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Results for "

lipoxygenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FLAP (13) Lipoxygenase (93) Apoptosis (10) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (2) Caspase (2) CDK (1) COX (22) DNA/RNA Synthesis (4) Drug Metabolite (1) Endogenous Metabolite (14) Epoxide Hydrolase (2) ERK (1) Ferroptosis (10) Fungal (2) GABA Receptor (1) GSK-3 (1) Histamine Receptor (2) Influenza Virus (3) Interleukin Related (2) Isotope-Labeled Compounds (3) Leukotriene Receptor (10) Mitochondrial Metabolism (1) NO Synthase (1) Opioid Receptor (1) Orthopoxvirus (1) p38 MAPK (3) PGE synthase (3) Phospholipase (3) PPAR (2) Prostaglandin Receptor (3) Reactive Oxygen Species (4) TRP Channel (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (30) Cardiovascular Disease (8) Endocrinology (5) Infection (7) Inflammation/Immunology (94) Metabolic Disease (9) Neurological Disease (8)

By Targets:

FLAP (13)

Lipoxygenase (93)

Apoptosis (10)

Autophagy (2)

Bacterial (1)

Biochemical Assay Reagents (2)

Caspase (2)

CDK (1)

COX (22)

DNA/RNA Synthesis (4)

Drug Metabolite (1)

Endogenous Metabolite (14)

Epoxide Hydrolase (2)

ERK (1)

Ferroptosis (10)

Fungal (2)

GABA Receptor (1)

GSK-3 (1)

Histamine Receptor (2)

Influenza Virus (3)

Interleukin Related (2)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (10)

Mitochondrial Metabolism (1)

NO Synthase (1)

Opioid Receptor (1)

Orthopoxvirus (1)

p38 MAPK (3)

PGE synthase (3)

Phospholipase (3)

PPAR (2)

Prostaglandin Receptor (3)

Reactive Oxygen Species (4)

TRP Channel (1)

Xanthine Oxidase (1)

By Research Areas:

Cancer (30)

Cardiovascular Disease (8)

Endocrinology (5)

Infection (7)

Inflammation/Immunology (94)

Metabolic Disease (9)

Neurological Disease (8)

146

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Lipoxygenase, general LOX	Endogenous Metabolite	Others
Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid .

4-MMPB	Lipoxygenase Apoptosis	Cancer
4-MMPB is a selective inhibitor of *15-lipoxygenase, with an IC₅₀* of 18 μM. 4-MMPB has IC₅₀s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer .

AHR-5333	Lipoxygenase	Endocrinology
AHR-5333 is a selective human blood neutrophil *5-lipoxygenase* inhibitor. AHR-5333 exhibits potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity .

(±)13-HpODE 13-Hydroperoxylinoleic acid; Linoleic acid 13-hydroperoxide	Others	Others
(±)13-HpODE (13-hydroperoxylinoleic acid) is a racemic mixture of hydroperoxides, which is produced by the oxidation of linoleic acid by lipoxygenase .

2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone	Lipoxygenase	Metabolic Disease Inflammation/Immunology
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone, isolated from Parinari hypochrysea (Chrysobalanaceae), exhibits antioxidant and lipoxygenase inhibition .

9-HETE (±)9-HETE	Endogenous Metabolite	Others
9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .

15-LOX-1 inhibitor 1	Lipoxygenase	Inflammation/Immunology
15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC₅₀ value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation .

Ro 3-1314 9a,12a-Octadecadiynoic acid	Lipoxygenase	Metabolic Disease Inflammation/Immunology
Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant *lipoxygenase* inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments .

9(S)-HETE	Endogenous Metabolite	Others
9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .

(9S,13R)-12-Oxo phytodienoic acid (9S,13R)-12-OPDA	Lipoxygenase	Others
9S,13R)-12-Oxo phytodienoic acid is the isomerization of 12-oxo PDA (HY-118828). (9S,13R)-12-Oxo phytodienoic acid is a lipoxygenase metabolite in the leaves of green plants .

(±)-Dihydroactinidiolide	Others	Others
(±)-Dihydroactinidiolide, an important aroma compound of black tea and tobacco, has been isolated from several plants. (±)-Dihydroactinidiolide can be formation from β-Carotene by the treatment of polyphenoloxidase, the lipoxygenase, and the xanthine oxidase .

