Search Result
Results for "
methyl
" in MCE Product Catalog:
13
Biochemical Assay Reagents
150
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
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- HY-W009082
-
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Methyl behenate
methyl docosanoate
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Others
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Others
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Methyl behenate (Methyl docosanoate) is a naturally fatty acid methyl ester isolated from the plant of Aspidopterys obcordata Lemsl.
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- HY-113972
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-
- HY-W011688
-
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Methyl palmitoleate
(Z)-methyl hexadec-9-enoate; methyl cis-9-Hexadecenoate
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Others
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Others
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Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties.
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- HY-107830
-
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Methyl cholate
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Others
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Metabolic Disease
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Methyl Cholate is methyl ester form of Cholic acid. Cholic acid is one of the major bile acids produced by the liver, where it is synthesized from cholesterol.
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-
- HY-W011297
-
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Methyl arachidonate
Arachidonic acid methyl ester
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Others
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Metabolic Disease
|
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Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.
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- HY-W037451
-
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Methyl L-leucinate
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Amino Acid Derivatives
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Others
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Methyl L-leucinate, methyl ester of L-leucine, is an alpha-amino acid ester. Methyl L-leucinate is a derivative of methyl ester and L-leucine, a class of compounds containing both amino and carboxyl groups in the molecule.
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- HY-N8438
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- HY-N7647
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- HY-134716
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-
- HY-Z0548
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-
- HY-W017212
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Methyl cinnamate
methyl 3-phenylpropenoate
|
Tyrosinase
Bacterial
AMPK
|
Infection
Metabolic Disease
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Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway.
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- HY-Y1298
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-
- HY-N0349
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Methyl Paraben
methyl 4-hydroxybenzoate
|
Bacterial
Endogenous Metabolite
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Infection
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Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity.
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- HY-W004291
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- HY-101461
-
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Methyl-β-cyclodextrin
methyl-beta-cyclodextrin
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Biochemical Assay Reagents
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Cancer
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Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic drugs based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis. Methyl-β-cyclodextrin blocks cell migrasome formation.
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- HY-32291
-
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Methyl L-pyroglutamate
(S)-methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester
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Others
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Others
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Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity.
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- HY-W004290
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-
- HY-137473
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Methyl pyropheophorbide-a
Pyropheophorbide-a methyl ester
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Apoptosis
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Cancer
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Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth.
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- HY-W018643
-
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Ferulic acid methyl ester
methyl ferulate
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p38 MAPK
Autophagy
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Inflammation/Immunology
Neurological Disease
Cancer
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Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages.
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- HY-W018643A
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- HY-N10452
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- HY-N2598
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Methyl oleate
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Others
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Others
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Methyl oleate is a fatty acid methyl ester (FAME). Methyl oleate substantially improves the antioxidation ability but markedly impaired the antiwear capacity of zinc dialkyldithiophosphate (ZDDP).
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- HY-21268
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- HY-W004288
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Methyl myristate
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Others
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Cancer
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Methyl myristate is a saturated fatty acid methyl ester obtained from the esterification of myristic acid. Methyl myristate shows a high melanin induction in B16F10 melanoma.
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- HY-N1434
-
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Methyl p-coumarate
methyl 4-hydroxycinnamate
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Fungal
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Cancer
Infection
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Methyl p-coumarate (Methyl 4-hydroxycinnamate), an esterified derivative of p-Coumaric acid (pCA), is isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens.
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- HY-W057434
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- HY-W004290S
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- HY-W004288S
-
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Methyl tetradecanoate-d27
Myristic acid methyl ester-d27
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Isotope-Labeled Compounds
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Cancer
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Methyl tetradecanoate-d27 is the deuterium labeled Methyl myristate. Methyl myristate is a saturated fatty acid methyl ester obtained from the esterification of myristic acid. Methyl myristate shows a high melanin induction in B16F10 melanoma[1].
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- HY-N2439
-
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Methyl isoeugenol
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Others
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Neurological Disease
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Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active.
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- HY-N6981
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- HY-116284A
-
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Methyl β-D-glucopyranoside hemihydrate
methyl β-D-glucoside hemihydrate
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Others
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Others
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Methyl β-D-glucopyranoside (Methyl β-D-glucoside) hemihydrate is a hemihydrate compound. Methyl β-D-glucopyranoside hemihydrate less reactive at higher PH. The formation of Methyl β-D-glucopyranoside hemihydrate is stereospecific.
