Search Result

Results for "

interferon

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IFNAR (17) STING (37) Akt (1) Antibiotic (2) Apoptosis (4) CD38 (1) Cyclic GMP-AMP Synthase (2) Drug-Linker Conjugates for ADC (3) EBV (1) Endogenous Metabolite (4) Fungal (1) HBV (1) HCV (2) HIF/HIF Prolyl-Hydroxylase (1) HPV (1) Influenza Virus (4) Integrin (1) Interleukin Related (2) JAK (4) Lactate Dehydrogenase (1) MAP4K (1) NF-κB (1) Nucleoside Antimetabolite/Analog (38) PD-1/PD-L1 (3) Phosphodiesterase (PDE) (1) Progesterone Receptor (1) PROTACs (1) STAT (2) TNF Receptor (1) Toll-like Receptor (TLR) (8)
By Research Areas:	Cancer (65) Infection (18) Inflammation/Immunology (43) Metabolic Disease (6) Neurological Disease (2)
Click Chemistry:	Alkynes (4)

125

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

161

Recombinant Proteins

Antibodies

Click Chemistry

Targets Recommended: IFNAR STING AIM2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112189

Interferon receptor inducer-1	IFNAR	Inflammation/Immunology
Interferon receptor inducer-1 (compound 6) is an interferon (IFN) receptor inducer. Used accordingly in the treatment of a disorder in which the induction of interferon is involved .

HY-P99666

Interferon alfa	IFNAR	Infection
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .

HY-12512

cGAMP 5+ Cited Publications Cyclic GMP-AMP; 3',3'-cGAMP	STING	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-110385

cGAMP disodium 5+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-110385A

cGAMP diammonium 5+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-123291

SM-276001	Toll-like Receptor (TLR) IFNAR	Inflammation/Immunology Cancer
SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active *interferon* (IFN) inducer .

HY-119648A

(E/Z)-CCR-11	CD38	Inflammation/Immunology
(E/Z)-CCR-11 (Comp 12) is a selective CD38 inhibitor, with an IC₅₀ of 20.8 μM against CD38 cyclase. (E/Z)-CCR-11 promotes increases in cellular NAD+ levels and interferon γ .

HY-138683

STING-IN-3 2 Publications Verification	STING	Inflammation/Immunology
STING-IN-3 is an inhibitor of *stimulator of interferon* genes (STING)**. STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING .

HY-131994

STING agonist-16	STING	Infection Cancer
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool .

HY-134315

8-Nitroguanosine	Nucleoside Antimetabolite/Analog	Others
8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152610

3′-C-Methylguanosine	Nucleoside Antimetabolite/Analog	Others
3′-C-Methylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152517

8-(Methylthio)guanosine	Nucleoside Antimetabolite/Analog	Others
8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154332

8-(Phenylmethoxy)guanosine	Nucleoside Antimetabolite/Analog	Cancer
8-(Phenylmethoxy)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152430

8-Hydroxymethyl guanosine	Nucleoside Antimetabolite/Analog	Cancer
8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-137406

1,2'-O-Dimethylguanosine	Nucleoside Antimetabolite/Analog	Others
1,2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154506

N2-Phenoxyacetylguanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-Phenoxyacetylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152673

9-(β-D-Xylofuranosyl)guanine	Nucleoside Antimetabolite/Analog	Cancer
9-(β-D-Xylofuranosyl)guanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152652

5’(R)-C-Methylguanosine	Nucleoside Antimetabolite/Analog	Cancer
5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154111

8-(N-Boc-aminomethyl)guanosine	Nucleoside Antimetabolite/Analog	Cancer
8-(N-Boc-aminomethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152742

8-(N,N-Dimethylaminomethyl)guanosine	Nucleoside Antimetabolite/Analog	Others
8-(N,N-Dimethylaminomethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152493

3’-O-(2-Methoxyethyl)guanosine	Nucleoside Antimetabolite/Analog	Others
3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152991

6-Deoxo-8-oxo-3’-deoxy-guanosine	Nucleoside Antimetabolite/Analog	Others
2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154484

