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low-toxicity

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144

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8

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Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111817
    ACT-451840

    		Parasite Infection
    ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial .
    ACT-451840
  • HY-132291
    HIV-1 inhibitor-8

    		HIV Infection
    HIV-1 inhibitor-8 is an orally active, low-toxicity and potent HIV‑1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-8 yields exceptionally potent antiviral activities (EC50=4.44~54.5 nM) against various HIV‑1 strains. The IC50 of HIV-1 inhibitor-8 against WT HIV-1 reverse transcriptase is 0.081 μM .
    HIV-1 inhibitor-8
  • HY-106993
    Cipralisant

    GT-2331

    		 Histamine Receptor Neurological Disease Endocrinology
    Cipralisant (GT-2331) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant has the potential for attention-deficit hyperactivity disorder research . Cipralisant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Cipralisant
  • HY-106993A
    Cipralisant maleate

    GT-2331 maleate

    		 Histamine Receptor Neurological Disease
    Cipralisant (GT-2331) (maleate) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant (maleate) has the potential for attention-deficit hyperactivity disorder research . Cipralisant (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Cipralisant maleate
  • HY-122746
    E67-2

    		Histone Methyltransferase Cancer
    E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC50 value of 3.4 µM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase as well as histone H3 lysine 4 (H3K4) demethylase .
    E67-2
  • HY-116387A
    WR99210 hydrochloride

    BRL 6231

    		 Dihydrofolate reductase (DHFR) Parasite Infection
    WR99210 hydrochloride is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 hydrochloride shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains as well as T. gondii .
    WR99210 hydrochloride
  • HY-120635
    BMS-1001 hydrochloride

    		PD-1/PD-L1 Inflammation/Immunology Cancer
    BMS-1001 is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 exhibits low-toxicity in cells. The IC50 value of BMS-1001 in a homogeneous time-resolved fluorescence (HTRF) binding assay is 2.25 nM .
    BMS-1001 hydrochloride
  • HY-120647
    BMS-1001

    		PD-1/PD-L1 Inflammation/Immunology Cancer
    BMS-1001 is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 exhibits low-toxicity in cells. The IC50 value of BMS-1001 in a homogeneous time-resolved fluorescence (HTRF) binding assay is 2.25 nM .
    BMS-1001
  • HY-116387
    WR99210
    2 Publications Verification

    BRL 6231 free base

    		 Dihydrofolate reductase (DHFR) Parasite Infection
    WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii .
    WR99210
  • HY-103689
    Cucurbit[8]uril

    		Others Others
    Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer .
    Cucurbit[8]uril
  • HY-123517
    DC07090 dihydrochloride

    		Enterovirus Infection
    DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM .
    DC07090 dihydrochloride
  • HY-N6640
    2-O-Acetyl-20-hydroxyecdysone

    20-Hydroxyeedysone 2-acetate

    		 Amyloid-β Neurological Disease
    2-O-Acetyl-20-hydroxyecdysone, an ecdysterones in insects and terrestrial plants, inhibits amyloid-β42 (Aβ42)-induced cytotoxicity. 2-O-Acetyl-20-hydroxyecdysone could decrease Aβ oligomer formation through promotion of fibrogenesis, transforming Aβ oligomers to the low-toxicity fibrils .
    2-O-Acetyl-20-hydroxyecdysone
  • HY-132817
    Gunagratinib

    ICP-192

    		 FGFR Cancer
    Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer . Gunagratinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Gunagratinib
  • HY-144332
    PHD2/HDACs-IN-1

    		HDAC HIF/HIF Prolyl-Hydroxylase Cancer
    PHD2/HDACs-IN-1 is a potent PHD2/HDACs hybrid inhibitor (IC50s of 1.15 μM, 19.75 μM, 26.60 μM and 15.98 μM for PHD2, HDAC1, HDAC2 and HDAC6, respectively). PHD2/HDACs-IN-1 is a low-toxicity renoprotective agent for research of cisplatin-induced acute kidney injury (AKI) .
    PHD2/HDACs-IN-1
  • HY-100334
    Pirinixil

