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Results for "

mGluRs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mGluR (107) Akt (2) Aminopeptidase (2) Apoptosis (2) CaSR (1) Endogenous Metabolite (3) ERK (2) iGluR (2) NF-κB (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (99)
Click Chemistry:	Alkynes (1)

122

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Screening Libraries

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Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: mGluR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100372

E4CPG (RS)-ECPG	mGluR	Neurological Disease
E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation .

HY-103562

DMeOB

3,3'-Dimethoxybenzaldazine
mGluR Neurological Disease

DMeOB is an agonist of mGluR5 receptor with an IC₅₀ of 3 μM. DMeOB has a negative modulatory effect .

DMeOB 3,3'-Dimethoxybenzaldazine	mGluR	Neurological Disease
DMeOB is an agonist of mGluR5 receptor with an IC₅₀ of 3 μM. DMeOB has a negative modulatory effect .

HY-162232

mGluR2 agonist 1	mGluR	Neurological Disease
mGluR2 agonist 1 (Compound 5b) is a potent and selective metabotropic glutamate 2 receptor (mGluR) agonist with an EC₅₀ of 82 nM. mGluR2 agonist 1 can be used for the research of central nervous system (CNS) diseases .

HY-162232A

mGluR2 agonist 1 hydrochloride	mGluR	Neurological Disease
mGluR2 agonist 1 hydrochloride is a potent selective agonist for metabotropic glutamate receptors mGluR 2 with EC₅₀ of 82 nM .

HY-19434A

cis-ACPD	iGluR mGluR	Neurological Disease
cis-ACPD is a potent agonist of NMDA receptor, with an IC₅₀ of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC₅₀s of 13 μM and 50 μM for *mGluR2* and *mGluR4*, respectively .

HY-103572

MNI137	mGluR	Neurological Disease
MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC₅₀s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization .

HY-108546

L-AP3 3-Phosphono-L-alanine	mGluR	Neurological Disease
L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC₅₀s of 368 μM and 2087 μM, respectively .

HY-122255

LY487379	mGluR	Neurological Disease
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research .

HY-103552

LY487379 hydrochloride	mGluR	Neurological Disease
LY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research .

HY-15129

O-Phospho-L-serine L-Serine O-phosphate; L-SOP	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the *group III mGluR* receptors** (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for *mGluR1* and a potent antagonist for *mGluR2* .

HY-100840

(S)-4C3HPG (S)-4-Carboxy-3-hydroxyphenylglycine	mGluR	Neurological Disease
(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of *metabotropic glutamate receptor 1a (mGluR* 1a) and an agonist of GluR2**. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice .

HY-100804

L-Cysteinesulfinic acid
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-W017230

L-Cysteinesulfinic acid monohydrate	mGluR Endogenous Metabolite	Neurological Disease
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-15129S

O-Phospho-L-serine-13C3,15N L-Serine O-phosphate-¹³C₃,¹⁵N; L-SOP-¹³C₃,¹⁵N	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].

HY-50906

LY404039 2 Publications Verification	mGluR	Neurological Disease
LY404039 is a potent, selective and orally active *mGluR2* and *mGluR3* agonist with K_is of 149 nM and 92 nM for recombinant human mGluR2 and *mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR*2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects .

HY-12598A

DHPG 2 Publications Verification (RS)-3,5-DHPG
DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs . DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D .

HY-141832

mGluR5 modulator 1	mGluR	Neurological Disease
mGluR5 modulator 1 is a *mGluR5* positive allosteric modulator. mGluR5 modulator 1 can be used for the research of the schizophrenia and cognitive impairments .

HY-14612

CPPHA	mGluR	Neurological Disease
CPPHA is potent and selective positive allosteric modulator (PAM) of the *mGluR5* and *mGluR1* (metabotropic glutamate receptor). CPPHA can potentiate responses of mGluR5 and mGluR1 to activation of these receptors. CPPHA is developed for the research of central nervous system disorders .

HY-110190

VU0422288 ML396	mGluR	Neurological Disease
VU0422288 (ML396) is a positive allosteric modulator of group III *mGluRs. VU0422288 inhibits mGluRs* with EC₅₀s of 125 nM, 146 nM, and 108 nM for *mGluR4, mGluR7, and mGluR8*, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice .

HY-147530

mGluR2 modulator 4	mGluR	Neurological Disease
mGluR2 modulator 4 (compound 47) is a potent *mGluR2* positive allosteric modulator with an EC₅₀ value of 0.8 μM. mGluR2 modulator 4 can be used for researching antipsychotic .

HY-155352

mGluR5 antagonist-1	mGluR	Others
mGluR5 antagonist-1 (compound 10) is a high-affinity *mGluR5* antagonist, with an IC₅₀ value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect .

HY-153132

mGluR3 modulator-1

mGluR Metabolic Disease

mGluR3 modulator-1 (compound 3) is a mGluR3 modulator, with an EC₅₀ of 1-10 μM in HEK293T-mGluR-Gqi5 Calcium Mobilization Assay .
HY-16766

Decoglurant

RO4995819
mGluR Neurological Disease

Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant .

mGluR3 modulator-1	mGluR	Metabolic Disease
mGluR3 modulator-1 (compound 3) is a *mGluR3* modulator, with an EC₅₀ of 1-10 μM in HEK293T-mGluR-Gqi5 Calcium Mobilization Assay .

Decoglurant RO4995819	mGluR	Neurological Disease
Decoglurant (RO4995819) is a negative allosteric modulator of *mGluR2* and *mGluR3*. Decoglurant is developed as an antidepressant .

HY-147528

mGluR2 modulator 2	mGluR	Neurological Disease
mGluR2 modulator 2 (compound 2) is a potent, selective and orally bioavailable *mGluR2* positive allosteric modulator with an EC₅₀ value of 0.13 μM. mGluR2 modulator 2 can be used for researching antipsychotic .

