independent

By Targets:	Adenosine Receptor (1) Adrenergic Receptor (1) Akt (2) AMPK (1) Androgen Receptor (2) Angiotensin Receptor (1) Antibiotic (2) Apelin Receptor (APJ) (2) Apoptosis (42) Arrestin (1) ASCT (1) Autophagy (14) Bacterial (3) Bcl-2 Family (1) Beta-lactamase (1) Biochemical Assay Reagents (2) c-Kit (1) c-Met/HGFR (1) c-Myc (2) Calcium Channel (2) Caspase (3) CD38 (1) CDK (1) CFTR (1) COX (4) CXCR (1) Discoidin Domain Receptor (1) DNA Alkylator/Crosslinker (3) DNA/RNA Synthesis (4) Drug Metabolite (2) Dynamin (1) EGFR (3) Endogenous Metabolite (4) Epigenetic Reader Domain (1) ERK (1) Estrogen Receptor/ERR (3) Ferroptosis (4) Fluorescent Dye (10) Glutaminase (1) GSK-3 (1) Guanylate Cyclase (3) Hedgehog (2) HSV (1) iGluR (1) Influenza Virus (1) Integrin (1) JNK (2) mAChR (3) MDM-2/p53 (5) mGluR (1) Mitochondrial Metabolism (1) Mitophagy (4) Molecular Glues (1) Monoamine Oxidase (1) mTOR (1) Myosin (2) NADPH Oxidase (1) Neurokinin Receptor (2) NF-κB (2) NOD-like Receptor (NLR) (1) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (1) Organoid (1) P-glycoprotein (1) PAK (3) Paraptosis (1) PDGFR (1) Phosphodiesterase (PDE) (1) Phospholipase (14) PKA (1) PKG (1) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (2) Progesterone Receptor (5) PROTACs (1) Protease Activated Receptor (PAR) (1) Proteasome (2) Ras (4) Reactive Oxygen Species (3) RET (1) Ribosomal S6 Kinase (RSK) (1) ROCK (1) SARS-CoV (2) Sigma Receptor (2) Sodium Channel (1) STING (1) TGF-β Receptor (3) Toll-like Receptor (TLR) (3) Topoisomerase (1) VEGFR (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (84) Cardiovascular Disease (13) Endocrinology (2) Infection (12) Inflammation/Immunology (25) Metabolic Disease (11) Neurological Disease (22)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101372A

Oxotremorine M iodide	mAChR	Neurological Disease
Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms .

HY-163002

viFSP1	Ferroptosis	Cancer
viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. viFSP1 targets the highly conserved NAD(P)H binding pocket of FSP1 and directly inhibits FSP1. viFSP1 induces lipid peroxidation and has anticancer activity .

HY-W112346

4-Amino-2-hydroxybenzohydrazide

Others Others

4-Amino-2-hydroxybenzohydrazide, an asymmetric unit, comprises two crystallographically independent molecules (A and B) .

4-Amino-2-hydroxybenzohydrazide	Others	Others
4-Amino-2-hydroxybenzohydrazide, an asymmetric unit, comprises two crystallographically independent molecules (A and B) .

HY-129944

MJ33-OH	Phospholipase	Inflammation/Immunology
MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .

HY-129944A

MJ33-OH lithium	Phospholipase	Inflammation/Immunology
MJ33-OH lithium is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .

HY-149930

YL5084	JNK Apoptosis	Cancer
YL5084, a covalent JNK inhibitor, exhibits selectivity for JNK2 and JNK3 over JNK1 with IC₅₀s of 70 nM, 84 nM and 2173 nM, respectively. YL5084 exhibits JNK2-independent antiproliferative effects and induces apoptosis in a JNK2-independent manner .

HY-123290

KCC009

Glutaminase Cancer

KCC009, a transglutaminase 2 (TG2) inhibitor, induces p53-independent radiosensitization .
HY-P3965

16-38-Thymosin β4 (cattle)

Myosin Neurological Disease

16-38-Thymosin β4 (cattle) is a Ca ²⁺-independent MLCK activator with high affinity .
HY-P3965A

16-38-Thymosin β4 (cattle) (TFA)

Myosin Neurological Disease

16-38-Thymosin β4 (cattle) TFA is a Ca ²⁺-independent MLCK activator with high affinity .
HY-136509

CIL62

Others Cancer

CIL62 is a caspase-3/7-independent cell death inducer. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death .