Benoxaprofen LRCL 3794	COX	Inflammation/Immunology
Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation .

12(S)-HPEPE	Prostaglandin Receptor	Inflammation/Immunology
12(S)-HPEPE is a lipoxygenase product and an intermediate metabolite that leads to downregulation of PGHS-2 and has potential anti-inflammatory activity. 12(S)-HPEPE reduces interleukin 1h (IL-1h)-induced PGHS-2 expression in human lung microvascular endothelial cells .

SKF-86002 2 Publications Verification	p38 MAPK	Inflammation/Immunology
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

SKF-86002 dihydrochloride	p38 MAPK	Inflammation/Immunology
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

Enazadrem	Lipoxygenase	Inflammation/Immunology
Enazadrem is a *5-lipoxygenase* inhibitor with antiinflammatory activities.

AZD 4407 ZD 4407	Lipoxygenase	Inflammation/Immunology
AZD 4407 is a potent *5-lipoxygenase* inhibitor.

Zileuton 5+ Cited Publications A 64077; Abbott 64077	Lipoxygenase Ferroptosis	Inflammation/Immunology Cancer
Zileuton is a potent and selective inhibitor of *5-lipoxygenase* with antiasthmatic properties.

LY 178002	COX Lipoxygenase Phospholipase	Inflammation/Immunology
LY 178002 is a potent inhibitor of *5-lipoxygenase* (5-LPO), phospholipase A2, with IC₅₀** of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

CMI977 LDP977	Lipoxygenase	Inflammation/Immunology
CMI977 is a potent *5-Lipoxygenase* (5-LO) inhibitor.

Zileuton sodium 5+ Cited Publications A 64077 sodium; Abbott 64077 sodium	Lipoxygenase	Inflammation/Immunology Cancer
Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of *5-lipoxygenase*, exhibiting inflammatory activities.

Lonapalene RS4317	Lipoxygenase	Inflammation/Immunology
Lonapalene (RS4317) is a topically effective *5-lipoxygenase* (5-LO) inhibitor.

5,6-Dehydroarachidonic acid	Lipoxygenase	Inflammation/Immunology
5,6-Dehydroarachidonic acid is a 5-lipoxygenase (Lipoxygenase) inhibitor that inhibits the biosynthesis of leukotrienes. However, 5,6-Dehydroarachidonic acid had no effect on vascular cell proliferation .

ML355 3 Publications Verification	Lipoxygenase	Inflammation/Immunology
ML355 is a potent and selective inhibitor of *12-Lipoxygenase* (12-LOX) with an IC₅₀** of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.

Caffeic acid 3 Publications Verification	TRP Channel Lipoxygenase Endogenous Metabolite	Inflammation/Immunology Cancer
Caffeic acid is an inhibitor of both TRPV1 ion channel and *5-Lipoxygenase* (5-LO).

Cirsiliol	Lipoxygenase	Neurological Disease
Cirsiliol is a potent and selective *5-lipoxygenase* inhibitor and a competitive low affinity benzodiazepine receptor ligand.

Fluindione	Lipoxygenase	Inflammation/Immunology
Fluindione is a inhibitor of *5-lipoxygenase* with the IC₅₀ of 15 μM. Fluindione has antiinflammatory activity .

FPL 62064	Lipoxygenase COX	Inflammation/Immunology
FPL 62064 is a potent *5-lipoxygenase* (5-LOX) and COX dual inhibitor, with IC₅₀** values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity .

Nordihydroguaiaretic acid 4 Publications Verification NDGA	Lipoxygenase Autophagy Ferroptosis	Neurological Disease Cancer
Nordihydroguaiaretic acid is a *5-lipoxygenase* (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

Docebenone AA 861	Lipoxygenase Ferroptosis	Inflammation/Immunology
Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

L-674573	Leukotriene Receptor	Cancer
L-674573 is a quinoline leukotriene synthesis inhibitor that selectively inhibits 5-lipoxygenase translocation .

ICI 211965 ZM-211965	Lipoxygenase	Inflammation/Immunology
ICI 211965 (ZM-211965) is a selective and orally potent *5-Lipoxygenase* (5-LPO) inhibitor.

