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63

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2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13977A
    PKR-IN-C16
    2 Publications Verification

    		 Apoptosis Neurological Disease
    PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neuroprotective properties and can rescue acute brain lesions .
    PKR-IN-C16
  • HY-133598
    3,4,5-Trichlorocatechol

    		Others Cancer
    3,4,5-Trichlorocatechol is a catechol derivative of pentachlorophenol and induces oxidative DNA lesions .
    3,4,5-Trichlorocatechol
  • HY-P5890
    YVAD-CHO

    		Interleukin Related Caspase Neurological Disease
    YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor that can partially delay motoneurone death in lesioned facial nerve mice .
    YVAD-CHO
  • HY-107248
    Escin IIa

    		Others Inflammation/Immunology
    Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats .
    Escin IIa
  • HY-107247
    Escin IIb

    		Others Inflammation/Immunology
    Escin IIb, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals . Escin IIb showed potent protective effects against ethanol-induced gastric mucosal lesions .
    Escin IIb
  • HY-18664
    PFI-4
    1 Publications Verification

    		 Epigenetic Reader Domain Cancer
    PFI-4 (compound 11) is a potent and highly selective BRPF1 Bromodomain (BRPF1B) inhibitor, with an IC50 of 172 nM. PFI-4 can be used to explore the functional mechanisms of the HBO1/BRPF1 complex and to study bone loss and osteolytic malignant bone lesions .
    PFI-4
  • HY-110161
    sst2 Receptor agonist-1

    		Somatostatin Receptor Cardiovascular Disease Endocrinology
    sst2 Receptor agonist-1 is a potent somatostatin receptor subtype 2 (sst2) agonist with a Ki value of 0.025 nM and a cAMP IC50 value of 4.8 nM. sst2 Receptor agonist-1 can inhibit rat growth hormone (GH) secretion and ocular neovascular lesion formation. Antiangiogenic effect .
    sst2 Receptor agonist-1
  • HY-142521
    BLT2 probe 1

    		Leukotriene Receptor Metabolic Disease
    BLT2 probe 1 (compound 13) is a fluorescent probe based on the synthetic BLT2 agonist CAY10583. BLT2 is a promising target for diabetic wound healing and gastrointestinal lesions. BLT2 probe 1 is suitable to investigate the pharmacology of BLT2 receptor ligands in a variety of assay systems .
    BLT2 probe 1
  • HY-147313
    TH10785

    		Others Metabolic Disease Cancer
    TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions .
    TH10785
  • HY-W010697
    Cholesteryl linoleate

    		Endogenous Metabolite Metabolic Disease
    Cholesteryl linoleate is shown to be the major cholesteryl ester contained in LDL and atherosclerotic lesions.
    Cholesteryl linoleate
  • HY-W013812
    Ethyl linoleate

    Linoleic Acid ethyl ester; Mandenol

    		 Others Cardiovascular Disease
    Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators .
    Ethyl linoleate
  • HY-W144308
    Tetrachlorohydroquinone

    TCHQ; Tetrachloroquinol

    		 Drug Metabolite Reactive Oxygen Species Others
    Tetrachlorohydroquinone (TCHQ) is a metabolite of pentachlorophenol. Tetrachlorohydroquinone increases DNA lesions and induce oxidative stress in rodents .
    Tetrachlorohydroquinone
  • HY-113338
    8-Hydroxyguanine

    		Endogenous Metabolite Others
    8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.
    8-Hydroxyguanine
  • HY-B1745
    Pyridoxylamine
    2 Publications Verification
    Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
    Pyridoxylamine
  • HY-B1745A
    Pyridoxylamine dihydrochloride
    2 Publications Verification
    Pyridoxylamine dihydrochloride is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions .
    Pyridoxylamine dihydrochloride
  • HY-17644
    Redaporfin

    LUZ11; F2BMet
    Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune-dependent destruction of malignant lesions .
    Redaporfin
  • HY-W013812S
    Ethyl linoleate-13C18

    Linoleic Acid-13C18 ethyl ester; Mandenol-13C18

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Ethyl linoleate- 13C18 is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators[1].
    Ethyl linoleate-13C18
  • HY-D1494
    FSB

