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Results for "

immunosuppressive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) AIM2 (1) Antibiotic (6) Antifolate (1) Apoptosis (27) Aryl Hydrocarbon Receptor (3) Autophagy (11) Bacterial (9) Calcineurin (3) Calcium Channel (1) CD73 (6) Complement System (2) Dengue virus (2) Dihydroorotate Dehydrogenase (2) DNA Alkylator/Crosslinker (4) DNA/RNA Synthesis (3) Drug Metabolite (3) EGFR (1) Endogenous Metabolite (10) ERK (1) Ferroptosis (1) FKBP (8) Flavivirus (3) Fungal (4) Glucocorticoid Receptor (14) Glucosidase (1) HBV (2) HCV (1) HDAC (2) HIV (2) HSP (1) IFNAR (2) iGluR (2) Isotope-Labeled Compounds (12) JAK (1) LPL Receptor (3) MAP4K (1) Microtubule/Tubulin (1) Monocarboxylate Transporter (1) mTOR (3) NF-κB (3) NO Synthase (1) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (8) Parasite (2) PD-1/PD-L1 (3) Phosphatase (5) PI4K (1) PKC (1) Potassium Channel (2) Prostaglandin Receptor (1) PROTACs (1) ROS Kinase (1) SHP2 (1) Sigma Receptor (2) Sirtuin (1) STAT (2) TGF-β Receptor (1) Tim3 (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) VD/VDR (1) VEGFR (1) Wnt (1)
By Research Areas:	Cancer (67) Cardiovascular Disease (2) Endocrinology (14) Infection (14) Inflammation/Immunology (95) Metabolic Disease (3) Neurological Disease (6)
Click Chemistry:	Alkynes (1)

129

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110044

MNITMT

Others Inflammation/Immunology

MNITMT is a more potent immunosuppressive agent without bone marrow toxicity .

MNITMT	Others	Inflammation/Immunology
MNITMT is a more potent immunosuppressive agent without bone marrow toxicity .

HY-119499

6-Thioguanosine 6-Mercaptoguanosine	Nucleoside Antimetabolite/Analog	Cancer
6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects .

HY-N7463

Serrin A

Others Others

Serrin A is an immunosuppressive ent-kaurene diterpenoid. Serrin A can be isolated from the aerial parts of Isodon serra .
HY-N10238

Mycestericin G

Endogenous Metabolite Inflammation/Immunology

Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

Serrin A	Others	Others
Serrin A is an immunosuppressive ent-kaurene diterpenoid. Serrin A can be isolated from the aerial parts of Isodon serra .

Mycestericin G	Endogenous Metabolite	Inflammation/Immunology
Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

HY-N10424

Brazilein	Apoptosis	Inflammation/Immunology
Brazilein is an important immunosuppressive component isolated from Caesalpinia sappan L. Brazilein induces apoptosis in mice spleen lymphocytes .

HY-P99292

Fontolizumab HuZAF; Anti-Human IFNG Recombinant Antibody	IFNAR	Inflammation/Immunology
Fontolizumab (HuZAF) is a humanized monoclonal anti-IFN-gamma antibody. Fontolizumab is an immunosuppressive agent. Fontolizumab can be used in research of Crohn’s disease .

HY-B1060

Methylprednisolone succinate sodium Methylprednisolone hydrogen succinate sodium	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium, a glucocorticoid, is a immunosuppressive agent with anti-inflammatory effects .

HY-121397

Phyltetralin	ROS Kinase	Inflammation/Immunology
Phyltetralin (Compound 10) is a natural product than can be isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Phyltetralin possesses immunosuppressive effects on different lineages of innate immune system .

HY-B0214

Prednisone 5+ Cited Publications Dehydrocortisone	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus .

HY-160421

TREM2-IN-1	Others	Inflammation/Immunology Cancer
TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 is capable of relieving immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency .

HY-N3968

Goniothalamin GTN; (R)-(+)-Goniothalamin	Apoptosis	Inflammation/Immunology Cancer
Goniothalamin (GTN) is styryllactone with anticancer, anti-inflammatory, immunosuppressive properties. Goniothalamin induces cytotoxicity, DNA damage and apoptosis of a variety of cancer cell lines .