3’-O-Me-G(iBu)-2’-phosphoramidite	Nucleoside Antimetabolite/Analog	Cancer
3’-O-Me-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154549

3’-O-MOE-G(iBu)-2’-phosphoramidite	Nucleoside Antimetabolite/Analog	Cancer
3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154336

N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine	Nucleoside Antimetabolite/Analog	Cancer
N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152993

2′-Deoxy-N-(2-furanylmethyl)guanosine	Nucleoside Antimetabolite/Analog	Others
2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-128139

2'-C-Methylguanosine 2'-C-beta-Methylguanosine	Nucleoside Antimetabolite/Analog	Others
2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152992

7-Cyano-7-deaza-2'-deoxy guanosine	Nucleoside Antimetabolite/Analog	Others
7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152988

N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine	Nucleoside Antimetabolite/Analog	Others
N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154547

N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154482

N2-iso-Butyroyl-3’-O-methylguanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-iso-Butyroyl-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154448

3,5-Bis-O-(2,4-dichlorobenzyl)guanosine	Nucleoside Antimetabolite/Analog	Cancer
3,5-Bis-O-(2,4-dichlorobenzyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152797

N4-Desmethyl-N5-Methyl wyosine	Nucleoside Antimetabolite/Analog	Others
N4-Desmethyl-N5-Methyl wyosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-152545

N1,N2-Dimethyl-2’-O-methylguanosine	Nucleoside Antimetabolite/Analog	Cancer
N1,N2-Dimethyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154606

2'-F-2'-ara-N2-ibu-dG Phosphoramidite	Nucleoside Antimetabolite/Analog	Cancer
2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154350

5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine	Nucleoside Antimetabolite/Analog	Cancer
5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-W073825

N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154507

N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154548

N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine	Nucleoside Antimetabolite/Analog	Others
N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-151264

BSP16	STING	Cancer
BSP16 is a potent, orally active *stimulator of interferon* genes (STING)** agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer .

HY-152547

N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154483

N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154351

N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite	Nucleoside Antimetabolite/Analog	Cancer
N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-154464

N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-W063968

RO8191 5+ Cited Publications CDM-3008; RO4948191	IFNAR JAK STAT HCV HBV	Infection
RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC₅₀ of 200 nM for HCV replicon . RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity .

HY-152478

3’-β-C-Ethynylguanosine	Nucleoside Antimetabolite/Analog	Cancer
3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154361

TLR7 agonist 13	Nucleoside Antimetabolite/Analog	Cancer
TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154349

N2-iso-Butyroyl-2’-O-propargylguanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152684

2′-O-2-Propyn-1-ylguanosine	Nucleoside Antimetabolite/Analog	Others
2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148420

CDN-A	STING	Inflammation/Immunology
CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes .

Cat. No.	Product Name

HY-L161

Cytokine Inhibitors Library

811 Compounds compounds

Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases.

MCE designs a unique collection of 811 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.

HY-L127

Anti-Orthopoxvirus Compound Library

36 compounds

Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. The orthopoxvirus genus consists of 12 viruses including variola virus, vaccinia virus (VV), cowpox viruses (CV), monkeypox virus, and camelpox virus. Smallpox has been eradicated worldwide in 1980, but some other orthopoxvirus, such as monkeypox virus, are still threats to human health.

There are not many drugs available for orthopoxvirus treatment. The only product currently available for treatment of complications of Orthopoxvirus infection is vaccinia immunoglobulin (VIG). In 2021, brincidofovir was approved by FDA for the treatment of smallpox and tecovirimat was approved by EMA for the treatment of monkeypox in 2022. A few active compounds including interferon and interferon inducers, and a variety of nucleosides or nucleotides have been reported to have activity against orthopoxvirus.

MCE carefully prepared a unique collection of 36 compounds reported with the anti- orthopoxvirus activity which can be used for drug screening and other research about orthopoxvirus.

HY-L088

1960 compounds

Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer).

