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Results for "

metabolisms

" in MCE Product Catalog:

420

Inhibitors & Agonists

24

Screening Libraries

7

Dye Reagents

11

Biochemical Assay Reagents

24

Peptides

84

Natural
Products

127

Isotope-Labeled Compounds

Targets Recommended: Mitochondrial Metabolism
Cat. No. Product Name Target Research Areas
  • HY-N6237
    Aspulvinone O

    Others Infection
    Aspulvinone O is a natural inhibitor of aspartate transaminase 1 (GOT1). GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 may serve as an important target in PDAC. Aspulvinone O suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism.
  • HY-145781
    β-L-Fucopyranosyl phosphate

    Others Metabolic Disease
    β-L-Fucopyranosyl phosphate can be used for the research of carbohydrate metabolism. Glycosyl phosphates play crucial roles in carbohydrate metabolism as metabolic regulators or ubiquitous intermediates for glycoconjugate biosynthesis.
  • HY-B1514
    Allantoic acid

    Endogenous Metabolite Others
    Allantoic acid is a degradative product of uric acid and associated with purine metabolism.
  • HY-100907
    (±)-Acetylcarnitine chloride

    Acetyl dl-carnitine chloride

    Others Neurological Disease
    (±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) is a weak cholinergic agonist with cholinergic properties. (±)-Acetylcarnitine chloride is an important intermediate in lipid metabolism.
  • HY-P3147
    IYPTNGYTR

    Drug Metabolite Others
    IYPTNGYTR, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR can be used to monitor in vivo Trastuzumab metabolism.
  • HY-P3147A
    IYPTNGYTR acetate

    Drug Metabolite Others
    IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism.
  • HY-145952
    (2E,9Z)-Octadeca-2,9-dienoic acid

    Others Metabolic Disease
    (2E,9Z)-Octadeca-2,9-dienoic acid, a polyunsaturated fatty acid, can be used for the research of lipoxygenase-dependent metabolism.
  • HY-136152
    MCHR1 antagonist 3

    MCHR1 (GPR24) Endocrinology Metabolic Disease
    MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism.
  • HY-147309
    16-Azidohexadecanoic acid

    Others Others
    16-Azidohexadecanoic acid, a synthetic fatty acid, can be used as a modification marker for nucleotides and a molecular probe for fatty acid metabolism.
  • HY-128851
    Coenzyme A

    Endogenous Metabolite Metabolic Disease
    Coenzyme A, a ubiquitous essential cofactor, is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the metabolism of carboxylic acids, including short- and long-chain fatty acids.
  • HY-Y1771
    2-Carboxybenzaldehyde

    Drug Metabolite Infection
    2-Carboxybenzaldehyde is the major metabolite found in phenanthrene metabolism. Phenanthrene can be degrade by Pseudomonas sp. Lphe-2 strain.
  • HY-147004
    A-908292

    Acetyl-CoA Carboxylase Metabolic Disease
    A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 of 38 nM. A-908292 can be used for the research of fatty acid metabolism.
  • HY-146164
    Tubulin polymerization-IN-21

    Microtubule/Tubulin Cancer Metabolic Disease
    Tubulin polymerization-IN-21 (compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-21 exhibits anti-cancer activity through disrupting cellular integrity and affecting glucose metabolism.
  • HY-124073
    Dihydrocapsiate

    TRP Channel Metabolic Disease
    Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease.
  • HY-136336
    Tofacitinib metabolite-1

    Drug Metabolite Others
    Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib.
  • HY-120696
    SR9186

    ML368

    Cytochrome P450 Parasite Infection
    SR9186 (ML368) is a potent CYP3A4 inhibitor with IC50 s for inhibition of midazolam → 1′hydroxymidazolam, testosterone → 6β-hydroxytestosterone, and vincristine → vincristine M1 of 9, 4, and 38 nM, respectively. SR-9186 inhibits liver-stage development of P. falciparum to block ivermectin metabolism.
  • HY-18642
    CYP3cide

    PF-4981517

    Cytochrome P450 Others
    CYP3cide (PF-4981517) is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC50 values for Midazolam 1’-hydroxylase activity are 0.03 μM, 17 μM, and 71 μM for CYP3A4, CYP3A5, and CYP3A7, respectively. CYP3cide can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism.
  • HY-B0172B
    Isolithocholic acid

    3β-Hydroxy-5β-cholanic acid; 3-Epilithocholic acid; β-Lithocholic acid

    Endogenous Metabolite Endocrinology
    Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.
  • HY-B0399
    L-Carnitine

    (R)-Carnitine; Levocarnitine

    Endogenous Metabolite Neurological Disease Cancer
    L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.
  • HY-134425
    β-Methylcrotonyl coenzyme A lithium

    Endogenous Metabolite Metabolic Disease
    β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase).
  • HY-W018499
    (S)-2-Hydroxybutanoic acid

    Endogenous Metabolite Others
    (S)-2-Hydroxybutanoic acid is the S-enantiomer of 2-Hydroxybutanoic acid. 2-Hydroxybutanoic acid, a coproduct of protein metabolism, is an insulin resistance (IR) biomarker.
  • HY-76199
    trans-4-Hydroxycyclohexanecarboxylic acid

    Others Metabolic Disease
    trans-4-Hydroxycyclohexanecarboxylic acid is a substrate for cyclohexanecarboxylic acid production. trans-4-Hydroxycyclohexanecarboxylic acid is the by-product of intestinal bacterial metabolism via urinary excretion.
  • HY-N8276
    Ro 3-1314

    9a,12a-Octadecadiynoic acid

    Lipoxygenase Metabolic Disease Inflammation/Immunology
    Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments.
  • HY-120872
    AJS1669 free acid

    Others Metabolic Disease
    AJS1669 free acid is a potent and orally available glycogen synthase (GS) activator. AJS1669 improves glucose metabolism and reduces body fat mass in mice[1].
  • HY-B2246
    L-Carnitine hydrochloride

    (R)-Carnitine hydrochloride; Levocarnitine hydrochloride

    Endogenous Metabolite Metabolic Disease
    L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.
  • HY-23148
    1-Methylisatin

    Others Others
    1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with Kis of 38.2 and 5.38 µM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of drug metabolism in vivo.
  • HY-114295
    Geranyl diphosphate

    Geranyl pyrophosphate

    Endogenous Metabolite Metabolic Disease
    Geranyl diphosphate is a key intermediate in the isoprenoid biosynthesis pathway (IBP). HY-114295 plays key roles in cellular metabolism and is responsible for the production of both sterol and non-sterol isoprenoids.
  • HY-134424
    Propionyl coenzyme A lithium

    Endogenous Metabolite Metabolic Disease
    Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms.
  • HY-122753
    SLMP53-1

    MDM-2/p53 Cancer
    SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels.
  • HY-N8461
    Reuterin

    3-Hydroxypropionaldehyde; 3-Hydroxypropanal

    Bacterial Infection
    Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates.
  • HY-114295A
    Geranyl pyrophosphate triammonium

    Others Metabolic Disease
    Geranyl pyrophosphate triammonium is a key intermediate in the isoprenoid biosynthesis pathway (IBP). Geranyl pyrophosphate triammonium plays key roles in cellular metabolism and is responsible for the production of both sterol and non-sterol isoprenoids.
  • HY-P1844A
    Chemerin-9 (149-157) (TFA)

    Akt ERK Reactive Oxygen Species Amyloid-β Inflammation/Immunology
    Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism.
  • HY-145249
    ATP-PEG8-Biotin

    PROTAC Linkers Inflammation/Immunology
    ATP-PEG8-Biotin is a PEG-based linker that incorporates ATP. ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
  • HY-147379
    Hepcidin antagonist-1

    Others Metabolic Disease
    Hepcidin antagonist-1 (example 104) is a potent hepcidin (hepcidine) antagonist with an IC50<50 μM. Hepcidin antagonist-1 can be used for researching iron metabolism disorders, such as anemias.
  • HY-19330
    DASA-58

    Pyruvate Kinase Cancer Metabolic Disease
    DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer.
  • HY-135024
    Phenylacetyl CoA

    Phenylacetyl Coenzyme A

    Endogenous Metabolite Metabolic Disease
    Phenylacetyl CoA is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica.
  • HY-147062
    N-Acetyl-D-galactosamine-6-phosphate

    Others Metabolic Disease
    N-acetyl-D-galactosamine 6-phosphate is a galactosamine phosphate that involved in galactose metabolism and phosphotransferase system (PTS). N-Acetyl-D-galactosamine-6-phosphate can be hydrolyze by NagA.
  • HY-B2176
    ATP

    Adenosine 5'-triphosphate

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
  • HY-W010735
    ATP disodium salt hydrate

    Adenosine 5'-triphosphate disodium salt hydrate

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation.
  • HY-B0345A
    ATP disodium salt

    Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.
  • HY-146240
    ALDH1A1-IN-3

    Aldehyde Dehydrogenase (ALDH) Metabolic Disease
    ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement.
  • HY-B2176B
    ATP dimagnesium

    Adenosine 5'-triphosphate dimagnesium

    Endogenous Metabolite Inflammation/Immunology
    ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation.
  • HY-B2176C
    ATP dipotassium

    Adenosine 5'-triphosphate dipotassium

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation.
  • HY-B2176D
    ATP ditromethamine

    Adenosine 5'-triphosphate ditromethamine

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP ditromethamine (Adenosine 5'-triphosphate ditromethamine) is a central component of energy storage and metabolism in vivo. ATP ditromethamine provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP ditromethamine is an important endogenous signaling molecule in immunity and inflammation.
  • HY-18062
    Pyrimethamine

    Pirimecidan; Pirimetamin; RP 4753

    Antifolate Parasite Infection
    Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate.
  • HY-130120
    HWL-088

    Free Fatty Acid Receptor PPAR Metabolic Disease
    HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) . HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects.
  • HY-P1844
    Chemerin-9 (149-157)

