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impurity

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By Targets:	5-HT Receptor (3) Adrenergic Receptor (1) Angiotensin Receptor (4) Antibiotic (3) Autophagy (2) Bacterial (5) Btk (6) Calcium Channel (1) Cholinesterase (ChE) (1) COX (5) Cytochrome P450 (1) DNA/RNA Synthesis (2) Dopamine Receptor (3) Drug Metabolite (118) EGFR (2) Endogenous Metabolite (1) Estrogen Receptor/ERR (2) Factor Xa (1) Fungal (1) Glucocorticoid Receptor (1) HCV (11) HDAC (1) Histamine Receptor (5) HIV (3) HMG-CoA Reductase (HMGCR) (2) iGluR (1) Influenza Virus (1) Isotope-Labeled Compounds (52) Keap1-Nrf2 (1) mAChR (2) Microtubule/Tubulin (3) NF-κB (1) Opioid Receptor (1) P-glycoprotein (1) PAK (1) Parasite (1) Phosphodiesterase (PDE) (1) PPAR (2) Reactive Oxygen Species (1) Reverse Transcriptase (1) SARS-CoV (3) SGLT (1) Thrombin (1) Toll-like Receptor (TLR) (1) VD/VDR (11) Virus Protease (3)
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COX (5)

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Drug Metabolite (118)

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Endogenous Metabolite (1)

Estrogen Receptor/ERR (2)

Factor Xa (1)

Fungal (1)

Glucocorticoid Receptor (1)

HCV (11)

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Histamine Receptor (5)

HIV (3)

HMG-CoA Reductase (HMGCR) (2)

iGluR (1)

Influenza Virus (1)

Isotope-Labeled Compounds (52)

Keap1-Nrf2 (1)

mAChR (2)

Microtubule/Tubulin (3)

NF-κB (1)

Opioid Receptor (1)

P-glycoprotein (1)

PAK (1)

Parasite (1)

Phosphodiesterase (PDE) (1)

PPAR (2)

Reactive Oxygen Species (1)

Reverse Transcriptase (1)

SARS-CoV (3)

SGLT (1)

Thrombin (1)

Toll-like Receptor (TLR) (1)

VD/VDR (11)

Virus Protease (3)

By Research Areas:

Cancer (30)

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Endocrinology (5)

Infection (27)

Inflammation/Immunology (24)

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Neurological Disease (10)

215

Inhibitors & Agonists

Peptides

MCE Kits

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-76937

Impurity of Doxercalciferol	VD/VDR	Endocrinology
Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.

HY-15264

MC 1046 impurity A of Calcipotriol	VD/VDR	Cancer
MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-15265

Impurity F of Calcipotriol
VD/VDR Cancer

Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

Impurity F of Calcipotriol	VD/VDR	Cancer
Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-13294

Impurity C of Alfacalcidol	VD/VDR	Metabolic Disease
Impurity of Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.

HY-13293

Impurity C of Calcitriol	VD/VDR	Cancer
Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-15266

24R-Calcipotriol PRI 2202; impurity D of Calcipotriol	VD/VDR	Cancer
24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-13292

Impurity B of Calcitriol 1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol	VD/VDR	Cancer
Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-131251

Cetirizine 3-chloro impurity
Drug Metabolite Others

Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro.
HY-131269

Febuxostat impurity 7
Drug Metabolite Others

Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131270

Febuxostat impurity 8
Drug Metabolite Others

Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131271

Febuxostat impurity 6
Drug Metabolite Others

Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131273

Febuxostat amide impurity
Drug Metabolite Others

Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM

Cetirizine 3-chloro impurity	Drug Metabolite	Others
Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro.

*Febuxostat impurity* 7**	Drug Metabolite	Others
Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

*Febuxostat impurity* 8**	Drug Metabolite	Others
Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

*Febuxostat impurity* 6**	Drug Metabolite	Others
Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

Febuxostat amide impurity	Drug Metabolite	Others
Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM

HY-131272

Febuxostat dicarboxylic acid impurity	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

HY-133777

*Ciprofibrate impurity* A**	PPAR	Cancer
Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha.

HY-100663

*Gefitinib impurity* 2**	EGFR	Others
Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.

HY-134686

*Edoxaban impurity* 4**	Factor Xa Thrombin	Cardiovascular Disease
Edoxaban impurity 4 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K_is of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention.

HY-133774

*Trityl olmesartan medoxomil impurity* III**	Drug Metabolite	Others
Trityl olmesartan medoxomil impurity III is an impurity of Trityl olmesartan medoxomil. Trityl olmesartan medoxomil is an intermediate of Olmesartan medoxomil.

HY-131255

Ziprasidone amino acid Ziprasidone impurity C; Ziprasidone open ring impurity	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone amino acid (Ziprasidone Impurity C) is an impurity of Ziprasidone. Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist. Ziprasidone exhibits potent effects of antipsychotic activity .

HY-141410

Fluticasone dimer impurity	Drug Metabolite	Others
Fluticasone dimer impurity is a dimeric impurity of Fluticasone Propionate. Fluticasone propionate is a corticosteroid with comparatively high receptor affinity and topical activity.