MCE offers a unique collection of 1960 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

HY-L073

Anti-Hepatitis C Virus Compound Library

278 compounds

Hepatitis C virus (HCV) is a hepatotropic enveloped positive- strand RNA virus (family Flaviviridae) that infects the parenchymal cells of the liver. HCV infection is a significant public health burden. Globally, an estimated 71 million people have chronic hepatitis C virus infection. A significant number of those who are chronically infected will develop cirrhosis or liver cancer. To date, there is no vaccine against HCV, and combination pegylated alpha interferon (pIFN-) and ribavirin, the main standard-of-care treatment for HCV, is effective in only a subset of patients and is associated with a wide spectrum of toxic side effects and complications. More recently, new therapeutic approaches that target essential components of the HCV life cycle have been developed, including direct-acting antiviral (DAA) that specifically block a viral enzyme or functional protein and host-targeted agents (HTA) that block interactions between host proteins and viral components that are essential to the viral life cycle. However, the genetic diversity of HCV viruses and the stage of liver disease (i.e., cirrhosis) are revealing themselves as obstacles for effective, pan-genotypic treatments. There still exists a need for the discovery and development of new HCV inhibitors. In particular, since the future of HCV therapy will likely consist of a cocktail approach using multiple inhibitors that target different steps of infection, new antivirals targeting all steps of the viral infection cycle.

MCE offers a unique collection of 278 compounds with identified and potential anti-HCV activity. MCE Anti- Hepatitis C Virus Compound Library is a useful tool for discovery new anti-HCV drugs and other anti-infection research.

Cat. No.	Product Name	Target	Research Area

HY-P2565

Pepinh-TRIF TFA 4 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction .

HY-P5364

B8R 20-27	Peptides	Others
B8R 20-27 is a biological active peptide. (This is amino acids 20 to 27 fragment of B8R, a vaccinia virus (VV) gene that encodes a secreted protein related to gamma interferon receptor. B8R binding to IFN-g neutralizes its antiviral activity.)

HY-P4717A

IFN-γ Antagonist 1 acetate	IFNAR	Inflammation/Immunology
IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) acetate is an antagonist of interferon γ (IFN γ). IFN-γ Antagonist 1 inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells with an IC₅₀ value of approximately 35 μM. IFN-γ Antagonist 1 has potential applications in immune regulation .

HY-106171

NBI-6024	Peptides	Metabolic Disease
NBI-6024, an altered peptide ligand (APL), is an epitope recognized by inflammatory interferon-gamma-producing T helper lymphocytes in type 1 diabetic patients .

HY-P4717

IFN-γ Antagonist 1	IFNAR	Inflammation/Immunology
IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) is an antagonist of interferon γ (IFN γ). IFN-γ Antagonist 1 inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells with an IC₅₀ value of approximately 35 μM. IFN-γ Antagonist 1 has potential applications in immune regulation .

HY-P5502

Influenza NP (311-325)	Peptides	Others
Influenza NP (311-325) is a biological active peptide. (This peptide is amino acids 311 to 325 fragment of the influenza virus nucleoprotein (NP). This bona fide MHC class II restricted epitope from influenza virus was used to study the host immunoresponse during the infection. This peptide elicits the strongest gamma interferon (IFN-gamma) production in the intracellular cytokine assays. It does not stimulate CD8 T-cells in mice.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name	Target	Research Area

HY-P99666

Interferon alfa	IFNAR	Infection
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .

HY-P99168

Anifrolumab	Inhibitory Antibodies	Inflammation/Immunology
Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research .

HY-P990036

Dazukibart

IFNAR Infection

Dazukibart is a mouse-derived, humanized IgG1κ antibody targeting interferon beta 1 (IFNB1) .

HY-P99427

Albinterferon alfa-2B alb-IFN	Inhibitory Antibodies	Infection Inflammation/Immunology
Albinterferon alfa-2B (alb-IFN) is a recombinant protein consisting of interferon alfa-2b genetically fused to human albumin. Albinterferon alfa-2B can be used for the research of chronic hepatitis C .

