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Results for "

management

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5-HT Receptor (1) Amyloid-β (1) Antibody-Drug Conjugates (ADCs) (2) Autophagy (3) Bacterial (4) Dopamine Receptor (1) Ferroptosis (3) Glucocorticoid Receptor (2) Glucosidase (1) HIV (1) HSV (1) Isotope-Labeled Compounds (3) Mineralocorticoid Receptor (1) Nectin-4 (2) Parasite (2) PD-1/PD-L1 (2) Phosphodiesterase (PDE) (2) Potassium Channel (6) Prostaglandin Receptor (2) Sodium Channel (6) STAT (1) TRP Channel (1) VD/VDR (2)
By Research Areas:	Cancer (10) Cardiovascular Disease (10) Endocrinology (5) Infection (2) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (8)

By Targets:

11β-HSD (1)

5-HT Receptor (1)

Amyloid-β (1)

Antibody-Drug Conjugates (ADCs) (2)

Autophagy (3)

Bacterial (4)

Dopamine Receptor (1)

Ferroptosis (3)

Glucocorticoid Receptor (2)

Glucosidase (1)

HIV (1)

HSV (1)

Isotope-Labeled Compounds (3)

Mineralocorticoid Receptor (1)

Nectin-4 (2)

Parasite (2)

PD-1/PD-L1 (2)

Phosphodiesterase (PDE) (2)

Potassium Channel (6)

Prostaglandin Receptor (2)

Sodium Channel (6)

STAT (1)

TRP Channel (1)

VD/VDR (2)

By Research Areas:

Cancer (10)

Cardiovascular Disease (10)

Endocrinology (5)

Infection (2)

Inflammation/Immunology (4)

Metabolic Disease (3)

Neurological Disease (8)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100129

JNJ-17203212 1 Publications Verification	TRP Channel	Neurological Disease
JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine .

HY-B0191

Bimatoprost AGN 192024	Prostaglandin Receptor	Endocrinology
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

HY-14286

Levosimendan 2 Publications Verification Simsndan; OR-1259	Potassium Channel Phosphodiesterase (PDE) Autophagy	Cardiovascular Disease
Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.

HY-N7659A

Glucobrassicin potassium	Others	Others
Glucobrassicin (potassium) is a glucosinolate (GSL) isolated from wild carrot (Raphanus raphanistrum L.). Glucobrassicin can be used in biological fumigation or allelopathy research for weed management .

HY-122217

Pyridate

CL 11344
Others Others

Pyridate (CL 11344) is a herbicide, which is used in the agricultural management of cereals, maize and rape .

Pyridate CL 11344	Others	Others
Pyridate (CL 11344) is a herbicide, which is used in the agricultural management of cereals, maize and rape .

HY-17359

Deferasirox 5 Publications Verification ICL 670	Bacterial Ferroptosis	Cancer
Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .

HY-107917

Desoxycorticosterone pivalate DOCP	Mineralocorticoid Receptor	Endocrinology
Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism .

HY-P99016A

Enfortumab vedotin-ejfv	Antibody-Drug Conjugates (ADCs) Nectin-4	Cancer
Enfortumab vedotin-ejfv is an anti-Nectin-4 antibody-drug conjugate for the management of urothelial carcinoma .

HY-P99016B

Enfortumab vedotin-ejfv (solution)	Antibody-Drug Conjugates (ADCs) Nectin-4	Cancer
Enfortumab vedotin-ejfv (solution) is an anti-Nectin-4 antibody-drug conjugate for the management of urothelial carcinoma .

HY-B2165

Bendazac L-Lysine	Others	Others
Bendazac L-Lysine is one of agents that have been introduced for the management of cataracts, protecting the level of vision in patients, thus delaying the need for surgical intervention.

HY-B1754

Rimexolone Org 6216; Rimexel
Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation .

HY-B0191S1

Bimatoprost-d4 AGN 192024-d₄	Prostaglandin Receptor	Endocrinology
Bimatoprost-d₄ is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

HY-B2008

Famoxadone DPX-JE874
Famoxadone (DPX-JE874) is a fungicide acting against a broad spectrum of fungi and is widely used in Integrated Pest Management strategies in different agricultural crops .

HY-10003

Alfacalcidol 2 Publications Verification 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3	VD/VDR	Metabolic Disease
Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis .

HY-17359S

Deferasirox-d4	Isotope-Labeled Compounds Bacterial Ferroptosis	Cancer
Deferasirox-d₄ is the deuterium labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3].

HY-W050000

OR-1855	Potassium Channel Phosphodiesterase (PDE) Autophagy	Cardiovascular Disease
OR-1855, an active metabolite of Levosimendan, has effect on human myometrial contractility. Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure .

HY-N1362

Salvianolic acid B Maximum Cited Publications 9 Publications Verification Lithospermic acid B	Autophagy	Cardiovascular Disease
Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.

HY-B1107

Naftidrofuryl oxalate Nafronyl oxalate salt	5-HT Receptor	Cardiovascular Disease
Naftidrofuryl oxalate (Nafronyl oxalate salt) is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.

HY-17359R

Deferasirox (Standard) ICL 670 (Standard)	Bacterial Ferroptosis	Cancer
Deferasirox (Standard) is the analytical standard of Deferasirox. This product is intended for research and analytical applications. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .

HY-17429

Flecainide acetate R-818	Sodium Channel	Cardiovascular Disease
Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

HY-13693

Mometasone furoate 2 Publications Verification Sch32088	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology Cancer
Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo

HY-10003S

Alfacalcidol-d7 1-hydroxycholecalciferol-d₇; 1.alpha.-Hydroxyvitamin D3-d₇	VD/VDR	Metabolic Disease
Alfacalcidol-d₇ is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis[1][2][3][4].

HY-N1023

11-O-Galloylbergenin
11-O-Galloylbergenin is a compound isolated from ethanolic extract of Mallotus philippinensis. 11-O-Galloylbergenin has analgesic and anti-inflammatory activities. 11-O-Galloylbergenin is a lead compound for management of pain and inflammation .

HY-151470

Chitinase-IN-5	Parasite	Others
Chitinase-IN-5 (8i) is a potent chitinase OfChi-h inhibitor with an IC₅₀ value of 0.051 μM. Chitinase-IN-5 shows good insecticidal activity, it can be used for the research of green pest control and management .

HY-17425B

Valacyclovir hydrochloride hydrate Valaciclovir hydrochloride hydrate	HSV Bacterial	Infection
Valacyclovir hydrochloride hydrate is a potent antiviral agent. Valacyclovir hydrochloride hydrate can be used in the management of herpes simplex, herpes zoster and herpes B. Valacyclovir hydrochloride hydrate can be formulate ocular inserts for the research of ocular herpes. Valacyclovir hydrochloride hydrate is a precursor and can be rapidly converted into acyclovir in vivo .

HY-14263

Pericyazine Propericiazine; RP 8909	Dopamine Receptor	Neurological Disease
Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis . Pericyazine is a selective D2-dopamine receptor antagonist . Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects .

HY-17429S

Flecainide-d4 acetate R-818-d₄	Sodium Channel	Cardiovascular Disease
Flecainide-d₄ (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].

HY-151469

Chitinase-IN-4	Parasite	Others
Chitinase-IN-4 (compound 8f), an azo-aminopyrimidine derivative, is a potent, selective OfChi-h inhibitor with an IC₅₀ value of 0.1 μM. Chitinase-IN-4 has good insecticidal activity. Chitinase-IN-4 can be used in research of green pest control and management .

HY-P2802

α-Glucosidase α-D-Glucosidase	Glucosidase	Metabolic Disease
α-Glucosidase (α-D-Glucosidase), a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. α-Glucosidase can facilitate the absorption of glucose by the small intestine. Inhibition of α-Glucosidase is an effective management of non-insulin-dependent diabetes mellitus (NIDDM) .

HY-13693R

Mometasone furoate (Standard) Sch32088 (Standard)	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology Cancer
Mometasone furoate (Standard) is the analytical standard of Mometasone furoate. This product is intended for research and analytical applications. Mometasone furoate (Sch32088) is a?glucocorticoid receptor?agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo

HY-B0563B

Ropivacaine hydrochloride 4 Publications Verification	Sodium Channel Potassium Channel	Cardiovascular Disease Neurological Disease Cancer
Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is widely used for neuropathic pain management in vivo .

HY-P1812

AUNP-12 NP-12	PD-1/PD-L1	Cancer
AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) .

HY-B0563

Ropivacaine 4 Publications Verification	Sodium Channel Potassium Channel	Cardiovascular Disease Neurological Disease
Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is used for the research of neuropathic pain management .

HY-B0563A

Ropivacaine hydrochloride monohydrate 4 Publications Verification	Sodium Channel Potassium Channel	Cardiovascular Disease Neurological Disease
Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is widely used for regional anesthesia and neuropathic pain management in vivo .

HY-P1812A

AUNP-12 TFA NP-12 TFA	PD-1/PD-L1	Cancer
AUNP-12 TFA (NP-12 TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 TFA exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) .

HY-N0407

Picroside I 6'-Cinnamoylcatalpol	STAT	Inflammation/Immunology
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .

HY-B0563S1

Ropivacaine-d7	Isotope-Labeled Compounds Sodium Channel Potassium Channel	Cardiovascular Disease Neurological Disease
Ropivacaine-d₇ is deuterium labeled Ropivacaine. Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of neuropathic pain management[1].

HY-B0563BS

Ropivacaine-d7 hydrochloride	Isotope-Labeled Compounds	Neurological Disease
Ropivacaine-d₇ hydrochloride is a deuterium labeled Ropivacaine (hydrochloride) (HY-B0563B) . Ropivacaine hydrochloride is a potent?sodium channel?blocker and blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is widely used for neuropathic pain?management in vivo .

HY-B1588S

Carbenoxolone-d4	Amyloid-β HIV 11β-HSD	Infection Neurological Disease Inflammation/Immunology
Carbenoxolone-d₄ is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties[3]. Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease[2]. Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD[1]. Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop[4].Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself[6].

Cat. No.	Product Name

HY-L0094V

Chinese National Compound Library	1,398,968 compounds
The Chinese National Compound Library (CNCL) composes 1.4 million compounds possessing diversified structures. Coupled with this library will be advanced sample handling, information management and quality control systems. Most compounds in the library are drug-like, conforming to “Lipinski’s Rule of Five”, such as MW < 500, logP < 5, Hydrogen Bond Donors < 5.

HY-L0118V

Asinex Covalent Inhibitors Library	8,085 compounds
A unique set of molecules containing mild electrophilic moieties that covalently interact with amino acid residues in the target protein. The diversity of our compounds for covalent drug discovery ranges from natural product-like scaffolds to macrocycles, creating multiple opportunities in hit generation for a selected target.

HY-L145

Antihypertensive Compound Library	481 compounds
The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs). MCE offers a unique collection of 481 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Antihypertensive Compound Library

481 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 481 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

α-Glucosidase α-D-Glucosidase	Biochemical Assay Reagents
α-Glucosidase (α-D-Glucosidase), a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. α-Glucosidase can facilitate the absorption of glucose by the small intestine. Inhibition of α-Glucosidase is an effective management of non-insulin-dependent diabetes mellitus (NIDDM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1362

Salvianolic acid B 5+ Cited Publications Lithospermic acid B	Cardiovascular Disease Structural Classification Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields	Autophagy
Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.

HY-N0407

Picroside I 6'-Cinnamoylcatalpol	Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	STAT
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .

Cat. No.	Product Name	Chemical Structure

HY-17429S

Flecainide-d4 acetate
Flecainide-d₄ (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].

HY-B0563S1

Ropivacaine-d7

Ropivacaine-d₇ is deuterium labeled Ropivacaine. Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of neuropathic pain management[1].

HY-B0191S1

Bimatoprost-d4
Bimatoprost-d₄ is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

HY-17359S

Deferasirox-d4
Deferasirox-d₄ is the deuterium labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3].

HY-10003S

Alfacalcidol-d7
Alfacalcidol-d₇ is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis[1][2][3][4].

HY-B0563BS

Ropivacaine-d7 hydrochloride

Ropivacaine-d₇ hydrochloride is a deuterium labeled Ropivacaine (hydrochloride) (HY-B0563B) . Ropivacaine hydrochloride is a potent?sodium channel?blocker and blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is widely used for neuropathic pain?management in vivo .

HY-B1588S

Carbenoxolone-d4

Carbenoxolone-d₄ is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties[3]. Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease[2]. Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD[1]. Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop[4].Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself[6].

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