RWJ 63556	COX Lipoxygenase	Inflammation/Immunology
RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

L 691816	Lipoxygenase	Inflammation/Immunology
L 691816 is a potent, selective and orally active inhibitors of *5-lipoxygenase*. L 691816 can be used for the research of allergies and asthma .

LP117	Lipoxygenase	Inflammation/Immunology
LP117 is a novel and potent inhibitor of *5-Lipoxygenase* (5-LO) product synthesis with an IC₅₀ of 1.1 μM.

Tepoxalin	COX Lipoxygenase	Inflammation/Immunology
Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with potent anti-inflammatory activity and a favorable gastrointestinal profile .

(-)-Bornyl ferulate	Lipoxygenase COX	Inflammation/Immunology
(-)-Bornyl ferulate is a *5-lipoxygenase* and COX inhibitor with IC₅₀s of 10.4 μM and 12.0 μM, respectively .

3-O-Acetyl-11-hydroxy-beta-boswellic acid	Lipoxygenase	Others
3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor .

Zileuton (Standard) A 64077 (Standard); Abbott 64077 (Standard)	Lipoxygenase Ferroptosis	Inflammation/Immunology Cancer
Zileuton (Standard) is the analytical standard of Zileuton. This product is intended for research and analytical applications. Zileuton is a potent and selective inhibitor of *5-lipoxygenase* with antiasthmatic properties.

U-73122 60+ Cited Publications	Phospholipase Lipoxygenase Ferroptosis	Inflammation/Immunology
U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC₅₀of 1-2.1 µM for PLC.

Zileuton-d4	Isotope-Labeled Compounds Lipoxygenase Ferroptosis	Inflammation/Immunology Cancer
Zileuton-d₄ is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties[1][2].

Picrinine	Lipoxygenase	Inflammation/Immunology
Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme .

HZ52	Lipoxygenase	Inflammation/Immunology
HZ52 is a potent, reversible *5-lipoxygenase* inhibitor, blocking leukotriene synthesis with an IC₅₀ of 0.7 μM in intact human polymorphonuclear leukocytes .

PGS-IN-1 KME-4	PGE synthase Lipoxygenase	Inflammation/Immunology
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC₅₀ of 0.28 μM; also inhibits *5-lipoxygenase* with an IC₅₀ of 1.05 μM.

Atuliflapon AZD5718	FLAP	Cardiovascular Disease
Atuliflapon (AZD5718) is an orally active inhibitor of *FLAP (5‑Lipoxygenase* activating protein), with an IC₅₀** of 2 nM. Atuliflapon is used in the study for coronary artery disease .

5-LOX-IN-4	Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
5-LOX-IN-4 is a *5-Lipoxygenase* inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10.

Cat. No.	Product Name

HY-L051

Ferroptosis Compound Library

922 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 922 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Cat. No.	Product Name	Type

HY-131384

8,11,14-Eicosatriynoic acid

8,11,14-Icosatriynoic acid

Biochemical Assay Reagents

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N7833

(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid

Heneicosapentaenoic acid

Biochemical Assay Reagents

Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

Species:	Human (4)
Tag:	His (4) SUMO (1) Tag Free (2) GST (1) Flag (1)
Source:	E. coli Cell-free (1) Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72076

	ALOX12 Protein, Human (His) 12 LOX; 12S; lipoxygenase ; 12-lipoxygenase; 12LO; 12S LOX; 12S-lipoxygenase; 12S-LOX; 12S-type; Alox12; Arachidonate 12 lipoxygenase; Arachidonate 12 lipoxygenase, 12S type; Arachidonate 12-lipoxygenase; Arachidonate 12-oxidoreductase; Lipoxin synthase 12-LO; LOG12; LOX12_HUMAN; P-12LO; Platelet 12-LOX; Platelet type lipoxygenase 12 ; platelet-type 12-lipoxygenase; Platelet-type lipoxygenase 12	Human	E. coli
	ALOX12 Protein, Human (His) is a recombinant ALOX12 protein with a His tag. ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated fatty acid substrates to produce biologically active lipid mediators including eicosanes and lipoxins.