HY-P99478

Bifarcept

IFNAR Inflammation/Immunology

Bifarcept is a recombinant antibody of interferon receptor type I (IFN-RI). Bifarcept can bind IFN-β and prolong its serum half-life .

HY-P99219

Sifalimumab MEDI-545; MDX 1103	IFNAR	Inflammation/Immunology
Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research .

HY-P99610

Ezabenlimab BI-754091	PD-1/PD-L1	Cancer
Ezabenlimab (BI-754091) is an anti-PD-1 mAb with binding constant K_d value of 6 nM (CHO cells). Ezabenlimab blocks the interaction of PD-1 with PD-L1 and PD-L2. Ezabenlimab increases interferon-γ secretion in T cells, and inhibits tumor growth in vivo .

HY-P99497

Cepeginterferon alfa-2b	Integrin HCV	Infection
Cepeginterferon alfa-2b is a pegylated interferon. And Cepeginterferon alfa-2b has PEG with molecular weight of 20 kDa as a pegylated base. Cepeginterferon alfa-2b can be used for research of various diseases, such as hepatitis C virus (HCV), polycythemia vera (PV) and essential thrombocythemia (ET) .

HY-P99735

Mipeginterferon alfa-2b	IFNAR	Infection
Mipeginterferon alfa-2b is an interferon alpha-2b (IFNA2b) analogue, with an average number of 5 substituted among 11 amino groups (one N-terminal and 10 lysine N6). Mipeginterferon alfa-2b has the relative molecular mass of 40 kDa .

HY-P99348

Ropeginterferon alfa-2b Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b	Apoptosis	Cancer
Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms .

Cat. No.	Product Name	Application	Reactivity

HY-P81815

Interferon beta Antibody (YA1560)

interferon beta; interferon β; IFN-beta; IFN-β; IFNβ; Fibroblast interferon; IFB; IFNB
WB, IP Human

HY-P81111

IFN gamma Antibody IFNG; IFG; IFI; IFN Gamma; IFN Immune; IFN-gamma; IFNG; IFNG_HUMAN; Immune interferon; interferon gamma; interferon Gamma Precursor; Macrophage Activating Factor; MAF; T Cell interferon; Type II interferon.	WB; ELISA; IHC-P; IHC-F; IF	Human,
IFN gamma Antibody is an unconjugated, approximately 15 kDa, rabbit-derived, anti-IFN gamma polyclonal antibody. IFN gamma Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, background without labeling.

HY-P82663

Interferon Regulatory Factor 4 Antibody (YA2408) IRF4; MUM1; interferon regulatory factor 4; IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5	WB, IHC-P, ICC/IF, IP, FC	Human

HY-P82139

IRF5 Antibody (YA1884)

interferon regulatory factor 5; interferon regulatory factor 5 bone marrow variant; IRF 5; SLEB10
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P83115

Fragilis Antibody (YA2860)

IFITM3; interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; interferon-inducible protein 1-8U
WB, IHC-F, IHC-P, ICC/IF Human
HY-P82329

Interferon gamma Receptor 1 Antibody (YA2074)

IFNGR1; interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD antigen CD119
WB, IHC-P, ICC/IF, FC Human
HY-P83373

IRF1 Antibody (YA3118)

IRF1; interferon regulatory factor 1; IRF-1
WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P83385

IRF2 Antibody (YA3130)

interferon regulatory factor 2; IRF 2
WB, IHC-P, ICC/IF Human, Mouse

HY-P83367

Interferon alpha/beta Receptor 1 Antibody (YA3112) IFNAR1; IFNAR; interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1	WB, IP	Human

HY-P82718

IRF7 Antibody (YA2463)

IRF7; interferon regulatory factor 7; IRF-7; IRF7A; IRF-7H
WB, IHC-F, IHC-P, ICC/IF, IP Human, Rat

HY-P81299

Phospho-PKR (Thr451) Antibody (YA1025) EIF2AK2; PKR; PRKR; interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k	WB	Human