KCC009	Glutaminase	Cancer
KCC009, a transglutaminase 2 (TG2) inhibitor, induces p53-independent radiosensitization .

16-38-Thymosin β4 (cattle)	Myosin	Neurological Disease
16-38-Thymosin β4 (cattle) is a Ca ²⁺-independent MLCK activator with high affinity .

16-38-Thymosin β4 (cattle) (TFA)	Myosin	Neurological Disease
16-38-Thymosin β4 (cattle) TFA is a Ca ²⁺-independent MLCK activator with high affinity .

CIL62	Others	Cancer
CIL62 is a caspase-3/7-independent cell death inducer. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death .

HY-N4225

Aaptamine	Adrenergic Receptor	Endocrinology Cancer
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner .

HY-120904

AMPK-IN-1

AMPK Metabolic Disease

AMPK-IN-1 is an activator of AMPK (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .

AMPK-IN-1	AMPK	Metabolic Disease
AMPK-IN-1 is an activator of AMPK (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .

HY-W854295

Phosphatidylinositol-1,2-dioctanoyl sodium PtdIns-(1,2-dioctanoyl) (sodium)	P-glycoprotein	Cancer
Phosphatidylinositol-1,2-dioctanoyl sodium significantly inhibits transmembrane P-gp transport in a reproducible, cell line-independent, and substrate-independent manner. Phosphatidylinositol-1,2-dioctanoyl sodium plays an important role in signal transduction and cell movement .

HY-114989

Fluorizoline 1 Publications Verification	Apoptosis	Cancer
Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner .

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-18672

SMER18

Autophagy Cancer

SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.
HY-12656

SCH 51344

Ras Cancer

SCH 51344 inhibits Ras induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts .

SMER18	Autophagy	Cancer
SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.

SCH 51344	Ras	Cancer
SCH 51344 inhibits Ras induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts .

HY-112041

Unesbulin 3 Publications Verification PTC596	Apoptosis	Cancer
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .

HY-W013053

Dibenz[a,h]anthracene DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene	DNA/RNA Synthesis Apoptosis MDM-2/p53	Cancer
Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .

HY-125927

8-Aminoadenosine 8-NH2-Ado	DNA/RNA Synthesis Akt mTOR Autophagy Apoptosis	Cancer
8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity .

HY-100200

SMER28 1 Publications Verification	Autophagy	Cancer
SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

HY-N1033

12-Hydroxyjasmonic acid

(-)-12-Hydroxyjasmonic acid

12-Hydroxyjasmonic acidis is a COI1-JAZ-independent activator of leaf-closing movement in Samanea saman .

12-Hydroxyjasmonic acid (-)-12-Hydroxyjasmonic acid
12-Hydroxyjasmonic acidis is a COI1-JAZ-independent activator of leaf-closing movement in Samanea saman .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages .

HY-119964

Cetaben	Others	Cardiovascular Disease
Cetaben is a PPARα-independent peroxisome proliferator. Cetaben is a non-fibrate hypolipidemic agent and potently reduces the concentration of cholesterol and triglycerides .

HY-131873

Dynapyrazole-A	Dynamin	Infection
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity .

HY-138990

GK563	Phospholipase Apoptosis	Inflammation/Immunology
GK563 is a selective Ca ²⁺-independent phospholipase A₂ (GVIA iPLA₂) inhibitor with an IC₅₀ value of 1 nM. GK563 is 22000 times more active against GVIA iPLA₂ than GIVA cPLA₂. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes .

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N3755

Dihydroresveratrol	Estrogen Receptor/ERR	Cancer
Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations .

HY-107716

Ro 8-4304 hydrochloride	iGluR	Neurological Disease
Ro 8-4304 hydrochloride is a potent NMDA receptor antagonist. Ro 8-4304 hydrochloride is a NR2B selective, non-competitive, voltage-independent antagonist .

HY-162397

Neopetromin	Others	Others
Neopetromin is a tripeptide with a rare heteroaromatic C-N cross-link between side chains of tryptophan and tyrosine. Neopetromin causes vacuole fragmentation in an actin-independent manner .

HY-15186

Ipatasertib 30+ Cited Publications GDC-0068; RG7440	Organoid Akt Apoptosis	Cancer
Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models .