    Akt ERK Reactive Oxygen Species Amyloid-β Inflammation/Immunology
    Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism.
  • HY-136584
    2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid

    Others Metabolic Disease Cardiovascular Disease
    2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid is a ketone compound extracted from patent WO2002030860A2, compound example II-9. 2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid can be used for the research of cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders.
  • HY-B2176A
    ATP disodium trihydrate

    Adenosine-5'-triphosphate disodium trihydrate

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation.
  • HY-N8139
    2-Amino-3-carboxy-1,4-naphthoquinone

    Others Metabolic Disease
    2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria.
  • HY-108022A
    MSDC-0602K

    Azemiglitazone potassium

    Insulin Receptor PPAR Metabolic Disease
    MSDC-0602K (Azemiglitazone potassium), a PPARγ-sparing thiazolidinedione (Ps-TZD), binds to PPARγ with the IC50 of 18.25 μM. MSDC-0602K modulates the mitochondrial pyruvate carrier (MPC). MSDC-0602K can be used for the research of fatty liver including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K, an insulin sensitizer, improves insulinemia and fatty liver disease in mice, alone and in combination with Liraglutide.
  • HY-139981
    Microtubule destabilizing agent-1

    Microtubule/Tubulin Cancer
    Microtubule destabilizing agent-1 (Compound 12b) acts as a microtubule destabilizing agent (MDA) based on hydroxamic acid, could serve as a potential MDA for further investigation. Microtubule destabilizing agent-1 shows favorable metabolism stability, high bioavailability, and potent antitumor activity.
  • HY-135849
    Catalase

    Reactive Oxygen Species Cancer
    Catalase is a key enzyme in the metabolism of H2O2 and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors. Free oxygen radical scavenger.
  • HY-129099
    N-Desmethyltamoxifen

    PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite Cancer
    N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
  • HY-129099A
    N-Desmethyltamoxifen hydrochloride

    PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite Cancer
    N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
  • HY-100017
    BAY-876

    GLUT Cancer
    BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth.
  • HY-135841
    CM10

    Aldehyde Dehydrogenase (ALDH) Cancer Metabolic Disease
    CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.
  • HY-113330
    12S-HHT

    12(S)-HHTrE

    Leukotriene Receptor Endogenous Metabolite Inflammation/Immunology
    12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity.
  • HY-14415
    SR8278

    REV-ERB Metabolic Disease Neurological Disease
    SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease.
  • HY-19594
    Teclozan

    WIN 13146

    Parasite Infection
    Teclozan (WIN 13146) is an antiprotozoal agent, class in benzylamine derivatives. Teclozan intervenes in the phospholipid metabolism preventes the formation of arachidonic acid. Teclozan acts in the intestinal lumen being effective in Anti-G. intestinalis. Teclozan can be used for the research of protozoan infections.
  • HY-12511
    SKF-86002

    p38 MAPK Inflammation/Immunology
    SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
  • HY-108641
    SKF-86002 dihydrochloride

    p38 MAPK Inflammation/Immunology
    SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
  • HY-Y1242
    Choline hydroxide

    Others Others
    Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism .
  • HY-18078
    PQ-10

    Phosphodiesterase (PDE) Neurological Disease
    PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia.
  • HY-N0376
    Liquiritin

    Reactive Oxygen Species Cancer Inflammation/Immunology Neurological Disease
    Liquiritin, a flavonoid isolated from Glycyrrhiza, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity.
  • HY-145963
    DRB18

    GLUT Cancer
    DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and increase oxidative stress and necrotic cell death. DRB18 has anti-tumor activity.
  • HY-113596A
    Acetyl coenzyme A lithium

    Acetyl-CoA lithium

    Endogenous Metabolite Autophagy Metabolic Disease Cardiovascular Disease
    Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis.
  • HY-113596
    Acetyl Coenzyme A trisodium

    Acetyl-CoA trisodium

    Endogenous Metabolite Autophagy Metabolic Disease
    Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis.
  • HY-12995A
    (S)-BI 665915

    FLAP Inflammation/Immunology
    (S)-BI 665915 is an orally active oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.7 nM for FLAP binding. (S)-BI 665915 inhibits FLAP functional in human whole blood with an IC50 of 45 nM. (S)-BI 665915 demonstrates an excellent cross-species drug metabolism and pharmacokinetics (DMPK) profile and a dose-dependent inhibition of LTB4 production.
  • HY-W176629
    Hydrocotarnine

    E1/E2/E3 Enzyme Metabolic Disease Inflammation/Immunology Neurological Disease
    Hydrocotarnine is a Cbl inhibitor, and results in inflammasome-mediated IL-18 secretion in colitis. Hydrocotarnine increases expression of GLUT1 and cellular glucose uptake in glycolytic metabolism. Hydrocotarnine acts as an agent that provides analgesic effect in cancer research.
  • HY-N7814
    2-Hydroxypalmitic acid

    Endogenous Metabolite Others
    2-Hydroxypalmitic acid is an intermediate in phytosphingosine metabolism.
  • HY-144060
    AKT-IN-10

    Akt Cancer
    AKT-IN-10 is a potent inhibitor of AKT. Protein kinase B (PKB, also known as AKT) is central to PI3K/AKT/mTOR signaling in cells, and its function is important for cell growth, survival, differentiation and metabolism. AKT-IN-10 has the potential for the research of breast and prostate cancer (extracted from patent WO2021185238A1, compound 4).
  • HY-144059
    AKT-IN-9

    Akt Cancer
    AKT-IN-9 is a potent inhibitor of AKT. Protein kinase B (PKB, also known as AKT) is central to PI3K/AKT/mTOR signaling in cells, and its function is important for cell growth, survival, differentiation and metabolism. AKT-IN-9 has the potential for the research of breast and prostate cancer (extracted from patent WO2021185238A1, compound 1).
  • HY-17598
    Rafoxanide

    Parasite Infection
    Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide can be used for the control of infestation with Hemonchus species and Fasciola species in sheep and cattle and Estrus ovis in sheep. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide eliminates 91-99% of the mature flukes and 50-90% of the younger flukes in ruminants.
  • HY-148048
    Pegozafermin

    Others Metabolic Disease Inflammation/Immunology
    Pegozafermin is a fibroblast growth factor FGF21 (HY-P7012) analog, which is an endogenous metabolic hormone and regulates energy expenditure and glucose and lipid metabolism. Pegozafermin decreases the level of triglyceride (TG), can be used for non-alcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG).
  • HY-123033A
    Nicotinamide riboside chloride

    Sirtuin Endogenous Metabolite Metabolic Disease Neurological Disease Cancer
    Nicotinamide riboside Chloride, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
  • HY-123033
    Nicotinamide riboside

    Sirtuin Endogenous Metabolite Metabolic Disease Neurological Disease Cancer
    Nicotinamide riboside, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
  • HY-P3444
    CD31

    PECAM-1

    Metabolic Disease Inflammation/Immunology
    CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation -.
  • HY-13771A
    Ursodeoxycholic acid sodium

    Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium

    G protein-coupled Bile Acid Receptor 1 FXR Endogenous Metabolite Cancer Metabolic Disease Inflammation/Immunology
    Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active.
  • HY-13771
    Ursodeoxycholic acid

    Ursodeoxycholate; Ursodiol; UDCA

    G protein-coupled Bile Acid Receptor 1 FXR Endogenous Metabolite Metabolic Disease Cancer
    Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active.
  • HY-W104368
    Nicotinic acid riboside

    Endogenous Metabolite Cancer Metabolic Disease
    Nicotinic acid riboside is a NAD + precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD + metabolism.
  • HY-123033B
    Nicotinamide riboside tartrate

    Sirtuin Metabolic Disease Neurological Disease
    Nicotinamide riboside tartrate, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
  • HY-123033C
    Nicotinamide riboside malate

    Sirtuin Metabolic Disease Neurological Disease
    Nicotinamide riboside malate, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
  • HY-12398A
    TEI-9648

    VD/VDR Metabolic Disease Inflammation/Immunology
    TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research.
  • HY-W015969
    1-Aminopropan-2-ol

    Endogenous Metabolite Metabolic Disease
    1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas.
  • HY-W015410
    Disodium succinate

    Endogenous Metabolite Metabolic Disease
    Disodium succinate is the disodium salt of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
  • HY-146617
    GLS1 Inhibitor-4

    Glutaminase Apoptosis Cancer
    GLS1 Inhibitor-4 (compound 41e) is a potent GLS1 inhibitor with an IC50 of 11.86 nM. GLS1 Inhibitor-4 shows antiproliferative activity, good metabolic stability, robust GLS1 binding affinity. GLS1 Inhibitor-4 blocks the glutamine metabolism and induce the production of ROS. GLS1 Inhibitor-4 induces apoptosis and shows antitumor activity.
  • HY-120103
    PF-06649298

    Others Metabolic Disease
    PF-06649298 is a sodium-coupled citrate transporter inhibitor. PF-06649298 specifically interacts with NaCT with an IC50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism.
  • HY-113224
    Desmosterol

    Endogenous Metabolite Metabolic Disease
    Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism.
  • HY-15453
    Devimistat

    CPI-613

    Apoptosis Mitochondrial Metabolism Cancer
    Devimistat (CPI-613) is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells.
  • HY-113328
    Aminoadipic acid

    Endogenous Metabolite Others
    Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.
  • HY-N1935
    Worenine

    Others Metabolic Disease
    Worenine is isolated from Coptis chinensis. Worenine in rat shows dehydrogenization, hydrogenation, hydroxylation, and demethylene reactions in phase I metabolism. The phase II metabolism sulfation and glucuronidation reactions.
  • HY-113121
    Vanillylmandelic acid

    Others Cardiovascular Disease
    Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM.
  • HY-12402
    SBC-115076

    Ser/Thr Protease Cardiovascular Disease
    SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism.
  • HY-W010040
    4-​Hydroxyphenylpyruvic acid

