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Results for "

mGlu2/3

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18941
    Eglumegad
    3 Publications Verification

    LY354740; Eglumetad

    		 mGluR Neurological Disease
    Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 nM and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively.
    Eglumegad
  • HY-18941B
    (rel)-Eglumegad

    (rel)-LY354740; (rel)-Eglumetad

    		 mGluR Neurological Disease
    (rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC50s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively .
    (rel)-Eglumegad
  • HY-18941C
    Eglumegad hydrochloride
    3 Publications Verification

    LY354740 hydrochloride; Eglumetad hydrochloride

    		 mGluR Neurological Disease
    Eglumegad (LY354740) hydrochloride is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad hydrochloride protects neurons from NMDA toxicity. Eglumegad hydrochloride has anxiolytic- and antipsychotic-like effects .
    Eglumegad hydrochloride
  • HY-105040C
    Pomaglumetad methionil hydrochloride

    LY2140023 hydrochloride

    		 mGluR Neurological Disease
    Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research [2].
    Pomaglumetad methionil hydrochloride
  • HY-131287
    MGS0028

    		mGluR Neurological Disease
    MGS0028 is a selective metabotropic glutamate 2/3 (mGlu2/3) receptor agonist. MGS0028 can be used for psychiatric disorders research .
    MGS0028
  • HY-14554
    Pomaglumetad methionil anhydrous

    LY2140023

    		 mGluR Neurological Disease
    Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research [2].
    Pomaglumetad methionil anhydrous
  • HY-117606
    LY3027788

    		mGluR Neurological Disease
    LY3027788, a diester analog of LY3020371 which is an mGlu2/3 receptor antagonist, is a potent and orally active prodrug of LY3020371. LY3027788 has antidepressant efficacy [2].
    LY3027788
  • HY-117606A
    LY3027788 hydrochloride

    		mGluR Neurological Disease
    LY3027788 hydrochloride, a diester analog of LY3020371 which is an mGlu2/3 receptor antagonist, is a potent and orally active prodrug of LY3020371. LY3027788 hydrochloride has antidepressant efficacy [2].
    LY3027788 hydrochloride
  • HY-105040
    Pomaglumetad methionil

    LY2140023 hydrate

    		 mGluR Neurological Disease
    Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific mGlu2/3 receptor agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used for schizophrenia [2].
    Pomaglumetad methionil
  • HY-123820
    LY3020371 hydrochloride

    		mGluR Neurological Disease
    LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM . LY3020371 hydrochloride exerts an antidepressant-like signature in vivo [2].
    LY3020371 hydrochloride
  • HY-103558
    LY379268

    		mGluR Neurological Disease
    LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects [2].
    LY379268
  • HY-131289
    LY3020371

    		mGluR Neurological Disease
    LY3020371 is a potent and selective antagonist of glutamate (mGlu) 2/3 receptor, with Kis of 5.26 and 2.50 nM for hmGluR2 and hmGluR3, respectively. LY3020371 can be used for the research of depression [2].
    LY3020371

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