HY-P74437

	*15 Lipoxygenase* 2 Protein, Human (sf9)** Polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-2; ALOX15B	Human	Sf9 insect cells
	15-Lipoxygenase 2 (15-LOX2) is a non-heme iron-containing dioxygenase crucial for peroxidation of polyunsaturated fatty acids (PUFAs). It exhibits peroxidase activity on arachidonate and linoleate, producing bioactive lipid mediators. Oxygenating arachidonyl derivatives, it generates 15-HETE-G, a peroxisome proliferator-activated receptor alpha agonist. 15-LOX2 class-switches pro-inflammatory mediators, participates in DHA oxidations to produce specialized pro-resolving mediators, and may influence cell cycle progression, proliferation, cytokine secretion, and macrophage differentiation. Importantly, it shows substrate specificity by not converting arachidonic acid to (15S)-HPETE. 15 Lipoxygenase 2 Protein, Human (sf9) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of 15 Lipoxygenase 2 Protein, Human (sf9) is 676 a.a., with molecular weight of 62-66 kDa.

HY-P702170

	lipoxygenase Protein, Pseudomonas aeruginosa lox; Linoleate 9/13-lipoxygenase; Oleate 10S-lipoxygenase	Others	E. coli
	The lipoxygenase protein catalyzes the oxygen-mediated conversion of linoleic acid to 9HPOD and spontaneously decomposes it into 9HOD. It converts linolenic acid into 13HPOD, which breaks down into 13HOD. lipoxygenase Protein, Pseudomonas aeruginosa is the recombinant lipoxygenase protein, expressed by E. coli , with tag free. The total length of lipoxygenase Protein, Pseudomonas aeruginosa is 678 a.a., .

HY-P702171

	lipoxygenase Protein, Pseudomonas aeruginosa (FLAG, His) lox; Linoleate 9/13-lipoxygenase; Oleate 10S-lipoxygenase	Others	E. coli
	The lipoxygenase protein catalyzes the oxygen-mediated conversion of linoleic acid to 9HPOD and spontaneously decomposes it into 9HOD. It converts linolenic acid into 13HPOD, which breaks down into 13HOD. lipoxygenase Protein, Pseudomonas aeruginosa (FLAG, His) is the recombinant lipoxygenase protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of lipoxygenase Protein, Pseudomonas aeruginosa (FLAG, His) is 678 a.a., .

HY-P74436

	*15 Lipoxygenase* 2 Protein, Human (sf9, His-GST)** Polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-2; ALOX15B	Human	Sf9 insect cells
	15-lipoxygenase 2 (15-LOX2) is a nonheme iron-containing dioxygenase essential for the peroxidation of polyunsaturated fatty acids (PUFA). It exhibits peroxidase activity towards arachidonic acid and linoleic acid, producing bioactive lipid mediators. 15 Lipoxygenase 2 Protein, Human (sf9, His-GST) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of 15 Lipoxygenase 2 Protein, Human (sf9, His-GST) is 676 a.a., with molecular weight of ~93 kDa.

HY-P702609

FLAP Protein, Human (Cell-Free, His-SUMO)

Arachidonate 5-lipoxygenase-activating protein; FLAP; ALOX5AP
Human E. coli Cell-free

Cat. No.	Product Name	Chemical Structure

HY-14164S

Zileuton-d4

Zileuton-d₄ is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties[1][2].

HY-B1452S1

Licofelone-d6
Licofelone-d₆ is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-113509S

Lipoxin A4-d5

Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3].

Cat. No.	Product Name	Application	Reactivity

HY-P81346

15 Lipoxygenase 1 Antibody (YA1091)

LOG15; LOG15; Polyunsaturated fatty acid lipoxygenase ALOX15; Polyunsaturated fatty acid lipoxygenase ALOX15
IHC-P Human
HY-P82293

12 Lipoxygenase Antibody (YA2038)

12 LOX; 12LO; 12S LOX; 12S-lipoxygenase; 12S-LOX; Alox12; LOG12; P-12LO
WB Human, Rat
HY-P82192

5 Lipoxygenase Antibody (YA1937)

5-LO; 5-LOX; 5LPG; LOG5; MGC163204
WB, IHC-F, IHC-P, ICC/IF, FC Human, Mouse, Rat

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lipoxygenase

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
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