    Endogenous Metabolite Metabolic Disease
    4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine.
  • HY-Y0781
    Pyruvic acid

    Acetylformic acid

    Endogenous Metabolite Others
    Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
  • HY-113285
    Ureidopropionic acid

    3-Ureidopropionic acid

    Endogenous Metabolite Others
    Ureidopropionic acid (3-Ureidopropionic acid) is an intermediate in the metabolism of uracil.
  • HY-101401
    3-(Methylthio)propionic acid

    3-Methylsulfanylpropionic acid

    Fungal Endogenous Metabolite Cancer
    3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.
  • HY-N0684S
    Vitamin K1 D7

    Endogenous Metabolite Cardiovascular Disease
    Vitamin K1 D7 (Phylloquinone D7) is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
  • HY-113224S
    Desmosterol-d6

    Endogenous Metabolite Metabolic Disease
    Desmosterol-d6 is the deuterium labeled Desmosterol. Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism.
  • HY-N1925
    Tea polyphenol

    Apoptosis Autophagy Cancer Inflammation/Immunology
    Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism.
  • HY-113131
    Dihydroxyacetone phosphate

    Endogenous Metabolite Metabolic Disease
    Dihydroxyacetone phosphate is an important intermediate in lipid biosynthesis and in glycolysis. It is a biochemical compound involved in many metabolic pathways, including the Calvin cycle in plants and glycolysis. Dihydroxyacetone phosphate is found to be associated with transaldolase deficiency, which is an inborn error of metabolism.
  • HY-B1184A
    (S)-Mephenytoin

    (+)-Mephenytoin

    Others Neurological Disease
    (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism.
  • HY-B0430
    D-Pantothenic acid

    Pantothenate; Vitamin B5

    Endogenous Metabolite Others
    D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.
  • HY-B0430A
    D-Pantothenic acid sodium

    Sodium pantothenate; Vitamin B5 sodium

    Apoptosis Metabolic Disease
    D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.
  • HY-W011082
    NLRP3-IN-2

    NOD-like Receptor (NLR) Cardiovascular Disease
    NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism.
  • HY-113143
    Galactose 1-phosphate

    Endogenous Metabolite Metabolic Disease
    Galactose 1-phosphate is an intermediate in the galactose metabolism and nucleotide sugars.
  • HY-111334
    Brassinin

    Brassinine

    Others Others
    Brassinin is the metabolism of a phytoalexin from Brassica species.
  • HY-113143A
    Galactose 1-phosphate Potassium salt

    Endogenous Metabolite Metabolic Disease
    Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars.
  • HY-W015608
    2-Phenylpropionic acid

    Endogenous Metabolite Metabolic Disease
    2-Phenylpropionic acid is an intermediate in alpha-Methylstyrene metabolism.
  • HY-N0684S1
    Vitamin K1-d4

    Phylloquinone-d4; Phytomenadione-d4

    Endogenous Metabolite Cardiovascular Disease
    Vitamin K1-d4 (Phylloquinone-d4) is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
  • HY-113131A
    Dihydroxyacetone phosphate hemimagnesium hydrate

    Endogenous Metabolite Metabolic Disease
    Dihydroxyacetone phosphate hemimagnesium hydrate is an important intermediate in lipid biosynthesis and in glycolysis. It is a biochemical compound involved in many metabolic pathways, including the Calvin cycle in plants and glycolysis. Dihydroxyacetone phosphate hemimagnesium hydrate is found to be associated with transaldolase deficiency, which is an inborn error of metabolism.
  • HY-101036
    Choline bitartrate

    mAChR Neurological Disease
    Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders. Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
  • HY-W008151
    Diphenyl Phosphate

    DPhP

    Others Metabolic Disease
    Diphenyl Phosphate inhibits growth and energy metabolism of zebrafish in a sex-specific manner.
  • HY-112885A
    nor-NOHA acetate

    Nω-Hydroxy-nor-L-arginine acetate

    Arginase Apoptosis Cancer Metabolic Disease Inflammation/Immunology
    nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism.
  • HY-N0327
    Lobetyolin

    Apoptosis Xanthine Oxidase Metabolic Disease
    Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism.
  • HY-101417
    Diethyl phosphate

    Diethyl phosphoric acid

    Endogenous Metabolite Others
    Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos.
  • HY-113121S1
    Vanillylmandelic acid-d1

    Others Endogenous Metabolite Cardiovascular Disease
    Vanillylmandelic acid-d1 is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM.
  • HY-126125
    CHIR-98023

    GSK-3 Metabolic Disease Neurological Disease
    CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism.
  • HY-113121S
    Vanillylmandelic acid-d3

    Others Endogenous Metabolite Cardiovascular Disease
    Vanillylmandelic acid-d3 is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM.
  • HY-W016887
    H-Gly-Pro-OH

    Endogenous Metabolite Metabolic Disease
    H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.
  • HY-77490
    (R)-(-)-1,3-Butanediol

    Endogenous Metabolite Metabolic Disease
    (R)-(-)-1,3-Butanediol is used to regulate the metabolism of carbohydrate and lipid.
  • HY-76847
    Chenodeoxycholic Acid

    CDCA

    FXR Endogenous Metabolite Autophagy Metabolic Disease Cancer
    Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
  • HY-B0399S
    L-Carnitine-d9

    (R)-Carnitine-d9; Levocarnitine-d9

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Carnitine-d9 (Levocarnitine-d9) is the deuterium labeled L-Carnitine. L-Carnitine (Levocarnitine) is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism.
  • HY-N0684
    Vitamin K1

    Phylloquinone; Phytomenadione

    Endogenous Metabolite Cardiovascular Disease
    Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
  • HY-14802D
    (-)-Talarozole

    RAR/RXR Autophagy Cancer
    (-)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.
  • HY-14802C
    (+)-Talarozole

    RAR/RXR Autophagy Cancer
    (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.
  • HY-135425
    10,12-Tricosadiynoic acid

    Acyltransferase Metabolic Disease
    10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.
  • HY-N0379
    D-Mannose

    Endogenous Metabolite Others
    D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific proteins.
  • HY-P0245
    Speract

    Mitochondrial Metabolism Metabolic Disease
    Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
  • HY-B0919
    Azaserine

    CI-337; O-Diazoacetyl-L-serine; P-165

    Bacterial Antibiotic Cancer Infection
    Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase, a key enzyme responsible for glutamine metabolism.
  • HY-113328S
    Aminoadipic acid-d3

    Endogenous Metabolite Others
    Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid. Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.
  • HY-146215
    IDO1-IN-20

    Indoleamine 2,3-Dioxygenase (IDO) Cancer
    Hy-146215 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.
  • HY-135601
    Cinacalcet metabolite M4

    Drug Metabolite Cardiovascular Disease
    Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease.
  • HY-112175
    N-Acetylhistamine

    N-Omega-acetylhistamine

    Histamine Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology
    N-Acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.
  • HY-W008772
    4-Hydroxymephenytoin

    Others Others
    4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate.
  • HY-76082
    L-Pyroglutamic acid

    Endogenous Metabolite Others
    L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
  • HY-113158
    4-Hydroxyhippuric acid

    Others Others
    4-Hydroxyhippuric acid is a by-product of metabolism of polyphenols and increases the microflora activity related to the refeeding.
  • HY-W017434
    3,4-Dimethylbenzoic acid

    Others Others
    3,4-Dimethylbenzoic acid acts as a product of dimethylbenzoate metabolism by Rhodococcus rhodochrous N75.
  • HY-N4104
    Agaric acid

    Agaricinic Acid

    Mitochondrial Metabolism Metabolic Disease
    Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca 2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism.
  • HY-113168
    Butyrylcarnitine

    Endogenous Metabolite Others
    Butyrylcarnitine is a metabolite in plasma, acts as a biomarker to improve the diagnosis and prognosis of heart failure, and is indicative of anomalous lipid and energy metabolism.
  • HY-107030
    Nitrefazole

    EMD-15700

    Aldehyde Dehydrogenase (ALDH) Metabolic Disease
    Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.
  • HY-129491
    O-Desmethyl Midostaurin

    CGP62221; O-Desmethyl PKC412

    PKC Cancer
    O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
  • HY-117147A
    GSK2945 hydrochloride

    Cytochrome P450 Metabolic Disease
    GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.
  • HY-117147
    GSK2945

    Cytochrome P450 Metabolic Disease
    GSK2945 is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.
  • HY-W014993
    1,3-Dimethyluric acid

    Endogenous Metabolite Others
    1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
  • HY-N0593
    Deoxycholic acid

    Cholanoic Acid; Desoxycholic acid

    G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite Metabolic Disease
    Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.
  • HY-B1654
    Flavin adenine dinucleotide

    FAD

    Endogenous Metabolite Cardiovascular Disease
    Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
  • HY-Y0801
    2,6-Dihydroxybenzoic acid

    Endogenous Metabolite Others
    2,6-Dihydroxybenzoic acid is a secondary metabolite of salicylic acid which has been hydrolyzed by liver enzymes during phase I metabolism.
  • HY-N0593A
    Deoxycholic acid sodium salt

    Sodium deoxycholate

    G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite Metabolic Disease
    Deoxycholic acid sodium salt (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.
  • HY-12642
    Diethylcarbamazine citrate

    Parasite Infection
    Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements.
  • HY-B0923
    Danthron

    Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

    AMPK Autophagy Bacterial Virus Protease Cancer
    Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
  • HY-N0229
    L-Alanine

    L-2-Aminopropionic acid

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-B1654A
    Flavin adenine dinucleotide disodium salt

    FAD disodium salt; FAD-Na2

    Endogenous Metabolite Cardiovascular Disease
    Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
  • HY-Y0781S
    Pyruvic acid 13C sodium

    Acetylformic acid 13C sodium

    Endogenous Metabolite Others
    Pyruvic acid 13C (Acetylformic acid 13C) sodium is the 13C-labeled Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
  • HY-N0593B
    Deoxycholic acid sodium hydrate