HY-100035

PT-262
PT-262 is a potent ROCK inhibitor with an IC₅₀ value of around 5 μM. PT-262 induces the loss of mitochondrial membrane potential and elevates the caspase-3 activation and apoptosis. PT-262 inhibits the ERK and CDC2 phosphorylation via a p53-independent pathway. PT-262 blocks cytoskeleton function and cell migration. PT-262 has anti-cancer activity .

HY-160076

APJ receptor agonist 8	Apelin Receptor (APJ)	Cardiovascular Disease
APJ receptor agonist 8 (compound 99) is an agonist of APJ receptor. APJ receptor agonist 8 increases the load independent cardiac contractility of isolated perfused rat hearts .

HY-137103

BTC-AM	Fluorescent Dye	Others
BTC-AM is a low affinity calcium indicator. BTC-AM has substantial calcium-independent fluorescence at all excitation wavelengths. BTC-AM is readily loaded into neurons and is rapidly hydrolysed .

HY-D0845

Nitrosoglutathione GSNO; RVC-588; S-Nitroso-L-glutathione	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses .

HY-130122

MG-277	Molecular Glues PROTACs Apoptosis	Cancer
MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC₅₀ of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC₅₀s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity .

HY-110374

NVS-CECR2-1	Epigenetic Reader Domain Apoptosis	Cancer
NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC₅₀=47 nM; K_D=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism .

HY-B0167S

Salicylic acid-d6 2-Hydroxybenzoic acid-d₆	COX Autophagy Mitophagy Apoptosis	Inflammation/Immunology Cancer
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-N6681

15-Acetoxyscirpenol	Caspase Bacterial Apoptosis Antibiotic	Infection
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3 .

HY-14570

Triphen diol	Apoptosis	Cancer
Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent .

HY-112197

PKG drug G1 2 Publications Verification	PKG	Cardiovascular Disease
PKG agent G1 targets C42 of PKG Iα. PKG agent G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.

HY-135367

pyCTZ Pyridyl CTZ	Fluorescent Dye	Others
pyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ generates strong blue bioluminescence in the presence of luciferases. pyCTZ can be used for aequorin-based calcium sensing .

HY-135367B

pyCTZ hydrochloride Pyridyl CTZ hydrochloride	Fluorescent Dye	Others
pyCTZ (Pyridyl CTZ) hydrochloride, a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ hydrochloride generates strong blue bioluminescence in the presence of luciferases. pyCTZ hydrochloride can be used for aequorin-based calcium sensing .

HY-115062

MJ33 lithium salt	Phospholipase	Metabolic Disease
MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .

HY-101013

D-SNAP S-Nitroso-N-acetylpenicillamine	Fluorescent Dye	Others
D-SNAP (S-Nitroso-N-acetylpenicillamine) can Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and stimulate calcium-independent synaptic vesicle release.

HY-124401

BT-13 2 Publications Verification	RET	Neurological Disease
BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat .

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cardiovascular Disease Cancer
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins .

HY-113926

BAY 60-2770	Guanylate Cyclase	Cardiovascular Disease
BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect .

HY-135585

LY88074	Others	Endocrinology
LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner .

Cat. No.	Product Name

HY-L158

Highly Selective Inhibitors Library

4653 compounds

According to reports, most known kinase inhibitors exert their effects through competitive binding in highly conserved ATP pockets. Although genetic techniques such as RNA interference can inactivate specific genes, most kinases are multi domain proteins, each of which has an independent function. Highly selective inhibitors have higher efficiency than non-selective inhibitors, and the selectivity to the target is at least 100 times higher. Therefore, ensuring the validation of targets with the most selective inhibitors is crucial for a more thorough understanding of the pharmacology of the kinase field. The Highly Selective Inhibitors Library contains 4653 compounds, covering multiple targets and subtypes, such as GPCR protein family, Ion channel, multiple kinases, etc. The Highly Selective Inhibitors Library is an effective tool for screening different phenotypes

Cat. No.	Product Name	Type

HY-135367

pyCTZ Pyridyl CTZ	Fluorescent Dyes/Probes
pyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ generates strong blue bioluminescence in the presence of luciferases. pyCTZ can be used for aequorin-based calcium sensing .

HY-135056

MitoTracker Green FM 3 Publications Verification	Fluorescent Dyes/Probes
Mito-Tracker Green is a green fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Green FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 490/523 nm.

HY-W247131

DASPEI	Fluorescent Dyes/Probes
DASPEI is a cationic styrenyl mitochondrial dye with large Stokes shift. DASPEI has excitation and emission wavelength at 550/573 nm, which has good light chromogenic property. DASPEI can stain mitochondria in living cells with good labeling property. And DASPEI can also be used to stain presynaptic nerve endings independently of neuronal activity .

