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Results for "

isoquinoline

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adenosine Receptor (2) Adrenergic Receptor (2) Akt (3) Angiotensin Receptor (2) Apoptosis (6) Autophagy (2) Bacterial (4) Beta-secretase (1) Calcium Channel (1) Cholinesterase (ChE) (6) Dopamine Receptor (1) Endogenous Metabolite (1) Enterovirus (1) Fluorescent Dye (1) Fungal (1) Influenza Virus (3) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) Mitophagy (2) Monoamine Oxidase (1) NF-κB (2) Opioid Receptor (1) Parasite (2) PI3K (2) Potassium Channel (1) Proteasome (1) RANKL/RANK (2)
By Research Areas:	Cancer (14) Cardiovascular Disease (4) Endocrinology (2) Infection (6) Inflammation/Immunology (12) Metabolic Disease (1) Neurological Disease (8)

By Targets:

5-HT Receptor (4)

Adenosine Receptor (2)

Adrenergic Receptor (2)

Akt (3)

Angiotensin Receptor (2)

Apoptosis (6)

Autophagy (2)

Bacterial (4)

Beta-secretase (1)

Calcium Channel (1)

Cholinesterase (ChE) (6)

Dopamine Receptor (1)

Endogenous Metabolite (1)

Enterovirus (1)

Fluorescent Dye (1)

Fungal (1)

Influenza Virus (3)

Isotope-Labeled Compounds (1)

Microtubule/Tubulin (1)

Mitophagy (2)

Monoamine Oxidase (1)

NF-κB (2)

Opioid Receptor (1)

Parasite (2)

PI3K (2)

Potassium Channel (1)

Proteasome (1)

RANKL/RANK (2)

By Research Areas:

Cancer (14)

Cardiovascular Disease (4)

Endocrinology (2)

Infection (6)

Inflammation/Immunology (12)

Metabolic Disease (1)

Neurological Disease (8)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W012732

*Isoquinoline* 1 Publications Verification	Others	Cancer
Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities .

HY-W012732S

Isoquinoline-d7	Isotope-Labeled Compounds	Cancer
Isoquinoline-d7 is the deuterium labeled Isoquinoline[1]. Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities[2].

HY-W012732R

Isoquinoline (Standard)	Others	Cancer
Isoquinoline (Standard) is the analytical standard of Isoquinoline. This product is intended for research and analytical applications. Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities .

HY-W029659

1-Benzyl-1,2,3,4-tetrahydro-isoquinoline	Endogenous Metabolite	Neurological Disease
1-Benzyl-1,2,3,4-tetrahydro-isoquinoline is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Parkinson's Disease .

HY-119731

Antidesmone

Others Others

Antidesmone is a isoquinoline alkaloid that can be isolated from Antidesma membranaceum .
HY-N11491

8-Demethoxycephatonine

Others Others

8-Demethoxycephatonine is an isoquinoline alkaloid, that can be isolated from Sinomenium acutum (Menispermaceae) .

Antidesmone	Others	Others
Antidesmone is a isoquinoline alkaloid that can be isolated from Antidesma membranaceum .

8-Demethoxycephatonine	Others	Others
8-Demethoxycephatonine is an isoquinoline alkaloid, that can be isolated from Sinomenium acutum (Menispermaceae) .

HY-N3035

Tetrahydroepiberberine	Fungal Influenza Virus	Infection
Tetrahydroepiberberine is a isoquinoline alkaloid isolated from Corydalis impatiens (Pall). Tetrahydroepiberberine has antifungal and selective inhibition against the PI-3 virus activities .

HY-N0586A

Norisoboldine hydrochloride (+)-Laurelliptine hydrochloride	Adenosine Receptor	Inflammation/Immunology
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-N0586

Norisoboldine (+)-Laurelliptine	Adenosine Receptor	Inflammation/Immunology
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-117616

Laurotetanine (+)-Laurotetanine	NF-κB	Cancer
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways .

HY-N7512

Asimilobine	Dopamine Receptor 5-HT Receptor Parasite	Infection Cancer
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity .

HY-113806

(±)-Trolline (±)-Oleracein E	Bacterial Influenza Virus Apoptosis	Infection Inflammation/Immunology
(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis .

HY-N2369

Chelidonine	Apoptosis Influenza Virus	Infection Cancer
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .

HY-N0926

Columbamine

Columbamin; Dehydroisocorypalmine
Others Others

Columbamine is a quaternary isoquinoline alkaloid extracted from plants.

Columbamine Columbamin; Dehydroisocorypalmine	Others	Others
Columbamine is a quaternary isoquinoline alkaloid extracted from plants.

HY-N11492

7(R)-7,8-Dihydrosinomenine	Others	Metabolic Disease
7(R)-7,8-Dihydrosinomenine, a isoquinoline alkaloid that can be isolated from Sinomenium acutum (Menispermaceae), possesses anti-osteoclastogenic effect .