    Cholanoic Acid sodium hydrate; Desoxycholic acid sodium hydrate

    Endogenous Metabolite G protein-coupled Bile Acid Receptor 1 Metabolic Disease
    Deoxycholic acid (cholanoic acid) sodium hydrate,a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.
  • HY-B0430S
    Pantothenic acid-13C3,15N hemicalcium

    Endogenous Metabolite Others
    Pantothenic acid-13C3,15N hemicalcium is the 13C-labeled and 15N-labeled D-Pantothenic acid. D-Pantothenic acid is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.
  • HY-W037817
    Dimethyl L-glutamate

    Dimethyl glutamate

    Potassium Channel Bacterial Infection Metabolic Disease
    Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism.
  • HY-B1251
    Guanethidine

    Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure
    by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.
  • HY-N0913
    Manninotriose

    Others Others
    Manninotriose is a novel and important player in the RFO(Raffinose family oligosaccharides) metabolism of red dead deadnettle; potential to improve the side effects of MTX for ALL treatment.
  • HY-B0312S1
    Dipyridamole-d16

    Phosphodiesterase (PDE) Cardiovascular Disease
    Dipyridamole-d16 is the deuterium labeled Dipyridamole. Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
  • HY-N10475
    4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone

    Endogenous Metabolite Others
    4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone (compound 3) is a hydroxylated microbial metabolite of Yangonin.
  • HY-138094
    N-(2-Hydroxyethyl)oxamic acid

    Drug Metabolite Infection
    N-(2-hydroxyethyl)-oxamic acid is formed when Metronidazole is reduced either chemically or by the action of the intestinal bacteria. Metronidazole, a nitroimidazole antibiotic, has activity against various protozoans and most Gram-negative and Gram-positive anaerobic bacteria.
  • HY-W012572
    D-Histidine

    Mitochondrial Metabolism Metabolic Disease
    D-Histidine is an enantiomer of L-histidine (HY-N0832). L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.
  • HY-139665
    VB124

    Monocarboxylate Transporter Cardiovascular Disease
    VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC50s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism.
  • HY-13966
    2-Deoxy-D-glucose

    2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

    Hexokinase HSV Apoptosis Cancer
    2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
  • HY-W010388AS
    Creatine-d3 hydrate

    Endogenous Metabolite Metabolic Disease
    Creatine-d3 hydrate is a deuterium labeled Creatine hydrate. Creatine hydrate is pivotal in energy metabolism of muscle and brain cells, both in physiological and in pathological conditions.
  • HY-B2246S
    L-Carnitine-d9 chloride

    (R)-Carnitine-d9 chloride; Levocarnitine-d9 chloride

    Endogenous Metabolite Metabolic Disease
    L-Carnitine-d9 chloride is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism.
  • HY-W403633
    Hexahydrohippuric acid

    Bacterial Infection
    Hexahydrohippuric acid is a metabolite of Shikimate acid in both liver and kidney, under microbial metabolism effect. Hexahydrohippuric acid is made of cyclohexane carboxylic acid and glycinamide, and shows antibacterial activity.
  • HY-126050
    (R)-Pantetheine

    Pantetheine

    Others Metabolic Disease
    (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA).
  • HY-113325
    NADP

    Endogenous Metabolite Others
    NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP +) and reduced (NADPH).
  • HY-B0312S
    Dipyridamole-d20

    Phosphodiesterase (PDE) Cardiovascular Disease
    Dipyridamole-d20 is the deuterium labeled Dipyridamole. Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
  • HY-F0002
    NADP sodium salt

    Sodium NADP

    Others Others
    NADP sodium salt (Sodium NADP), a nicotinamide adenine dinucleotide, is a redox cofactor. NADP sodium salt is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP +) and reduced (NADPH).
  • HY-134426
    DL-β-Hydroxybutyryl coenzyme A lithium

    Endogenous Metabolite Metabolic Disease
    DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase.
  • HY-76847S
    Chenodeoxycholic Acid-d4

    CDCA-d4

    FXR Endogenous Metabolite Autophagy Metabolic Disease Cancer
    Chenodeoxycholic Acid-d4 (CDCA-d4) is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
  • HY-N0379S11
    D-Mannose-d

    Endogenous Metabolite Others
    D-Mannose-d is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-76847S3
    Chenodeoxycholic acid-d5

    CDCA-d5

    FXR Endogenous Metabolite Autophagy Metabolic Disease Cancer
    Chenodeoxycholic acid-d5 (CDCA-d5) is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
  • HY-113143AS
    Galactose 1-phosphate-13C potassium

    Endogenous Metabolite Metabolic Disease
    Galactose 1-phosphate-13C potassium is the 13C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug.
  • HY-136647
    8-Bromoadenosine 5'-triphosphate tetrasodium

    8-Br-ATP tetrasodium

    Others Others
    8-Bromoadenosine 5'-triphosphate tetrasodium (8-Br-ATP tetrasodium) is an ATP analogue. ATP is a central component of energy storage and metabolism in vivo.
  • HY-113325A
    NADP sodium hydrate

    Endogenous Metabolite Others
    NADP sodium hydrate, a β-Nicotinamide adenine dinucleotide phosphate sodium salt, is a redox cofactor. NADP sodium hydrate is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP +) and reduced (NADPH).
  • HY-76847S1
    Chenodeoxycholic Acid-d9

    CDCA-d9

    FXR Endogenous Metabolite Autophagy Metabolic Disease Cancer
    Chenodeoxycholic Acid-d9 (CDCA-d9) is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
  • HY-113410
    3-Methylglutaric acid

    Endogenous Metabolite Metabolic Disease
    3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH).
  • HY-N0420S1
    Succinic-2,2,3,3-d4 acid

    Endogenous Metabolite Metabolic Disease
    Succinic-2,2,3,3-d4 acid is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
  • HY-N0420S
    Succinic acid-d6

    Wormwood acid-d6

    Endogenous Metabolite Metabolic Disease
    Succinic acid-d6 (Wormwood acid-d6) is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
  • HY-76082S
    L-Pyroglutamic acid-d5

    Endogenous Metabolite
    L-Pyroglutamic acid-d5 is the deuterium labeled L-Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
  • HY-B0171
    Antipyrine

    Phenazone; Phenazon

    Others Inflammation/Immunology
    Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe drug for oxidative drug metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity.
  • HY-19727
    FOY 251 free base

    Ser/Thr Protease SARS-CoV Infection Metabolic Disease
    FOY 251 free base, an anti-proteolytic active metabolite of Camostate (HY-13512), acts as a proteinase inhibitor. FOY 25 free base inhibits SARS-CoV-2 infection in cells assay.
  • HY-108787
    Parathyroid hormone

    PTH; Parathyroidin; Parathyrin

    Endogenous Metabolite Endocrinology
    Parathyroid hormone (PTH) is a circulating hormone comprised of 84 amino acids. Parathyroid hormone is produced in the parathyroid glands and acts primarily on bone and kidney to maintain extracellular calcium levels within normal limits. Parathyroid hormone can be used for osteoporosis research.
  • HY-121744
    PS10

    PDHK Inflammation/Immunology
    PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM). PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy.PDK: pyruvate dehydrogenase kinase
  • HY-19727A
    FOY 251

    Ser/Thr Protease SARS-CoV Metabolic Disease
    FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay.
  • HY-132832
    Sirpiglenastat

    DRP-104

    Others Cancer
    Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response.
  • HY-N0379S19
    D-Mannose-d-4

    Endogenous Metabolite Others
    D-Mannose-d-4 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-N0379S21
    D-Mannose-d2

    Endogenous Metabolite Others
    D-Mannose-d2 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-13417A
    AICAR phosphate

    Acadesine phosphate; AICA Riboside phosphate

    AMPK Autophagy YAP Mitophagy Endogenous Metabolite Cancer
    AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor.
  • HY-N0379S17
    D-Mannose-d-3

    Endogenous Metabolite Others
    D-Mannose-d-3 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-113143AS1
    Galactose 1-phosphate-13C-1 potassium

    Endogenous Metabolite Metabolic Disease
    Galactose 1-phosphate-13C-1 potassium is the 13C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug.
  • HY-W017522
    Adipic acid

    Endogenous Metabolite Metabolic Disease
    Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.
  • HY-N0379S12
    D-Mannose-d-1

    Endogenous Metabolite Others
    D-Mannose-d-1 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-139577
    Ninerafaxstat

    Others Cancer
    Ninerafaxstat hifts cellular metabolism from fatty acid oxidation to glucose oxidation.Ninerafaxstat decreases fatty acid oxidation and improve overall mitochondrial respiration.Ninerafaxstat inhibit the growth and proliferation of cancer cells.
  • HY-N9363
    Corymbiferin

    Others Metabolic Disease
    Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells.
  • HY-N0379S15
    D-mannose-d7

    Endogenous Metabolite Others
    D-mannose-d7 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-13417
    AICAR

    Acadesine; AICA Riboside

    AMPK Autophagy YAP Mitophagy Endogenous Metabolite Cancer
    AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor.
  • HY-F0002A
    NADP disodium salt

    Disodium NADP

    Others Others
    NADP disodium salt (Disodium NADP), a nicotinamide adenine dinucleotide, is a redox cofactor. NADP disodium salt is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP +) and reduced (NADPH).
  • HY-N0379S13
    D-Mannose-d-2

    Endogenous Metabolite Others
    D-Mannose-d-2 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-Y0520
    Itaconic acid

    Endogenous Metabolite Inflammation/Immunology
    Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors.
  • HY-121460
    Spiraprilat

    Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF).
  • HY-113013
    Hydroxypyruvic acid

    β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid

    Endogenous Metabolite Metabolic Disease
    Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
  • HY-N7144A
    Citronellyl acetate

    Apoptosis Cancer Infection
    Citronellyl acetate is a monoterpene product of the secondary metabolism of plants, with antinociceptive activity. Citronellyl acetate exhibits pro-apoptotic activity in human hepatoma cells. Citronellyl acetate shows fungicidal, larvicidal, bactericidal and repelling/insecticidal effects.
  • HY-12853
    Mesotrione