HY-131265

*Mesalamine impurity* P**	PPAR PAK NF-κB	Cancer Inflammation/Immunology
Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-131276

Olmesartan lactone impurity	Angiotensin Receptor	Cardiovascular Disease
Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.

HY-133780

*Afatinib impurity* 11**	EGFR Autophagy	Cancer
Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2, respectively.

HY-131256A

*Cetirizine Impurity* C dihydrochloride**	Histamine Receptor	Endocrinology Inflammation/Immunology
Cetirizine Impurity C dihydrochloride is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist^{[1]^{^{[2]^.}}}

HY-131256

*Cetirizine Impurity* C**	Histamine Receptor	Endocrinology Inflammation/Immunology
Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist^{[1]^{^{[2]^.}}}

HY-121899

1-Oxo Ibuprofen Ibuprofen EP impurity J	Drug Metabolite	Others
1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-107495

*Betahistine EP Impurity* C** NSC19005	Histamine Receptor	Inflammation/Immunology
Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA).

HY-100069

*Fluazinam impurity* 1**	Fungal	Infection
Fluazinam impurity 1 is an impurity of Fluazinam with antifungal activity. Fluazinam impurity 1 is active against *Sphaerotheca fuliginea, Pyricularia oryzae* and *Rhizoctonia solani*.

HY-136589

*Verapamil EP Impurity* C hydrochloride** NSC-609249 hydrochloride	Calcium Channel P-glycoprotein Cytochrome P450	Metabolic Disease
NSC-609249 hydrochloride is an *impurity* of Verapamil (HY-14275). Verapamil is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor.

HY-131281

*Ivabradine impurity* 1**	Drug Metabolite	Others
Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.

HY-131282

*Ivabradine impurity* 2**	Drug Metabolite	Others
Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.

HY-131258

*Ibuprofen impurity* 1**	COX	Inflammation/Immunology
Ibuprofen impurity 1 is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-75035

Calcipotriol Impurity C
VD/VDR Inflammation/Immunology

Calcipotriol Impurity C is the impurity of Calcipotriol, Calcipotriol is a ligand of VDR-like receptors.
HY-142217S

Quetiapine dimer impurity-d8
Isotope-Labeled Compounds Drug Metabolite Others

Quetiapine dimer impurity-d₈ is the deuterium labeled Quetiapine dimer impurity[1].

*Calcipotriol Impurity* C**	VD/VDR	Inflammation/Immunology
Calcipotriol Impurity C is the impurity of Calcipotriol, Calcipotriol is a ligand of VDR-like receptors.

*Quetiapine dimer impurity-d8*	Isotope-Labeled Compounds Drug Metabolite	Others
Quetiapine dimer impurity-d₈ is the deuterium labeled Quetiapine dimer impurity[1].

HY-136124

*Cetilistat impurity* 1**	Drug Metabolite	Others
Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat, an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively.

HY-133248

Daclatasvir Impurity C
Drug Metabolite Others

Daclatasvir Impurity C is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor.
HY-133247

Daclatasvir Impurity B
Drug Metabolite Others

Daclatasvir Impurity B is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor.

*Daclatasvir Impurity* C**	Drug Metabolite	Others
Daclatasvir Impurity C is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor.

*Daclatasvir Impurity* B**	Drug Metabolite	Others
Daclatasvir Impurity B is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor.

HY-100087

*Budesonide impurity* C**	Glucocorticoid Receptor	Cancer Inflammation/Immunology
Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist.

HY-133775

Olmesartan impurity	Angiotensin Receptor	Metabolic Disease
Olmesartan impurity is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist has the potential for high blood pressure study.

HY-16675

7-Epi-10-oxo-docetaxel Docetaxel impurity 2	Microtubule/Tubulin	Cancer
7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is a impurity of docetaxel detected by high performance liquid chromatography (HPLC).

HY-W021399S

Lidocaine impurity 5-d6
Isotope-Labeled Compounds Drug Metabolite Others

Lidocaine impurity 5-d₆ is deuterium labeled Lidocaine impurity 5.

*Lidocaine impurity* 5-d6**	Isotope-Labeled Compounds Drug Metabolite	Others
Lidocaine impurity 5-d₆ is deuterium labeled Lidocaine impurity 5.

HY-100640

*Roflumilast Impurity* E**	Phosphodiesterase (PDE)	Inflammation/Immunology
Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a agent which acts as a selective and long-acting inhibitor of the enzyme PDE-4 with an IC₅₀ value of 0.8 nM.

HY-15005B

*Sofosbuvir impurity* C**	Drug Metabolite	Others
Sofosbuvir impurity C is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-I0727

*Sofosbuvir impurity* E**	Drug Metabolite	Others
Sofosbuvir impurity E is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-I0719

*Sofosbuvir impurity* B**	Drug Metabolite	Others
Sofosbuvir impurity B is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-131274

*Fexofenadine Impurity* F**	Drug Metabolite	Others
Fexofenadine Impurity F is the impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.

