Search Result

Results for "

malarial

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (5) Antifolate (1) Apoptosis (3) Autophagy (8) Bacterial (4) Bcl-2 Family (4) Biochemical Assay Reagents (1) Caspase (4) Dengue virus (4) Drug Metabolite (1) Endogenous Metabolite (4) ERK (1) FAK (1) Ferroptosis (3) FKBP (1) Flavivirus (4) Fluorescent Dye (1) Fungal (2) GLUT (1) HCV (2) HDAC (2) Histamine Receptor (1) HIV (4) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (1) Mitophagy (1) NF-κB (2) p38 MAPK (5) Parasite (47) PARP (4) PKA (1) Potassium Channel (4) SARS-CoV (3) STAT (1) Toll-like Receptor (TLR) (2) Topoisomerase (2)
By Research Areas:	Cancer (11) Infection (46) Inflammation/Immunology (9) Neurological Disease (3)

By Targets:

Akt (2)

Antibiotic (5)

Antifolate (1)

Apoptosis (3)

Autophagy (8)

Bacterial (4)

Bcl-2 Family (4)

Biochemical Assay Reagents (1)

Caspase (4)

Dengue virus (4)

Drug Metabolite (1)

Endogenous Metabolite (4)

ERK (1)

FAK (1)

Ferroptosis (3)

FKBP (1)

Flavivirus (4)

Fluorescent Dye (1)

Fungal (2)

GLUT (1)

HCV (2)

HDAC (2)

Histamine Receptor (1)

HIV (4)

Isotope-Labeled Compounds (1)

Mitochondrial Metabolism (1)

Mitophagy (1)

NF-κB (2)

p38 MAPK (5)

Parasite (47)

PARP (4)

PKA (1)

Potassium Channel (4)

SARS-CoV (3)

STAT (1)

Toll-like Receptor (TLR) (2)

Topoisomerase (2)

By Research Areas:

Cancer (11)

Infection (46)

Inflammation/Immunology (9)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107566

Conessine	Histamine Receptor Parasite	Infection
Conessine, a steroidal alkaloid, is a potent and selective histamine H₃ receptor antagonist with K_is of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H₃ receptor, respectively. Anti-malarial activity .

HY-111817

ACT-451840	Parasite	Infection
ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial .

HY-N0402

Artemether Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Parasite	Infection Inflammation/Immunology Cancer
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-141621

ACT-606559	Parasite Drug Metabolite	Infection
ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial .

HY-111529

Tafenoquine

WR 238605
Parasite Infection

Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent .
HY-N2899

Arteannuin M

Parasite Infection

Arteannuin M can be isolated from Artemisia annua, and can be used for anti-malarial research .
HY-N2900

Arteannuin N

Parasite Infection

Arteannuin N can be isolated from Artemisia annua, and can be used for anti-malarial research .

Tafenoquine WR 238605	Parasite	Infection
Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent .

Arteannuin M	Parasite	Infection
Arteannuin M can be isolated from Artemisia annua, and can be used for anti-malarial research .

Arteannuin N	Parasite	Infection
Arteannuin N can be isolated from Artemisia annua, and can be used for anti-malarial research .

HY-111529A

Tafenoquine Succinate 4 Publications Verification WR 238605 (Succinate)	Parasite	Infection
Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent .

HY-B1370A

(S)-Hydroxychloroquine (S)-HCQ	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection
(S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine . Hydroxychloroquine, a synthetic antimalarial agent, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro .

HY-B1370B

(R)-Hydroxychloroquine (R)-HCQ	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection
(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine . Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-14749

Pyronaridine	Parasite	Infection
Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection .

HY-14749A

Pyronaridine tetraphosphate 2 Publications Verification	Parasite	Infection
Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection .

HY-114197

Antimalarial agent 14	Mitochondrial Metabolism Parasite	Infection
Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent .

HY-B0803S1

Lumefantrine-d9 Benflumetol-d₉	Isotope-Labeled Compounds Parasite Autophagy	Infection
Lumefantrine-d₉ is the deuterium labeled Lumefantrine. Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs.