    Reactive Oxygen Species Others
    Mesotrione is a herbicide belongs to the benzoylcyclohexanedione family. Mesotrione is a potent and competitive and reversible inhibitor of HPPD enzyme. Mesotrione is selective to maize due to rapid metabolism and relative high tolerance by the susceptible crop plant.
  • HY-129035
    Vanin-1-IN-1

    Others Metabolic Disease Inflammation/Immunology
    Vanin-1-IN-1 is an inhibitor of vanin-1 enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation.
  • HY-17640
    Nicodicosapent

    Fatty Acid Synthase (FASN) Autophagy Metabolic Disease
    Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
  • HY-N0379S5
    D-Mannose-13C

    Endogenous Metabolite Others
    D-Mannose-13C is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-W008772S
    4-Hydroxymephenytoin D3

    Others Others
    4-Hydroxymephenytoin D3 is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate.
  • HY-129982
    SC-435

    Others Metabolic Disease
    SC-435 is an apical sodium-dependent Bile acid (BA) transporter inhibitor. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations.
  • HY-W008990
    Xanthosine 5'-monophosphate sodium salt

    5'-Xanthylic acid sodium salt

    Others Metabolic Disease
    Xanthosine 5'-monophosphate sodium salt (5'-Xanthylic acid sodium salt) is an intermediate in purine metabolism. Xanthosine 5'-monophosphate sodium salt can be used for genetic code, nucleic acid structure, and DNA, RNA and protein synthesis research.
  • HY-120160
    Darglitazone

    CP-86325

    PPAR Metabolic Disease Neurological Disease
    Darglitazone (CP-86325), a thiazolidinedione, is a potent, selective, and orally active PPAR-γ agonist. Darglitazone is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research.
  • HY-B0158
    Cytidine

    Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Neurological Disease
    Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
  • HY-W012708
    3-Amino-4-methylpentanoic acid

    Endogenous Metabolite Others
    3-Amino-4-methylpentanoic acid is a beta amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase.
  • HY-N0379S2
    D-Mannose-18O

    Endogenous Metabolite Others
    D-Mannose-18O is the 18O labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-76847S2
    Chenodeoxycholic acid-13C

    CDCA-13C

    FXR Endogenous Metabolite Autophagy Metabolic Disease Cancer
    Chenodeoxycholic acid-13C (CDCA-13C) is the 13C-labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
  • HY-13738A
    Raloxifene hydrochloride

    Keoxifene hydrochloride; LY156758; LY139481 hydrochloride

    Estrogen Receptor/ERR Autophagy Endocrinology Cancer
    Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue.
  • HY-B0158S4
    Cytidine-d1

    Cytosine β-D-riboside-d1; Cytosine-1-β-D-ribofuranoside-d1

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Neurological Disease
    Cytidine-d1 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol
  • HY-B0923S
    Danthron-d6

    Dantron-d6; Chrysazin-d6; 1,8-Dihydroxyanthraquinone-d6

    AMPK Autophagy Bacterial Virus Protease Cancer
    Danthron-d6 (Dantron-d6) is the deuterium labeled Danthron. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
  • HY-B0389S24
    D-Glucose-d4

    Glucose-d4; D-(+)-Glucose-d4; Dextrose-d4

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-d4 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
  • HY-145965
    Ferroportin-IN-1

    Others Metabolic Disease
    Ferroportin-IN-1 is a ferroportin inhibitor extracted from patent WO2020123850A1 compound 23. Ferroportin-IN-1 can be used for the research of diseases caused by a lack of hepcidin or iron metabolism disorders.
  • HY-N6923
    N-Benzyloleamide

    FAAH Autophagy Metabolic Disease
    N-Benzyloleamide is a maccamide isolated from Lepidium meyenii (Maca). N-Benzyloleamide irreversibly inhibits fatty acid amide hydrolase (FAAH). N-benzyloleamide influences the energy metabolism and reveals antioxidant and antifatigue activities.
  • HY-B0158S3
    Cytidine-d2-1

    Cytosine β-D-riboside-d2-1; Cytosine-1-β-D-ribofuranoside-d2-1

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Neurological Disease
    Cytidine-d2-1 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catech
  • HY-B0389S1
    D-Glucose-d1

    Glucose-d; D-(+)-Glucose-d; Dextrose-d1

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-d1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
  • HY-N0379S1
    D-Mannose-18O2

    Endogenous Metabolite Others
    D-Mannose-18O2 is the 18O labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-B0158S1
    Cytidine-13C

    Cytosine β-D-riboside-13C; Cytosine-1-β-D-ribofuranoside-13C

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Neurological Disease
    Cytidine-13C is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine
  • HY-120160A
    Darglitazone Sodium

    CP 86325 Sodium

    PPAR Metabolic Disease Neurological Disease
    Darglitazone Sodium, a thiazolidinedione, is an orally active, potent, and selective PPAR-γ (peroxisome proliferator-activated receptor) agonist. Darglitazone Sodium is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research.
  • HY-N0379S7
    D-Mannose-13C-2

    Endogenous Metabolite Others
    D-Mannose-13C-2 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-N0379S8
    D-Mannose-13C-3

    Endogenous Metabolite Others
    D-Mannose-13C-3 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-N0379S3
    D-Mannose-18O-1

    Endogenous Metabolite Others
    D-Mannose-18O-1 is the 18O labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-N0379S9
    D-Mannose-13C-4

    Endogenous Metabolite Others
    D-Mannose-13C-4 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-N0379S
    D-Mannose-18O6

    Endogenous Metabolite Others
    D-Mannose-18O6 is the 18O labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-B0389S23
    D-Glucose-d2-1

    Glucose-d2-1; D-(+)-Glucose-d2-1; Dextrose-d2-1

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-d2-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol
  • HY-N0034
    Arctiin

    Arctii; NSC 315527; Arctigenin-4-glucoside

    Others Cancer
    Arctiin(NSC 315527), a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis.
  • HY-118793
    Inosine oxime

    6-Hydroxyadenosine

    Endogenous Metabolite Others
    Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells.
  • HY-N0379S6
    D-Mannose-13C-1

    Endogenous Metabolite Others
    D-Mannose-13C-1 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-N0379S10
    D-Mannose-13C-5

    Endogenous Metabolite Others
    D-Mannose-13C-5 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-N0379S14
    D-Mannose-13C,d

    Endogenous Metabolite Others
    D-Mannose-13C,d is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-B0389S26
    D-Glucose-d2-2

    Glucose-d2-2; D-(+)-Glucose-d2-2; Dextrose-d2-2

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-d2-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol
  • HY-N2361
    N-Benzyllinoleamide

    Others Neurological Disease
    N-Benzyllinoleamide, isolated from Lepidium meyenii Walp., has pharmaceutical property against exercise-induced fatigue.
  • HY-151185
    Sirt2-IN-7

    Sirtuin Cancer
    Sirt2-IN-7 (compound 22) is a selective inhibitor of SIRT2. Sirt2-IN-7 inhibits SIRT2 with an IC50 value and a Ki value of 178.2 nM and 154.3 nM, respectively. Sirt2-IN-7 can be used for the research of cancer.
  • HY-N2157
    Pteryxin

    (+)-Pteryxin

    Cholinesterase (ChE) Metabolic Disease Neurological Disease
    Pteryxin, a coumarin in Peucedanum japonicum Thunb leaves, exerts antiobesity activity. Pteryxin is a potent butyrylcholinesterase (BChE) inhibitor, with an IC50 of 12.96 μg/ml.
  • HY-16942
    Damulin B

    Apoptosis Cancer
    Damulin B is a dammarane-type saponin found in Gynostemma pentaphyllum.Damulin B can induce cell apoptosis and has anti-cancer activities in vitro.
  • HY-119893
    Diamfenetide

    Parasite Infection
    Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica.
  • HY-W013046
    Phosphoribosyl pyrophosphate pentasodium

    PRPP pentasodium

    Endogenous Metabolite Others
    Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP.
  • HY-113013A
    Hydroxypyruvic acid lithium hydrate

    β-Hydroxypyruvic acid lithium hydrate; 3-Hydroxypyruvic acid lithium hydrate

    Endogenous Metabolite Metabolic Disease
    Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
  • HY-B0389S29
    D-Glucose-18O

    Glucose-18O; D-(+)-Glucose-18O; Dextrose-18O

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-18O is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules
  • HY-124237A
    N-Octanoyl-L-homoserine lactone

    Bacterial Infection
    N-octanoyl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. N-octanoyl-L-Homoserine lactone can be used for the infection prevention and regulation of virulence in cystic fibro.
  • HY-B0389
    D-Glucose

    Glucose; D-(+)-Glucose; Dextrose

    Endogenous Metabolite Metabolic Disease
    D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-N0379S16
    D-Mannose-13C,d-1

    Endogenous Metabolite Others
    D-Mannose-13C,d-1 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-N0379S20
    D-Mannose-13C,d-2

    Endogenous Metabolite Others
    D-Mannose-13C,d-2 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-B0158S2
    Cytidine-13C-1

    Cytosine β-D-riboside-13C-1; Cytosine-1-β-D-ribofuranoside-13C-1

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Neurological Disease
    Cytidine-13C-1 is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami
  • HY-W018772S6
    D-Ribose-d

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-d is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gly
  • HY-B0389S19
    D-Glucose-13C,d

    Glucose-13C,d; D-(+)-Glucose-13C,d; Dextrose-13C,d

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sign
  • HY-B0389S27
    D-Glucose-13C,d1-2

    Glucose-13C,d1-2; D-(+)-Glucose-13C,d1-2; Dextrose-13C,d1-2

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-13C,d1-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling
  • HY-B0389S31
    D-Glucose-18O-2