HY-I0723

*Sofosbuvir impurity* D**	Drug Metabolite	Others
Sofosbuvir impurity D is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-I1196

*Sofosbuvir impurity* L**	HCV	Infection
Sofosbuvir impurity L, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-15005C

*Sofosbuvir impurity* A**	HCV	Infection
Sofosbuvir impurity A, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-131449

*Terazosin dimer impurity* dihydrochloride**	Adrenergic Receptor	Others
Terazosin dimer impurity dihydrochloride, a dimer of Terazosin, is an impurity of Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist.

HY-143984S

Minodronic acid impurity 2-d4
Isotope-Labeled Compounds Drug Metabolite Others

Minodronic acid impurity 2-d₄ is the deuterium labeled Minodronic acid impurity 2[1].
HY-143988S

Nefazodone impurity 3-d6
Isotope-Labeled Compounds Drug Metabolite Others

Nefazodone impurity 3-d₆ is the deuterium labeled Nefazodone impurity 3[1].
HY-143961S

Givinostat impurity 5-d4
Isotope-Labeled Compounds Drug Metabolite Others

Givinostat impurity 5-d₄ is the deuterium labeled Givinostat impurity 5[1].
HY-143975S

Loxapine impurity 2-d8
Isotope-Labeled Compounds Drug Metabolite Others

Loxapine impurity 2-d₈ is the deuterium labeled Loxapine impurity 2[1].
HY-143964S

Irbesartan impurity 14-d4
Isotope-Labeled Compounds Drug Metabolite Others

Irbesartan impurity 14-d₄ is the deuterium labeled Irbesartan impurity 14[1].
HY-144146S

Pramipexole impurity 7-d10
Isotope-Labeled Compounds Drug Metabolite Others

Pramipexole impurity 7-d₁₀ is the deuterium labeled Pramipexole impurity 7[1].
HY-143968S

Ketotifen impurity 3-d4
Isotope-Labeled Compounds Drug Metabolite Others

Ketotifen impurity 3-d₄ is the deuterium labeled Ketotifen impurity 3[1].
HY-143956S

Fluorofenidone impurity 1-d3
Isotope-Labeled Compounds Drug Metabolite Others

Fluorofenidone impurity 1-d₃ is the deuterium labeled Fluorofenidone impurity 1[1].

HY-143954S

*Epinephrine impurity* 19-d3 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Epinephrine impurity 19-d₃ (hydrochloride) is the deuterium labeled Epinephrine impurity 19[1].

HY-144913S

Bempedoic acid impurity 1-d4
Isotope-Labeled Compounds Others

Bempedoic acid impurity 1-d₄ is the deuterium labeled Bempedoic acid impurity 1[1].
HY-143963S

Irbesartan impurity 20-d4
Isotope-Labeled Compounds Drug Metabolite Others

Irbesartan impurity 20-d₄ is the deuterium labeled Irbesartan impurity 20[1].
HY-143980S

Losartan impurity 21-d4
Isotope-Labeled Compounds Drug Metabolite Others

Losartan impurity 21-d₄ is the deuterium labeled Losartan impurity 21[1].
HY-143951S

Disulfiram impurity 1-d10
Isotope-Labeled Compounds Drug Metabolite Others

Disulfiram impurity 1-d₁₀ is the deuterium labeled Disulfiram impurity 1[1].
HY-143974S

Imiquimod impurity 1-d6
Isotope-Labeled Compounds Drug Metabolite Others

Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].
HY-143970S

Ivabradine impurity 7-d6
Isotope-Labeled Compounds Drug Metabolite Others

Ivabradine impurity 7-d₆ is the deuterium labeled Ivabradine impurity 7[1].

HY-I0515

*Sofosbuvir impurity* K**	HCV	Infection
Sofosbuvir impurity K, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0512

*Sofosbuvir impurity* I**	HCV	Infection
Sofosbuvir impurity I, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0513

*Sofosbuvir impurity* N**	HCV	Others
Sofosbuvir impurity N, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0938

*Sofosbuvir impurity* H**	HCV	Infection
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0975

*Sofosbuvir impurity* J**	HCV	Infection
Sofosbuvir impurity J, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0735

*Sofosbuvir impurity* M**	HCV	Infection
Sofosbuvir impurity M, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0406

*Sofosbuvir impurity* F**	HCV	Infection
Sofosbuvir impurity F, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0408

*Sofosbuvir impurity* G**	HCV	Others
Sofosbuvir impurity G, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-128696

Amlodipine aspartic acid impurity Amlodipine aspartate	Drug Metabolite	Cardiovascular Disease
Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties.

HY-136142

Prasugrel chloride impurity	Drug Metabolite	Others
Prasugrel chloride impurity is a catp impurity of Prasugrel, exacted from patent US20130345428A1, line 0053. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.

HY-133779

*Gefitinib impurity* 5**	Drug Metabolite	Others
Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.

HY-131257

*Gefitinib impurity* 1**	Drug Metabolite	Others
Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.