HY-137103

BTC-AM	Fluorescent Dyes/Probes
BTC-AM is a low affinity calcium indicator. BTC-AM has substantial calcium-independent fluorescence at all excitation wavelengths. BTC-AM is readily loaded into neurons and is rapidly hydrolysed .

HY-101013

D-SNAP S-Nitroso-N-acetylpenicillamine	Fluorescent Dyes/Probes
D-SNAP (S-Nitroso-N-acetylpenicillamine) can Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and stimulate calcium-independent synaptic vesicle release.

Cat. No.	Product Name	Type

HY-100168

BAPTA

20+ Cited Publications

Biochemical Assay Reagents

BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-100168B

BAPTA tetrapotassium

20+ Cited Publications

Biochemical Assay Reagents

BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-W010736A

1,2-Dipalmitoyl-rac-glycerol

Biochemical Assay Reagents

1,2-Dipalmitoyl-rac-glycerol is a diacylglycerol containing palmitic acid at the sn-1 and sn-2 positions (Cat. No. 10006627). It is found in a variety of vegetable oils, including palm, soybean, canola, and corn. 1 \n 1,2-Dipalmitoyl-rac-glycerol MaxSpec Standard is a quantitative grade standard of 1,2-dipalmitoyl-rac-glycerol prepared for mass spectrometry and related applications requiring quantitative reproducibility . The solution has been prepared gravimetrically and contained in argon-sealed deactivated glass ampoules. Concentrations were verified by comparison to independently prepared calibration standards. This 1,2-dipalmitoyl-rac-glycerol MaxSpec Standard is guaranteed to meet specifications for identity, purity, stability, and concentration and is supplied with a batch-specific Certificate of Analysis. Ongoing stability testing is performed to ensure concentrations remain accurate throughout the shelf life of the product. Note: Add more solution to the vial than listed. Therefore, accurate volume measurements are necessary to prepare calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Cat. No.	Product Name	Target	Research Area

HY-P3965

16-38-Thymosin β4 (cattle)

Myosin Neurological Disease

16-38-Thymosin β4 (cattle) is a Ca ²⁺-independent MLCK activator with high affinity .
HY-P3965A

16-38-Thymosin β4 (cattle) (TFA)

Myosin Neurological Disease

16-38-Thymosin β4 (cattle) TFA is a Ca ²⁺-independent MLCK activator with high affinity .

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages .

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

HY-P3617

Glucagon (22-29)	Peptides	Metabolic Disease
Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca ²⁺ pump in liver plasma membranes independently of adenylate cyclase activation .

HY-P2261

STAD 2	PKA	Infection
STAD 2 is a potent and selective disruptor of PKA-RII, with a K_d of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism .

HY-P4766

Adrenomedullin (porcine)	Peptides	Cardiovascular Disease
Adrenomedullin (porcine) is a peptide that regulates vasodilation. Adrenomedullin (porcine) induces endothelium-dependent relaxation in rat aorta with IC₅₀ value of 2.4 nM. Adrenomedullin (porcine) induces endothelium-independent relaxation of porcine coronary arteries with an IC₅₀ of 27.6 nM .

HY-P10086

TREM-1 inhibitory peptide GF9 Human TREM-1(213-221)	Peptides	Inflammation/Immunology
TREM-1 inhibitory peptide GF9 (Human TREM-1(213-221)) is a ligand‐independent TREM‐1 inhibitory nonapeptide GF9 that can blunt excessive inflammation caused by rheumatoid arthritis (RA) .

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .

HY-P3990

Coibamide A	VEGFR Autophagy Apoptosis	Cancer
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts .

HY-P2249

ELA-21 (human)	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
ELA-21 (human) is an apelin receptor agonist with a pK_i of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways .

HY-P3970

KRFK	TGF-β Receptor	Inflammation/Immunology
KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach .

HY-P3970A

KRFK TFA 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
KRFK TFA, a peptide derived from TSP-1, can activate TGF-β. KRFK TFA promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach .

HY-P2265

SAH-SOS1A	Ras	Cancer
SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC₅₀=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS .

HY-P2265A

SAH-SOS1A TFA	Ras	Cancer
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC₅₀=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS .

HY-P5357

SFNGGP-NH2	Protease Activated Receptor (PAR)	Others
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

Cat. No.	Product Name

HY-KE8006

Terminal Deoxynucleotidyl Transferase (TdT)
Terminal Deoxynucleotidyl Transferase (TdT) is a template-independent DNA polymerase that catalyzes the binding of deoxynucleotides to the 3' hydroxyl end of oligonucleotides, single-stranded DNA, or double-stranded DNA.

Cat. No.	Product Name	Target	Research Area

HY-P99936

Elgemtumab LJM716	EGFR	Cancer
Elgemtumab(LJM716) is a fully human IgG monoclonal antibody. Elgemtumab can specifically bind to HER3, block ligand-dependent and independent HER3 signal transduction and cell proliferation, and has good anti-tumor potential .

HY-P99192

Emibetuzumab LY2875358	c-Met/HGFR	Cancer
Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both *HGF*-dependent and *HGF*-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer .

HY-P9976A

Isatuximab (anti-CD38) 1 Publications Verification	CD38	Cancer
Isatuximab (anti-CD38) is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38.Isatuximab induces tumor cell killing via fragment crystallizable (Fc)-dependent or Fc-independent mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC) .

HY-P99437

Anbenitamab KN-026	EGFR	Cancer
Anbenitamab (KN-026) is a bispecific antibody simultaneously targeting the extracellular domains II and IV of the human HER2. Anbenitamab blocks both ligand-dependent and ligand-independent HER2 signaling pathway. The IgG1 Fc fragment of Anbenitamab binds FcRγIIIa mediates potent antibody dependent cell-mediated cytotoxicity (ADCC) and inhibits tumor cell proliferation. Anbenitamab has the potential for HER2-positive metastatic breast cancer (MBC) research .

HY-P99306

Modotuximab DS 1024; Sym 004	Inhibitory Antibodies	Cancer
Modotuximab (Anti-Human EGFR Recombinant Antibody) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab contains a portion of Futuximab that binds to two independent, non-overlapping epitopes on EGFR. Modotuximab promotes cross-linking of EGFR on the cell surface and promotes EGFR cellular internalization and degradation. Modotuximab has antitumor activity in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125927

8-Aminoadenosine 8-NH2-Ado	Structural Classification Natural Products Source classification Endogenous metabolite	DNA/RNA Synthesis Akt mTOR Autophagy Apoptosis
8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity .

HY-B0167

Salicylic acid Maximum Cited Publications 7 Publications Verification 2-Hydroxybenzoic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Agricultural Research Monophenols other families Microorganisms Ketones, Aldehydes, Acids Phenols Phytohormone Inflammation/Immunology Disease Research Fields Cancer	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N3755

Dihydroresveratrol	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Phenols Polyphenols Dioscorea bulbifera Linn. Plants Endogenous metabolite Disease Research Fields Cancer Dioscoreaceae	Estrogen Receptor/ERR
Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations .

HY-N4225

Aaptamine	Alkaloids Classification of Application Fields Animals Source classification Marine natural products Quinoline Alkaloids Sponge Disease Research Fields Endocrinology	Adrenergic Receptor
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner .

HY-162397

Neopetromin	Structural Classification Monophenols Microorganisms Source classification Phenols	Others
Neopetromin is a tripeptide with a rare heteroaromatic C-N cross-link between side chains of tryptophan and tyrosine. Neopetromin causes vacuole fragmentation in an actin-independent manner .

HY-N6681

15-Acetoxyscirpenol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Caspase Bacterial Apoptosis Antibiotic
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3 .

HY-B0167R

Salicylic acid (Standard) 2-Hydroxybenzoic acid (Standard)	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Agricultural Research other families Ketones, Aldehydes, Acids Phenols Phytohormone Inflammation/Immunology Disease Research Fields Cancer	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite
Salicylic acid (Standard) is the analytical standard of Salicylic acid. This product is intended for research and analytical applications. Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-113915

Kuguaglycoside C	Structural Classification Natural Products Source classification Cucurbitaceae Plants Momordica charantia Linn.	Apoptosis
Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF) .

HY-B2171A

Carubicin hydrochloride Carminomycin hydrochloride; Carminomicin I hydrochloride	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Apoptosis
Carubicin hydrochloride is a microbially-derived compound. Carubicin hydrochloride is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin hydrochloride also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin hydrochloride has the potential for the research of cancer diseases .