    Glucose-18O-2; D-(+)-Glucose-18O-2; Dextrose-18O-2

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-18O-2 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
  • HY-B0486
    Lonidamine

    AF-1890; Diclondazolic Acid; DICA

    Hexokinase Mitochondrial Metabolism Apoptosis Cancer Inflammation/Immunology
    Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis.
  • HY-B0389S30
    D-Glucose-18O-1

    Glucose-18O-1; D-(+)-Glucose-18O-1; Dextrose-18O-1

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-18O-1 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
  • HY-B0389S32
    D-Glucose-18O-3

    Glucose-18O-3; D-(+)-Glucose-18O-3; Dextrose-18O-3

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-18O-3 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
  • HY-B0389S28
    D-Glucose-13C,d1-3

    Glucose-13C,d1-3; D-(+)-Glucose-13C,d1-3; Dextrose-13C,d1-3

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-13C,d1-3 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling
  • HY-W018772S9
    D-Ribose-d-3

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-d-3 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein g
  • HY-W018772S12
    D-Ribose-d6

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-d6 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gl
  • HY-W018772S10
    D-Ribose-d2

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-d2 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gl
  • HY-W018772S14
    D-Ribose-d5

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-d5 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gl
  • HY-N0379S4
    D-Mannose-13C,18O

    Endogenous Metabolite Others
    D-Mannose-13C,18O is the 18O and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-W018772S8
    D-Ribose-d-2

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-d-2 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein g
  • HY-W018772S7
    D-Ribose-d-1

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-d-1 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein g
  • HY-B0389S25
    D-Glucose-13C,d1

    Glucose-13C,d1; D-(+)-Glucose-13C,d1; Dextrose-13C,d1

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-13C,d1 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
  • HY-B0389S20
    D-Glucose-13C,d-1

    Glucose-13C,d-1; D-(+)-Glucose-13C,d-1; Dextrose-13C,d-1

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-13C,d-1 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
  • HY-B0389S21
    D-Glucose-13C,d2

    Glucose-13C,d2; D-(+)-Glucose-13C,d2; Dextrose-13C,d2

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-13C,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
  • HY-15781
    Morinidazole

    Bacterial Infection
    Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N +-glucuronidation and sulfation. Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.
  • HY-147374
    Bromodomain inhibitor-9

    Epigenetic Reader Domain Metabolic Disease Inflammation/Immunology
    Bromodomain inhibitor-9 is a Bromodomains inhibitor that selectively inhibits BRD4-1 (Kd: 12 nM). Bromodomain inhibitor-9 can be used in the research of diseases or conditions associated with systemic or tissue inflammation, lipid metabolism, fibrosis or chronic autoimmune diseases.
  • HY-N0379S18
    D-mannose-13C6,d7

    Endogenous Metabolite Others
    D-mannose-13C6,d7 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific prote.
  • HY-W018772S
    D-Ribose-18O

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-18O is the 18O labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
  • HY-B0143A
    Niacin hydrochloride

    Nicotinic acid hydrochloride; Vitamin B3 hydrochloride

    Endogenous Metabolite Apoptosis Cancer Metabolic Disease Cardiovascular Disease
    Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases.
  • HY-N0684S3
    Vitamin K1-13C6

    Phylloquinone-13C6; Phytomenadione-13C6

    Endogenous Metabolite Cardiovascular Disease
    Vitamin K1-13C6 (Phylloquinone-13C6) is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
  • HY-B0511A
    Biotin sodium

    Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium

    Endogenous Metabolite Metabolic Disease
    Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
  • HY-B0511
    Biotin

    Vitamin B7; Vitamin H; D-Biotin

    Endogenous Metabolite Metabolic Disease
    Biotin (Vitamin B7) is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
  • HY-W018772S1
    D-Ribose-13C

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-13C is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
  • HY-W018772S11
    D-Ribose-13C,d

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-13C,d is the deuterium and 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in
  • HY-126741
    Azadirachtin

    Apoptosis Others
    Azadirachtin, one of the most promising botanical insecticides, is widely used for pest control. Azadirachtin induces apoptosis in insect cell lines, including Sf9, SL-1 and BTI-Tn-5B1-4.
  • HY-W009993
    3,4-Methylenedioxycinnamic acid

    Others Others
    3,4-Methylenedioxycinnamic acid is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase. 3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid.
  • HY-144075
    JAK-IN-19

    JAK Inflammation/Immunology
    JAK-IN-19 is a potent JAK inhibitor (PBMC IFNγ pIC50=7.2 and HLF Eotaxin pIC50=7.7). JAK-IN-19 has good retentive properties in the lung via mitigating being metabolized by Aldehyde Oxidase (AO), with diminished VEGFR2 selectivity (VEGFR2 pIC50=7.0, Aurora B pIC50=5.8).
  • HY-129529
    6-Hydroxyluteolin 7-glucoside

    Others Inflammation/Immunology
    6-Hydroxyluteolin 7-glucoside is a flavonoid from Tanacetum parthenium and T. vulgare. 6-Hydroxyluteolin 7-glucoside inhibits the major pathways of arachidonate metabolism in leukocytes. 6-Hydroxyluteolin 7-glucoside has anti-inflammatory effect.
  • HY-142820
    B-Raf IN 5

    Raf Cancer
    B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.
  • HY-N0229S13
    L-Alanine-d7

    L-2-Aminopropionic acid-d7

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-d7 (L-2-Aminopropionic acid-d7) is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-146067
    β-Nor-lapachone

    Fungal Reactive Oxygen Species Infection
    β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity.
  • HY-143421
    Curcumin monoglucuronide

    CMG

    Drug Metabolite Cancer
    Curcumin monoglucuronide is known as a glucuronic acid conjugate, which is one of the in vivo metabolites of curcumin. Curcumin monoglucuronide is used for research on the metabolism of curcumin and examination of its development as a pharmaceutical. Curcumin monoglucuronide has the potential for the research of cancer disease (extracted from patent WO2022004873A1).
  • HY-13966S
    2-Deoxy-D-glucose-d1

    2-DG-d1; 2-Deoxy-D-arabino-hexose-d1; D-Arabino-2-deoxyhexose-d1

    HSV Hexokinase Apoptosis Cancer
    2-Deoxy-D-glucose-d1 is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
  • HY-P1184
    HNGF6A

    Reactive Oxygen Species Metabolic Disease Neurological Disease Cardiovascular Disease
    HNGF6A is a humanin analogue. HNGF6A increases glucose-stimulated insulin secretion and glucose metabolism, and has the potential for diabetes research. HNGF6A inhibits of ROS production during oxidative stress. HNGF6A can prevent endothelial dysfunction and atherosclerosis in vivo.
  • HY-N0229S3
    L-Alanine-d4

    L-2-Aminopropionic acid-d4

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-d4 (L-2-Aminopropionic acid-d4) is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-N0229S12
    L-Alanine-d3

    L-2-Aminopropionic acid-d3

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-d3 (L-2-Aminopropionic acid-d3) is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-142830
    B-Raf IN 6

    Raf Cancer
    B-Raf IN 6 (compound 2c) is a potent inhibitor of protein kinase B-Raf with an IC50 of 1.7 nM. B-Raf IN 6 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.
  • HY-B0389S22
    D-Glucose-13C2,d2

    Glucose-13C2,d2; D-(+)-Glucose-13C2,d2; Dextrose-13C2,d2

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-13C2,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
  • HY-100822A
    (S)-(-)-HA 966

    (-)-HA 966

    iGluR Neurological Disease
    (S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear.
  • HY-B0389S33
    D-Glucose-18O2,13C

    Glucose-18O2,13C; D-(+)-Glucose-18O2,13C; Dextrose-18O2,13C

    Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose-18O2,13C is the 18O and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signali
  • HY-N0229S15
    L-Alanine-13C2,15N

    L-2-Aminopropionic acid-13C2,15N

    Endogenous Metabolite
    L-Alanine-13C2,15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-W018772S13
    D-Ribose-13C,d-1

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-13C,d-1 is the deuterium and 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active
  • HY-Y0520S
    Itaconic acid-13C5

    Endogenous Metabolite Inflammation/Immunology
    Itaconic acid-13C5 is the 13C labeled Itaconic acid. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors.
  • HY-W018772S2
    D-Ribose-13C-1

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-13C-1 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
  • HY-15781A
    Morinidazole (R enantiomer)

    R-Morinidazole

    Bacterial Infection
    Morinidazole R enantiomer (R-Morinidazole) is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N +-glucuronidation and sulfation. Morinidazole R enantiomer can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.
  • HY-W018772
    D-Ribose(mixture of isomers)

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner.
  • HY-W018772S4
    D-Ribose-13C-3

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-13C-3 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
  • HY-137662
    5'-Phosphoguanylyl-(3',5')-guanosine

    pGpG

    Others Metabolic Disease
    5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl-(3',5')-guanosine can be used to detect the metabolism of nucleic acids.
  • HY-W018772S5
    D-Ribose-13C-4

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-13C-4 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
  • HY-W018772S3
    D-Ribose-13C-2

    Endogenous Metabolite Inflammation/Immunology Cancer
    D-Ribose-13C-2 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
  • HY-P3102
    GLP-1(32-36)amide

    GCGR Metabolic Disease
    GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.
  • HY-13966S2
    2-Deoxy-D-glucose-13C

    2-DG-13C; 2-Deoxy-D-arabino-hexose-13C; D-Arabino-2-deoxyhexose-13C

    HSV Hexokinase Apoptosis Cancer
    2-Deoxy-D-glucose-13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
  • HY-B0389S5
    D-Glucose-d2

    Endogenous Metabolite Metabolic Disease
    D-Glucose-d2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-B0389S6
    D-Glucose-d7

    Endogenous Metabolite Metabolic Disease
    D-Glucose-d7 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-14531
    Talarozole

    R115866

    RAR/RXR Cytochrome P450 Autophagy Inflammation/Immunology
    Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.
  • HY-B0389S2
    D-Glucose-d12-1

