

Estradiol-d4
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0234S2

Estrone-d4
Estrone-d₄ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B0234S4

Estrone-d2-1
Estrone-d₂-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B1192S

Estradiol benzoate-d3
Estradiol benzoate-d₃ is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].

HY-B0234S

Estrone-13C3
Estrone-¹³C₃ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].

HY-B0141S4

Estradiol-13C6
Estradiol-¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S5

Estradiol-13C2
Estradiol-¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0234S3

Estrone-13C2
Estrone-¹³C₂ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

HY-13632S

Exemestane-d2
Exemestane-d₂ is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

HY-13632S2

Exemestane-d3
Exemestane-d₃ is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

HY-18569S4

3-Indoleacetic acid-13C6
3-Indoleacetic acid-¹³C₆ is the ¹³C labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-18569S3

3-Indoleacetic acid-d7
3-Indoleacetic acid-d₇ is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-B0390S

Mestranol-d2
Mestranol-d₂ is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a?progestin in vivo?and can be used for?the research of menopausal hormone or?menstrual disorders[1][2][3].

HY-13632S1

Exemestane-13C3
Exemestane-¹³C₃ is the ¹³C-labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].

HY-B0390S1

Mestranol-d4
Mestranol-d₄ is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a?progestin in vivo?and can be used for?the research of menopausal hormone or?menstrual disorders[1][2][3].

HY-12956S

Dinoprost-d4
Dinoprost-d₄ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

HY-B0075S

Melatonin-d4
Melatonin-d₄ is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

HY-12956S1

Dinoprost-d9
Dinoprost-d₉ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

HY-101952S1

Prostaglandin E2-d9
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-18569S2

3-Indoleacetic acid-2,2-d2
3-Indoleacetic acid-2,2-d₂ is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-101952S

Prostaglandin E2-d4
Prostaglandin E2-d₄ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-113313S1

Aldosterone-d7

Aldosterone-d₇ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

HY-B1617AS1

Zuclomiphene-d5 citrate
Zuclomiphene-d₅ (citrate) is the deuterium labeled Zuclomiphene citrate[1]. Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[2][3][4][5].

HY-129974S

3,3'-Diiodo-L-thyronine-13C6
3,3'-Diiodo-L-thyronine-¹³C₆ is the ¹³C labeled 3,3'-Diiodo-L-thyronine[1]. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[2][3].

HY-W016784S

Indole-3-

hormone

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