HY-N3354

Lupiwighteone 8-prenylgenistein	Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	Apoptosis
Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway .

HY-N2602

Sanggenol L	Flavonoids Classification of Application Fields Morus mongolica (Bur.) Schneid. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	MDM-2/p53
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

HY-B2171

Carubicin Carminomycin; Carminomicin I	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Apoptosis
Carubicin (Carminomycin) is a microbially-derived compound. Carubicin is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin has the potential for the research of cancer diseases .

HY-B0167A

Sodium Salicylate Maximum Cited Publications 7 Publications Verification Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Asclepiadaceae Phenols Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Cancer	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-N2369

Chelidonine	Infection Alkaloids Structural Classification Classification of Application Fields Chelidonium majus Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Apoptosis Influenza Virus
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-120241

Reticulol K 251-1	Structural Classification Microorganisms Source classification Phenols Polyphenols	Phosphodiesterase (PDE)
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma .

Species:	Human (14)
Tag:	His (12) Tag Free (3) Strep (5) GST (1) MBP (1) Flag (1)
Source:	HEK293 (3) E. coli Cell-free (1) Sf9 insect cells (9) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P702121

	fum Protein, Corynebacterium glutamicum fumC; Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase	Others	E. coli
	Fum proteins crucially catalyze the interconversion of fumarate to L-malate in the tricarboxylic acid (TCA) cycle, maintaining metabolite flow in cellular energy metabolism. This critical step, if precisely regulated, helps generate energy and generates intermediates critical to cellular processes. fum Protein, Corynebacterium glutamicum is the recombinant fum protein, expressed by E. coli , with tag free. The total length of fum Protein, Corynebacterium glutamicum is 469 a.a., .

HY-P702122

	fum Protein, Corynebacterium glutamicum (His) fumC; Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase	Others	E. coli
	Fum proteins crucially catalyze the interconversion of fumarate to L-malate in the tricarboxylic acid (TCA) cycle, maintaining metabolite flow in cellular energy metabolism. This critical step, if precisely regulated, helps generate energy and generates intermediates critical to cellular processes. fum Protein, Corynebacterium glutamicum (His) is the recombinant fum protein, expressed by E. coli , with N-6*His labeled tag. The total length of fum Protein, Corynebacterium glutamicum (His) is 469 a.a., .

HY-P76063

	SGK3 Protein, Human (sf9, GST) Serine/threonine-protein kinase Sgk3; Cytokine-independent survival kinase; SGK3; CISK; SGKL	Human	Sf9 insect cells
	The SGK3 protein is an important serine/threonine protein kinase that complexly controls diverse ion channels, transporters, and key cellular processes, affecting growth, proliferation, survival, and migration. SGK3 exhibits multiple effects by upregulating channels such as Na(+), K(+), epithelial Ca(2+), chloride, and transporters such as creatine. SGK3 Protein, Human (sf9, GST) is the recombinant human-derived SGK3 protein, expressed by Sf9 insect cells , with GST tag.

HY-P702439

	SLC26A4 Protein, Human (Cell-Free, His) Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4	Human	E. coli Cell-free
	SLC26A4 Protein, a sodium-independent transporter, crucially facilitates chloride and iodide transport, mediating electroneutral chloride-bicarbonate, chloride-iodide, and chloride-formate exchanges, each with a 1:1 stoichiometry. It's also implicated in electroneutral iodide-bicarbonate exchange, highlighting its versatility in transporting essential anions. The precise stoichiometry and electrogenic nature underscore its significance in maintaining cellular ion balance and regulating chloride and iodide ions. SLC26A4 emerges as a key player in cellular physiology, contributing to critical processes where chloride and iodide homeostasis is essential. SLC26A4 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC26A4 protein, expressed by E. coli Cell-free , with N-6*His labeled tag and H723R mutation. The total length of SLC26A4 Protein, Human (Cell-Free, His) is 780 a.a., with molecular weight of 86.7 kDa.

HY-P702440

	SLC26A4-VLPs Protein, Human (HEK293, His) Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4	Human	HEK293
	The SLC26A4 protein is a sodium-independent transporter that can significantly promote the transport of chloride ions and iodide ions, mediating electrically neutral chlorine-bicarbonate, chlorine-iodide, and chlorine-formate exchanges, each The stoichiometry of species exchange is 1:1. It also involves electrically neutral iodide-bicarbonate exchange, highlighting its versatility in transporting essential anions. SLC26A4-VLPs Protein, Human (HEK293, His) is the recombinant human-derived SLC26A4-VLPs protein, expressed by HEK293 , with N-6*His labeled tag. The total length of SLC26A4-VLPs Protein, Human (HEK293, His) is 780 a.a., with molecular weight of 86.7 kDa.