    Endogenous Metabolite Metabolic Disease
    D-Glucose-d12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-D1584
    C12 NBD Sphingomyelin

    Phospholipase Others
    C12 NBD sphingomyelin is an active derivative of sphingomyelin (HY-113498) that is tagged with fluorescent C12 nitrobenzoxadiazole (C12 NBD). C12 NBD sphingomyelin can be used as a sphingomyelinase substrate for studying the metabolism and transport of sphingomyelins (Ex=470 nm, Em=525 nm).
  • HY-147368
    PKM2 activator 2

    Pyruvate Kinase Cancer
    PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells.
  • HY-B0389S4
    D-Glucose-d1-2

    Endogenous Metabolite Metabolic Disease
    D-Glucose-d1-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-B0389S7
    D-Glucose-d1-3

    Endogenous Metabolite Metabolic Disease
    D-Glucose-d1-3 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-F0001
    NADH disodium salt

    Disodium NADH

    Endogenous Metabolite Metabolic Disease
    NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.
  • HY-13966S4
    2-Deoxy-D-glucose-13C-1

    2-DG-13C-1; 2-Deoxy-D-arabino-hexose-13C-1; D-Arabino-2-deoxyhexose-13C-1

    HSV Hexokinase Apoptosis Cancer
    2-Deoxy-D-glucose-13C-1 is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
  • HY-128923
    SKF-34288 hydrochloride

    3-Mercaptopicolinic acid hydrochloride

    Others Metabolic Disease
    SKF-34288 hydrochloride (3-Mercaptopicolinic acid) is a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor. SKF-34288 hydrochloride is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway. SKF-34288 hydrochloride inhibits Asn metabolism and results in an increase in amino acids and amides.
  • HY-P3102A
    GLP-1(32-36)amide TFA

    GCGR Metabolic Disease
    GLP-1(32-36)amide TFA, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide TFA could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.
  • HY-16100
    BI 99179

    Fatty Acid Synthase (FASN) Cancer Metabolic Disease
    BI 99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats.
  • HY-B0389S8
    D-Glucose-d1-4

    Endogenous Metabolite Metabolic Disease
    D-Glucose-d1-4 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-P1184A
    HNGF6A TFA

    Reactive Oxygen Species Metabolic Disease Neurological Disease Cardiovascular Disease
    HNGF6A TFA is a humanin analogue. HNGF6A TFA increases glucose-stimulated insulin secretion and glucose metabolism, and has the potential for diabetes research. HNGF6A TFA inhibits of ROS production during oxidative stress. HNGF6A TFA can prevent endothelial dysfunction and atherosclerosis in vivo.
  • HY-B0389S3
    D-Glucose-d1-1

    Endogenous Metabolite Metabolic Disease
    D-Glucose-d1-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-106198
    Lidorestat

    IDD-676

    Aldose Reductase Metabolic Disease
    Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation.
  • HY-N0723
    Neomangiferin

    Others Metabolic Disease
    Neomangiferin is a natural C-glucosyl xanthone isolated from m the dried rhizome of Anemarrhena asphodeloides. Neomangiferin has significant therapeutic effects on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats.
  • HY-116247
    ST247

    PPAR Metabolic Disease Inflammation/Immunology
    ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ.
  • HY-147039
    BOLD-100

    HSP Autophagy Cancer
    BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.
  • HY-B0389S13
    D-Glucose-13C-3

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-N0229S7
    L-Alanine-2-13C

    L-2-Aminopropionic acid-2-13C

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-2-13C (L-2-Aminopropionic acid-2-13C) is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-B0143
    Niacin

    Nicotinic acid; Vitamin B3

    Autophagy Endogenous Metabolite Cancer Metabolic Disease Cardiovascular Disease
    Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases.
  • HY-B0389S17
    D-Glucose-13C-5

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-122534
    Mensacarcin

    Mitochondrial Metabolism ADC Cytotoxin Apoptosis Cancer
    Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs).
  • HY-N0229S6
    L-Alanine-3-13C

    L-2-Aminopropionic acid-3-13C

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-3-13C (L-2-Aminopropionic acid-3-13C) is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-113498
    Sphingomyelin

    Endogenous Metabolite Metabolic Disease Inflammation/Immunology Neurological Disease
    Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann–Pick disease.
  • HY-111539
    BAY-1316957

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC50 of 15.3 nM for human EP4-R. BAY-1316957 has excellent drug metabolism and pharmacokinetics properties, and can be used for endometriosis research.
  • HY-B1836
    Mildronate

    Meldonium; MET-88; Quaterin

    Others Metabolic Disease Cardiovascular Disease
    Mildronate (Meldonium) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes.
  • HY-N0229S1
    L-Alanine-1-13C

    L-2-Aminopropionic acid-1-13C

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-1-13C (L-2-Aminopropionic acid-1-13C) is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-B0158S
    Cytidine-d2

    Cytosine β-D-riboside-d2; Cytosine-1-β-D-ribofuranoside-d2

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Neurological Disease
    Cytidine-d2 (Cytosine β-D-riboside-d2) is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
  • HY-N0229S2
    L-Alanine-15N

    L-2-Aminopropionic acid-15N

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-15N (L-2-Aminopropionic acid-15N) is the 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-139409A
    2-Deoxy-D-glucose 6-phosphate disodium

    Others Metabolic Disease
    2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
  • HY-113446
    Leukotriene C4

    Endogenous Metabolite Inflammation/Immunology Cardiovascular Disease
    Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. Leukotriene C4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. Leukotriene C4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.
  • HY-N0229S8
    L-Alanine-13C3

    L-2-Aminopropionic acid-13C3

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-13C3 (L-2-Aminopropionic acid-13C3) is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-112179
    GSK180

    Others Inflammation/Immunology
    GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition.
  • HY-Z0283
    Benzamide

    Benzenecarboxamide; Phenylamide

    Endogenous Metabolite PARP Others
    Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature.
  • HY-W014993S
    1,3-Dimethyluric acid-13C4,15N3

    Endogenous Metabolite Others
    1,3-Dimethyluric Acid-13C4,15N3 is the 13C-labeled and 15N-labeled 1,3-Dimethyluric acid. 1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
  • HY-N0229S9
    L-Alanine-13C2

    L-2-Aminopropionic acid-13C2

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-13C2 (L-2-Aminopropionic acid-13C2) is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-B0389S15
    D-Glucose-13C2-4

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C2-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-B0389S9
    D-Glucose-13C3-2

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C3-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-135430
    SRS16-86

    Ferroptosis Inflammation/Immunology
    SRS16-86 is a potent inhibitor of ferroptosis. SRS16-86 is more stable than more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research.
  • HY-106019C
    Liarozole dihydrochloride

    R75251 dihydrochloride

    Cytochrome P450 RAR/RXR Cancer Metabolic Disease Inflammation/Immunology
    Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties.
  • HY-B1836A
    Mildronate dihydrate

    Meldonium dihydrate; MET-88 dihydrate; Quaterin dihydrate

    Others Metabolic Disease Cardiovascular Disease
    Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes.
  • HY-113884B
    (S)-Coriolic acid

    13(S)-HODE

    PPAR Mitochondrial Metabolism Cancer Inflammation/Immunology
    (S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.
  • HY-B0389S10
    D-Glucose-13C

    Glucose-13C; D-(+)-Glucose-13C; Dextrose-13C

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C (Glucose-13C) is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-106019
    Liarozole

    R75251

    Cytochrome P450 RAR/RXR Cancer Metabolic Disease Inflammation/Immunology
    Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid (IC50=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties.
  • HY-N0229S4
    L-Alanine-13C,d1

    L-2-Aminopropionic acid-13C,d1

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-13C,d1 (L-2-Aminopropionic acid-13C,d1) is the 13C- and deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-139188
    CC260

    Others Cancer Metabolic Disease
    CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research.
  • HY-N0229S14
    L-Alanine-15N,d4

    L-2-Aminopropionic acid-15N,d4

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-15N,d4 (L-2-Aminopropionic acid-15N,d4) is the deuterium and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-135746
    OR-1896

    Potassium Channel Phosphodiesterase (PDE) Drug Metabolite Apoptosis Cardiovascular Disease
    OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K + channels and has Ca 2+-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation.
  • HY-145306
    DX3-234

    Mitochondrial Metabolism Cancer
    DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-234 shows significant tumor suppression in the Pan02 syngeneic model of pancreatic cancer.
  • HY-133590
    Heliotrine N-oxide

    Others Cancer
    Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo.
  • HY-B0510C
    Trimethoprim lactate

    Antifolate Bacterial Antibiotic Infection
    Trimethoprim lactate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim lactate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc.
  • HY-B0510A
    Trimethoprim sulfate

    Antifolate Bacterial Antibiotic Influenza Virus Infection
    Trimethoprim sulfate is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim sulfate is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim sulfate has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim sulfate can inhibit infection of Influenza A virus in chick embryo when combinated with zinc.
  • HY-101597
    NVX-207

    Apoptosis Cancer
    NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC50=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP.
  • HY-125209
    TH5427

    Others Cancer
    TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells.
  • HY-129328
    Magnesium glycinate

    Magnesium bisglycinate; Magnesium diglycinate

    Others Others
    Magnesium glycinate (Magnesium bisglycinate), the magnesium salt of glycine, is a nutrient supplement. Magnesium glycinate has satisfactory physico-chemical properties and bioactivities. Metal glycinate chelates are formed by glycine and metal compounds through chemical reactions. Magnesium is an essential mineral that plays a critical role in the human body. Magnesium takes part in the process of energy metabolism and assists the maintenance of normal muscle function.
  • HY-P0005
    Glucagon (Human)

    Glukagon; Hyperglycemic-glycogenolytic factor

    Others Metabolic Disease
    Glucagon exhibits marked effects on protein and amino acid metabolism. Glucagon inhibits the incorporation of amino acids into protein of liver, muscle, and pancreas, to increase excretion of nitrogen, to promote hepatic urea synthesis, and to increase the concentration of hepatic transaminases and urea cycle enzymes. Glucagon can promote the hepatic uptake of amino acids, to enhance their incorporation into liver glycogen, and to depress the concentration of amino acids in blood.
  • HY-135390
    Hydroxy desmethyl Bosentan