    BR-931

    		 Others Metabolic Disease
    Pirinixil is a hypolipidemic agent of low toxicity.
    Pirinixil
  • HY-151483
    TK-129

    		Histone Demethylase Cardiovascular Disease
    TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease .
    TK-129
  • HY-D1583
    Cyanine5 DBCO
    1 Publications Verification

    DBCO-Cy5; Cyanine5 dibenzocyclooctyne

    		 Fluorescent Dye Others
    Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) .
    Cyanine5 DBCO
  • HY-B1073
    Morantel tartrate

    		Parasite Infection
    Morantel tartrate is a broad spectrum anthelmintic, effective and low toxicity.
    Morantel tartrate
  • HY-142287
    Con B-1

    		Anaplastic lymphoma kinase (ALK) Cancer
    ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .
    Con B-1
  • HY-B1217
    Bronopol

    BNPD; BNPK

    		 Bacterial Infection
    Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria).
    Bronopol
  • HY-118165
    Phenthoate

    		Cholinesterase (ChE) Neurological Disease
    Phenthoate is an organophosphorus pesticide having low toxicity in animals. Phenthoate is also a AChE inhibitor .
    Phenthoate
  • HY-B0755
    Etimicin sulfate

    		Antibiotic Infection
    Etimicin (sulfate), a fourth-generation aminoglycoside antibiotic, is now widely clinically used due to its high efficacy and low toxicity.
    Etimicin sulfate
  • HY-151581
    HCVcc-IN-1

    		Virus Protease Infection
    HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity .
    HCVcc-IN-1
  • HY-13705
    NM-3

    		Others Cardiovascular Disease Inflammation/Immunology
    NM-3 is an isocoumarin with antiarthritic and antiangiogenic effects. NM-3 is an orally active antiangiogenic agent with low toxicity .
    NM-3
  • HY-B2010
    Fomesafen

    Fomesafen is a type of efficient and selective protoporphyrinogen IX oxidase (PPO) inhibitor. Fomesafen is a herbicide and has the advantages of low toxicity and high selectivity .
    Fomesafen
  • HY-139735
    Antitumor agent-29

    		Others Cancer
    Antitumor agent-29 is a novel hepatocyte-targeting antitumor proagent, which exhibits good antitumor activity and low toxic side effects.
    Antitumor agent-29
  • HY-149673
    XPW1

    		CDK Cancer
    XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity .
    XPW1
  • HY-N7262
    Hydroxyvalerenic acid

    		Others Cancer
    Hydroxyvalerenic acid is isolated from Verbena officinalis, has a low toxicity with IC50 values of 123 and 165 μM against GLC4 and COLO 320 cells, respectively .
    Hydroxyvalerenic acid
  • HY-163153
    Anticancer agent 184

    		Apoptosis Cancer
    Anticancer agent 184 (Compound 6o) is a novel, effective and low toxic anticancer drug. Anticancer agent 184 induces apoptosis by blocking the S phase .
    Anticancer agent 184
  • HY-118992
    Aurodox

    X 5108; Goldinomycin

    		 Antibiotic Bacterial Infection
    Aurodox is an antibiotic obtained from a streptomyces variant, Aurodox can against a number of gram-positive bacteria. Aurodox shows a very low toxicity in mice and promoted poultry growth .
    Aurodox
  • HY-B0525
    Carbenicillin

    		Antibiotic Bacterial Infection
    Carbenicillin is a broad-spectrum semi-synthetic penicillin antibiotic for gram-negative bacteria. Carbenicillin can interfere the cell wall synthesis while displaying low toxicity to plant tissue .
    Carbenicillin
  • HY-D0711
    Indocyanine green
    15+ Cited Publications

    Foxgreen; IC Green; Cardiogreen

    		 Fluorescent Dye Others
    Indocyanine green (Foxgreen) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .
    Indocyanine green
  • HY-D0227
    THAM

    Tris; Tris(hydroxymethyl)aminomethane

    		 Biochemical Assay Reagents Metabolic Disease Cancer
    THAM (Tris) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM is an effective amine compound for pH control in the physiological range .
    THAM
  • HY-D0227B
    THAM acetate