HY-131286A

Talaglumetad hydrochloride LY-544344 hydrochloride	mGluR	Neurological Disease
Talaglumetad hydrochloride is a precursor of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the research of anxiety.

HY-100405

FTIDC
FTIDC is an orally active, noncompetitive, selective allosteric *metabotropic glutamate receptor (mGluR) 1* antagonist with an IC₅₀ of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1 .

HY-130630

mGluR2 modulator 1	mGluR	Neurological Disease
mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated *mGluR2* (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC₅₀ of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research .

HY-18654

ADX88178 1 Publications Verification	mGluR	Neurological Disease
ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC₅₀ of 4 nM for human mGluR4.

HY-147529

mGluR2 modulator 3	mGluR	Neurological Disease
mGluR2 modulator 3 (compound 1) is a potent *mGluR2* positive allosteric modulator with an EC₅₀ value of 0.87 μM. mGluR2 modulator 3 has activity in psychosis disease models such as methamphetamine-induced hyperactivity and mescaline-induced scratching in mice .

HY-11095

NPS 2390	mGluR CaSR	Cardiovascular Disease Neurological Disease
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5 . NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor .

HY-133555

mGluR2 antagonist 1	mGluR	Neurological Disease
mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of *mGluR2* negative allosteric modulator (IC₅₀ of 9 nM) with excellent brain permeability .

HY-12598

(S)-3,5-DHPG	mGluR	Neurological Disease
(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with K_i values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively . (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia .

HY-103561

DCB	mGluR	Neurological Disease
DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of themetabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB). DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB) .

HY-110122

AZ 12216052 1 Publications Verification	mGluR	Neurological Disease
AZ 12216052 is a *mGluR8* positive allosteric modulator, and helps *mGluR8* modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect .

HY-153615

CVN636	mGluR	Neurological Disease
CVN636 is a potent, orally active and selective *mGluR7* allosteric agonist with an EC₅₀ value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability .

HY-103564

ACDPP	mGluR	Neurological Disease
ACDPP is a specific *mGluR5* antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist) .

HY-100382

FPTQ	mGluR	Others
FPTQ is potent *mGluR₁* antagonist with IC₅₀ values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively . FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo .

HY-107516

(S)-3,4-DCPG (S)-3,4-Dicarboxyphenylglycine	mGluR	Neurological Disease
(S)-3,4-DCPG is a selective agonist of metabotropic glutamate receptor 8a (mGluR8a) with an EC₅₀ of 31 nM in AV12-664 cells expressing human mGluR8 .

HY-110254

AZD 9272

mGluR Neurological Disease

AZD 9272 is a brain penetrant mGluR5 antagonist.

AZD 9272	mGluR	Neurological Disease
AZD 9272 is a brain penetrant *mGluR5* antagonist.

HY-114863

PHCCC(4Me) THCCC	mGluR	Neurological Disease
PHCCC(4Me) (THCCC), a PHCCC analog, is a dual *mGluR2* (IC₅₀ of 1.5 μM) negative allosteric modulator and *mGluR3* (EC₅₀ of 8.9 μM) positive allosteric modulator .

HY-100786

DL-AP3

DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect .

DL-AP3
DL-AP3 is a competitive *mGluR1* and *mGluR5* antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect .

HY-14417

VU0155041	mGluR	Neurological Disease
VU0155041 is a potent, selective positive allosteric modulator (PAM) of *mGluR4, with EC₅₀s of 798 nM and 693 nM for human and rat mGluR*4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD) .

HY-14417B

VU0155041 sodium	mGluR	Neurological Disease
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of *mGluR4, with EC₅₀s of 798 nM and 693 nM for human and rat mGluR*4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD) .

HY-103570

MCPG sodium	mGluR	Neurological Disease
MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) .

HY-125717

VU0029251	mGluR	Neurological Disease
VU0029251 is a *mGluR5* partial antagonist (K_i: 1.07 μM). VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC₅₀: 1.7 μM) .

HY-100406

(S)-MCPG 1 Publications Verification (+)-MCPG	mGluR	Neurological Disease
(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371) . (S)-MCPG can be used for the study of the function of mGluRs in spatial learning .

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and *mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀* of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .

HY-100838A

L-CCG-I
L-CCG-I is an extended isomer of conformationally restricted glutamate analog. L-CCG-I also is a potent agonist for *mGluR2* with an EC₅₀ value of 0.3 nM. L-CCG-I can be used for the research of mGluR family .

HY-118022

VU0361747	mGluR	Neurological Disease
VU0361747 is a potent and selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4?PAM). VU0361737 has neuroprotective effect. VU0361737 significantly reverses Amphetamine-induced hyperlocomotion in vivo .

HY-107507

Ro 01-6128

mGluR Neurological Disease

Ro 01-6128 is a positive allosteric modulator of mGluR1 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15129

O-Phospho-L-serine L-Serine O-phosphate; L-SOP	Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	mGluR Endogenous Metabolite
O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the *group III mGluR* receptors** (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for *mGluR1* and a potent antagonist for *mGluR2* .

HY-W017230

L-Cysteinesulfinic acid monohydrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	mGluR Endogenous Metabolite
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-12597

Quisqualic acid L-Quisqualic acid	Structural Classification Ketones, Aldehydes, Acids Combretaceae Source classification Plants Quisqualis indica Linn.	iGluR mGluR
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and *mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀* of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .

Cat. No.	Product Name	Chemical Structure

HY-15129S

O-Phospho-L-serine-13C3,15N
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].

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mGluRs

Inhibitors & Agonists

Screening Libraries

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products