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- HY-N3270
-
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Methyl orsellinate
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Fungal
Lipoxygenase
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Infection
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Methyl orsellinate is a phytotoxic compound with antifungal activities. Methyl orsellinate is a 5-lipoxygenase inhibitor with an IC50 value of 59.6 μM. Methyl orsellinate can be used for fungal infection research.
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- HY-W018865
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- HY-W004287S
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- HY-N6587
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- HY-W004262
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- HY-W004287
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- HY-W109613
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- HY-D0163
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Methyl Green
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DNA Stain
Others
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Others
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Methyl Green is a potent fluorescent dye. Methyl Green is a DNA stains of cells and electrophoretic gels. Methyl Green can be used as a stain for direct measuring of viability by both microscopy and flow cytometry, with peaks at 633 and 677 nm.
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- HY-W009276
-
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γ-Linolenic Acid methyl ester
methyl GLA
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Apoptosis
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Cancer
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γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of γ-Linolenic Acid (GLA), which is an ω-6 fatty acid, serves as melanoma cell proliferation inhibitors. γ-Linolenic Acid methyl ester inhibits ADP-induced blood platelet aggregation and induces apoptosis.
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- HY-A0169
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- HY-A0169A
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- HY-W004285S
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- HY-W087943S
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- HY-W007648
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Methyl 3-aminopropanoate hydrochloride
β-Alanine methyl ester hydrochloride
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Others
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Others
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Methyl 3-aminopropanoate hydrochloride is prepared by esterification of Β-Alanine (I). Methyl 3-aminopropanoate hydrochloride can be used in the synthesis of bidentate pyridine-acid ligand.
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- HY-W573700
-
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Methyl everninate
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Others
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Others
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Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model.
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- HY-D0003
-
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Methyl Blue
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Fluorescent Dye
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Infection
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Methyl blue belongs to the group of triaminotriphenylmethane dyes. Methyl blue is widely used as antiseptic dye in polychrome staining method and has applications in histological and microbiological staining solutions. Methyl blue has been used as a model to study the effect of various catalysts on photodegradation of dyes.
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- HY-W011297S
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- HY-W011297S1
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- HY-W004289
-
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Methyl pentadecanoate
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Others
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Others
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Methyl pentadecanoate is a fatty acid ester, can be isolated from L. wallichi extracts. Methyl pentadecanoate is obtained by condensation of the carboxy group of pentadecanoic acid with the hydroxy group of methanol.
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- HY-136150
-
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Methyl carnosate
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Bacterial
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Infection
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Methyl camosate is a diterpene isolated from Salvia officinalis or Rosmarinus officinalis. Methyl camosate has potent antioxidant and anti-bacterial activity.
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- HY-B1934S1
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- HY-W007704
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- HY-W015342
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- HY-B1695
-
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Methyl nicotinate
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Others
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Inflammation/Immunology
|
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Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain.
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- HY-N1482S1
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Methyl palmitate-d31
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Isotope-Labeled Compounds
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|
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Methyl palmitate-d31 is the deuterium labeled Methyl palmitate. Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects[1][2][3].
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- HY-N2492
-
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(E)-Methyl 4-coumarate
methyl trans-p-coumarate
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Bacterial
Apoptosis
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Cancer
Infection
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(E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate), found in several plants, such as Allium cepa or Morinda citrifolia L. leaves. (E)-Methyl 4-coumarate cooperates with Carnosic Acid in inducing apoptosis and killing acute myeloid leukemia cells, but not normal peripheral blood mononuclear cells. Antioxidant and antimicrobial activity.
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- HY-143926S
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- HY-W016172S1
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- HY-W016172S2
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- HY-Y1401S
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- HY-W004289S
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- HY-75342
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- HY-W002116
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- HY-W067056
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Methyl (E)-cinnamate
methyl (E)-3-phenylpropenoate
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Others
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Inflammation/Immunology
|
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Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry.
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- HY-101541
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- HY-D0950A
-
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Methyl Green zinc chloride
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DNA Stain
Others
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Others
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Methyl Green zinc chloride is a potent fluorescent dye. Methyl Green zinc chloride is a DNA stains of cells and electrophoretic gels. Methyl Green zinc chloride can be used as direct measuring of viability by both microscopy and flow cytometry, with peaks at 633 and 677 nm.
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- HY-N1482
-
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Methyl palmitate
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Parasite
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Inflammation/Immunology
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Methyl palmitate, an acaricidal compound occurring in Lantana camara, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects.