HY-143938S

*Cyclobenzaprine impurity* 2-d3 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Cyclobenzaprine impurity 2-d₃ (hydrochloride) is the deuterium labeled Cyclobenzaprine impurity 2 hydrochloride[1].

HY-144142S

*Orphenadrine impurity* 6-d3 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Orphenadrine impurity 6-d₃ (hydrochloride) is the deuterium labeled Orphenadrine impurity 6 hydrochloride[1].

HY-143960S

*Givinostat impurity* 1-d10 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Givinostat impurity 1-d₁₀ (hydrochloride) is the deuterium labeled Givinostat impurity 1 hydrochloride[1].

HY-144141S

*Nortriptyline impurity* 3-d3 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Nortriptyline impurity 3-d₃ (hydrochloride) is the deuterium labeled Nortriptyline impurity 3 hydrochloride[1].

HY-131259

*Ibuprofen Impurity* F**	COX	Inflammation/Immunology
Ibuprofen Impurity F is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-131260

*Ibuprofen Impurity* K**	COX	Inflammation/Immunology
Ibuprofen Impurity K is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-128723

Dapagliflozin impurity
SGLT Others

Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor.
HY-131280

Devaleryl Valsartan Impurity
Drug Metabolite Others

Devaleryl Valsartan Impurity is an intermediate in the synthesis of Valsartan.

HY-131107

*Cefpodoxime proxetil impurity* B**	Bacterial Antibiotic	Infection
Cefpodoxime proxetil impurity B is an impurity of Cefpodoxime proxetil (HY-N7101). Cefpodoxime Proxetil is a first oral and broad spectrum antibiotic that belongs to the third generation of cephalosporin.

HY-143965S

*Imidacloprid impurity* 2-d4 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Imidacloprid impurity 2-d₄ (hydrochloride) is the deuterium labeled Imidacloprid impurity 2-d₄ (hydrochloride)[1].

HY-144242S

Voriconazole EP impurity D-d3
Isotope-Labeled Compounds Drug Metabolite Others

Voriconazole EP impurity D-d₃ is the deuterium labeled Voriconazole EP impurity D[1].
HY-143990S

Modafinil EP impurity B-d5
Isotope-Labeled Compounds Drug Metabolite Others

Modafinil EP impurity B-d₅ is the deuterium labeled Modafinil EP impurity B[1].
HY-142592S

Clozapine EP impurity D-d8
Isotope-Labeled Compounds Drug Metabolite Others

Clozapine EP impurity D-d₈ is the deuterium labeled Clozapine EP impurity D[1].
HY-143987S

DM51 impurity 1-d9
Isotope-Labeled Compounds Drug Metabolite Others

DM51 impurity 1-d₉ is the deuterium labeled DM51 impurity 1[1].
HY-143986S

DM50 impurity 1-d9
Isotope-Labeled Compounds Drug Metabolite Others

DM50 impurity 1-d₉ is the deuterium labeled DM50 impurity 1[1].
HY-143907S

Atorvastatin EP impurity H-d5
Isotope-Labeled Compounds Drug Metabolite Others

Atorvastatin EP impurity H-d₅ is the deuterium labeled Atorvastatin EP impurity H[1].
HY-143977S

Loxapine impurity 3-d8 iodide
Isotope-Labeled Compounds Drug Metabolite Others

Loxapine impurity 3-d₈ (iodide) is the deuterium labeled Loxapine impurity 3 iodide[1].

HY-143941S

*Hydroxychloroquine EP impurity* D-d5 dihydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Hydroxychloroquine EP impurity D-d₅ (dihydrochloride) is the deuterium labeled Hydroxychloroquine EP impurity D dihydrochloride[1].

HY-144203S

Trospium EP impurity C-d8 chloride
Isotope-Labeled Compounds Drug Metabolite Others

Trospium EP impurity C-d₈ (chloride) is the deuterium labeled Trospium EP impurity C chloride[1].

HY-143982S

*Mianserin EP impurity* E-d4 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Mianserin EP impurity E-d₄ (hydrochloride) is the deuterium labeled Mianserin EP impurity E hydrochloride[1].

HY-136185

Atorvastatin Epoxy Tetrahydrofuran Impurity	Drug Metabolite	Others
Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation products of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.

HY-100660A

*Cetirizine Impurity* B dihydrochloride**	Drug Metabolite	Others
Cetirizine Impurity B dihydrochloride is an impurity of Cetirizine dihydrochloride. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.

HY-100661

*Cetirizine Impurity* D**	Histamine Receptor	Endocrinology Inflammation/Immunology
Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.

HY-16674

10-Oxo Docetaxel Docetaxel impurity 1	Microtubule/Tubulin	Cancer
10-Oxo Docetaxel (Docetaxel Impurity 1) is a novel taxoid having remarkable anti-tumor properties and a Docetaxel intermediate.

HY-131263

*Hydroxychloroquine Impurity* F**	Drug Metabolite	Others
Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.

HY-143986S1

DM50 impurity 1-d9-1
Isotope-Labeled Compounds Drug Metabolite Others

DM50 impurity 1-d₉-1 is the deuterium labeled DM50 impurity 1[1].

