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inhaled

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (2) Adrenergic Receptor (6) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (2) c-Fms (1) c-Kit (1) Cytochrome P450 (1) Drug Metabolite (1) Fluorescent Dye (1) Glucocorticoid Receptor (6) Influenza Virus (2) Isotope-Labeled Compounds (1) JAK (2) Lipoxygenase (1) mAChR (4) p38 MAPK (2) PDGFR (1) Phosphodiesterase (PDE) (2) PI3K (2) RSV (1) Smo (1) Src (1) STAT (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Endocrinology (5) Infection (7) Inflammation/Immunology (20) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0629

Mometasone	Glucocorticoid Receptor	Metabolic Disease
Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis .

HY-W040269

Dehydrothio-p-toluidine 1 Publications Verification DHPT	Fluorescent Dye	Others
Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions .

HY-119708

Ensifentrine RPL-554	Phosphodiesterase (PDE)	Inflammation/Immunology
Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC₅₀s of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activities. Ensifentrine can be used for chronic obstructive pulmonary disease (COPD) research .

HY-13580

Budesonide 3 Publications Verification	Glucocorticoid Receptor ADC Cytotoxin	Inflammation/Immunology Cancer
Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-132849

Nezulcitinib TD-0903	JAK	Infection Inflammation/Immunology
Nezulcitinib (TD-0903) is an inhaled and lung-selective pan-Janus kinase (JAK) inhibitor. Nezulcitinib can be used for the research of COVID-19 associated acute lung injury and impaired oxygenation .

HY-B0603

Fluticasone	Smo Glucocorticoid Receptor	Infection Inflammation/Immunology Endocrinology
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC₅₀ value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells .

HY-B1112

Fluorothyl

Bis(2,2,2-trifluoroethyl) ether; Flurothyl
Others Others

Fluorothyl (Flurothyl) is a inhaling volatile liquid.
HY-19940

Olitigaltin

Maximum Cited Publications

11 Publications Verification

TD139; GB0139

TD139 is an inhaled galectin-3 inhibitor with a K_d of 14 nM.

Fluorothyl Bis(2,2,2-trifluoroethyl) ether; Flurothyl	Others	Others
Fluorothyl (Flurothyl) is a inhaling volatile liquid.

Olitigaltin Maximum Cited Publications 11 Publications Verification TD139; GB0139
TD139 is an inhaled galectin-3 inhibitor with a K_d of 14 nM.

HY-120802

Navafenterol AZD-8871; LAS191351	mAChR Adrenergic Receptor	Inflammation/Immunology
Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC₅₀ is 9.5 for human M3 receptor, and the pEC₅₀ is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile .

HY-120802A

Navafenterol saccharinate AZD-8871 saccharinate; LAS191351 saccharinate	mAChR Adrenergic Receptor	Infection Inflammation/Immunology
Navafenterol (AZD-8871) saccharinate is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC₅₀ is 9.5 for human M3 receptor, and the pEC₅₀ is 9.5 for β2-adrenoceptor. Navafenterol saccharinate can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile .

HY-103672

AZD7624

p38 MAPK Autophagy Inflammation/Immunology

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

AZD7624	p38 MAPK Autophagy	Inflammation/Immunology
AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

HY-W039897

Methyl α-D-mannopyranoside 1 Publications Verification α-Methyl-D-mannoside	Bacterial	Inflammation/Immunology
Methyl α-D-mannopyranoside could target macrophages in anti-tuberculosis inhalation therapy .

HY-100087

Budesonide impurity C

Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .
HY-122317

Menthol glucuronide

Drug Metabolite Others

Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .
HY-115870

AZD8154

PI3K Inflammation/Immunology

AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease.

Budesonide impurity C
Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .

Menthol glucuronide	Drug Metabolite	Others
Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .

AZD8154	PI3K	Inflammation/Immunology
AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease.

HY-B1481B

Isoetharine hydrochloride Isoetarine hydrochloride	Others	Infection
Isoetharine hydrochloride is selective, short-acting and orally active β-agonist which is widely used as a bronchodilator in the research of inhalation research .

HY-131551

Drometrizole	Biochemical Assay Reagents	Others
Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies .

HY-N2085

L-Perillaldehyde (S)-(-)-Perillaldehyde; (S)-Perillaldehyde	Others	Neurological Disease
L-Perillaldehyde is a major component in the essential oil containing in Perillae Herba. Inhalation of L-Perillaldehyde shows antidepressant-like activity through the olfactory nervous function .

HY-157568S

Budesonide acid-d8	Isotope-Labeled Compounds	Others
Budesonide acid-d8 is a deuterium labeled Budesonide acid. Budesonide acid is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .

HY-108243

AZD5423 1 Publications Verification	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM) . AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma .

HY-115871

PDE4-IN-4

Phosphodiesterase (PDE) mAChR Others

PDE4-IN-4 is a dual M3 (pIC₅₀ = 10.2) antagonist-PDE4 (pIC₅₀ = 8.8) inhibitor for the inhaled research of pulmonary diseases.

PDE4-IN-4	Phosphodiesterase (PDE) mAChR	Others
PDE4-IN-4 is a dual M3 (pIC₅₀ = 10.2) antagonist-PDE4 (pIC₅₀ = 8.8) inhibitor for the inhaled research of pulmonary diseases.