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- HY-101541S
-
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Docosahexaenoic acid-d5 methyl ester
methyl docosahexaenoate-d5; all cis-DHA methyl ester-d5
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Isotope-Labeled Compounds
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Neurological Disease
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Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].
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- HY-N0165
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- HY-W001084
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Methyl 4-hydroxyphenylacetate
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Others
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Others
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Methyl 4-hydroxyphenylacetate, a natural compound, is a methyl ester resulting from the formal condensation of the carboxy group of 4-Hydroxyphenylacetic acid with methanol.
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- HY-N1481
-
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Methyl linoleate
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Others
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Metabolic Disease
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Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins.
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- HY-N9540
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- HY-N8819
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Methyl ganoderate H
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Others
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Others
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Methyl ganoderate H is a natural product that can be isolated from Ganoderma lucidum. Methyl ganoderate H has moderate inhibitory effect to NO production.
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- HY-N1482S
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- HY-76705
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Methyl N-methylanthranilate
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Others
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Others
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Methyl N-methylanthranilate, a terpene, is a pungent compound that can be found in Citrus reticulate Blanco leaves. Methyl N-methylanthranilate has the potential for pain research.
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- HY-N8588
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- HY-118907
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- HY-141239
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- HY-N6996
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Methyl Eugenol
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Others
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Others
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Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly.
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- HY-N7624
-
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Methyl oleanonate
3-Oxoolean-12-en-28-oic acid methyl ester
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PPAR
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Cancer
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Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia. Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects.
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- HY-Y1033S
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- HY-100084
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- HY-W004285
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- HY-W007828
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- HY-Z0548S1
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- HY-W010076
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- HY-Y0949
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Methyl 2-furoate
methyl furan-2-carboxylate
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Endogenous Metabolite
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Others
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Methyl 2-furoate (Methyl furan-2-carboxylate) is a building block in chemical synthesis. A flavoring agent in food. Found in cranberries, guava fruits, raisins and other fruits. Also present in baked potato, roasted filberts, roasted peanut, tomatoes, coffee, cocoa, okra, etc.
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- HY-W087943
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- HY-I0924
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- HY-Y0754
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- HY-W037443
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- HY-33319
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- HY-W002773
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- HY-141240
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- HY-79708A
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- HY-W008219
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- HY-B1934
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- HY-N6996S
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Methyl Eugenol-13C,d3
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Isotope-Labeled Compounds
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Others
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Methyl Eugenol- 13C,d3 is the 13C- and deuterium labeled Methyl Eugenol. Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly[1].
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- HY-N1503
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- HY-N6005
-
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Methyl caffeate
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Bacterial
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Cancer
Infection
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Methyl caffeate, an antimicrobial agent, shows moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate also exhibits α-glucosidase inhibition activity, oxidative stress inhibiting activity, anti-platelet activity, antiproliferative activity in cervix adenocarcinoma and anticancer activity in lung and leukmia cell lines.
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- HY-W018501
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-
- HY-W004286
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- HY-N7084
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-
- HY-101541S1
-
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- HY-101572
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MHP
methyl caprooyl tyrosinate
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SphK
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Inflammation/Immunology
Cancer
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MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production. MHP (Methyl caprooyl tyrosinate) enhances antimicrobial defense and innate immunity.
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- HY-124824
-
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Methyl gerfelin
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Glyoxalase (GLO)
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Others
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Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class.
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- HY-N10902
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-
- HY-N7965
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-
- HY-23174
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-
- HY-W089785
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Methyl α-D-galactopyranoside monohydrate
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Others
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Others
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Methyl α-D-galactopyranoside monohydrate is an alpha-D-galactoside having a methyl substituent at the anomeric position. Methyl α-D-galactopyranoside inhibits debaryomyces hansenii UFV-1 extracellular and intracellular α-galactosidases with Ki values of 0.82 and 1.12 mM, respectively.
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- HY-Y1298S
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Methyl acetylacetate-13C4
Acetoacetate methyl ester-13C4; methyl 3-oxobutanoate-13C4; methyl acetoacetate-13C4
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Endogenous Metabolite
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Others
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Methyl acetylacetate- 13C4 is an isotopically labeled compound. Methyl acetylacetate- 13C4 can be used for various biochemical studies[1].
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- HY-N3291
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- HY-Y1661
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- HY-41318
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- HY-W072177
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- HY-W091734
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- HY-N2010
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- HY-Y1789
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-
- HY-33615
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- HY-128737
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- HY-N2044
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Methyl 3,4,5-trimethoxybenzoate
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Others
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Others
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Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents.