    Tris acetate; Tris(hydroxymethyl)aminomethane acetate
    Trometamol acetate (Tromethamine acetate) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol acetate is an effective amine compound for pH control in the physiological range .
    THAM acetate
  • HY-140656F
    Biotin-PEG-Biotin (MW 20000)

    		Fluorescent Dye Others
    Biotin-PEG-Biotin (MW 20000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity.
    Biotin-PEG-Biotin (MW 20000)
  • HY-D0227A
    THAM hydrochloride

    Tris HCl; Tris(hydroxymethyl)aminomethane hydrochloride
    THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range .
    THAM hydrochloride
  • HY-152081
    DENV-IN-7

    		Flavivirus Dengue virus HIV DNA/RNA Synthesis Infection
    DENV-IN-7, a flavone analog, is a dengue virus (DENV) inhibitor with an EC50 value of 70 nM. DENV-IN-7 has low toxicity against normal cell and anti-dengue activity .
    DENV-IN-7
  • HY-160533
    IKZF1-degrader-2

    		IKZF Family Cancer
    IKZF1-degrader-2 (Compound 3) is an IKZF1 degrader. IKZF1-degrader-2 has anticancer activity and low toxicity .
    IKZF1-degrader-2
  • HY-B0525A
    Carbenicillin disodium
    4 Publications Verification

    Sodium carbenicillin

    		 Antibiotic Bacterial Infection
    Carbenicillin disodium (Sodium carbenicillin) is a broad-spectrum semi-synthetic penicillin antibiotic for gram-negative bacteria. Carbenicillin disodium can interfere the cell wall synthesis while displaying low toxicity to plant tissue .
    Carbenicillin disodium
  • HY-117288
    S55746
    1 Publications Verification

    BCL201

    		 Bcl-2 Family Cancer
    S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity .
    S55746
  • HY-117288A
    S55746 hydrochloride
    1 Publications Verification

    BCL201 hydrochloride

    		 Bcl-2 Family Cancer
    S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity .
    S55746 hydrochloride
  • HY-155471
    IMP 245

    		Others Others
    IMP 245 is a symmetric di-HSG bivalent hapten. IMP 245 has low toxicity, high affinity binding to available antibodies and absence of cross reactivity or non-specific binding with body components .
    IMP 245
  • HY-147693
    COX-1/2-IN-3

    		COX Inflammation/Immunology
    COX-1/2-IN-3 (Compound 7a) is a COX-1 and COX-2 inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity .
    COX-1/2-IN-3
  • HY-147648
    Glyoxalase I inhibitor 6

    		Glyoxalase (GLO) Cancer
    Glyoxalase I inhibitor 6 (Compound 9j) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.13 μM. Glyoxalase I inhibitor 6 can be used as anticancer agent with low toxicity .
    Glyoxalase I inhibitor 6
  • HY-132297A
    PARP1-IN-5 dihydrochloride
    1 Publications Verification

    		 PARP Cancer
    PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer .
    PARP1-IN-5 dihydrochloride
  • HY-132297
    PARP1-IN-5

    		PARP Cancer
    PARP1-IN-5 is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 can be used for the research of cancer .
    PARP1-IN-5
  • HY-115996
    Antitumor agent-51

    		Others Cancer
    Antitumor agent-51 possesses potent and selective inhibitory for osteosarcoma cell growth and migration with IC50 of 21.9 nM in MNNG/HOS cells. Antitumor agent-51 has a considerable bioavailability and a low toxicity .
    Antitumor agent-51
  • HY-151442
    Antifungal agent 43

    		Fungal Infection
    Antifungal agent 43 (compound B05) is an antifungal agent. Antifungal agents 43 has antifungal activity by inhibiting biofilm formation. Antifungal agent 43 has low toxicity in human cancer cell lines .
    Antifungal agent 43
  • HY-N5058
    Dehydroeffusol

    		Apoptosis Cancer
    Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity .
    Dehydroeffusol
  • HY-19856
    Valnivudine hydrochloride

    FV-100
    FV-100 is a potent, selective and orally active anti-varicella zoster virus agent. FV-100 is a proagent of CF-1743. FV-100 exhibits very low toxicity in vivo .
    Valnivudine hydrochloride

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