HY-P71242

	PTGDS Protein, Human (HEK293, His) 1 Publications Verification Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; Prostaglandin-D2 Synthase; PGD2 Synthase; PGDS; PGDS2; PTGDS; PDS	Human	HEK293
	The PTGDS protein catalyzes the conversion of PGH2 to PGD2, a prostaglandin that affects smooth muscle activity and platelet aggregation. It plays a role in central nervous system functions such as sedation, sleep, and allodynia. PTGDS Protein, Human (HEK293, His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PTGDS Protein, Human (HEK293, His) is 168 a.a., with molecular weight of 20-29 kDa.

HY-P71242A

	PTGDS Protein, Human (HEK293, C-His) Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; Prostaglandin-D2 Synthase; PGD2 Synthase; PGDS; PGDS2; PTGDS; PDS	Human	HEK293
	The PTGDS protein serves a multifaceted role in various physiological processes. It catalyzes the conversion of PGH2 to PGD2, a prostaglandin with implications in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Beyond its involvement in these vascular functions, PTGDS plays a crucial role in diverse central nervous system (CNS) activities, including sedation, NREM sleep, and PGE2-induced allodynia, and may exhibit an anti-apoptotic function in oligodendrocytes. Notably, PTGDS has a broad substrate-binding capacity, interacting with small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid, and thyroid hormone. This suggests its potential role as a scavenger for harmful hydrophobic molecules and as a transporter for secretory retinoids and thyroid hormones. Additionally, PTGDS is implicated in the development and maintenance of various blood barriers, including the blood-brain, blood-retina, blood-aqueous humor, and blood-testis barriers, indicating its significance in barrier function. Furthermore, it plays essential roles in the maturation and maintenance of the central nervous system and the male reproductive system, as well as participates in PLA2G3-dependent maturation of mast cells, further emphasizing its intricate involvement in diverse biological processes. PTGDS Protein, Human (HEK293, C-His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PTGDS Protein, Human (HEK293, C-His) is 168 a.a., with molecular weight of ~21 kDa.

HY-P701350

	UBE2C Protein, Human (Sf9, His, Strep) UBE2C; Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C	Human	Sf9 insect cells
	The UBE2C protein is a key ubiquitin-proteasome system component that acts as an E2 ubiquitin-conjugating enzyme and is the core of the covalent linkage of ubiquitin to target proteins. In vitro, UBE2C expertly promotes “Lys-11” and “Lys-48” linked polyubiquitination, demonstrating the versatility of ubiquitin chain formation. UBE2C Protein, Human (Sf9, His, Strep) is the recombinant human-derived UBE2C protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UBE2C Protein, Human (Sf9, His, Strep) is 178 a.a., .

HY-P701346

	UbcH6/UBE2E1 Protein, Human (Sf9) UBE2E1; Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1	Human	Sf9 insect cells
	The UbcH6/UBE2E1 protein is an important ubiquitination component that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin in the E1 complex and catalyzing its covalent attachment to proteins. It is versatile and also facilitates covalent attachment of ISG15, playing a role in a variety of ubiquitin-like modifications. UbcH6/UBE2E1 Protein, Human (Sf9) is the recombinant human-derived UbcH6/UBE2E1 protein, expressed by Sf9 insect cells , with tag free. The total length of UbcH6/UBE2E1 Protein, Human (Sf9) is 192 a.a., .

HY-P702019

	SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) SLCO1A2; Solute carrier organic anion transporter family member 1A2; OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3	Human	Sf9 insect cells
	SLC21A3 is a Na(+)-independent transporter that greatly facilitates cellular uptake of a variety of organic anions, including bile salts necessary for intestinal absorption. SLC21A3 is responsible for transporting substances such as DHEAS, estrone 3-sulfate, and atROL in human retinal pigment epithelial cells to maintain the integrity of the visual cycle. SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC21A3 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) is 669 a.a., .