HY-13592

HDAC-IN-7 Chidamide impurity	HDAC	Cancer
HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor.

HY-143985S

Maytansinoid DM4 impurity 5-d6
Isotope-Labeled Compounds Drug Metabolite Others

Maytansinoid DM4 impurity 5-d₆ is the deuterium labeled Maytansinoid DM4 impurity 5[1].
HY-144221S

Tiotropium bromide EP impurity A-d6
Isotope-Labeled Compounds Drug Metabolite Others

Tiotropium bromide EP impurity A-d₆ is the deuterium labeled Tiotropium bromide EP impurity A[1].
HY-143992S

Maytansinoid DM4 impurity 2-d6
Isotope-Labeled Compounds Drug Metabolite Others

Maytansinoid DM4 impurity 2-d₆ is the deuterium labeled Maytansinoid DM4 impurity 2[1].

HY-143997S

*(Rac)-Nicotine EP impurity* A-d4 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
(Rac)-Nicotine EP impurity A-d₄ (hydrochloride) is the deuterium labeled (Rac)-Nicotine EP impurity A hydrochloride[1].

HY-143993S

Maytansinoid DM4 impurity 3-d6
Isotope-Labeled Compounds Drug Metabolite Others

Maytansinoid DM4 impurity 3-d₆ is the deuterium labeled Maytansinoid DM4 impurity 3[1].
HY-143925S

Betahistine impurity 5-13C,d3
Isotope-Labeled Compounds Drug Metabolite Others

Betahistine impurity 5-¹³C,d₃ is the ¹³C- and deuterium labeled Betahistine impurity 5[1].

HY-137768

*Captopril EP Impurity* B**	Drug Metabolite	Others
Captopril EP Impurity B is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM).

HY-137772

*Captopril EP Impurity* E**	Drug Metabolite	Others
Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM).

HY-134753

*Teriflunomide impurity* 3** 4-Amino-N-(4-trifluoromethylphenyl)benzamide	COX	Inflammation/Immunology
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC₅₀ of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC₅₀>100 µM).

HY-131264

*Olmesartan medoxomil impurity* C** Dehydro Olmesartan medoxomil	Angiotensin Receptor	Metabolic Disease
Olmesartan medoxomil impurity C is an Olmesartan medoxomil impurity. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC₅₀ of 66.2 μM.

HY-136597

Remdesivir O-desphosphate acetonide impurity	DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

HY-136586

Loperamide phenyl
Opioid Receptor Metabolic Disease Neurological Disease

Loperamide phenyl is an impurity of Loperamide (HY-B0418A). Loperamide is an opioid receptor agonist.

HY-100079

9-Propenyladenine Mutagenic impurity of Tenofovir Disoproxil; Tenofovir impurity 2	HIV	Infection
9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase inhibitors, which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

HY-144150S

Pelubiprofen impurity 2-13C2,d6
Isotope-Labeled Compounds Drug Metabolite Others

Pelubiprofen impurity 2-¹³C₂,d₆ is the ¹³C- and deuterium labeled Pelubiprofen impurity 2[1].

HY-W015332

*Captopril EP Impurity* D** 3-Bromoisobutyric acid	Drug Metabolite	Others
Captopril EP Impurity D is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM).

HY-W013886

*Captopril EP Impurity* J** S-Acetylcaptopril	Drug Metabolite	Others
Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM).

HY-137769

*Captopril EP Impurity* C** 3-Mercaptoisobutyric acid	Drug Metabolite	Others
Captopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM).

HY-100648

Keto Ziprasidone	5-HT Receptor Dopamine Receptor	Neurological Disease
Keto Ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.

HY-131275

*Imatinib Impurity* E**	Drug Metabolite	Others
Imatinib Impurity E is the impurity of Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

HY-W178868S

Lodoxamide impurity 1-d5
Isotope-Labeled Compounds Drug Metabolite Others

Lodoxamide impurity 1-d₅ is deuterium labeled n-Ethyl-2-hydroxyacetamide.
HY-W270557S

Lodoxamide impurity 2-d10
Isotope-Labeled Compounds Drug Metabolite Others

Lodoxamide impurity 2-d₁₀ is deuterium labeled 2-(Diethylamino)-2-oxoacetic acid.
HY-131267

Febuxostat sec-butoxy acid
Drug Metabolite Others

Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-131253

Febuxostat isopropyl isomer
Drug Metabolite Others

Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.

HY-Z1430S

*Paroxetine EP impurity* D-d4 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Paroxetine EP impurity D-d₄ (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity）.

HY-131579

Deschloro Cetirizine dihydrochloride	Drug Metabolite	Inflammation/Immunology
Deschloro Cetirizine Dihydrochloride is a Cetirizine impurity. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist.

HY-13204S2

rel-Biperiden EP impurity A-d5
mAChR Neurological Disease

rel-Biperiden EP impurity A-d₅ is deuterium labeled Biperiden (hydrochloride).
HY-13204S3

rel-Biperiden EP impurity B-d5
mAChR Neurological Disease

rel-Biperiden EP impurity B-d₅ is deuterium labeled Biperiden (hydrochloride).
HY-131266

Febuxostat n-butyl isomer
Drug Metabolite Others

Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM.
HY-20390S

Lapatinib impurity 18-d4
Isotope-Labeled Compounds Drug Metabolite Others

Lapatinib impurity 18-d₄ is deuterium labeled 3-Chloro-4-((3-fluorobenzyl)oxy)aniline.

HY-135356

m-Nifedipine	Drug Metabolite	Cardiovascular Disease
m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-136583

28-Epirapamycin
Drug Metabolite Others

28-Epirapamycin is an impurity of Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells.

HY-135358

(Rac)-5-Keto Fluvastatin 3-Hydroxy-5-Keto Fluvastatin	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease
(Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) is an impurity of Fluvastatin (XU 62320). Fluvastatin is a HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM.

HY-133776

Rivastigmine carbamate impurity 3-Nitrophenyl ethyl(methyl)carbamate	Cholinesterase (ChE)	Neurological Disease
Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively.

HY-Z2106S

*Vonoprazan impurity* 11-d5 fumarate**	Isotope-Labeled Compounds Drug Metabolite	Others
Vonoprazan impurity 11-d₅ (fumarate) is deuterium labeled 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylmethanamine (Vonoprazan Impurity).

HY-133624

1,1,3-Tribromoacetone	Drug Metabolite	Cancer
1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.

HY-66004

4-Acetamidophenyl acetate	Bacterial Parasite	Inflammation/Immunology Cancer
4-Acetamidophenyl acetate is an impurity of Acetaminophen (paracetamol). Acetaminophen, an analgesic agent, is a selective COX-2 inhibitor (IC₅₀=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-135359

RP 48497	Drug Metabolite	Neurological Disease
RP 48497, an impurity of Eszopiclone, is a photodegradation product of Eszopiclone. Eszopiclone is a non-benzodiazepine agent used in the treatment of insomnia.

HY-125691

LY-338979
Pemetrexed 6-oxo diacid impurity
Drug Metabolite Cancer

LY-338979 (Pemetrexed 6-oxo diacid impurity) is a metabolite of LY231514 (Pemetrexed; HY-10820).
HY-105967A

Dicresulene diammonium
Bacterial Infection

Dicresulene diammonium is an impurity of Policresulen, an organic acid with hemostatic, antimicrobial and antiviral activities.

HY-135375

O-Methyl Atorvastatin hemicalcium	Drug Metabolite	Metabolic Disease Inflammation/Immunology
O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.

HY-131262

*Hydroxychloroquine Impurity* E** 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol	SARS-CoV Toll-like Receptor (TLR)	Others
Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.

HY-135325

4-Hydroxyacetophenone oxime	Drug Metabolite	Inflammation/Immunology
4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic agent.

HY-133246

Monodes(N-carboxymethyl)valine Daclatasvir Daclatasvir impurity A	HCV	Infection
Monodes(N-carboxymethyl)valine Daclatasvir (Daclatasvir Impurity A) is the main degradation product of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor.

HY-135374

(3R,5S)-Atorvastatin sodium	Drug Metabolite	Metabolic Disease Inflammation/Immunology
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively.

HY-135397

(R)-Linezolid (R)-PNU-100766	Drug Metabolite	Infection
(R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis.

HY-W336012S

*Metoprolol EP impurity* O-d7 hydrochloride**	Isotope-Labeled Compounds Drug Metabolite	Others
Metoprolol EP impurity O-d₇ (hydrochloride) is the deuterium labeled 3,3'-(Isopropylazanediyl)bis(1-(4-(2-methoxyethyl)phenoxy)propan-2-ol)[1].

HY-14881S2

*Bedaquiline impurity* 2-d6**	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[2].

HY-135363

Valsartan Ethyl Ester	Angiotensin Receptor	Cardiovascular Disease
Valsartan Ethyl Ester is an impurity of Valsartan. Valsartan is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.

HY-100657

meta-Fexofenadine meta-MDL-16455; meta-Terfenadine carboxylate	Drug Metabolite	Inflammation/Immunology
meta-Fexofenadine (meta-MDL-16455) is an impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.

HY-148053

Rezivertinib analogue 1	Drug Metabolite	Cancer
Rezivertinib analogue 1 is a process *impurity* of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer.

HY-100079A

(Z)-9-Propenyladenine (Z)-Mutagenic impurity of Tenofovir Disoproxil	HIV	Infection
(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

HY-135151

Difluoro atorvastatin Fluoroatorvastatin	Drug Metabolite	Cardiovascular Disease
Difluoro atorvastatin (Fluoroatorvastatin) is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively.

HY-136613

Demethyl linezolid	Bacterial	Infection
Demethyl linezolid is a impurity of linezolid. Demethyl linezolid is a useful antimicrobial agent extracted from patent WO1995007271A1, example 9, effective against a number of human and veterinary pathogens.

HY-104077S2

*Remdesivir impurity* 9-d4**	DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir impurity 9-d₄ is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

HY-135194

Risperidone E-oxime	Drug Metabolite	Others
Risperidone E-oxime is an impurity of Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .

HY-135373

Desfluoro-atorvastatin	Drug Metabolite	Metabolic Disease Inflammation/Immunology
Desfluoro-atorvastatin is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.

HY-135330

Lamivudine 13C,15N2	HIV Reverse Transcriptase	Infection
Lamivudine 13C,15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus.

HY-136059

Desfluoro-ezetimibe	Keap1-Nrf2 Autophagy	Cancer Cardiovascular Disease
Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-135404

Anhydrosimvastatin Dehydro simvastatin	Drug Metabolite	Cardiovascular Disease Cancer
Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase.

HY-16676

7-Epi-docetaxel
4-epi-Docetaxel; 7-Epidocetaxel; 7-Epitaxotere
Microtubule/Tubulin Cancer

7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere) is a impurity of docetaxel.

HY-N2396

N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide	Drug Metabolite	Others
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide (Macamide impurity 10) is the impurity of Macamide.

HY-75041

Calcitriol Impurities A	VD/VDR	Metabolic Disease
Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-77274

Calcitriol Impurities D	VD/VDR	Metabolic Disease
Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-136381

N-Nitrosoglyphosate sodium N-Nitroso-N-(phosphonoMethyl)glycine sodium; Glyphosate-N-nitroso sodium	Drug Metabolite	Others
N-Nitrosoglyphosate sodium is the nitrosamine degradation product and synthetic impurity of glyphosate herbicide.

HY-115292

Simvastatin hydroxy acid sodium Tenivastatin sodium; Simvastatin impurity A sodium	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Inflammation/Immunology Cardiovascular Disease
Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.

HY-Y0607S

4-Nitrobenzoic acid-d4	Isotope-Labeled Compounds	Others
4-Nitrobenzoic acid-d₄ is the deuterium labeled 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate (Vonoprazan Impurity）[1].

HY-145482

W36017
Drug Metabolite Neurological Disease

W3601 is the impurity of Lidocaine. W3601 exhibits nerve blocking activity with the pK_a of 7.4.

HY-43575

Oseltamivir-acetate	Influenza Virus	Infection
Oseltamivir-acetate is an impurity of Oseltamivir. Oseltamivir is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

HY-B2121

6-Methoxy-2-naphthoic acid
Naproxen impurity O
iGluR Neurological Disease

6-Methoxy-2-naphthoic acid is an NMDA receptor modulator extracted from patent WO 2012019106 A2.

HY-118139

Desmethyl Celecoxib	COX	Inflammation/Immunology
Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC₅₀=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%.

HY-137773

N-Methyl pemetrexed
Drug Metabolite Cancer

N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer.
HY-133110

Afatinib N-Oxide
Drug Metabolite Others

Afatinib N-Oxide is an impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor.

HY-135101

Methotrexate γ-Methyl Ester Methotrexate 5-methyl ester; γ-EMTX	Others	Others
Methotrexate γ-Methyl Ester (Methotrexate 5-methyl ester) is an impurity of the folate antagonist Methotrexate (HY-14519).

HY-Z9063

1-epi-Regadenoson
Drug Metabolite Others

1-epi-Regadenoson is an αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist.

HY-Z1917S

(S)-1-(6-amino-9H-purin-9-yl)propan-2-ol-d6	Isotope-Labeled Compounds	Others
(S)-1-(6-amino-9H-purin-9-yl)propan-2-ol-d₆ is the deuterium labeled (S)-1-(6-amino-9H-purin-9-yl)propan-2-ol? (Tenofovir Impurity）[1].

HY-78727

Ibrutinib deacryloylpiperidine IBT4A	Btk	Cancer
Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM.

HY-136434

m-Chloramphenicol m-threo-Chloramphenicol	Antibiotic	Others
m-Chloramphenicol (m-threo-Chloramphenicol) is an impurity of Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis.

HY-135180

1H-1-Ethyl Candesartan Cilexetil
Drug Metabolite Others

1H-1-Ethyl Candesartan Cilexetil is a potential impurity found in bulk preparations of Candesartan Cilexetil (HY-17505).

HY-100649

Hydroxy ziprasidone	5-HT Receptor Dopamine Receptor	Neurological Disease
Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.

HY-Z9064

1-epi-Regadenoson ethyl ester	Others	Others
1-epi-Regadenoson ethyl ester is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist.

HY-135410

ABZ-amine Amino albendazole	Drug Metabolite	Infection
ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations.

HY-Z9065

1-epi-Regadenoson hydrazone	Others	Others
1-epi-Regadenoson hydrazone is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist.

HY-128379

Labetalone hydrochloride	Drug Metabolite	Others
Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites.

HY-136113

Ibrutinib dimer	Btk	Cancer
Ibrutinib dimer is a Dimer of Ibrutinib. Ibrutinib dimer is an impurity of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM.

HY-Z0081

2S,4R-Sacubitril	Drug Metabolite	Cardiovascular Disease
2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

HY-78847

2R,4S-Sacubitril	Drug Metabolite	Cardiovascular Disease
2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

HY-78841

(2S,4S)-Sacubitril	Drug Metabolite	Cardiovascular Disease
(2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure.

HY-78846

2R,4R-Sacubitril	Drug Metabolite	Cardiovascular Disease
2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

HY-18719D

Endoxifen (E-isomer) E-Endoxifen	Estrogen Receptor/ERR	Cancer
Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer exhibits antiestrogenic effects.

HY-W016644

(S)-1-Benzylpyrrolidin-3-ol	Others	Others
(S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322).

HY-135381

3-Oxo Atorvastatin	Drug Metabolite	Cardiovascular Disease
3-Oxo Atorvastatin is an impurity of 3-Oxo Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.

HY-18719C

Endoxifen E-isomer hydrochloride E-Endoxifen hydrochloride	Estrogen Receptor/ERR	Cancer
Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects.

HY-Z0075

(Z)2S,4R-Sacubitril	Drug Metabolite	Cardiovascular Disease
(Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

HY-131279

Olmesartan ethyl ester	Drug Metabolite	Others
Olmesartan ethyl ester (compound 11) is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to in the high blood pressure study.

HY-135379

Atorvastatin acetonide	Drug Metabolite	Cardiovascular Disease
Atorvastatin acetonide is an impurity of Atorvastatin, and extracted from patent WO2011131605A1, Compound 4. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.

HY-131284

(S)-Dehydro Venlafaxine	Drug Metabolite	Others
(S)-Dehydro Venlafaxine is an inactive S-enantiomer of Dehydro Venlafaxine. Dehydro Venlafaxine is an impurity of Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a potent serotonin (5-HT) / norepinephrine (NE) reuptake dual inhibitor.

HY-12966

Cetirizine methyl ester	Histamine Receptor	Endocrinology Inflammation/Immunology
Cetirizine methyl ester is an impurity of Cetirizine (HY-17042). Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist.

HY-133772

Venetoclax N-oxide	Drug Metabolite	Others
Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM.

HY-13036A

IBT6A	Btk	Cancer
IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM.

HY-13036B

IBT6A hydrochloride	Btk	Cancer
IBT6A hydrochloride is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM.

HY-Z3421S1

Vonoprazan-d4 fumarate	Isotope-Labeled Compounds	Others
Vonoprazan-d₄ (fumarate) is deuterium labeled 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate (Vonoprazan Impurity）.

HY-135377

Atorvastatin 3-Deoxyhept-2E-Enoic Acid (2E)-2,3-Dehydroxy Atorvastatin	Drug Metabolite	Metabolic Disease Inflammation/Immunology
Atorvastatin 3-Deoxyhept-2E-Enoic Acid ((2E)-2,3-Dehydroxy Atorvastatin) is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.

HY-13036C

(Rac)-IBT6A hydrochloride	Btk	Cancer
(Rac)-IBT6A hydrochloride is a racemate of IBT6A hydrochloride. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM.

HY-13036

(Rac)-IBT6A	Btk	Cancer
(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM.

HY-100657S

Meta-Fexofenadine-d6 meta-MDL-16455-d₆; meta-Terfenadine carboxylate-d₆	Isotope-Labeled Compounds	Inflammation/Immunology
Meta-Fexofenadine-d₆ is the deuterium labeled meta-Fexofenadine. meta-Fexofenadine (meta-MDL-16455) is an impurity of Fexofenadine[1]. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial[2].

HY-15398A

5,6-trans-Vitamin D3 5,6-trans-Cholecalciferol; 5,6-trans-Colecalciferol; Cholecalciferol EP impurity A	VD/VDR	Metabolic Disease
5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct of vitamin D3. Vitamin D3 is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-145949

Remdesivir de(ethylbutyl 2-aminopropanoate)	Drug Metabolite	Infection
Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC₅₀s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

HY-112023

Lumisterol 3 (>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP impurity C	Endogenous Metabolite	Metabolic Disease
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D.

HY-136573

5-Hydroxytoluene-2,4-disulphonic acid diammonium	Virus Protease	Infection
5-Hydroxytoluene-2,4-disulphonic acid diammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability.

HY-136575

4-Hydroxy-2-methylbenzenesulfonic acid ammonium	Virus Protease	Infection
4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability.

HY-136574

2-Hydroxy-4-methylbenzenesulphonic acid ammonium	Virus Protease	Infection
2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability.

HY-Z4561S

Bortezomib trimer-d15	Isotope-Labeled Compounds	Others
Bortezomib trimer-d₁₅ is deuterium labeled N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-phenylpropane-1,2-diyl))tris(pyrazine-2-carboxamide)（Bortezomib Impurity）.

Cat. No.	Product Name	Target	Research Area

HY-P4457

Leuprolide Acetate EP Impurity D
Peptides Cancer

Leuprolide Acetate EP Impurity D is the impurity of Leuprolide (Leuprorelin).
HY-P4454

Goserelin EP Impurity E
Peptides Cancer

Goserelin EP Impurity E is the impurity of Goserelin (HY-13673).