Search Result

Results for "

long-lasting

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (1) Adrenergic Receptor (2) Aldehyde Dehydrogenase (ALDH) (1) Angiotensin Receptor (9) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (3) Apoptosis (5) Autophagy (8) Bacterial (3) Biochemical Assay Reagents (1) Bradykinin Receptor (2) Calcium Channel (11) Caspase (2) CGRP Receptor (2) Dipeptidyl Peptidase (2) EGFR (1) Endogenous Metabolite (1) Epigenetic Reader Domain (2) FAK (1) FGFR (1) Fungal (3) GPR109A (1) HCV (1) Histamine Receptor (3) Isotope-Labeled Compounds (7) mAChR (2) mTOR (1) nAChR (1) Neurokinin Receptor (1) Neurotensin Receptor (2) NF-κB (2) Opioid Receptor (4) p38 MAPK (2) PDGFR (1) Potassium Channel (3) PPAR (2) Prostaglandin Receptor (1) PROTACs (4) Reactive Oxygen Species (4) Sodium Channel (3) Src (1) STAT (1) TRP Channel (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (24) Endocrinology (8) Infection (8) Inflammation/Immunology (8) Metabolic Disease (10) Neurological Disease (16)

By Targets:

5-HT Receptor (1)

Acyltransferase (1)

Adrenergic Receptor (2)

Aldehyde Dehydrogenase (ALDH) (1)

Angiotensin Receptor (9)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (3)

Apoptosis (5)

Autophagy (8)

Bacterial (3)

Biochemical Assay Reagents (1)

Bradykinin Receptor (2)

Calcium Channel (11)

Caspase (2)

CGRP Receptor (2)

Dipeptidyl Peptidase (2)

EGFR (1)

Endogenous Metabolite (1)

Epigenetic Reader Domain (2)

FAK (1)

FGFR (1)

Fungal (3)

GPR109A (1)

HCV (1)

Histamine Receptor (3)

Isotope-Labeled Compounds (7)

mAChR (2)

mTOR (1)

nAChR (1)

Neurokinin Receptor (1)

Neurotensin Receptor (2)

NF-κB (2)

Opioid Receptor (4)

p38 MAPK (2)

PDGFR (1)

Potassium Channel (3)

PPAR (2)

Prostaglandin Receptor (1)

PROTACs (4)

Reactive Oxygen Species (4)

Sodium Channel (3)

Src (1)

STAT (1)

TRP Channel (2)

By Research Areas:

Cancer (7)

Cardiovascular Disease (24)

Endocrinology (8)

Infection (8)

Inflammation/Immunology (8)

Metabolic Disease (10)

Neurological Disease (16)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108009A

Rezafungin acetate Biafungin acetate; CD101 acetate; SP-3025 acetate	Fungal	Infection
Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .

HY-U00212

Aranidipine

MPC1304
Calcium Channel Cardiovascular Disease

Aranidipine (MPC1304) is a Ca ²⁺ channel antagonist with potent and long-lasting antihypertensive effects.

Aranidipine MPC1304	Calcium Channel	Cardiovascular Disease
Aranidipine (MPC1304) is a Ca ²⁺ channel antagonist with potent and long-lasting antihypertensive effects.

HY-108009

Rezafungin Biafungin; CD101; SP-3025	Fungal	Infection
Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .

HY-120802

Navafenterol AZD-8871; LAS191351	mAChR Adrenergic Receptor	Inflammation/Immunology
Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC₅₀ is 9.5 for human M3 receptor, and the pEC₅₀ is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile .

HY-120802A

Navafenterol saccharinate AZD-8871 saccharinate; LAS191351 saccharinate	mAChR Adrenergic Receptor	Infection Inflammation/Immunology
Navafenterol (AZD-8871) saccharinate is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC₅₀ is 9.5 for human M3 receptor, and the pEC₅₀ is 9.5 for β2-adrenoceptor. Navafenterol saccharinate can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile .

HY-14806

Teneligliptin 5+ Cited Publications MP-513	Dipeptidyl Peptidase	Metabolic Disease
Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC₅₀s of approximately 1 nM .

HY-117040

nor-Binaltorphimine Norbinaltorphimine; NorBNI	Opioid Receptor	Others
nor-Binaltorphimine is a selective antagonist of kappa-opioid receptor. nor-Binaltorphimine has a long-lasting effect in vivo .

HY-B1430

Butamben Butyl 4-aminobenzoate	Calcium Channel Sodium Channel Potassium Channel	Neurological Disease
Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions .

HY-101223

DIPPA hydrochloride
DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant .

HY-137459

Vocacapsaicin CA-008	TRP Channel	Neurological Disease
Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief .

HY-137459A

Vocacapsaicin hydrochloride CA-008 hydrochloride	TRP Channel	Neurological Disease
Vocacapsaicin (CA-008) hydrochloride, a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin hydrochloride can provide meaningful and long-lasting pain relief .

HY-W002438

6-Hydroxyindole	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

HY-14806S

Teneligliptin-d8 MP-513 D8
Teneligliptin-d₈ is a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor[1].

HY-101347

Chlorisondamine diiodide	nAChR	Neurological Disease
Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way .

HY-P5873

Jingzhaotoxin-X JZTX-X	Potassium Channel	Neurological Disease
Jingzhaotoxin-X (JZTX-X) is a selective Kv4.2 and Kv4.3 potassium channels inhibitor. Jingzhaotoxin-X causes long-lasting mechanical hyperalgesia .

HY-P1913

Calcitonin Gene Related Peptide (CGRP) II, rat	CGRP Receptor	Cardiovascular Disease
Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II can be used in the research of cardiovascular diseases .

HY-B1430S

Butamben-d9 Butyl 4-aminobenzoate-d₉	Isotope-Labeled Compounds Calcium Channel Sodium Channel Potassium Channel	Neurological Disease
Butamben-d₉ is the deuterium labeled Butamben. Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions[1][2].

HY-P1913A

Calcitonin Gene Related Peptide (CGRP) II, rat TFA	CGRP Receptor	Cardiovascular Disease
Calcitonin Gene Related Peptide (CGRP) II, rat TFA, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II TFA can be used in the research of cardiovascular diseases .

HY-106277A

Fasitibant chloride hydrochloride MEN16132	Bradykinin Receptor	Metabolic Disease
Fasitibant chloride hydrochloride (MEN16132) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B₂ (BK₂) receptor antagonist. Fasitibant chloride hydrochloride has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis .

HY-106277

Fasitibant free base	Bradykinin Receptor	Metabolic Disease
Fasitibant (free base) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B₂ (BK₂) receptor antagonist. Fasitibant (free base) has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis .

HY-P1338

PL-017	Opioid Receptor	Neurological Disease
PL-017 is a potent and selective μ opioid receptor agonist with an IC₅₀ of 5.5 nM for ¹²⁵I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats .

HY-13511A

Rupatadine Fumarate 1 Publications Verification UR-12592 Fumarate	Histamine Receptor Autophagy	Inflammation/Immunology
Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with K_is of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria .

HY-P1338A

PL-017 TFA	Opioid Receptor	Neurological Disease
PL-017 TFA is a potent and selective μ opioid receptor agonist with an IC₅₀ of 5.5 nM for ¹²⁵I-FK 33,824 binding to μ site. PL-017 TFA produces long-lasting, reversible analgesia in rats .

HY-13511

Rupatadine UR-12592	Histamine Receptor Autophagy	Inflammation/Immunology
Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with K_is of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria .

HY-135785

OSMI-3	Acyltransferase	Metabolic Disease
OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells .

HY-B0205

Candesartan 4 Publications Verification CV 11974	Angiotensin Receptor PPAR	Cardiovascular Disease Endocrinology Cancer
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) .