HY-P701347

	UbcH6/UBE2E1 Protein, Human (Sf9, His, Strep) UBE2E1; Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1	Human	Sf9 insect cells
	The UbcH6/UBE2E1 protein is an important ubiquitination component that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin in the E1 complex and catalyzing its covalent attachment to proteins. It is versatile and also facilitates covalent attachment of ISG15, playing a role in a variety of ubiquitin-like modifications. UbcH6/UBE2E1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UbcH6/UBE2E1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UbcH6/UBE2E1 Protein, Human (Sf9, His, Strep) is 192 a.a., .

HY-P71145

	PRDX6 Protein, Human (His) Peroxiredoxin-6; 1-Cys Peroxiredoxin; 1-Cys PRX; 24 kDa Protein; Acidic Calcium-independent Phospholipase A2; aiPLA2; Antioxidant Protein 2; Liver 2D PAGE Spot 40; Non-Selenium Glutathione Peroxidase; NSGPx; Red Blood Cells Page Spot 12; PRDX6; AOP2; KIAA0106	Human	E. coli
	The PRDX6 protein is a thiol-specific peroxidase that plays a crucial role in cellular defense against oxidative stress. It catalyzes the reduction of hydrogen peroxide and various organic hydroperoxides to water and alcohols. PRDX6 Protein, Human (His) is the recombinant human-derived PRDX6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PRDX6 Protein, Human (His) is 224 a.a., with molecular weight of 30-33 kDa.

HY-P79448

	UBE2R1/CDC34 Protein, Human (Sf9, His, Strep) Ubiquitin-conjugating enzyme E2 R1; CDC34; (E3-independent) E2 ubiquitin-conjugating enzyme R1 (EC:2.3.2.24); E2 ubiquitin-conjugating enzyme R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protei	Human	Sf9 insect cells
	The UBE2R1/CDC34 protein is an important ubiquitin-proteasome system component that functions as an E2 ubiquitin-conjugating enzyme, capable of proficiently accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to a variety of protein substrates. . In vitro, UBE2R1 efficiently mediates “Lys-48”-linked polyubiquitination. UBE2R1/CDC34 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UBE2R1/CDC34 protein, expressed by Sf9 insect cells , with N-Strep, N-His labeled tag. The total length of UBE2R1/CDC34 Protein, Human (Sf9, His, Strep) is 235 a.a., .

HY-P701493

	UBE2O Protein, Human (Sf9, His, Strep) UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O	Human	Sf9 insect cells
	UBE2O protein acts as a hybrid E2/E3 ubiquitin protein ligase capable of monoubiquitinating target proteins. It negatively regulates TRAF6-mediated NF-kappa-B activation independently of E2 activity. UBE2O Protein, Human (Sf9, His, Strep) is the recombinant human-derived UBE2O protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UBE2O Protein, Human (Sf9, His, Strep) is 1291 a.a., .

HY-P701494

	UBE2O Protein, Human (Sf9) UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O	Human	Sf9 insect cells
	UBE2O protein acts as a hybrid E2/E3 ubiquitin protein ligase capable of monoubiquitinating target proteins. It negatively regulates TRAF6-mediated NF-kappa-B activation independently of E2 activity. UBE2O Protein, Human (Sf9) is the recombinant human-derived UBE2O protein, expressed by Sf9 insect cells , with tag free. The total length of UBE2O Protein, Human (Sf9) is 1291 a.a., .

HY-P702065

	UB2D3 Protein, Human (Sf9, His, Strep) UBE2D3; Ubiquitin-conjugating enzyme E2 D3; (E3-independent) E2 ubiquitin-conjugating enzyme D3; E2 ubiquitin-conjugating enzyme D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3	Human	Sf9 insect cells
	The UBE2D3 protein is a key player in ubiquitination. It accepts ubiquitin from the E1 complex and covalently attaches it to a variety of proteins, demonstrating multifunctionality. It catalyzes "Lys-11" and "Lys-48" linked polyubiquitination in vitro, regulating protein ubiquitination patterns. UB2D3 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UB2D3 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UB2D3 Protein, Human (Sf9, His, Strep) is 146 a.a., .

Cat. No.	Product Name	Chemical Structure

HY-B0167S

Salicylic acid-d6
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-111614S2

Melengestrol acetate-d3

Melengestrol acetate-d₃ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-117433S

4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

HY-111614S

Melengestrol acetate-d6

Melengestrol acetate-d₆ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-111614S1

Melengestrol acetate-d2

Melengestrol acetate-d₂ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .

Cat. No.	Product Name	Application	Reactivity

HY-P81754

IGF2R Antibody (YA1499) IGF2R; MPRI; Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat


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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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Remarks

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

independent

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products