HY-135670

Glycosidase-IN-1	Glucosidase	Metabolic Disease
Glycosidase-IN-1 (Compound 9) is a glycosidase inhibitor synthesized from D-mannose. Glycosidase-IN-1 be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors. Glycosidase-IN-1 has hypoglycemic activity .

HY-16035

Alatrofloxacin	DNA/RNA Synthesis Antibiotic	Cancer
Alatrofloxacin, the parenteral proagent of Trovafloxacin, is a fluoronaphthyridone which contains an L-alanyl-L-alanyl salt. Alatrofloxacin functions similar to other fluoroquinolone antibiotics in that it not only has antibiotic activity to kill invading organisms by interfering with DNA synthesis, it possesses immunosuppressive activity .

HY-N0854

Alisol F	HBV	Infection
Alisol F is a triterpene isolated from Alisma orinentale, has immunosuppressive and anti-virus functions. Alisol F exhibits inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the HepG2.2.15 cell line with an IC₅₀ of 0.6 μM .

HY-118438

10-Cl-BBQ	Aryl Hydrocarbon Receptor	Inflammation/Immunology
10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations .

HY-156565

S1P1 agonist 6	LPL Receptor	Inflammation/Immunology
S1P1 agonist 6 (Compound I) is a S1P1 agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 can be used as an immunosuppressive agent in the study of various autoimmune diseases research .

HY-13570

Betamethasone 1 Publications Verification	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis .

HY-13570A

Betamethasone hydrochloride	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology
Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis .

HY-108493

CS-2100	LPL Receptor	Inflammation/Immunology
CS-2100 (Compound 10b) is a potent, selective, orally active and S1P₃-sparing S1P₁ agonist with an EC₅₀ of 4.0 nM for human S1P₁. CS-2100 shows in vivo immunosuppressive efficacy in rats with an ID₅₀ (infective dose) of 0.407 mg/kg for HvGR .

HY-N7766

Rubropunctatin	Apoptosis	Inflammation/Immunology Cancer
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity .

HY-13751

SR-31747	Sigma Receptor	Inflammation/Immunology
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .

HY-13751A

SR-31747 free base	Sigma Receptor	Inflammation/Immunology
SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .

HY-14518

Aminopterin 4-Aminofolic acid; APGA	Antifolate	Inflammation/Immunology Cancer
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K_i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia .

HY-100711A

Prodigiosin hydrochloride 1 Publications Verification Prodigiosine hydrochloride	Bacterial Apoptosis Fungal Wnt Parasite	Infection Inflammation/Immunology Cancer
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-P3410

Trichomide A	SHP2 Phosphatase	Inflammation/Immunology
Trichomide A is a potent activator of SHP2. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases .

HY-108050

4-Hydroxyoxyphenbutazone	Bacterial	Infection Inflammation/Immunology
4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard agents. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive agent and has the potential for rheumatoid arthritis research .

HY-A0158

Diflorasone 1 Publications Verification	Others	Inflammation/Immunology
Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis .

HY-P99618

Fidasimtamab IBI-315; BH2950	EGFR PD-1/PD-L1	Inflammation/Immunology Cancer
Fidasimtamab (IBI-315; BH2950) is a recombinant human IgG1 bispecific antibody that targets, binds and inhibits both HER2 and PD-1 and their downstream signalling pathways, and links PD-1 expressing T cells to HER2 expressing tumour cells. Fidasimtamab has potential immunosuppressive and antitumor activity .

HY-156520

Immunosuppressant-1	Apoptosis	Inflammation/Immunology
Immunosuppressant-1 (Compound 31) inhibits anti-CD3/anti-CD28 co-stimulated T-cell proliferation. Immunosuppressant-1 has immunosuppressive activity, and induces apoptosis by activating caspase-3 and PARP in activated lymph node cells .

HY-B0245

Busulfan 5+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-15701B

ADH-503 (Z)-Leukadherin-1 choline	Complement System	Cancer
ADH-503 ((Z)-Leukadherin-1 choline) is an orally active and allosteric CD11b agonist. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses .

HY-123794

MP07-66	Phosphatase	Cancer
MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation .

HY-155175

TIM-3-IN-2	Tim3	Cancer
TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (K_D: 0.61 μM). TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines .

HY-15701A

(Z)-Leukadherin-1 ADH-503 free base	Complement System	Cancer
(Z)-Leukadherin-1 (ADH-503 free base) is an orally active and allosteric CD11b agonist. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses .

HY-B0421

Mycophenolic acid 5+ Cited Publications Mycophenolate	Dengue virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0421A

Mycophenolic acid sodium Mycophenolate sodium	Dengue virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-103721

SIRT6-IN-2	Sirtuin	Cancer
SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC₅₀: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects .

HY-147588

CD73-IN-7	CD73	Cancer
CD73-IN-7 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-7 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022052886A1, compound 13) .

HY-147589

CD73-IN-8	CD73	Cancer
CD73-IN-8 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-8 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022052886A1, compound 57) .

HY-147590

CD73-IN-9	CD73	Inflammation/Immunology
CD73-IN-9 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-9 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022068929A1, compound 2) .

HY-147592

CD73-IN-11	CD73	Inflammation/Immunology Cancer
CD73-IN-11 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-11 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022068929A1, compound 24) .

HY-147591

CD73-IN-10	CD73	Inflammation/Immunology Cancer
CD73-IN-10 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-10 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022068929A1, compound 4) .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-119996A

AR-C141990 hydrochloride	Monocarboxylate Transporter	Inflammation/Immunology
AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pK_i values of 7.6, 6.6 for MCT-1 and MCT-2, respectively . AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response .

HY-119347

Cirsilineol 1 Publications Verification	IFNAR STAT	Inflammation/Immunology Cancer
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 ⁺ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .

HY-161255

3,4-DAA	NO Synthase	Inflammation/Immunology
3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4 ⁺CD25 ⁺ T cells expression . 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide .

HY-106345

ILS-920	FKBP Calcium Channel	Neurological Disease Inflammation/Immunology
ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12 .

HY-150751

ODN TTAGGG ODN A151	Toll-like Receptor (TLR) AIM2	Inflammation/Immunology
ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-N6961

Lapachol 1 Publications Verification	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-B0421S2

Mycophenolic acid-13C17 Mycophenolate-¹³C₁₇	Isotope-Labeled Compounds Flavivirus	Cancer
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

Cat. No.	Product Name	Target	Research Area

HY-P3325

P8RI D-P8RI	Peptides	Inflammation/Immunology
P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway .

HY-P3410

Trichomide A	SHP2 Phosphatase	Inflammation/Immunology
Trichomide A is a potent activator of SHP2. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases .

HY-P5150

alpha-Cobratoxin	Peptides	Neurological Disease
alpha-Cobratoxin is a neurotoxin, which can be isolated from the venom of the Thailand cobra. alpha-Cobratoxin exhibits neuromodulatory, antiviral, and analgesic activity. alpha-Cobratoxin also shows potent immunosuppressive activity for acute and chronic multiple sclerosis. alpha-Cobratoxin is further on research in adrenomyeloneuropathy .

HY-P3316

OSK-1	Potassium Channel	Neurological Disease Inflammation/Immunology
OSK-1 is a potent K_v channel blocker with IC₅₀s of of 0.6 nM, 5.4 nM, 0.014 nM for K_v1.1, K_v1.2 and K_v1.3, respectively. OSK1 is a moderate blocker of Ca ²⁺-activated K_Ca3.1 channel with an IC₅₀ of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent .

HY-P3351

ASP5286

HCV Infection

ASP5286 is a novel non-immunosuppressive cyclophilin inhibitor for the research of HCV.
HY-P5058

Cyclolinopeptide B

Peptides Inflammation/Immunology

Cyclolinopeptide B is a cyclic nonapeptide with immunosuppressive activity on human peripheral blood lymphocytes .

HY-P1354

Cyclosporin A-Derivative 2	Calcineurin	Others
Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-P1973

Cyclosporin B	Peptides	Inflammation/Immunology
Cyclosporin B is a group of nonpolar cyclic oligopeptides with immunosuppressive activity. Cyclosporin B is used for the prevention of graft rejection in organ transplantation .