    		Amyloid-β Neurological Disease
    FSB is a fluorescent dye that can be used to detect filamentous tau and to label human amyloid lesions with high sensitivity and specificity (excitation: 390 nm, emission: 520 nm) .
    FSB
  • HY-154988
    MARK4 inhibitor 4

    		Others Neurological Disease Cancer
    MARK4 inhibitor 4 is a MARK4 inhibitor with an IC50 of 1.49 μM. MARK4 inhibitor 4 can be used in cancer and tau lesion-related research .
    MARK4 inhibitor 4
  • HY-139579
    Pafolacianine

    OTL 38

    		 Fluorescent Dye Cancer
    Pafolacianine (OTL 38) is a fluorescent marker made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775 nm and emits at 794 to 796 nm .
    Pafolacianine
  • HY-111940
    LUT014

    		Raf Inflammation/Immunology
    LUT014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment. Extracted from patent WO 2019026065A2 .
    LUT014
  • HY-108038
    ABT-107

    		nAChR Neurological Disease
    ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions .
    ABT-107
  • HY-150042
    TDI-011536

    		YAP Cardiovascular Disease Others
    TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration .
    TDI-011536
  • HY-13703A
    Nimustine hydrochloride
    1 Publications Verification

    ACNU

    		 DNA/RNA Synthesis DNA Alkylator/Crosslinker Apoptosis Cancer
    Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas .
    Nimustine hydrochloride
  • HY-135014
    Undecylenoyl phenylalanine

    		Melanocortin Receptor Adrenergic Receptor Others
    Undecylenoyl phenylalanine is an antagonist for α-melanocyte-stimulating hormone (MSH) and β-adrenergic receptor (β-ADR) to reduce the melanogenesis in melanocytes, reduces hyperpigmentation and thus ameliorates melasma lesions and solar lentigines .
    Undecylenoyl phenylalanine
  • HY-131468
    Picoplatin

    AMD473; ZD0473

    		 Others Cancer
    Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA .
    Picoplatin
  • HY-D1443
    BSB

    (trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene

    		 Amyloid-β Others
    BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease .
    BSB
  • HY-147230
    EZH2-IN-13

    		Histone Methyltransferase Cancer
    EZH2-IN-13 is a potent EZH2 inhibitor, for details please refer to compound 73 in patent WO2017139404. EZH2-IN-13 can be used to study cancers or precancerous lesions associated with EZH2 activity .
    EZH2-IN-13
  • HY-128760
    COH34
    1 Publications Verification

    		 Poly(ADP-ribose) Glycohydrolase (PARG) Cancer
    COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors .
    COH34
  • HY-N1553
    Pseudolaric acid D

    Pseudolaric acid D is a compound with oral activity that can be isolated from Pseudolarix kaempferi Gorden. Pseudolaric acid D can significantly improve lipid metabolism, reduce atherosclerotic lesion area, and alleviate atherosclerotic changes in vascular wall. Pseudolaric acid D significantly inhibits the inflammatory reaction .
    Pseudolaric acid D
  • HY-W013812S2
    Ethyl linoleate-d2

    Linoleic Acid ethyl ester-d2; Mandenol-d2

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Ethyl linoleate-d2 (Linoleic Acid ethyl ester-d2; Mandenol-d2) is the deuterium labeled Ethyl linoleate (HY-W013812). Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators .
    Ethyl linoleate-d2
  • HY-156466
    QL-1200186

    		JAK Inflammation/Immunology
    QL-1200186 is anorally activeand selective inhibitor ofTYK2. Oral administration of QL-1200186, dose-dependently inhibitsinterferon-γ(IFNγ) production afterinterleukin-12(IL-12) challenge and significantly ameliorates skin lesions in psoriatic mice .
    QL-1200186
  • HY-100413
    CS-526

    CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H +,K +-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease .
    CS-526
  • HY-129214
    (2S,3R)-DEPMPO-Biotin

    		Reactive Oxygen Species Inflammation/Immunology
    (2S,3R)-DEPMPO-Biotin is a spin trapping agent consists of DEPMPO (HY-120976) and Biotin (HY-B0511). (2S,3R)-DEPMPO-Biotin captures macromolecule free radicals in lesions .
    (2S,3R)-DEPMPO-Biotin
  • HY-B1496
    Tranylcypromine hemisulfate
    4 Publications Verification

