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il-4r-alpha-protein-mouse-hek-293-fc

" in MCE Product Catalog:

By Targets:	Interleukin Related (2)
By Research Areas:	Cancer (1) Inflammation/Immunology (2)

2

Inhibitors & Agonists

2

Inhibitory Antibodies

20

Recombinant Proteins

Targets Recommended: 5 alpha Reductase Interleukin Related IFNAR IRAK α-synuclein PGC-1α Itk

Cat. No.	Product Name	Target	Research Areas

HY-P99724

Manfidokimab
AK120
Interleukin Related Inflammation/Immunology

Manfidokimab (AK120) is an anti-interleukin 4 receptor alpha (IL-4Rα) IgG4 monoclonal antibody.

Dupilumab REGN-668; SAR-231893	Interleukin Related	Inflammation/Immunology Cancer
Dupilumab (REGN-668) is a fully human mAb to *IL-4 receptor α (IL-4Rα)* that inhibits both *IL-4* and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

Cat. No.	Product Name	Target	Research Area

HY-P99724

Manfidokimab
AK120
Interleukin Related Inflammation/Immunology

Manfidokimab (AK120) is an anti-interleukin 4 receptor alpha (IL-4Rα) IgG4 monoclonal antibody.

Dupilumab REGN-668; SAR-231893	Interleukin Related	Inflammation/Immunology Cancer
Dupilumab (REGN-668) is a fully human mAb to *IL-4 receptor α (IL-4Rα)* that inhibits both *IL-4* and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

Species:	Human (5) Rat (2) Mouse (9) Cynomolgus (3) Canine (1)
Tag:	His (7) Tag Free (1) Fc (12)
Source:	HEK293 (20)

Cat. No.	Product Name	Species	Source

IL-4R Protein, Cynomolgus (HEK293, Fc) Interleukin-4 receptor subunit alpha; il4r alpha; il4r; CD124	Cynomolgus	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Cynomolgus consists of 825 amino acids (M1-S825). IL-4R alpha/CD124 Protein, Cynomolgus (M1-R232) is produced in HEK293 cells, including a Fibronectin typr III domain (125-224 a.a) and a C-Terminal hFc-tag.

IL-4R Protein, Cynomolgus (HEK293, His) Interleukin-4 receptor subunit alpha; il4r alpha; il4r; CD124	Cynomolgus	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Cynomolgus consists of 825 amino acids (M1-S825). IL-4R alpha/CD124 Protein, Cynomolgus (M1-R232) is produced in HEK293 cells, including a Fibronectin typr III domain (125-224 a.a) and a C-Terminal His-tag.

IL-4R alpha/CD124 Protein, Rat (HEK293, Fc) Interleukin-4 receptor subunit alpha; il4r alpha; il4r	Rat	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Rat consists of 801 amino acids (M1-S801), exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Rat has an immunoreceptor tyrosine inhibitor motif (ITIM) (698-703 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124, Rat has a a soluble form (1-229 a.a) and a transmembrane domain (233-256 a.a). The soluble IL-4R (sIL4R) inhibits IL4-induced spleen cell proliferation. IL-4R alpha/CD124, Rat (M1-R232) is produced in HEK293 cells, including a Fibronectin typr III domain (125-223 a.a) and a C-Terminal hFc-tag.

IL-4R alpha/CD124 Protein, Mouse (233a.a, HEK293, Fc) Interleukin-4 receptor subunit alpha; il4r alpha; il4r	Mouse	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Mouse consists of 810 amino acids (M1-S810), exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Mouse has an immunoreceptor tyrosine inhibitor motif (ITIM) (707-712 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124, Mouse has a transmembrane domain (234-257 a.a). IL-4R alpha/CD124 Protein, Mouse (R1-R233) is produced in HEK293 cells, including a Fibronectin typr III domain (126-224 a.a) and a C-terminal hFC-tag.

IL-4R alpha/CD124 Protein, Human (HEK293) rHuil-4r; il4r; il-4rA; CD124	Human	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (G24-H232) is produced in HEK293 cells with a full length of 209 amino acids.

HY-P700001

IL-4R alpha protein, Canine (HEK293, His)
Interleukin-4 receptor subunit alpha; il-4 receptor subunit alpha; il-4r subunit alpha; il-4r-alpha; il-4rA; CD124
Canine HEK293

IL-4R alpha/CD124 Protein, Human (HEK293, Fc) Interleukin-4 receptor subunit alpha; il-4 receptor subunit alpha; il-4r subunit alpha; il-4r-alpha; il-4rA; CD124; il-4-binding protein; il4-BP; il4r; il4rA	Human	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M26-Q231) is produced in HEK293 cells with a C-Terminal hFc-tag.

IL-4R alpha/CD124 Protein, Rat (HEK293, His) Interleukin-4 receptor subunit alpha; il-4r-alpha; il-4rA; CD124; il4-BP; il4r	Rat	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Rat consists of 801 amino acids (M1-S801), exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Rat has an immunoreceptor tyrosine inhibitor motif (ITIM) (698-703 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124, Rat has a soluble form (1-229 a.a) and a transmembrane domain (233-256 a.a). The soluble IL-4R (sIL4R) inhibits IL4-induced spleen cell proliferation. IL-4R alpha/CD124 Protein, Rat (M1-R232) is produced in HEK293 cells, including a Fibronectin typr III domain (125-223 a.a) and a C-Terminal His-tag.

