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Results for "

menthol

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

3

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-75161
    (-)-Menthol
    1 Publications Verification

    		 TRP Channel Endogenous Metabolite Cancer
    (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca 2+-permeable nonselective cation channel, to increase [Ca 2+]i . Antitumor activity .
    (-)-<em>Menthol</em>
  • HY-N1369
    Menthol
    4 Publications Verification
    Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .
    <em>Menthol</em>
  • HY-W017277
    (+)-Menthol

    D-menthol

    		 Others Neurological Disease
    (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .
    (+)-<em>Menthol</em>
  • HY-122317
    Menthol glucuronide

    		Drug Metabolite Others
    Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .
    <em>Menthol</em> glucuronide
  • HY-N1369S
    Menthol-d4

    		Isotope-Labeled Compounds Calcium Channel Neurological Disease
    Menthol-d4 is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes[1].
    <em>Menthol</em>-d4
  • HY-Y1683
    DL-Menthol

    Racementhol
    DL-Menthol is a relative configuration of (-)-Menthol. DL-Menthol relates to the activation of GABAA receptor .
    DL-<em>Menthol</em>
  • HY-N7132
    Menthyl acetate

    L-Menthyl acetate; (-)-Menthyl acetate

    		 Others Others
    ​Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. ​Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .
    Menthyl acetate
  • HY-108449
    Acoltremon

    WS-12; AR-15512; AVX-012

    		 TRP Channel Cancer
    Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .
    Acoltremon
  • HY-18662
    RQ-00203078
    2 Publications Verification

    		 TRP Channel Neurological Disease Cancer
    RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC50s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels .
    RQ-00203078
  • HY-W317408
    (+)-Menthyl acetate

    		Others Others
    (+)-Menthyl acetate is a compound isolated from natural Cunila angustifolia Benth essential oil. The selectivity of (+)-Menthyl acetate is higher than that of MCF-7 cell line, IC50=34.0 μg?mL -1, and lower than that of SK-Mel-28 cell line, IC50=279.9 μg?mL -1, on A549 cell without fatal .
    (+)-Menthyl acetate
  • HY-115506
    PF-05105679

    		TRP Channel Neurological Disease
    PF-05105679 is an orally active and selective TRPM8 antagonist with an IC50 of 103 nM. PF-05105679 has the potential for cold-related pain .
    PF-05105679

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