HY-130612

PROTAC BRD2/BRD4 degrader-1	Epigenetic Reader Domain PROTACs	Cancer
PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader, connected by ligands for Cereblon and BET. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. It effectively inhibits solid tumors with low cytotoxic effect. PROTAC BRD2/BRD4 degrader-1 is composed of the BET inhibitor, a linker, and the ligand thalidomide for cereblon (CRBN)/cullin 4A .

HY-P1256

JMV 449	Neurotensin Receptor	Neurological Disease
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [ ¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P1256C

JMV 449 acetate	Neurotensin Receptor	Neurological Disease
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC₅₀ of 0.15 nM for inhibition of ¹²⁵I-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-144110

HCV-IN-37	HCV	Infection
HCV-IN-37 (Compound 3d) is a potent inhibitor of HCV. HCV-IN-37 is orally available and long-lasting in rat plasma after oral administration to rats by a single dose of 15 mg/kg. The high potency of active derivative HCV-IN-37 is primarily driven by the inhibitory effect on the virus entry stage .

HY-14806S1

Teneligliptin-d4 MP-513-d₄	Isotope-Labeled Compounds Dipeptidyl Peptidase	Metabolic Disease
Teneligliptin-d₄ is deuterium labeled Teneligliptin. Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM[1].

HY-P10203

μ/κ/δ opioid receptor agonist 1	Opioid Receptor	Inflammation/Immunology
μ/κ/δ opioid receptor agonist 1 is a μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR) agonist. μ/κ/δ opioid receptor agonist 1 produces a strong and long-lasting analgesic effect through peripheral MOR and KOR in the tail-flick test .

HY-13511AR

Rupatadine Fumarate (Standard) UR-12592 Fumarate (Standard)	Histamine Receptor Autophagy	Inflammation/Immunology
Rupatadine (Fumarate) (Standard) is the analytical standard of Rupatadine (Fumarate). This product is intended for research and analytical applications. Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with K_is of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria .

HY-124701

Filastatin	Fungal	Infection
Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC₅₀ of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect .

HY-143793

RBP4 inhibitor 1	Others	Metabolic Disease
RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC₅₀s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice .

HY-129602

SD-36 5 Publications Verification	PROTACs STAT Apoptosis	Cancer
SD-36 is a potent and efficacious STAT3 PROTAC degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase . SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132296

GSK215	FAK PROTACs	Cancer
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC₅₀ of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect .

HY-Q40876

BBT	Calcium Channel	Metabolic Disease
BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ)-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway .

HY-B0205R

Candesartan (Standard) CV 11974 (Standard)	Angiotensin Receptor PPAR	Cardiovascular Disease Endocrinology Cancer
Candesartan (Standard) is the analytical standard of Candesartan. This product is intended for research and analytical applications. Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) .

HY-B0347

Lacidipine 1 Publications Verification	Calcium Channel Reactive Oxygen Species Caspase Apoptosis	Cardiovascular Disease
Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-107425

MZ 1 Maximum Cited Publications 14 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
MZ 1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. MZ 1 potently and rapidly induces reversible, long-lasting, and selective removal of BRD4 over BRD2 and BRD3. K_ds of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively .

HY-107318

Alacepril Cetapril; DU-1219	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Alacepril (Cetapril) is an orally active angiotensin converting enzyme (ACE) inhibitor with long lasting antihypertensive effect .

HY-119222

GSK256073 1 Publications Verification	GPR109A	Metabolic Disease
GSK256073 is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC₅₀ of 7.5 (human HCA2). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia . GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2

HY-107030

Nitrefazole EMD-15700	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.

HY-B0347S1

Lacidipine-13C8	Apoptosis Caspase Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

HY-U00231

KF 13218	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
KF 13218 is a potent, selective and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC₅₀ value of 5.3±1.3 nM.

HY-112345

PD-089828	FGFR PDGFR EGFR Src	Cancer
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC₅₀s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC₅₀=0.18 µM). PD-089828 also inhibits MAPK with an IC₅₀ of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity .

HY-153808A

Incomplete Freund's adjuvant (IFA) Montanide ISA-51	Others	Inflammation/Immunology
Incomplete Freund's adjuvant (IFA) (Montanide ISA-51) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund. Incomplete Freund's adjuvant (IFA) does not contain inactivated tuberculosis bacilli and consists of petroleum jelly containing lanolin. Incomplete Freund's adjuvant (IFA) induces high antibody titers and long-lasting effector T cell responses with no long-term effects on collagen disease, tumors, or death. Complete Freund's adjuvant (CFA) (HY-153808) is another type of Freund's Adjuvant that stimulates a stronger immune response .

HY-13955

Telmisartan 10+ Cited Publications BIBR 277	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-106616

Muzolimine BAY-g 2821; Edrul	Others	Cardiovascular Disease
Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive effects. Muzolimine can be used for the research of cardiovascular disease .

Cat. No.	Product Name	Target	Research Area

HY-P1913A

Calcitonin Gene Related Peptide (CGRP) II, rat TFA	CGRP Receptor	Cardiovascular Disease
Calcitonin Gene Related Peptide (CGRP) II, rat TFA, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II TFA can be used in the research of cardiovascular diseases .

HY-P5873

Jingzhaotoxin-X JZTX-X	Potassium Channel	Neurological Disease
Jingzhaotoxin-X (JZTX-X) is a selective Kv4.2 and Kv4.3 potassium channels inhibitor. Jingzhaotoxin-X causes long-lasting mechanical hyperalgesia .

HY-P1913

Calcitonin Gene Related Peptide (CGRP) II, rat	CGRP Receptor	Cardiovascular Disease
Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II can be used in the research of cardiovascular diseases .

HY-P3819

Delta (Phospho) Sleep Inducing Peptide DSIP-P	Peptides	Neurological Disease
Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats .

HY-P1338

PL-017	Opioid Receptor	Neurological Disease
PL-017 is a potent and selective μ opioid receptor agonist with an IC₅₀ of 5.5 nM for ¹²⁵I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats .

HY-P1338A

PL-017 TFA	Opioid Receptor	Neurological Disease
PL-017 TFA is a potent and selective μ opioid receptor agonist with an IC₅₀ of 5.5 nM for ¹²⁵I-FK 33,824 binding to μ site. PL-017 TFA produces long-lasting, reversible analgesia in rats .

HY-P1256

JMV 449	Neurotensin Receptor	Neurological Disease
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [ ¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P1256C

JMV 449 acetate	Neurotensin Receptor	Neurological Disease
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC₅₀ of 0.15 nM for inhibition of ¹²⁵I-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P10203

μ/κ/δ opioid receptor agonist 1	Opioid Receptor	Inflammation/Immunology
μ/κ/δ opioid receptor agonist 1 is a μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR) agonist. μ/κ/δ opioid receptor agonist 1 produces a strong and long-lasting analgesic effect through peripheral MOR and KOR in the tail-flick test .

HY-P3733

Big Endothelin-1 (22-38), human	Peptides	Cardiovascular Disease
Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W002438

6-Hydroxyindole	Structural Classification Alkaloids Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Indole Alkaloids	Biochemical Assay Reagents Endogenous Metabolite
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

Cat. No.	Product Name	Chemical Structure

HY-B0612DS1

Lercanidipine-d3 hydrochloride
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-B1430S

Butamben-d9
Butamben-d₉ is the deuterium labeled Butamben. Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions[1][2].

HY-14806S1

Teneligliptin-d4
Teneligliptin-d₄ is deuterium labeled Teneligliptin. Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM[1].

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-13955S1

Telmisartan-d4
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-13955S

Telmisartan-d3
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-13955S2

Telmisartan-13C,d3
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-B0612AS

Lercanidipine-13C,d3 hydrochloride
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride[1]. Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[2][3][4].

HY-13955S3

Telmisartan-d7
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-B0337S1

Sulfadimethoxine-d6

Sulfadimethoxine-d₆ is the deuterium labeled Sulfadimethoxine. Sulfadimethoxine is a sulfonamide antibiotic used to treat many infections[1].

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