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Results for "

hub

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Inhibitory Antibodies

2

Natural
Products

3

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-171658
    R1-ICR-5

    		PROTACs Ser/Thr Kinase TNF Receptor Toll-like Receptor (TLR) NF-κB p38 MAPK Inflammation/Immunology Cancer
    R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the TNFR1 and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation .
    R1-ICR-5
  • HY-146268
    CaMKIIα-IN-1

    		CaMK Neurological Disease
    CaMKIIα-IN-1 (Compound 4d) is an orally active Ca 2+/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a KD of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability .
    CaMKIIα-IN-1
  • HY-P991640
    Anti-TDGF1 antibody (huB3F6)

    BIIB015 antibody

    		 ADC Antibody Cancer
    Anti-TDGF1 antibody (huB3F6) (BIIB015 antibody) is a CHO-expressed human antibody that targets TDGF1. Anti-TDGF1 antibody has huIgG1 heavy chain and huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-TDGF1 antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001). Anti-TDGF1 antibody (huB3F6) can be used for synthesis of ADCs .
    Anti-TDGF1 antibody (huB3F6)
  • HY-134529
    D-Ribofuranose1-dihydrogenphosphate

    Ribose 1-phosphate

    		 Endogenous Metabolite Others
    D-Ribofuranose 1-dihydrogenphosphate (Ribose 1-phosphate) dicyclohexanamine is a pentose phosphate and serves as a key intermediate metabolite in the salvage synthesis pathway of purine and pyrimidine nucleotides. In nucleotide salvage synthesis, D-Ribofuranose 1-dihydrogenphosphate dicyclohexanamine directly "transfers" the ribosyl group from purine nucleosides to pyrimidine bases, acting as a hub molecule linking nucleoside/base metabolism with pentose phosphate metabolism .
    D-Ribofuranose1-dihydrogenphosphate
  • HY-123161
    JBIR-15

    		Drug Derivative Others
    JBIR-15 is a new aspochracin derivative. JBIR-15 is isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04 .
    JBIR-15
  • HY-RS04295
    ELAVL2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ELAVL2 Human Pre-designed siRNA Set A contains three designed siRNAs for ELAVL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ELAVL2 Human Pre-designed siRNA Set A
    ELAVL2 Human Pre-designed siRNA Set A
  • HY-135167
    HOCPCA

    		CaMK Neurological Disease
    HOCPCA is a compound with neuroprotective activity that improves sensorimotor function in mice after experimental stroke. HOCPCA selectively binds to the CaMKIIα hub domain, modulates signaling of different CaMKII pools, and alleviates abnormal CaMKII signaling after cerebral ischemia. HOCPCA promotes hippocampal neuronal activity and enhances working memory. HOCPCA also normalizes Thr286 autophosphorylation in the cytoplasm after ischemia and downregulates ischemia-specific expression of active CaMKII enzymatic cleavage fragments. HOCPCA binds to the GHB binding site with 27-fold higher affinity than GHB and has good blood-brain barrier penetration ability .
    HOCPCA
  • HY-186075
    PS1097

    		Flavivirus Orthopoxvirus SARS-CoV CHIKV Enterovirus Infection
    PS1097 is a broad-spectrum antiviral inhibitor with a BVDV RdRp IC50 of 0.64 μM. PS1097 selectively reduces RTN3 protein levels, causes partial RTN3 mRNA reduction, and leaves other endoplasmic reticulum-resident proteins unaffected. PS1097 inhibits replication of Zika virus and multiple viruses that use the endoplasmic reticulum as a replication hub. PS1097 inhibits BVDV RdRp enzymatic activity and exerts activity against Bovine Viral Diarrhea Virus. PS1097 can be used for the research of zika virus infection, usutu virus infection, west nile virus infection, COVID-19, coxsackie b virus 5 infection, chikungunya virus infection, vaccinia virus infection .
    PS1097

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