    Ro 64-1056

    Drug Metabolite Cardiovascular Disease
    Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension.
  • HY-B0389S16
    D-Glucose-13C-4

    Glucose-13C-4; D-(+)-Glucose-13C-4; Dextrose-13C-4

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C-4 (Glucose-13C-4) is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-145597
    KL-11743

    GLUT Cancer Metabolic Disease
    KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death.
  • HY-B0389S14
    D-Glucose-13C2

    Glucose-13C2; D-(+)-Glucose-13C2; Dextrose-13C2

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C2 (Glucose-13C2) is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-15259
    CP-640186

    Acetyl-CoA Carboxylase Metabolic Disease
    CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation.
  • HY-B0389S11
    D-Glucose-13C-1

    Glucose-13C-1; D-(+)-Glucose-13C-1; Dextrose-13C-1

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C-1 (Glucose-13C-1) is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-B0389S12
    D-Glucose-13C-2

    Glucose-13C-2; D-(+)-Glucose-13C-2; Dextrose-13C-2

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C-2 (Glucose-13C-2) is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-15259A
    CP-640186 hydrochloride

    Acetyl-CoA Carboxylase Metabolic Disease
    CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation.
  • HY-130237
    Cinnamtannin B-1

    ROS Kinase Cancer Metabolic Disease
    Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers.
  • HY-145605
    Vutiglabridin

    HSG4112

    Others Metabolic Disease
    Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability.
  • HY-146453
    TGR5 Receptor Agonist 3

    G protein-coupled Bile Acid Receptor 1 Metabolic Disease
    TGR5 Receptor Agonist 3 (Compound 19) is a soft-drug G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonist with reduced gallbladder-filling effects (favorable gallbladder safety), with EC50s of 16.4 and 209 nM for hTGR5 and mTGR5, respectively.
  • HY-N8518
    Malabaricone C

    Others Metabolic Disease
    Malabaricone C is a natural sphingomyelin synthase (SMS) inhibitor with IC50s of 3 and 1.5 μM for SMS 1 and 2, respectively.
  • HY-116175
    BIBB 515

    Others Metabolic Disease
    BIBB 515 is a potent, selective and orally active 2,3-oxidosqualene cyclase (OSC) inhibitor with ED50 values of 0.2-0.5 mg/kg and 0.36-33.3 mg/kg in rats and mice (1-5 hours), respectively. BIBB 515 exerts lipid-lowering effect mainly by inhibiting the production of low-density lipoprotein (LDL).
  • HY-N4190
    Britannilactone diacetate

    1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactone

    NO Synthase Inflammation/Immunology Neurological Disease
    Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property.
  • HY-N0229S11
    L-Alanine-1-13C,15N

    L-2-Aminopropionic acid-1-13C,15N

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-1-13C,15N (L-2-Aminopropionic acid-1-13C,15N) is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-150023
    BI-1622

    EGFR Itk PI4K Btk CDK Raf JAK Cancer
    BI-1622 is an orally active, potent and highly selective HER2 (ERBB2) inhibitor, with an IC50 of 7 nM. BI-1622 shows greater than 25-fold selectivity over EGFR. BI-1622 shows high antitumor efficacy in vivo in xenograft mouse tumor models with engineered H2170 and PC9 cells and had a favorable drug metabolism and pharmacokinetics profile.
  • HY-B0389S18
    D-Glucose-13C3-1

    Glucose-13C3-1; D-(+)-Glucose-13C3-1; Dextrose-13C3-1

    Endogenous Metabolite Metabolic Disease
    D-Glucose-13C3-1 (Glucose-13C3-1) is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
  • HY-N0229S10
    L-Alanine-13C3,15N

    L-2-Aminopropionic acid-13C3,15N

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-13C3,15N (L-2-Aminopropionic acid-13C3,15N) is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-128895
    KL1333

    Mitochondrial Metabolism Metabolic Disease
    KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures.
  • HY-113456S
    Leukotriene D4-d5

    Drug Metabolite Endogenous Metabolite Inflammation/Immunology Cardiovascular Disease
    Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.
  • HY-12688
    Succinyl phosphonate

    Endogenous Metabolite Reactive Oxygen Species Neurological Disease
    Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ.
  • HY-N6720
    T-2 Triol

    Endogenous Metabolite Metabolic Disease
    T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin. T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t1/2λz), Peak plasma concentrations (Cmax) and Tmax values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively.
  • HY-15671
    GKA50

    Glucokinase Metabolic Disease
    GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats.
  • HY-W250154
    β-Nicotinamide adenine dinucleotide reduced dipotassium

    Endogenous Metabolite Metabolic Disease
    β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.
  • HY-N0229S
    L-Alanine-2-13C,15N

    L-2-Aminopropionic acid-2-13C,15N

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-2-13C,15N (L-2-Aminopropionic acid-2-13C,15N) is the 13C-labeled and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-124364
    RO6889678

    HBV Cytochrome P450 Infection Metabolic Disease
    RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation.
  • HY-15671A
    GKA50 quarterhydrate

    Glucokinase Metabolic Disease
    GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats.
  • HY-121495
    BKI-1369

    Parasite Infection
    BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves.
  • HY-142932
    BTK-IN-6

    Btk Cancer Inflammation/Immunology Neurological Disease
    BTK-IN-6 is a potent inhibitor of Bruton's Tyrosine Kinase (BTK). BTK is a member of the Tec family of tyrosine kinases and plays an important role in the regulation of early B-cell development and mature B-cell activation and survival. BTK-IN-6 has the potential for the research of immune disorders, cancer, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders, and neurological disorders (extracted from patent WO2021136219A1, compound 8).
  • HY-N0229S5
    L-Alanine-13C3,15N,d4

    L-2-Aminopropionic acid-13C3,15N,d4

    Endogenous Metabolite Metabolic Disease Neurological Disease
    L-Alanine-13C3,15N,d4 (L-2-Aminopropionic acid-13C3,15N,d4) is the deuterium, 13C-, and 15-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
  • HY-12688A
    Succinyl phosphonate trisodium salt

    Endogenous Metabolite Reactive Oxygen Species Cancer Metabolic Disease Neurological Disease
    Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ.
  • HY-115463
    EB-3D

    AMPK Apoptosis Cancer
    EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity.
  • HY-N0092
    Inosine

    Adenosine Receptor Endogenous Metabolite Inflammation/Immunology Neurological Disease
    Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
  • HY-131445A
    SS-RJW100

    Others Metabolic Disease Inflammation/Immunology
    SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability.
  • HY-144900
    Topramezone

    Reactive Oxygen Species
    Topramezone is a potent 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide, used for the post-emergence control of broadleaf and grass weeds in corn.
  • HY-14165
    Veliflapon

    BAY X 1005; DG-031

    FLAP Leukotriene Receptor Inflammation/Immunology Cardiovascular Disease
    Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor. Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.
  • HY-122723
    GOT1 inhibitor-1

    Others Cancer
    GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC).
  • HY-123981
    5MPN

    Others Cancer
    5MPN is a first-in-class, potent, orally active and selective 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) inhibitor. 5MPN appears to be a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN does not inhibit PFK-1 or PFKFB3. 5MPN targets the sugar metabolism of tumors and suppresses proliferation of multiple human cancer cell lines.
  • HY-N0303
    Idebenone

    Mitochondrial Metabolism Apoptosis Neurological Disease
    Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM). Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells. Idebenone quickly crosses the blood-brain barrier.
  • HY-13771S1
    Ursodeoxycholic acid-13C

    Ursodeoxycholate-13C; Ursodiol-13C; UDCA-13C

    G protein-coupled Bile Acid Receptor 1 FXR Endogenous Metabolite
    Ursodeoxycholic acid-13C is the 13C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active.
  • HY-13771S
    Ursodeoxycholic acid-d5

    Ursodiol-d5; UDCA-d5

    G protein-coupled Bile Acid Receptor 1 FXR Endogenous Metabolite Metabolic Disease Cancer
    Ursodeoxycholic acid-d5 (Ursodiol-d5) is the deuterium labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active.
  • HY-100008
    Peretinoin

    NIK333

    RAR/RXR SphK Autophagy HCV Cancer Infection
    Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM.
  • HY-B0510
    Trimethoprim

    Antifolate Bacterial Antibiotic Influenza Virus Infection
    Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc.
  • HY-B0510B
    Trimethoprim hydrochloride

    Antifolate Bacterial Antibiotic Influenza Virus Infection
    Trimethoprim hydrochloride is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim hydrochloride is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim hydrochloride has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim hydrochloride can inhibit infection of Influenza A virus in chick embryo when combinated with zinc.
  • HY-141645
    IMM-H007

    WS070117

    AMPK TGF-β Receptor NF-κB JNK AP-1 Metabolic Disease Inflammation/Immunology Cardiovascular Disease
    IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis.
  • HY-150057
    CB1R Allosteric modulator 4

    Cannabinoid Receptor Others
    CB1R Allosteric modulator 4 is a positive allosteric modulator of cannabinoid type-1 (CB1R) with good biological activity. CB1R Allosteric modulator 4 inhibits cAMP production and shows robust activity in β-arrestin-2 recruitment.
  • HY-13582
    Carbendazim

    Fungal Infection Cancer
    Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as SeproriaFusarium and Sclerotina. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.
  • HY-126077
    MTI-31

    mTOR Cancer Inflammation/Immunology
    MTI-31 is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 μM ATP. MTI-31 can be used for the research of breast cancer.
  • HY-N6792
    T-2 Toxin

    T-2 Mycotoxin

    Apoptosis DNA/RNA Synthesis Metabolic Disease
    T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD50 values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BW a,respectively . T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates. T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues.