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Results for "

joint

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Bacterial (2) Bradykinin Receptor (1) COX (2) Discoidin Domain Receptor (1) EBI2/GPR183 (1) Endogenous Metabolite (1) Glucocorticoid Receptor (4) IKK (1) Interleukin Related (3) Isotope-Labeled Compounds (5) JAK (1) Melanocortin Receptor (1) Prostaglandin Receptor (2) Protease Activated Receptor (PAR) (1) ROR (1) TNF Receptor (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (1) Infection (2) Inflammation/Immunology (30) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13681

Methylprednisolone acetate	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo .

HY-B1079

Suxibuzone

Others Inflammation/Immunology

Suxibuzone is a drug used for joint and muscular pain, is a prodrug of the non steroidal anti inflammatory drug Phenylbutazone.

Suxibuzone	Others	Inflammation/Immunology
Suxibuzone is a drug used for joint and muscular pain, is a prodrug of the non steroidal anti inflammatory drug Phenylbutazone.

HY-U00103

Triamcinolone hexacetonide	Others	Inflammation/Immunology
Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases.

HY-14886

Fasitibant chloride MEN16132 free base	Bradykinin Receptor	Cardiovascular Disease Neurological Disease
Fasitibant chloride (MEN16132 free base) is a potent and selective nonpeptide bradykinin B2 receptor (B2R) antagonist. Fasitibant chloride reduces joint pain and diminishes joint oedema in Carrageenan-induced arthritis rat model .

HY-122049

ENMD-1068 hydrobromide	Protease Activated Receptor (PAR)	Inflammation/Immunology
ENMD-1068 hydrobromide is a potent PAR2 antagonist. ENMD-1068 hydrobromide attenuates joint inflammation in a dose-dependent manner. ENMD-1068 hydrobromide can be used in research of joint inflammation .

HY-N9794

Isoboldine	Others	Inflammation/Immunology
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

HY-145726

ISIS 104838	TNF Receptor	Inflammation/Immunology
ISIS 104838 is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis.

HY-145726A

ISIS 104838 sodium	TNF Receptor	Inflammation/Immunology
ISIS 104838 sodium is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis.

HY-P99690

Ledelabricin alfa	Endogenous Metabolite	Inflammation/Immunology
Ledelabricin alfa is a human proteoglycan 4 (PRG4) isoform A variant. PRG4 is a joint/boundary lubricant. Ledelabricin Alfa can be used for the research arthropathy .

HY-P99820

Ranevetmab NV-01	TNF Receptor	Inflammation/Immunology
Ranevetmab (NV-01) is a caninised anti-NGF monoclonal antibody (mAb). Ranevetmab can alleviate pain, and is used for the research of degenerative joint disease (DJD) pain .

HY-17591

Penicillin G potassium Maximum Cited Publications 11 Publications Verification Benzylpenicillin potassium	Antibiotic Bacterial	Infection
Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas .

HY-N2016

Arteannuin B

2 Publications Verification

Arteannuin B, No. 2000 can be jointly submitted with the blue material. Arteannuin B had anti-SARS-CoV-2 activity, EC₅₀=10.28 μM .

Arteannuin B 2 Publications Verification
Arteannuin B, No. 2000 can be jointly submitted with the blue material. Arteannuin B had anti-SARS-CoV-2 activity, EC₅₀=10.28 μM .

HY-N0283R

Diacerein (Standard) Diacerhein(Standard); Diacetylrhein (Standard)	Interleukin Related	Inflammation/Immunology
Diacerein (Standard) is the analytical standard of Diacerein. This product is intended for research and analytical applications. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.

HY-N0283S

Diacerein-d6 Diacerhein-d₆; Diacetylrhein-d₆	Interleukin Related	Inflammation/Immunology
Diacerein-d₆ is the deuterium labeled Diacerein[1]. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases[2].

HY-142123

Fluocortolone	Others	Inflammation/Immunology
Fluocortolone is an orally active anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adjuvanted joint inflammation (3-12 mg/kg) .

HY-17591S

Penicillin G-d5 potassium Benzylpenicillin-d₅ potassium	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Penicillin G-d₅ (potassium) is the deuterium labeled Penicillin G potassium. Penicillin G potassium is a fast-acting antibiotic; used to treat bacterial infections that affect the blood, heart, lungs, joints, and genital areas[1][2].

HY-13681R

Methylprednisolone acetate (Standard)	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone acetate (Standard) is the analytical standard of Methylprednisolone acetate. This product is intended for research and analytical applications. Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid?hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo .

HY-13681S

Methylprednisolone acetate-d6	Glucocorticoid Receptor Isotope-Labeled Compounds	Inflammation/Immunology
Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo .

HY-W009706

Alclofenac Allopydin; W-7320	Prostaglandin Receptor	Inflammation/Immunology
Alclofenac (Allopydin) is a non-steroidal anti-inflammatory agent (NSAID). Alclofenac is a prostaglandin H2 synthase inhibitor. Alclofenac can be used for rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis research .

HY-120012

Mizacorat 4 Publications Verification AZD9567	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC₅₀ of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation .

HY-119447

Mavacoxib	COX	Inflammation/Immunology
Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs .

HY-10794

MF498 1 Publications Verification	Prostaglandin Receptor	Metabolic Disease Inflammation/Immunology Cancer
MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a K_i value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis .

HY-163412

IKKβ-IN-3	IKK	Inflammation/Immunology
IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC₅₀ value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis .

HY-B1695S

Methyl nicotinate-d4	Isotope-Labeled Compounds	Inflammation/Immunology
Methyl nicotinate-d₄ is the deuterium labeled Methyl nicotinate[1]. Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain[2].

HY-107565

2-Pyridylethylamine hydrochloride	Others	Inflammation/Immunology
2-Pyridylethylamine is a histamine-1 (H1R) receptor agonist. 2-Pyridylethylamine can reduce the joint injury induced by formalin in rats. 2-Pyridylethylamine can be used to study the spinal cord release of neuropeptide (NPY) .

HY-B1456A

Fenoprofen LILLY-53858
Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation .

HY-157121

JAK-IN-34	JAK	Inflammation/Immunology
JAK-IN-34 (compound 11n) is a potent against of JAKs with IC₅₀** values of 0.40, 0.83, 2.10, 1.95 nM target JAK1, JAK2, JAK3, TYK2, respectively. JAK-IN-34 reduces joint swelling with good safety .**

HY-B1695

Methyl nicotinate Nicotinic acid methyl ester
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-119447S

Mavacoxib-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Mavacoxib-d₄ is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs[1].

HY-B1456AS

Fenoprofen-13C6(sodium salt hydrate)	Isotope-Labeled Compounds Melanocortin Receptor	Inflammation/Immunology
Fenoprofen- ¹³C₆ (sodium hydrate) is the ¹³C labeled Fenoprofen (HY-B1456A). Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation[1][2][3].

HY-126252

A-9758	ROR Interleukin Related	Inflammation/Immunology
A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC₅₀=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation .

HY-162011

GPR183 antagonist-2	EBI2/GPR183	Inflammation/Immunology
GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases .

HY-114169

WRG-28	Discoidin Domain Receptor	Inflammation/Immunology Cancer
WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC₅₀ of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice .

Cat. No.	Product Name

HY-L095

Mechanoreceptors Compound Library	250 compounds
Mechanoreceptors convert different stimuli from the outside into electrical signals, enabling us to quickly respond to our environment. Mechanoreceptors are distributed throughout the body, including in the skin, tendons, muscles, joint capsules and viscera. In addition to the channels of TRP and Piezo mentioned in the Nobel Prize, there are also targets such as KCNK, ENaC and ASIC2, which play an important role in the environment perception and homeostasis of living organisms. MCE offers a unique collection of 250 compounds related to mechanoreceptors, which targeting different mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc. MCE mechanoreceptors compound library is a powerful tool for studying mechanoreceptors and life perception.

Mechanoreceptors Compound Library

250 compounds

Mechanoreceptors convert different stimuli from the outside into electrical signals, enabling us to quickly respond to our environment. Mechanoreceptors are distributed throughout the body, including in the skin, tendons, muscles, joint capsules and viscera. In addition to the channels of TRP and Piezo mentioned in the Nobel Prize, there are also targets such as KCNK, ENaC and ASIC2, which play an important role in the environment perception and homeostasis of living organisms.

MCE offers a unique collection of 250 compounds related to mechanoreceptors, which targeting different mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc. MCE mechanoreceptors compound library is a powerful tool for studying mechanoreceptors and life perception.

HY-L114

Anti-inflammatory Traditional Chinese Medicine Active Compound Library	1060 compounds
Inflammation promotes physiological and pathological processes by the activation of the immune system, local vascular system, and various cells within the damaged tissue. Accumulating epidemiological and clinical evidence shows that chronic inflammation is causally linked to various human diseases, including cerebrovascular, cardiovascular, joint, cutaneous, pulmonary, blood, liver, and intestinal diseases as well as diabetes. Various natural products from Traditional Chinese Medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. MCE designs a unique collection of 1060 Traditional Chinese Medicine active compounds with anti-inflammatory activity, which are derived from Coptis chinensis, Radix isatidis, Flos Lonicerae, Forsythia suspensa, etc. MCE Anti-inflammatory Traditional Chinese Medicine Active Compound Library is a useful tool for discovery anti-inflammatory drugs from TCM.

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

1060 compounds

Inflammation promotes physiological and pathological processes by the activation of the immune system, local vascular system, and various cells within the damaged tissue. Accumulating epidemiological and clinical evidence shows that chronic inflammation is causally linked to various human diseases, including cerebrovascular, cardiovascular, joint, cutaneous, pulmonary, blood, liver, and intestinal diseases as well as diabetes.

Various natural products from Traditional Chinese Medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. MCE designs a unique collection of 1060 Traditional Chinese Medicine active compounds with anti-inflammatory activity, which are derived from Coptis chinensis, Radix isatidis, Flos Lonicerae, Forsythia suspensa, etc. MCE Anti-inflammatory Traditional Chinese Medicine Active Compound Library is a useful tool for discovery anti-inflammatory drugs from TCM.

Cat. No.	Product Name	Target	Research Area

HY-P2642

Peptide 78	Peptides	Inflammation/Immunology
Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family. ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA) .

HY-P10136

IA9 human TREM-2 182-190	Peptides	Inflammation/Immunology
IA9 (human TREM-2 182-190) is a TREM-2 inhibitor , and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model .

HY-P10136A

IA9 TFA human TREM-2 182-190 TFA	Peptides	Inflammation/Immunology
IA9 TFA (human TREM-2 182-190 TFA) is a TREM-2 inhibitor , and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model .

Cat. No.	Product Name	Target	Research Area

HY-P99690

Ledelabricin alfa	Endogenous Metabolite	Inflammation/Immunology
Ledelabricin alfa is a human proteoglycan 4 (PRG4) isoform A variant. PRG4 is a joint/boundary lubricant. Ledelabricin Alfa can be used for the research arthropathy .

HY-P99820

Ranevetmab NV-01	TNF Receptor	Inflammation/Immunology
Ranevetmab (NV-01) is a caninised anti-NGF monoclonal antibody (mAb). Ranevetmab can alleviate pain, and is used for the research of degenerative joint disease (DJD) pain .

Penicillin G potassium 10+ Cited Publications Benzylpenicillin potassium	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Disease Research Fields	Antibiotic Bacterial
Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas .

Isoboldine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Phenols Polyphenols Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

Cat. No.	Product Name	Chemical Structure

HY-17591S

Penicillin G-d5 potassium
Penicillin G-d₅ (potassium) is the deuterium labeled Penicillin G potassium. Penicillin G potassium is a fast-acting antibiotic; used to treat bacterial infections that affect the blood, heart, lungs, joints, and genital areas[1][2].

HY-B1695S

Methyl nicotinate-d4
Methyl nicotinate-d₄ is the deuterium labeled Methyl nicotinate[1]. Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain[2].

HY-N0283S

Diacerein-d6
Diacerein-d₆ is the deuterium labeled Diacerein[1]. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases[2].

HY-13681S

Methylprednisolone acetate-d6
Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo .

HY-119447S

Mavacoxib-d4
Mavacoxib-d₄ is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs[1].

HY-B1456AS

Fenoprofen-13C6(sodium salt hydrate)

Fenoprofen- ¹³C₆ (sodium hydrate) is the ¹³C labeled Fenoprofen (HY-B1456A). Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation[1][2][3].

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joint

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
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