HY-111144

Abediterol AZD0548; LAS100977	Adrenergic Receptor	Inflammation/Immunology
Abediterol (LAS100977) is an inhaled long-acting β2-adrenoceptor agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-14144

Aclidinium Bromide 5 Publications Verification LAS 34273; LAS-W 330	mAChR	Inflammation/Immunology
Aclidinium Bromide (LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist. Aclidinium Bromide has the potential for chronic obstructive pulmonary disease (COPD) research .

HY-14296

PF-610355	Adrenergic Receptor	Inflammation/Immunology
PF-610355 is a long-acting inhaled β₂-adrenoreceptor agonist, with an EC₅₀ of 0.26 nM. PF-610355 has the potential for the study of asthma and COPD .

HY-A0234

Stepronin Prostenoglycine; TTPG; Tiase	Others	Endocrinology
Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl ^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .

HY-102038

PC786	RSV	Infection
PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against RSV-A (IC₅₀ <0.09 to 0.71 nM) and RSV-B (IC₅₀, 1.3 to 50.6 nM) .

HY-109190

Seralutinib 1 Publications Verification GB002; PK10571	PDGFR c-Fms c-Kit	Cardiovascular Disease
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC₅₀s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .

HY-14818A

Laninamivir octanoate CS-8958	Influenza Virus	Infection
Laninamivir octanoate (CS-8958), a proagent of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses .

HY-14818C

Laninamivir octanoate hydrate CS-8958 hydrate	Influenza Virus	Infection
Laninamivir octanoate hydrate (CS-8958 hydrate), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate hydrate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses .

HY-13580S

Budesonide-d8	Glucocorticoid Receptor	Inflammation/Immunology Cancer
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3].

HY-13580R

Budesonide (Standard) 3 Publications Verification	Glucocorticoid Receptor ADC Cytotoxin	Inflammation/Immunology Cancer
Budesonide (Standard) is the analytical standard of Budesonide. This product is intended for research and analytical applications. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-14301

Olodaterol 1 Publications Verification BI1744	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Olodaterol (BI1744) is a selective, long acting β₂-adrenoceptor (β₂-AR) agonist (EC₅₀=0.1 nM and pK_i= 9.14 for human β₂-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis .

HY-14301A

Olodaterol hydrochloride 1 Publications Verification BI1744 hydrochloride	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Olodaterol (BI1744) hydrochloride is a selective, long acting β₂-adrenoceptor (β₂-AR) agonist (EC₅₀=0.1 nM and pK_i= 9.14 for human β₂-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis .

HY-115871A

(Rac)-PDE4-IN-4	Others	Others
(Rac)-PDE4-IN-4 is the diastereomer mixture of PDE4-IN-4 (HY-115871). PDE4-IN-4 is a dual M3 (pIC₅₀ = 10.2) antagonist-PDE4 (pIC₅₀ = 8.8) inhibitor for the inhaled research of pulmonary diseases .

HY-120595

JNJ-49095397 RV568	p38 MAPK Src	Inflammation/Immunology
JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma .

HY-131910

IHMT-PI3Kδ-372	PI3K Cytochrome P450	Inflammation/Immunology
IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC₅₀ of 14 nM. IHMT-PI3Kδ-372 shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research .

HY-18862

PF-03715455
PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC₅₀ values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC₅₀=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease) .

HY-103158

BW B70C	Lipoxygenase	Others
BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent .

HY-125019

iJak-381	JAK STAT	Inflammation/Immunology
iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR) .

HY-W250172

Triton X-405	Biochemical Assay Reagents	Others
Triton X-405 is a nonionic surfactant commonly used in a variety of industrial and research applications. Triton X-405 belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in emulsions, detergents and solubilizers. Triton X-405 is particularly useful in the study of membrane proteins, where it is used to solubilize and stabilize proteins for structural analysis techniques. It is also used in a variety of other applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Additionally, Triton X-405 is used in the production of microemulsions, salves and lotions due to its emulsifying and solubilizing properties. However, it can be toxic if ingested or inhaled, so proper handling and safety precautions are required.

Triton X-405	Biochemical Assay Reagents
Triton X-405 is a nonionic surfactant commonly used in a variety of industrial and research applications. Triton X-405 belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in emulsions, detergents and solubilizers. Triton X-405 is particularly useful in the study of membrane proteins, where it is used to solubilize and stabilize proteins for structural analysis techniques. It is also used in a variety of other applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Additionally, Triton X-405 is used in the production of microemulsions, salves and lotions due to its emulsifying and solubilizing properties. However, it can be toxic if ingested or inhaled, so proper handling and safety precautions are required.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2085

L-Perillaldehyde (S)-(-)-Perillaldehyde; (S)-Perillaldehyde	Other Monoterpenes Neurological Disease Classification of Application Fields Terpenoids Labiatae Source classification Plants Erigeron breviscapus (Vant.) Hand.-Mazz. Disease Research Fields	Others
L-Perillaldehyde is a major component in the essential oil containing in Perillae Herba. Inhalation of L-Perillaldehyde shows antidepressant-like activity through the olfactory nervous function .

Cat. No.	Product Name	Chemical Structure

HY-13580S

Budesonide-d8
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3].

HY-157568S

Budesonide acid-d8
Budesonide acid-d8 is a deuterium labeled Budesonide acid. Budesonide acid is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .

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inhaled

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products