HY-P81299A

Phospho-PKR (Thr446) Antibody (YA1026) EIF2AK2; PKR; PRKR; interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k	WB, IHC-P, IP, ChIP	Human

HY-P81154

CXCL10/IP10 Antibody 10 kDa interferon gamma induced protein; C7; Chemokine (C X C motif) ligand 10; Chemokine CXC motif ligand 10; Crg 2; CRG2; CXCL 10; CXCL10; Gamma IP10; gIP 10; GIP10; IFI 10; IFI10; INP 10; INP10; interferon activated gene 10; interferon gamma induced cell line; interferon inducible cytokine IP 10; MOB1; SCYB 10; SCYB10; Small inducible cytokine B10; Small inducible cytokine B10 precursor; Small inducible cytokine subfamily B (Cys X Cys) member 10; Gamma-IP-10.	ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat,
CXCL10/IP10 Antibody is an unconjugated, approximately 10 kDa, rabbit-derived, anti-CXCL10/IP10 polyclonal antibody. CXCL10/IP10 Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, background without labeling.

HY-P82917

IRF6 Antibody (YA2662)

interferon regulatory factor 6; IRF 6; LPS; OFC 6; PIT; PPS; PPS1; VWS; VWS1
WB, IHC-P, ICC/IF Human, Mouse, Rat

HY-P80723

IL-6 Antibody IL6; IFNB2; Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; interferon beta-2; IFN-beta-2	WB, IHC-P, ELISA	Human
IL-6 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 24 kDa, targeting to IL-6. It can be used for WB,IHC-P,ELISA assays with tag free, in the background of Human.

HY-P81188

CXCR3 Antibody CXCR3_HUMAN; interferon-inducible protein 10 receptor; IP-10 receptor; C-X-C chemokine receptor type 3; CD 183; CD183; CD183 antigen; G protein-coupled receptor 9; G Protein Coupled Receptor 9; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; C-X-C Chemokine receptor; CXC Motif Receptor 3; Chemokine CXC Motif Receptor 3; CKRL2; CKR L2; CKR-L2; GPR9; CXC-R3; CXCR-3; IP10 receptor.	WB	Human, Mouse, Rat(predicted: Dog, Pig, Cow, Rabbit, Guinea Pig)
CXCR3 Antibody is an unconjugated, approximately 40 kDa, rabbit-derived, anti-CXCR3 polyclonal antibody. CXCR3 Antibody can be used for: WB expriments in human, mouse, rat, and predicted: dog, pig, cow, rabbit, guinea pig background without labeling.

HY-P82797

IP10 Antibody (YA2542)

CXCL10; INP10; SCYB10; C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10
WB Human

HY-P81180

CXCL9 Antibody MIG; CMK; C-X-C motif chemokine 9; CXCL9; chemokine (C-X-C motif) ligand 9; crg-10; Humig; monokine induced by gamma interferon; SCYB9; Small inducible cytokine B9; small inducible cytokine subfamily B member 9.	ELISA; IHC-P; IHC-F; IF	Human, Mouse(predicted: Rat, Pig, Cow, Horse)
CXCL9 Antibody is an unconjugated, approximately 14 kDa, rabbit-derived, anti-CXCL9 polyclonal antibody. CXCL9 Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat, pig, cow, horse background without labeling.

HY-P81356

PRDM1/Blimp1 Antibody (YA1101) PRDM1; BLIMP1; PR domain zinc finger protein 1; BLIMP-1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1 (PRDI-BF1; PRDI-binding factor 1)	IHC-P	Human

HY-P81182

PTGES2 Antibody C9orf15; FLJ14038; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF 1; GBF1; Membrane associated prostaglandin E synthase 2; MGC11289; Microsomal prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; PTGES 2; PGES2_MOUSE.	ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat(predicted: Chicken, Dog, Pig, Cow)
PTGES2 Antibody is an unconjugated, approximately 43 kDa, rabbit-derived, anti-PTGES2 polyclonal antibody. PTGES2 Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow background without labeling.

Cat. No.	Product Name		Classification