HY-N2281

Leachianone A	Apoptosis	Inflammation/Immunology Cancer
Leachianone A, isolated from Radix Sophorae, has anti-malarial, anti-inflammatory, and cytotoxic potent . Leachianone A induces apoptosis involved both extrinsic and intrinsic pathways .

HY-149961

Anti-inflammatory agent 40	Parasite	Infection Inflammation/Immunology
Anti-inflammatory agent 40 is a potential and orally active anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo.

HY-B0439

Sulfadoxine Sulphadoxine	Parasite HIV Antibiotic Endogenous Metabolite	Infection
Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-B0529A

Azlocillin sodium salt Sodium azlocillin	Bacterial Parasite Antibiotic	Infection
Azlocillin sodium salt (Sodium azlocillin), a semisynthetic penicillin, is a broad spectrum β-lactam antibiotic. Azlocillin sodium salt shows antipseudomonal activity, and also potent against the malarial parasite Plasmodium falciparum .

HY-10529

Betulinic acid Maximum Cited Publications 22 Publications Verification Lupatic acid; Betulic acid	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Inflammation/Immunology Cancer
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties .

HY-32004

Coumalic acid	Biochemical Assay Reagents	Others
Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavours, fragrances and cosmetics industries, as polymer components, and as pharmaceutical scaffolds displaying anti-bronchial and -malarial activity .

HY-16762

Artefenomel 2 Publications Verification OZ439	Parasite Ferroptosis SARS-CoV	Infection
Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2 .

HY-N2903

Artoheterophyllin B	Parasite	Infection
Artoheterophyllin B can be isolated from A. heterophyllus. Artoheterophyllin B shows antiplasmodial activity (IC₅₀: 13.7 μM against FcB1 strain). Artoheterophyllin B can be used for anti-malarial research .

HY-151568

UCB7362

Parasite Infection

UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC₅₀ of 7 nM. UCB7362 inhibits parasite growth .

UCB7362	Parasite	Infection
UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC₅₀ of 7 nM. UCB7362 inhibits parasite growth .

HY-D0954

Jenner's Stain	Fluorescent Dye	Others
Jenner's Stain is a dye that is used in microscopy for staining blood smears. Jenner's Stain can be used for the chromosome stain by C-banding technique. Jenner's Stain can be used for the stain for routine blood examinations and malarial staining .

HY-N12077

Eurycomanol 2-O-β-D-glucopyranoside	Parasite	Infection
Eurycomanol 2-O-β-D-glucopyranoside (compound 4) is a natural product that can be obtained from Eurycoma longifolia. Eurycomanol 2-O-β-D-glucopyranoside has the potential for anti-malarial research .

HY-18062

Pyrimethamine 5 Publications Verification Pirimecidan; Pirimetamin; RP 4753	Antifolate Parasite	Infection
Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .

HY-B0439S

Sulfadoxine-d4 Sulphadoxine-d₄	Parasite HIV Antibiotic Endogenous Metabolite	Infection
Sulfadoxine-d₄ is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-131708A

FNDR-20123	HDAC Parasite	Infection
FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC₅₀s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC₅₀=41 nM) and sexual blood stage (IC₅₀=190 nM for male gametocytes). FNDR-20123 inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC₅₀=25/29/2/11/282 nM, respectively.) and inhibits Class III HDAC isoforms at nanomolar concentrations .

HY-14749AS

Pyronaridine-d4 tetraphosphate	Parasite	Infection
Pyronaridine-d₄ (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].

HY-N2795

9-Hydroxycalabaxanthone Xanthone I	Parasite Bacterial	Infection
9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC₅₀=1.2-1.5 µM) .

HY-B0439R

Sulfadoxine (Standard) Sulphadoxine (Standard)	Parasite HIV Antibiotic Endogenous Metabolite	Infection
Sulfadoxine (Standard) is the analytical standard of Sulfadoxine. This product is intended for research and analytical applications. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-131708

FNDR-20123 free base	HDAC Parasite	Infection
FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC₅₀s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC₅₀=41 nM) and sexual blood stage (IC₅₀=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC₅₀=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations .

HY-B0433A

Quinine hydrochloride dihydrate 2 Publications Verification	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-156843

Antiproliferative agent-38	Others	Cancer
Antiproliferative agent-38 (com 18) is a tetracyclic ring, but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .

HY-D0143A

Quinine dihydrochloride	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0094

Artemisinin 10+ Cited Publications Qinghaosu; NSC 369397	HCV Parasite Akt Ferroptosis	Infection Neurological Disease Cancer
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an *anti-malarial* agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-N5005

Guanfu base H Atisinium chloride	Parasite	Infection
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial *Plasmodium falciparum* strains TM4/8.2 (wild type) and K1CB1 with IC₅₀ values of 4 μM and 3.6 μM, respectively .

HY-B0433B

Quinine hemisulfate	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-N7030

5,7,3',4'-Tetramethoxyflavone	Fungal Parasite Bacterial	Infection
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .

HY-W010668

Quinine sulfate hydrate 2 Publications Verification	Flavivirus Dengue virus Parasite Potassium Channel	Others
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-N1074

Warangalone Scandenolone	Parasite PKA	Infection Inflammation/Immunology
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

HY-B0094S

Artemisinin-d3 Qinghaosu-d₃; NSC 369397-d₃	Akt Ferroptosis HCV Parasite	Infection Neurological Disease Cancer
Artemisinin-d₃ is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

HY-N1457

Chrysosplenetin
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A .

HY-136476D

Ga(III) protoporphyrin IX	Bacterial	Infection
Ga(III)protoporphyrin-IX is a model for the key interporphyrin interactions in malaria pigment. Ga(III)protoporphyrin-IX acts as a potent antibacterial against gram-negative, gram-positive, and acid-fast bacteria. Ga(III)protoporphyrin-IX is readily soluble in methanol (MeOH). Ga(III)protoporphyrin IX are as malarial pigment analogues for agent development and as potential antibacterial agents .

HY-153612

MMV009085	GLUT Parasite	Infection Inflammation/Immunology
MMV009085 is a potent *PfHT1 (Plasmodium falciparum hexose* transporter)*-specific inhibitor and a potential anti-malarial* agent . MMV009085 is also a human glucose transporter inhibitor, it has high potency in inhibiting both glucose uptake (IC₅₀: 2.6 μM in glucose uptake assay) and growth of the parasites (EC₅₀: 1.23±0.04 μM against 3D7) .

HY-147850

JMI-346	Parasite	Infection
JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ ^S (3D7; IC₅₀=13 µM) and CQ ^R (RKL-9; IC₅₀=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent .

HY-N0674A

Dehydrocorydaline chloride Maximum Cited Publications 22 Publications Verification 13-Methylpalmatine chloride	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Cancer
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0674

Dehydrocorydaline Maximum Cited Publications 22 Publications Verification 13-Methylpalmatine	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Cancer
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0498

Nitidine chloride 2 Publications Verification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Inflammation/Immunology Cancer
Nitidine chloride, a potential *anti-malarial* lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107566

Conessine	Infection Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids	Histamine Receptor Parasite
Conessine, a steroidal alkaloid, is a potent and selective histamine H₃ receptor antagonist with K_is of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H₃ receptor, respectively. Anti-malarial activity .

HY-N0402

Artemether Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	Parasite
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-N2281

Leachianone A	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Leachianone A, isolated from Radix Sophorae, has anti-malarial, anti-inflammatory, and cytotoxic potent . Leachianone A induces apoptosis involved both extrinsic and intrinsic pathways .

HY-N2899

Arteannuin M	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Artemisia annua L. Compositae	Parasite
Arteannuin M can be isolated from Artemisia annua, and can be used for anti-malarial research .

HY-N2900

Arteannuin N	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Artemisia annua L. Compositae	Parasite
Arteannuin N can be isolated from Artemisia annua, and can be used for anti-malarial research .

HY-B0439

Sulfadoxine Sulphadoxine	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Parasite HIV Antibiotic Endogenous Metabolite
Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-10529

Betulinic acid Maximum Cited Publications 22 Publications Verification Lupatic acid; Betulic acid	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties .

HY-32004

Coumalic acid	Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Smilacis Glabrae Rhizoma Plants Disease Research Fields	Biochemical Assay Reagents
Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavours, fragrances and cosmetics industries, as polymer components, and as pharmaceutical scaffolds displaying anti-bronchial and -malarial activity .

HY-N2903

Artoheterophyllin B	Structural Classification Source classification Phenols Polyphenols Plants Moraceae	Parasite
Artoheterophyllin B can be isolated from A. heterophyllus. Artoheterophyllin B shows antiplasmodial activity (IC₅₀: 13.7 μM against FcB1 strain). Artoheterophyllin B can be used for anti-malarial research .

HY-N12077

Eurycomanol 2-O-β-D-glucopyranoside	Structural Classification Simaroubaceae Source classification Plants Saccharides Monosaccharides	Parasite
Eurycomanol 2-O-β-D-glucopyranoside (compound 4) is a natural product that can be obtained from Eurycoma longifolia. Eurycomanol 2-O-β-D-glucopyranoside has the potential for anti-malarial research .

HY-B0439R

Sulfadoxine (Standard) Sulphadoxine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Parasite HIV Antibiotic Endogenous Metabolite
Sulfadoxine (Standard) is the analytical standard of Sulfadoxine. This product is intended for research and analytical applications. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-B0433A

Quinine hydrochloride dihydrate 2 Publications Verification	Infection Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Quinoline Alkaloids Plants Disease Research Fields Cinchona ledgeriana (Howard) Moens et Trim	Flavivirus Dengue virus Parasite Potassium Channel
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-D0143A

Quinine dihydrochloride	Cinchona succirubra Pav. ex Klotzsch Natural Products Source classification Rubiaceae Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0094

Artemisinin 10+ Cited Publications Qinghaosu; NSC 369397	Infection Structural Classification Piscidia erythrina L. Neurological Disease Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields	HCV Parasite Akt Ferroptosis
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an *anti-malarial* agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-N5005

Guanfu base H Atisinium chloride	Infection Alkaloids Classification of Application Fields Source classification Ranunculaceae Quinoline Alkaloids Aconitum carmichaeli Debx. Plants Disease Research Fields	Parasite
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial *Plasmodium falciparum* strains TM4/8.2 (wild type) and K1CB1 with IC₅₀ values of 4 μM and 3.6 μM, respectively .

HY-B0433B

Quinine hemisulfate	Cinchona succirubra Pav. ex Klotzsch Source classification Rubiaceae Quinoline Alkaloids Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Neurological Disease Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	FKBP Parasite Fungal Antibiotic
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-N7030

5,7,3',4'-Tetramethoxyflavone	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Rutaceae Plants Disease Research Fields Murraya exotica L. Mant.	Fungal Parasite Bacterial
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .

HY-W010668

Quinine sulfate hydrate 2 Publications Verification	Source classification Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-N1074

Warangalone Scandenolone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Erythrina variegata Linn.	Parasite PKA
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

HY-N0674A

Dehydrocorydaline chloride Maximum Cited Publications 22 Publications Verification 13-Methylpalmatine chloride	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0674

Dehydrocorydaline Maximum Cited Publications 22 Publications Verification 13-Methylpalmatine	Infection Alkaloids Structural Classification Classification of Application Fields Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0498

Nitidine chloride 2 Publications Verification	Alkaloids Classification of Application Fields Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential *anti-malarial* lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N0674B

Dehydrocorydaline (hydroxyl) 20+ Cited Publications 13-Methylpalmatine (hydroxyl)	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N4238

Dehydrocorydaline nitrate 20+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

Cat. No.	Product Name	Chemical Structure

HY-B0803S1

Lumefantrine-d9
Lumefantrine-d₉ is the deuterium labeled Lumefantrine. Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs.

HY-B0439S

Sulfadoxine-d4
Sulfadoxine-d₄ is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-14749AS

Pyronaridine-d4 tetraphosphate
Pyronaridine-d₄ (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].

HY-B0094S

Artemisinin-d3

Artemisinin-d₃ is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

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