integration

By Targets:	Antibiotic (1) Apoptosis (4) Autophagy (1) ClpP (1) DNA/RNA Synthesis (1) Fluorescent Dye (1) Fungal (1) HIV (3) HIV Integrase (1) Nucleoside Antimetabolite/Analog (1) PKC (1) RABV (1) TRP Channel (1) β-catenin (1)
By Research Areas:	Cancer (5) Infection (5) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112041

Unesbulin 3 Publications Verification PTC596	Apoptosis	Cancer
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .

HY-B0359

Fenticonazole Nitrate 1 Publications Verification REC 15-1476	Fungal Antibiotic	Infection
Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis .

HY-132871

MEIS-IN-3

Others Others

MEIS-IN-3 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor.
HY-132870

MEIS-IN-2

Others Others

MEIS-IN-2 is a myeloid ecotropic viral integration site 1 (MEIS1) inhibitor.
HY-132869

MEIS-IN-1

Others Others

MEIS-IN-1 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor to induce murine and human hematopoietic stem-cell expansion.

MEIS-IN-3	Others	Others
MEIS-IN-3 is a potent *myeloid ecotropic viral integration* site (MEIS)** inhibitor.

MEIS-IN-2	Others	Others
MEIS-IN-2 is a *myeloid ecotropic viral integration* site 1 (MEIS1)** inhibitor.

MEIS-IN-1	Others	Others
MEIS-IN-1 is a potent *myeloid ecotropic viral integration* site (MEIS)** inhibitor to induce murine and human hematopoietic stem-cell expansion.

HY-163319

NCA029	ClpP Apoptosis	Cancer
NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC₅₀ of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death .

HY-10834

β-catenin-IN-6	β-catenin	Cancer
β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model .

HY-108460

A-784168	TRP Channel	Neurological Disease
A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration .

HY-152073

BETA-1	Fluorescent Dye	Others
BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro .

HY-163177

HIV-1 inhibitor-63	HIV	Infection
HIV-1 inhibitor-63 (compound S17) is a potent HIV-1 inhibitor. HIV-1 inhibitor-63 inhibits integrase-Ku70 complex formation with an IC₅₀ value of 12 µM. HIV-1 inhibitor-63 inhibits HIV-1 post-integration DNA repair .

HY-106634

Mitoguazone 1 Publications Verification Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG	HIV Apoptosis	Infection Cancer
Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment .

HY-147653

Integrase-LEDGF/p75 allosteric inhibitor 1	HIV Integrase	Infection
Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC₅₀ of 3.9 nM against HIV-1 recombinant molecular clone NL432 .

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand .

HY-18980

Rottlerin 5 Publications Verification Mallotoxin; NSC 56346; NSC 94525	PKC Autophagy Apoptosis HIV RABV	Infection Cancer
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

Cat. No.	Product Name

HY-L039

Reprogramming Compound Library	2038 compounds
Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells. MCE Reprogramming Compound Library contains a unique collection of 2038 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Reprogramming Compound Library

2038 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 2038 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

HY-L047

Endocrinology Compound Library	883 compounds
The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function. The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease. MCE offers a unique collection of 883 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Endocrinology Compound Library

883 compounds

The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function.

The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease.

MCE offers a unique collection of 883 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18980

Rottlerin 5 Publications Verification Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

Species:	Human (3)
Tag:	His (1) Fc (2)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75757

	EVI2A Protein, Human (HEK293, Fc) Protein EVI2A; Ecotropic viral integration site 2A protein homolog; EVI-2A; EVDA; EVI2	Human	HEK293
	EVI2A may be a component of a cell surface receptor that forms a complex with itself or other proteins within the membrane, suggesting a role in mediating cellular responses through complex molecular interactions. Its ability to participate in self-complex formation or to interact with other proteins implies involvement in the organization of membrane-associated receptor structures. EVI2A Protein, Human (HEK293, Fc) is the recombinant human-derived EVI2A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EVI2A Protein, Human (HEK293, Fc) is 103 a.a., with molecular weight of ~64.1 kDa.

HY-P700313

	Wnt4 protein, Human (HEK293, C-hFc) WNT4; wingless-typeMMTV integration site family, member 4; WNT-4; SERKAL; protein Wnt-4; UNQ426/PRO864	Human	HEK293
	The Wnt4 protein is a Frizzled receptor ligand that plays a critical role in embryonic urogenital tract and lung development. It is critical for embryonic kidney development and the formation of early renal vesicles and the mesenchymal to epithelial transition. Wnt4 protein, Human (HEK293, C-hFc) is the recombinant human-derived Wnt4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Wnt4 protein, Human (HEK293, C-hFc) is 329 a.a., with molecular weight of 65.6 kDa.

HY-P70453A

	Wnt3a Protein, Human (His) 4 Publications Verification MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a	Human	E. coli
	Wnt3a protein is a ligand of Frizzled receptors and can activate TCF/LEF transcription factors in the canonical Wnt pathway. It is essential for embryonic mesoderm development, caudal somite formation, neural tube morphogenesis, and intestinal crypt stem cell self-renewal. Wnt3a Protein, Human (His) is the recombinant human-derived Wnt3a protein, expressed by E. coli , with N-6*His labeled tag. The total length of Wnt3a Protein, Human (His) is 333 a.a., with molecular weight of ~40 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P83092

FLI1 Antibody (YA2837)

FLI1; Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB
WB, IHC-P Human, Rat
HY-P81237

Wnt10a Antibody

FLJ14301; OODD; Protein Wnt-10a ; SSPS; STHAG4; Wingless type MMTV integration site family member 10A antibody; WN10A_HUMAN; wnt10a;
WB; IF-Cell:; IHC-P; Human, Mouse

HY-P80932

Wnt3a Antibody MGC119418; MGC119419; MGC119420; Protein Wnt 3a Precursor; Protein Wnt-3a; Wingless type MMTV integration site family member 3A; Wnt 3a; WNT3A protein.	WB, IHC-P, IHC-F, IF, ELISA	Human, Mouse, Rat (predicted: Pig)
Wnt3a Antibody is a non-conjugated and Rabbit origined Polyclonal antibody about 39 kDa, targeting to Wnt3a . It can be used for WB, IHC-P, IHC-F, IF, ELISA assays with tag free, in the background of Human.

HY-P83228

Wnt2 Antibody (YA2973) Int 1 related protein; INT1L 1; INT1L1; IRP; IRP protein; ONCOGENE INT1 LIKE 1; Protein Wnt-2; Secreted growth factor; Wingless type MMTV integration site family member 2; WNT2	WB	Human, Mouse, Rat

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