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Results for "

immunosuppression

" in MCE Product Catalog:

By Targets:	5-HT Receptor (2) Antibiotic (2) Apoptosis (5) Arginase (1) Autophagy (2) Bacterial (2) CD28 (1) CD73 (3) Endogenous Metabolite (1) Eukaryotic Initiation Factor (eIF) (1) Galectin (1) Glucocorticoid Receptor (1) HIV (1) HSV (2) iGluR (1) Interleukin Related (1) Microtubule/Tubulin (1) NF-κB (1) PI3K (1) ROR (1) Syk (1) Tim3 (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (13) Endocrinology (1) Infection (4) Inflammation/Immunology (18) Metabolic Disease (2) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-136978

OP-5244	CD73	Cancer Inflammation/Immunology
OP-5244 is a potent and orally active inhibitor of CD73, with an IC₅₀ of 0.25 nM. OP-5244 reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research.

HY-136978A

OP-5244 sodium	CD73	Cancer Inflammation/Immunology
OP-5244 sodium is a potent and orally active inhibitor of CD73, with an IC₅₀ of 0.25 nM. OP-5244 sodium reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research.

HY-P2251

T-peptide	HIV Microtubule/Tubulin	Cancer Infection Inflammation/Immunology
T-peptide, a Tuftsin analog, can be used for the research of human immunodeficiency virus (HIV) infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection.

HY-113008A

cis-Urocanic acid (Z)-Urocanic acid; cis-UCA	5-HT Receptor	Inflammation/Immunology
cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (K_d=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.

HY-P99044

Sabatolimab MBG453	Tim3	Inflammation/Immunology
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells.

HY-145240

eIF4E-IN-1	Eukaryotic Initiation Factor (eIF)	Cancer Infection
eIF4E-IN-1 is a potent inhibitor of eIF4E. eIF4E-IN-1 inhibits immunosuppression components such as immune checkpoint proteins PD-1, PD-L1, LAG3, TIM3, and/or IDO, in order to inhibit or release immune suppression in certain diseases, such as cancer and infectious disease (extracted from patent WO2021003194A1, compound Y).

HY-17389

Genipin (+)-Genipin	Autophagy	Cancer Metabolic Disease Inflammation/Immunology Neurological Disease
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research.

HY-136198

SRX3207	Syk PI3K	Cancer
SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC₅₀ values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.

HY-N1501

Beta-asarone	Others	Inflammation/Immunology Neurological Disease
Beta-asarone is a major ingredient of Acorus tatarinowii Schott, penetrates blood brain barrier, with the properties of immunosuppression, central nervous system inhibition, sedation, and hypothermy. Beta-asarone protects against Parkinson’s disease.

HY-32736

Triptonide NSC 165677; PG 492	Wnt β-catenin Apoptosis Autophagy	Cancer Inflammation/Immunology
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC₅₀ of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.

HY-137246

CD73-IN-3	CD73	Cancer
CD73-IN-3 is a potent CD73 inhibitor (IC₅₀=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research.

HY-112885A

nor-NOHA acetate Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Cancer Metabolic Disease Inflammation/Immunology
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism.

HY-108813

Belatacept BMS 224818; LEA 29Y	Others	Inflammation/Immunology
Belatacept (BMS 224818) is a selective T-cell costimulation blocker. Belatacept binds to CD 80/86 ligands and thereby inhibits the CD-28-mediated T-cell costimulation. Belatacept can be used in the research of Immunosuppression in organ transplants.

HY-104037

Cintirorgon LYC-55716	ROR	Cancer
Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.

HY-114440

Belapectin GR-MD-02	Galectin Apoptosis	Cancer
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity K_i of 2.8 μM.

HY-113008AS

cis-Urocanic acid-13C3 (Z)-Urocanic acid-¹³C₃; cis-UCA-¹³C₃	5-HT Receptor	Inflammation/Immunology
cis-Urocanic acid-¹³C₃ is the ¹³C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].

HY-136301

Acid secretion-IN-1	Others	Inflammation/Immunology
Acid secretion-IN-1 is a polycyclic compound extracted from patent WO2018024188A1, Compound Example 17.4. Acid secretion-IN-1 is synthesized and used in the IDO inhibitor synthetic experiment.

HY-102090

B7/CD28 interaction inhibitor 1
CD28 Inflammation/Immunology

B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC₅₀ of 50 nM.

B7/CD28 interaction inhibitor 1	CD28	Inflammation/Immunology
B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC₅₀ of 50 nM.

HY-17422A

Acyclovir sodium Aciclovir sodium; Acycloguanosine sodium	HSV Apoptosis Antibiotic Bacterial	Cancer Infection
Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC₅₀ values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia.

HY-110177

SP-100030	NF-κB	Inflammation/Immunology
SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC₅₀s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA).

HY-18620

DZ2002	Others	Inflammation/Immunology
DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (K_i=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis.

HY-17422

Acyclovir Aciclovir; Acycloguanosine	HSV Apoptosis Antibiotic Bacterial	Cancer Infection
Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC₅₀ values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia.

HY-B1618

Corticosterone 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Glucocorticoid Receptor Endogenous Metabolite iGluR	Endocrinology Inflammation/Immunology Neurological Disease
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.

HY-110133

JTE-607	Interleukin Related	Inflammation/Immunology
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607.

Cat. No.	Product Name	Target	Research Area

HY-P2251

T-peptide	HIV Microtubule/Tubulin	Cancer Infection Inflammation/Immunology
T-peptide, a Tuftsin analog, can be used for the research of human immunodeficiency virus (HIV) infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection.

Cat. No.	Product Name	Target	Research Area

HY-P99503

Ziralimumab
ABX-RB2
Inhibitory Antibodies Inflammation/Immunology

Ziralimumab (ABX-RB2) is an anti-human CD147/BSG monoclonal antibody that can be used for immunosuppression.

Ziralimumab ABX-RB2	Inhibitory Antibodies	Inflammation/Immunology
Ziralimumab (ABX-RB2) is an anti-human CD147/BSG monoclonal antibody that can be used for immunosuppression.

HY-P99044

Sabatolimab MBG453	Tim3	Inflammation/Immunology
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells.

Cat. No.	Product Name	Target	Category

HY-17389

Genipin (+)-Genipin	Autophagy	Terpenoids Iridoids Classification of Application Fields Disease Research Fields Inflammation/Immunology Metabolic Disease Neurological Disease Source classification Plants Rubiaceae Gardenia jasminoides Ellis
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research.

HY-N1501

Beta-asarone	Others	Phenylpropanoids Simple Phenylpropanols Source classification Plants Araceae Acorus tatarinowii Schott
Beta-asarone is a major ingredient of Acorus tatarinowii Schott, penetrates blood brain barrier, with the properties of immunosuppression, central nervous system inhibition, sedation, and hypothermy. Beta-asarone protects against Parkinson’s disease.

HY-32736

Triptonide NSC 165677; PG 492	Wnt β-catenin Apoptosis Autophagy	Terpenoids Diterpenoids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Celastraceae Tripterygium wilfordii Hook. f.
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC₅₀ of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.

HY-B1618

Corticosterone 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Glucocorticoid Receptor Endogenous Metabolite iGluR	Steroids Neurological Disease Disease Research Fields Classification of Application Fields Endocrinology Source classification Endogenous metabolite
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.

Cat. No.	Product Name

HY-113008AS

cis-Urocanic acid-13C3
cis-Urocanic acid-¹³C₃ is the ¹³C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].

immunosuppression

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products