    SKF 385 hemisulfate

    		 Monoamine Oxidase Histone Demethylase Neurological Disease
    Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects .
    Tranylcypromine hemisulfate
  • HY-123026
    Salannin

    		Bacterial Infection
    Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .
    Salannin
  • HY-125098
    Illudin S

    		DNA Alkylator/Crosslinker Apoptosis Infection Cancer
    Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .
    Illudin S
  • HY-17447SA
    Tranylcypromine-d5 hydrochloride

    SKF 385-d5 hydrochloride

    		 Monoamine Oxidase Histone Demethylase Neurological Disease
    Tranylcypromine-d5 (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis[1][2].
    Tranylcypromine-d5 hydrochloride
  • HY-B0025
    Voglibose

    		Glucosidase Metabolic Disease
    Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.
    Voglibose
  • HY-16219
    Gadoxetate Disodium

    Gd-EOB-DTPA Disodium; ZK 139834

    		 Biochemical Assay Reagents Cancer
    Gadoxetate Disodium (Gd-EOB-DTPA Disodium) is a contrast agent in magnetic resonance imaging (MRI) of the hepatobiliary system, which accumulates in normal, functioning hepatocytes. Gadoxetate Disodium (Gd-EOB-DTPA Disodium) is used to evaluate focal liver lesions, such as hepatocellular carcinoma or liver metastasis on T1-weighted imaging .
    Gadoxetate Disodium
  • HY-157916
    ARP

    Aldehyde reactive probe

    		 Fluorescent Dye Others
    ARP (Aldehyde reactive probe) is an aldehyde reactive probe for detecting abasic site (common DNA lesions and intermediates in mutagenesis and carcinogenesis) in DNA, which specificially tags AP site with biotin residues. ARP is highly sensitive with a femtomolar-level basic site detection capabilities (less than one site per 10 4 nucleotides) .
    ARP
  • HY-N0351
    p-Coumaric acid
    1 Publications Verification

    trans-4-Hydroxycinnamic acid

    		 Endogenous Metabolite Bacterial Apoptosis Inflammation/Immunology Cancer
    p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities .
    p-Coumaric acid
  • HY-103197
    2-Methoxyidazoxan monohydrochloride

    RX821002 hydrochloride

    		 Adrenergic Receptor Neurological Disease
    2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2) .
    2-Methoxyidazoxan monohydrochloride
  • HY-120893
    trans-4,5-Epoxy-(E)-2-decenal

    		Others Others
    trans-4,5-Epoxy-(E)-2-decenal is an oxygenated α,β-unsaturated aldehyde found in mammalian blood that gives blood its characteristic metallic odor. It is used by predators to locate blood or prey .
    trans-4,5-Epoxy-(E)-2-decenal
  • HY-W027951
    N,N'-Dimethylthiourea

    DMTU

    		 Reactive Oxygen Species Inflammation/Immunology
    N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action .
    N,N'-Dimethylthiourea
  • HY-144743
    ATX inhibitor 12

    		Phosphodiesterase (PDE) Others
    ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC50 of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research .
    ATX inhibitor 12
  • HY-124304
    Pinokalant

    LOE-908

    		 TRP Channel SARS-CoV Neurological Disease
    Pinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity .
    Pinokalant
  • HY-P99590
    Sotatercept

    ACE-011

    		 TGF-β Receptor Inflammation/Immunology Cancer
    Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions .
    Sotatercept
  • HY-18340
    (R)​-​CR8

    CR8, (R)-Isomer

    		 Molecular Glues CDK Apoptosis Neurological Disease Cancer
    (R)​-​CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)​-​CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)​-​CR8 induces apoptosis and has neuroprotective effect . (R)-CR8 acts as a molecular glue degrader that depletes cyclin K .
    (R)​-​CR8
  • HY-18340A
    (R)-CR8 trihydrochloride

    CR8, (R)-Isomer trihydrochloride

    		 Molecular Glues CDK Apoptosis Neurological Disease Cancer
    (R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect . (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K .
    (R)-CR8 trihydrochloride

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