HY-N0793A

Protopine hydrochloride Corydinine hydrochloride	Cholinesterase (ChE)	Infection Neurological Disease Inflammation/Immunology Cancer
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-22385A

Salsolidine hydrochloride	Monoamine Oxidase	Neurological Disease
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.

HY-N0793

Protopine Corydinine	Cholinesterase (ChE)	Infection Neurological Disease Inflammation/Immunology Cancer
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-102010

Pancratistatin (+)-Pancratistatin	Apoptosis	Cancer
Pancratistatin is an isoquinoline alkaloid that can be isolated from Hymenocallis littoralis. Pancratistatin induces apoptosis of human melanoma cells. Pancratistatin can be used for the research of neuroblastoma, leukemia and breast cancer .

HY-13764

Tetrandrine 5+ Cited Publications NSC-77037; d-Tetrandrine	Calcium Channel Potassium Channel Parasite	Inflammation/Immunology Cancer
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca ²⁺ current (ICa) and Ca ²⁺-activated K ⁺ current.

HY-N12186

Sibiricine	Others	Inflammation/Immunology
Sibiricine (Compound 8) is an isoquinoline alkaloid derived from the medicinal plant Corydalis crispa. Sibiricine has significant anti-inflammatory activity on TNF-α production by LPS-activated THP-1 cells .

HY-N0427

Phellodendrine	Akt NF-κB	Inflammation/Immunology
Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendron amurense. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect .

HY-N1219

Stephanine (-)-Stephanine; l-Stephanine
Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer .

HY-D2095

Medical fluorophore 33	Fluorescent Dye	Cancer
Medical fluorophore 33 is a novel quinoline-isoquinoline salt. Medical fluorophore 33 exhibits a strong fluorescent signal, good microsomal stability and high biocompatibility in vivo. Medical fluorophore 33 has antitumor activity in colorectal cancer mice .

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Microtubule/Tubulin Beta-secretase Apoptosis	Cancer
Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells .

HY-N10824

2,3,5,6-Tetramethoxyaporphine	Others	Others
2,3,5,6-Tetramethoxyaporphine is an antitussive agent, a medicinally valuable benzyl isoquinoline alkaloid. 2,3,5,6-Tetramethoxyaporphine can be isolated from the yellow hornpoppy, Glaucium flavum Cr. (Fam. Papaveraceae) .

HY-N2003

D-Tetrahydropalmatine
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .

HY-N0484

Liensinine Maximum Cited Publications 8 Publications Verification	Autophagy Mitophagy Apoptosis	Cardiovascular Disease Cancer
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-N3177

Norglaucine hydrochloride

Others Others

Norglaucine hydrochloride is an alkaloid that can be isolated from Aconitum carmichaelii .

Norglaucine hydrochloride	Others	Others
Norglaucine hydrochloride is an alkaloid that can be isolated from Aconitum carmichaelii .

HY-N0923

Corydaline (+)-Corydaline; Corydalin	Cholinesterase (ChE) Enterovirus Opioid Receptor	Neurological Disease
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 µM. Corydaline is a μ-opioid receptor (K_i of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-144452

Immunoproteasome inhibitor 1	Proteasome	Cancer
Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (K_is of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the research of certain neoplastic diseases .

HY-N0485

Liensinine Diperchlorate Maximum Cited Publications 8 Publications Verification	Autophagy Mitophagy	Cardiovascular Disease
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-N6973R

Boldine (Standard)	RANKL/RANK	Inflammation/Immunology
Boldine (Standard) is the analytical standard of Boldine. This product is intended for research and analytical applications. Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis .

HY-N6973

Boldine	RANKL/RANK Apoptosis	Inflammation/Immunology
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research .

HY-15477

YS-49 5+ Cited Publications	Akt PI3K Angiotensin Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .

HY-15477A

YS-49 monohydrate	Akt PI3K Angiotensin Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .

HY-N1934

Dihydroberberine
Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy .

HY-N0749

Jatrorrhizine	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N0740

Jatrorrhizine chloride	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N0749A

Jatrorrhizine hydroxide	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

Natural Product-like Compound Library	581 compounds
Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways. MCE provides a unique collection of 581 natural product-like compounds that are structurally like Steroids, Tannins, Flavonoids, Quinones, Isoquinolines, etc. This library is an important source of lead compounds for drug discovery.

Alkaloids Library	528 compounds
Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds. MCE designs a unique collection of 528 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Medical fluorophore 33	Fluorescent Dyes/Probes
Medical fluorophore 33 is a novel quinoline-isoquinoline salt. Medical fluorophore 33 exhibits a strong fluorescent signal, good microsomal stability and high biocompatibility in vivo. Medical fluorophore 33 has antitumor activity in colorectal cancer mice .

Cat. No.	Product Name	Category	Target	Chemical Structure