IL-4R alpha/CD124 Protein, Human (207a.a, HEK293, His) Interleukin-4 receptor subunit alpha; il-4 receptor subunit alpha; il-4r subunit alpha; il-4r-alpha; il-4rA; CD124; il-4-binding protein; il4-BP; il4r; il4rA	Human	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M26-H232) is produced in HEK293 cells with a C-Terminal His-tag.

IL-4R alpha/CD124 Protein, Human (232a.a, HEK293, His) Interleukin-4 receptor subunit alpha; il-4r-alpha; il-4rA; CD124; il4-BP; il4r	Human	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M1-H232) is produced in HEK293 cells with a C-Terminal His-tag.

IL-4R alpha/CD124 Protein, Human (HEK293, mFc) rHuInterleukin-4 receptor subunit alpha/il-4 RA, mfc; Interleukin-4 receptor subunit alpha; il-4 receptor subunit alpha; il-4r subunit alpha; il-4r-alpha; il-4rA; CD124; il-4-binding protein; il4-BP; il4r; il4rA	Human	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M26-Q231) is produced in HEK293 cells with a C-Terminal mFc-tag.

IL-4R alpha/CD124 Protein, Mouse (HEK293, His) Interleukin-4 receptor subunit alpha; il-4rA; il-4r-alpha; CD124; il4-BP	Mouse	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Mouse consists of 810 amino acids (M1-S810), exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Mouse has an immunoreceptor tyrosine inhibitor motif (ITIM) (707-712 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124, Mouse has a transmembrane domain (234-257 a.a). IL-4R alpha/CD124 Protein, Mouse (I26-R233) is produced in HEK293 cells, including a Fibronectin typr III domain (126-224 a.a) and a C-terminal His-tag.

IL-4R alpha/CD124 Protein, Cynomolgus (HEK293, His) rCynInterleukin-4 receptor subunit alpha/il-4ra, His; Interleukin-4 receptor subunit alpha; il-4r-alpha; CD124; il4-BP; Soluble il-4r-alpha; il-4rA	Cynomolgus	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Cynomolgus consists of 825 amino acids (M1-S825). IL-4R alpha/CD124 Protein, Cynomolgus (M26-R232) is produced in HEK293 cells, including a Fibronectin typr III domain (125-224 a.a) and a C-Terminal His-tag.

IL-4R alpha/CD124 Protein, Mouse (208a.a, HEK293, Fc) rMuInterleukin-4 receptor subunit alpha/il-4rA, fc; Interleukin-4 receptor subunit alpha; il-4r-alpha; CD124; il4-BP; Soluble il-4r-alpha; il-4rA	Mouse	HEK293
IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Mouse consists of 810 amino acids (M1-S810), exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Mouse has an immunoreceptor tyrosine inhibitor motif (ITIM) (707-712 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124, Mouse has a transmembrane domain (234-257 a.a). IL-4R alpha/CD124 Protein, Mouse (I26-R233) is produced in HEK293 cells, including a Fibronectin typr III domain (126-224 a.a) and a C-terminal hFC-tag.

HY-P78341

PILR-alpha Protein, Mouse (HEK293, Fc)
PilRA; FDF03; PilRalpha; PilR-alpha
Mouse HEK293
HY-P74645

PDGF R alpha Protein, Mouse (HEK293, Fc)
Platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGFR-2; CD140a; PDGFRA
Mouse HEK293
HY-P74269

CD8 alpha Protein, Mouse (HEK293, Fc)
T-cell surface glycoprotein CD8 alpha chain; CD8a; CD8A; MAL
Mouse HEK293

*IL-20R alpha Protein, Mouse* (HEK293, Fc)** il-20R-alpha; il-20RA; CRF2-8; il-20R1; ZcytoR7; FLJ40993	Mouse	HEK293
IL-20R alpha Protein (IL20RA) is the alpha subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway. The IL20RA/IL20RB dimer is a receptor for IL-19, IL-20 and IL-24, while the IL20RA/IL10RB dimer is a receptor for IL-26. IL-20R alpha Protein is consists of 553 amino acids (M1-N553) with a transmembrane domain (254-274 a.a.). IL-20R alpha Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal His-tag.

*IL-18R alpha Protein, Mouse* (HEK293, Fc)** Interleukin-18 receptor 1; il-18R1; CDw218a; il-1Rrp; il-18R-alpha; CD218a; il18R1	Mouse	HEK293
IL-18R alpha (interleukin-18 receptor alpha) is an interleukin receptor of the immunoglobulin superfamily. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines. IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6, which phosphorylates nuclear factor kβ- inducing kinase, with subsequent activation of nuclear factor kβ. IL-18R alpha inhibits the production of IFN-γ stimulated with the combination of rhIL-2 and rhIL-18. IL-18R alpha Protein, Mouse (HEK293, Fc) is a recombinant protein with a Fc label that consists of 326 amino acids (M1-G326) and is produced by HEK293 cells.

*IL-10R alpha Protein, Mouse* (HEK293, Fc)** Interleukin-10 receptor subunit alpha; il-10R subunit alpha; il-10RA; CDw210a; Interleukin-10 receptor subunit 1; il-10R1; CD210; il10RA	Mouse	HEK293
IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region (L242-I262) with a -hFc tag at the C-terminus.

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