HY-P4705

Hymenistatin I	Peptides	Inflammation/Immunology
Hymenistatin I is a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-ile-Ile-)] with immunosuppressive activity in both humoral and cellular immune responses .

HY-P1355

Cyclosporin A-Derivative 1	Calcineurin	Inflammation/Immunology
Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-P1355A

Cyclosporin A-Derivative 1 Free base	Calcineurin	Others
Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

Cat. No.	Product Name	Target	Research Area

HY-P99460

Bapotulimab BAY-1905254	Inhibitory Antibodies	Inflammation/Immunology Cancer
Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects .

HY-P99618

Fidasimtamab IBI-315; BH2950	EGFR PD-1/PD-L1	Inflammation/Immunology Cancer
Fidasimtamab (IBI-315; BH2950) is a recombinant human IgG1 bispecific antibody that targets, binds and inhibits both HER2 and PD-1 and their downstream signalling pathways, and links PD-1 expressing T cells to HER2 expressing tumour cells. Fidasimtamab has potential immunosuppressive and antitumor activity .

HY-P99726

Maslimomab

Inhibitory Antibodies Inflammation/Immunology

Maslimomab is a murine monoclonal antibody targeting T-cell receptor. Maslimomab is an immunosuppressive agent .

HY-P99292

Fontolizumab HuZAF; Anti-Human IFNG Recombinant Antibody	IFNAR	Inflammation/Immunology
Fontolizumab (HuZAF) is a humanized monoclonal anti-IFN-gamma antibody. Fontolizumab is an immunosuppressive agent. Fontolizumab can be used in research of Crohn’s disease .

HY-P99569

Telimomab aritox T101-ricin A chain immunotoxin; T101-RTA	Inhibitory Antibodies	Inflammation/Immunology
Telimomab aritox (T101-ricin A chain immunotoxin) is a mouse monoclonal antibody that linked to the A chain of the ricin protein. Telimomab aritox can be used as an immunosuppressive agent .

HY-P99841

Dalutrafusp alfa AGEN-1423; GS-1423	CD73 TGF-β Receptor	Inflammation/Immunology
Dalutrafusp alfa (AGEN-1423; GS-1423) is a specific bifunctional antibody against CD73 and TGF-β, which is involved in the immunosuppressive pathway .

HY-P99475

Betifisolimab MSB-2311	PD-1/PD-L1	Cancer
Betifisolimab (MSB-2311) is a humanized monoclonal antibody directed against the immunosuppressive ligand PD-L1. Betifisolimab has the potential for advanced solid tumors and hematological malignancies research .

HY-P99325

Toralizumab IDEC-131; Anti-Human CD40 ligand Recombinant Antibody	TNF Receptor	Inflammation/Immunology
Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research .

HY-P99963

Sudubrilimab HS636	PD-1/PD-L1	Cancer
Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0214

Prednisone 5+ Cited Publications Dehydrocortisone	Classification of Application Fields Disease Research Fields Endocrinology Cancer	Glucocorticoid Receptor Apoptosis
Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus .

HY-N3968

Goniothalamin GTN; (R)-(+)-Goniothalamin	Structural Classification Natural Products Lythraceae Source classification Plants Lythrum salicaria L.	Apoptosis
Goniothalamin (GTN) is styryllactone with anticancer, anti-inflammatory, immunosuppressive properties. Goniothalamin induces cytotoxicity, DNA damage and apoptosis of a variety of cancer cell lines .

HY-N7463

Serrin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Baccharis darwinii Hook. & Arn.	Others
Serrin A is an immunosuppressive ent-kaurene diterpenoid. Serrin A can be isolated from the aerial parts of Isodon serra .

HY-N10238

Mycestericin G	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity .

HY-N10424

Brazilein	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Pigments Plants Inflammation/Immunology Disease Research Fields Food Research	Apoptosis
Brazilein is an important immunosuppressive component isolated from Caesalpinia sappan L. Brazilein induces apoptosis in mice spleen lymphocytes .

HY-N0854

Alisol F	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Alisma orinentale (Samuel.) Juz. Plants Alismataceae Disease Research Fields	HBV
Alisol F is a triterpene isolated from Alisma orinentale, has immunosuppressive and anti-virus functions. Alisol F exhibits inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the HepG2.2.15 cell line with an IC₅₀ of 0.6 μM .

HY-N7766

Rubropunctatin	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Pigments Disease Research Fields Inflammation/Immunology Food Research	Apoptosis
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity .

HY-100711A

Prodigiosin hydrochloride 1 Publications Verification Prodigiosine hydrochloride	Infection Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Pigments Inflammation/Immunology Disease Research Fields Food Research	Bacterial Apoptosis Fungal Wnt Parasite
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-B0421

Mycophenolic acid 5+ Cited Publications Mycophenolate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Dengue virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0421A

Mycophenolic acid sodium Mycophenolate sodium	Infection Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Dengue virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-119347

Cirsilineol 1 Publications Verification	Laburnum anagyroides Medic. Flavonoids Monophenols Classification of Application Fields Flavones Source classification Phenols Plants Compositae Disease Research Fields Inflammation/Immunology	IFNAR STAT
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 ⁺ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .

HY-N6961

Lapachol 1 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Tabebuia avellanedae Plants Bignoniaceae Naphthalene Quinones Inflammation/Immunology Disease Research Fields	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-N4319

Jasminoside B	Triterpenes Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Disease Research Fields Inflammation/Immunology	Others
Jasminoside B is a natural compound with immunosuppressive activity .

HY-N5028

Enmein	Natural Products Classification of Application Fields Labiatae Source classification Plants Baccharis darwinii Hook. & Arn. Disease Research Fields Inflammation/Immunology	Others
Enmein is isolated from I. serra with immunosuppressive effect .

HY-W012352

2-Hydroxyanthraquinone	Quinones Monophenols Classification of Application Fields Anthraquinones Source classification Morinda umbellata Rubiaceae Phenols Plants Disease Research Fields Cancer	Others
2-Hydroxyanthraquinone, a natural compound, possesses antitumor and immunosuppressive activity .

HY-N3508

Hyponine D (+)-Hyponine D	Alkaloids Classification of Application Fields Source classification Celastraceae Pyridine Alkaloids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology	Others
Hyponine D is an immunosuppressive sesquiterpene alkaloid that could be isolated from Tripterygium wilfordii .

HY-N0423

Sophoricoside	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Sophora japonica (L.) Schott Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones	Others
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-16569

Colchicine 25+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-13677

6-Mercaptopurine 5+ Cited Publications Mercaptopurine; 6-MP	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite
6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

HY-N3103

p-Coumaric Acid Ethyl Ester Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate	Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology	Drug Metabolite
p-Coumaric Acid Ethyl Ester is the ethyl ester of p-Coumaric acid . p-Coumaric Acid is a potential immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis .

HY-32735

Triptolide 35+ Cited Publications PG490	Structural Classification Classification of Application Fields Anti-aging Source classification Celastraceae Plants Tripterygium wilfordii Hook. f. Biological Pesticide Research Agricultural Research Terpenoids Diterpenoids Disease Research Fields Cancer	NF-κB Apoptosis
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-N11906

Diayangambin Syringaresinol dimethyl ether; Lirioresinol C dimethyl ether	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper fimbriulatum C.DC.	Others
Diayangambin (Syringaresinol dimethyl ether; Lirioresinol C dimethyl ether) is a cell proliferation inhibitor with an IC₅₀ value of 1.5 μM against human monocytes. Diayangambin also has immunosuppressive and anti-inflammatory effects .

HY-N11015

Withaphysalin R	Structural Classification Physalis minima Linn. Source classification Plants Solanaceae Steroids	Others
Withaphysalin R (compound 5) is a Withanolide that can be isolated from the Solanaceae. Withanolide is a steroid ester with an ergosterol skeleton, and some of these compounds have some significant activities, including cytotoxic and immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant .

HY-13756A

Tacrolimus monohydrate Maximum Cited Publications 65 Publications Verification FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	Phosphatase FKBP Autophagy Bacterial Antibiotic
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-13756

Tacrolimus Maximum Cited Publications 65 Publications Verification FK506; Fujimycin; FR900506	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Animals Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	Phosphatase FKBP Bacterial Autophagy Antibiotic
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-113573

Protosappanin A PTA	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	JAK STAT
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3 .

HY-128747

α-D-Glucose-1-phosphate disodium	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides Monosaccharides	Endogenous Metabolite
α-D-Glucose-1-phosphate disodium is used as a starting material for synthesis of glucuronic acid. α-D-Glucose-1-phosphate disodium can be used as a cytostatic compound essential for cardiopathic therapy, as an antibiotic, as an immunosuppressive agent, and as a circulatory system therapy element .

HY-128747A

α-D-Glucose-1-phosphate disodium hydrate	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides Monosaccharides	Endogenous Metabolite
α-D-Glucose-1-phosphate disodium hydrate is used as a starting material for synthesis of glucuronic acid. α-D-Glucose-1-phosphate disodium hydrate can be used as a cytostatic compound essential for cardiopathic therapy, as an antibiotic, as an immunosuppressive agent, and as a circulatory system therapy element .

HY-N6857

Armepavine	Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Nymphaeaceae	NF-κB
Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades .

HY-N10092

Saucerneol (-)-Saucerneol	Structural Classification Monophenols Saururaceae Saururus chinensis (Lour.) Baill. Source classification Phenols Plants	Others
Saucerneol is a lignans that can be isolated from Saururus chinensis. Saucerneol inhibits LPS-induced or Con A-induced lymphocytes proliferation. Saucerneol inhibits mixed lymphocyte response. Saucerneol also inhibits mitogens-induced cytokines secretion .

HY-N7119

Cimicifugoside	Triterpenes Classification of Application Fields Terpenoids Source classification Ranunculaceae Plants Cimicifuga foetida Linn. Disease Research Fields Inflammation/Immunology	Others
Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity . Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function .

HY-N6939

Pseudolaric Acid B 1 Publications Verification	Infection Structural Classification Classification of Application Fields Pinaceae Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Cancer	HBV Fungal Apoptosis Autophagy Ferroptosis
Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes . Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy .

HY-N0587

Demethylzeylasteral 2 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Source classification Celastraceae Plants Tripterygium wilfordii Hook. f. Inflammation/Immunology Disease Research Fields	Apoptosis
Demethylzeylasteral is a triterpene compound isolated from Tripterygium wilfordii Hook F, with anti-inflammatory, immunosuppressive and anti-tumor activities . Demethylzeylasteral can significantly alleviates atherosclerosis (AS) . Demethylzeylasteral inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways .

HY-B1618

Corticosterone 25+ Cited Publications 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-B1618R

Corticosterone (Standard) 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard)	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-B0421S2

Mycophenolic acid-13C17

Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-10218S

Everolimus-d4
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2].

HY-13571S

Betamethasone dipropionate-d10
Betamethasone dipropionate-d₁₀ is the deuterium labeled Betamethasone dipropionate. Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.

HY-17420AS

Cyclophosphamide-d8 hydrate
Cyclophosphamide-d₈ (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

HY-13570S

Betamethasone-d5
Betamethasone-d₅ is the deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

HY-13570S1

Betamethasone-d5-1
Betamethasone-d₅-1 is deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

HY-W751099

Corticosterone-13C3
Corticosterone- ¹³C₃ is a ¹³C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.

HY-13677S

6-Mercaptopurine-d2
6-Mercaptopurine-d₂ is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent[1][2].

HY-13571AS1

Beclometasone dipropionate-d10
Beclometasone dipropionate-d₁₀ is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-32735S

Triptolide-d3
Triptolide-d₃ is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].

HY-13571AS

Beclometasone dipropionate-d6
Beclometasone dipropionate-d₆ is deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-13677S1

6-Mercaptopurine-13C2,15N
6-Mercaptopurine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-13756S

Tacrolimus-13C,d2
Tacrolimus- ¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

HY-B0256S

Azathioprine-d3
Azathioprine-d3 (BW 57-322-d3) is the deuterium labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .

HY-B0256S1

Azathioprine-13C4
Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .

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