macromolecule

By Targets:	ADC Linker (1) Apoptosis (1) Biochemical Assay Reagents (2) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fluorescent Dye (2) Fungal (1) HIV (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Na+/K+ ATPase (2) PKC (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (4) Infection (3) Inflammation/Immunology (3) Metabolic Disease (1)
Click Chemistry:	TCO (1) Labeling and Fluorescence Imaging (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W077242

1,4-Anthraquinone	DNA/RNA Synthesis	Cancer
1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia .

HY-141667

MBD 7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole	Fluorescent Dye	Others
MBD (7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole), a new fluorescent probe for protein and nucleoprotein conformation, is applied to bacterial ribosomes and to bovine trypsinogen and trypsin. MBD is strongly fluorescent upon binding to a hydrophobic area of a macromolecule .

HY-114299

Salcaprozate sodium SNAC	Others	Others
Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .

HY-W250110

Polyethylenimine (branched) 2 Publications Verification	Biochemical Assay Reagents	Infection Others
Polyethylenimine (PEI) branched is a organic macromolecule with high cationic-charge-density potential. PEI can ensnare DNA as well as attach to cell membrane, PEI also retains a substantial buffering capacity at virtually any pH. PEI is widely used as transfection reagent .

HY-137295

Ingenol 3,20-dibenzoate	PKC Apoptosis	Inflammation/Immunology
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-W014125

Undecanedioic acid

Endogenous Metabolite Metabolic Disease

Undecanedioic acid is associated with intercellular matrix macromolecules and specifically with elastin.
HY-133954

19-Heptatriacontanol

19-Hydroxyheptatriacontane
Others Others

19-Heptatriacontanol is used to combine macromolecules and small molecules.

Undecanedioic acid	Endogenous Metabolite	Metabolic Disease
Undecanedioic acid is associated with intercellular matrix macromolecules and specifically with elastin.

19-Heptatriacontanol 19-Hydroxyheptatriacontane	Others	Others
19-Heptatriacontanol is used to combine macromolecules and small molecules.

HY-P4108

TAT-HA2 Fusion Peptide	Influenza Virus	Others
TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide induces the cellular uptake of macromolecules into endosomes via the TAT moiety and to respond to the acidifying lumen of endosomes to cause membrane leakage and release of macromolecules into cells via the HA2 moiety .

HY-P1491

HIV-1 TAT (48-60)	HIV	Infection
HIV-1 TAT (48-60) is a cell-penetrating peptide derived from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way.

HY-B1843

Fuberidazole BAY 33172; Furidazole	Fungal	Infection
Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pK_a shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea .

HY-105129A

Pimonidazole 4 Publications Verification	Others	Cancer
Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .

HY-105129

Pimonidazole hydrochloride 4 Publications Verification	Others	Cancer
Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .

HY-129214

(2S,3R)-DEPMPO-Biotin	Reactive Oxygen Species	Inflammation/Immunology
(2S,3R)-DEPMPO-Biotin is a spin trapping agent consists of DEPMPO (HY-120976) and Biotin (HY-B0511). (2S,3R)-DEPMPO-Biotin captures macromolecule free radicals in lesions .

HY-P1565

Transdermal Peptide Disulfide TD 1 Disulfide(peptide)	Na+/K+ ATPase	Inflammation/Immunology
Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide can enhance the transdermal delivery of many macromolecules .

HY-D0215

Safranin Safranine T	Fluorescent Dye	Others
Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration .

HY-P1565A

Transdermal Peptide Disulfide TFA TD 1 Disulfide(peptide) TFA	Na+/K+ ATPase	Others
Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules .

HY-105129AS

Pimonidazole-d10	Isotope-Labeled Compounds	Cancer
Pimonidazole-d₁₀ is the deuterium labeled Pimonidazole. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].

HY-157236

AEX Anion-exchange resin 1	Others	Others
AEX Anion-exchange resin 1 is a strong anion exchange chromatography resin, based on monodisperse polystyrene/divinylbenzene (PS-DVB), with a particle size of 50 μm and an ionic ligand of –CH₂N ⁺ (CH₃)₃. AEX Anion-exchange resin 1 can be used for the separation and purification of biological macromolecules such as proteins, antibodies, and viral vaccines.

HY-B2247A

PLGA (75:25) poly(lactic-co-glycolic acid) (75:25)	Biochemical Assay Reagents	Others
PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides .

HY-151769

TCO-PEG2-Sulfo-NHS ester-EDC Urea	ADC Linker	Others
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Cat. No.	Product Name

HY-L064

Glutamine Metabolism Compound Library	898 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH. Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. MCE owns a unique collection of 898 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Glutamine Metabolism Compound Library

898 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 898 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Cat. No.	Product Name	Type

HY-D0215

Safranin Safranine T	Dyes
Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration .

Safranin

Safranine T

Dyes

Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration .

Cat. No.	Product Name	Target	Research Area

HY-P0123

SPACE peptide 3 Publications Verification	Peptides	Others
SPACE peptide is a skin penetrating peptide (SPPs). SPACE peptide can enhance topical delivery of a macromolecule, hyaluronic acid .

HY-P4108

TAT-HA2 Fusion Peptide	Influenza Virus	Others
TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide induces the cellular uptake of macromolecules into endosomes via the TAT moiety and to respond to the acidifying lumen of endosomes to cause membrane leakage and release of macromolecules into cells via the HA2 moiety .

HY-P1491

HIV-1 TAT (48-60)	HIV	Infection
HIV-1 TAT (48-60) is a cell-penetrating peptide derived from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way.

HY-P6020

HBpep-SA	Peptides	Others
HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines .

HY-P1565

Transdermal Peptide Disulfide TD 1 Disulfide(peptide)	Na+/K+ ATPase	Inflammation/Immunology
Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide can enhance the transdermal delivery of many macromolecules .

HY-P1565A

Transdermal Peptide Disulfide TFA TD 1 Disulfide(peptide) TFA	Na+/K+ ATPase	Others
Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-137295

Ingenol 3,20-dibenzoate	Classification of Application Fields Terpenoids Source classification Diterpenoids Euphorbiaceae Euphorbia esula L. Plants Inflammation/Immunology Disease Research Fields	PKC Apoptosis
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-W014125

Undecanedioic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Undecanedioic acid is associated with intercellular matrix macromolecules and specifically with elastin.

Cat. No.	Product Name	Chemical Structure

HY-105129AS

Pimonidazole-d10
Pimonidazole-d₁₀ is the deuterium labeled Pimonidazole. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].

Pimonidazole-d10

Pimonidazole-d₁₀ is the deuterium labeled Pimonidazole. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].

Cat. No.	Product Name		Classification

HY-151769

TCO-PEG2-Sulfo-NHS ester-EDC Urea		TCO Labeling and Fluorescence Imaging
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

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