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- HY-116284
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- HY-W039897
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- HY-W005963
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- HY-113949A
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- HY-W012002
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- HY-42569
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- HY-N7436
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- HY-79635
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Methyl indole-3-carboxylate
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Bacterial
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Infection
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Methyl indole-3-carboxylate is a natural product isolated from Sorangium cellulosum strain Soce895. Methyl indole-3-carboxylate shows a weak activity against the Gram-positive Nocardia sp with a MIC value of 33.33 μg/mL.
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- HY-W052310
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- HY-W039758
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- HY-W039180
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- HY-N3266
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Methyl rosmarinate
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Tyrosinase
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Cancer
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Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase.
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- HY-22167
-
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Methyl 2-hydroxy-4-methylvalerate
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Others
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Others
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Methyl 2-hydroxy-4-methylvalerate is one of dominant volatile compounds in Zhenjiang aromatic vinegar. Methyl 2-hydroxy-4-methylvalerate is used for charting flavour biosynthesis networks of vinegar microbiota.
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- HY-W018045
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- HY-N3287
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Methyl 3-hydroxy-4,5-dimethoxybenzoate
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Bacterial
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Infection
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Methyl 3-hydroxy-4,5-dimethoxybenzoate is a gallic acid derivant isolated from myricaria Laxiflora. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows obvious antimicrobial activities. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows fairly active for oxidation resistance in the presence of H2O2.
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- HY-Y0189
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Methyl Salicylate
Wintergreen oil
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COX
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Inflammation/Immunology
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Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products. A systemic acquired resistance (SAR) signal in tobacco. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor.
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- HY-130186
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- HY-101006
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- HY-W096155
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- HY-W098273
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- HY-W042039
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- HY-132095
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- HY-132092
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- HY-W094307
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- HY-W012862
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- HY-N10792
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- HY-W001154
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- HY-W015224S
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- HY-N3269
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- HY-N3267
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- HY-N4277
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Methyl protogracillin
NSC-698793
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Others
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Cancer
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|
Methyl protogracillin (NSC-698793), isolated from the roots of Dioscorea opposite Thunb, exhibits strong anti-cancer activity.
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- HY-W005014
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- HY-40151
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- HY-W019226
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- HY-Z0424
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- HY-W440039
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- HY-138462
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- HY-N10520
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- HY-103334
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- HY-W015224
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- HY-125861D
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- HY-W050444
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- HY-W144096
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- HY-N0863
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Methyl protodioscin
NSC-698790; Smilax saponin B
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Apoptosis
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Cancer
|
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Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest.
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- HY-141638
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Me-IQ
methyl-IQ
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Others
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Cancer
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Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits.
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- HY-79676
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- HY-W011547
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- HY-N8101
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- HY-N6669
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- HY-42356
-
-
- HY-100072
-
|
(2E,4E,6Z)-Methyl deca-2,4,6-trienoate
methyl (2E,4E,6Z)-decatrienoate
|
Others
|
Infection
|
|
(2E,4E,6Z)-Methyl deca-2,4,6-trienoate (Methyl (2E,4E,6Z)-decatrienoate) is the aggregation pheromone of the brown-winged green bug, Plautia stali. (2E,4E,6Z)-Methyl deca-2,4,6-trienoate exposed to daylight in solutions and/or on dispensers used for field trapping can readily isomerize to form complex mixtures of isomers, thus causing a concern about lure stability and longevity.
|
-
- HY-114772
-
|
Methyl reserpate
NSC 81464; Me reserpate
|
Others
|
Others
|
|
Methyl reserpate (NSC 81464) is a Yohimbine (HY-12715) type alkaloid, that can be isolated from Rauwolfia vomitoria roots and leaves.
|
-
- HY-113949
-
-
- HY-N10261
-
-
- HY-75401
-
-
- HY-N2908
-
|
Atraric acid
methyl atrarate
|
Androgen Receptor
NO Synthase
p38 MAPK
NF-κB
|
Cancer
Inflammation/Immunology
|
|
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases.
|
-
- HY-112076
-
|
Atropine methyl bromide
methylatropine bromide
|
mAChR
|
Neurological Disease
|
|
Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine.
|
-
- HY-I0125
-
-
- HY-W048334
-
-
- HY-W013507
-
-
- HY-135591
-
-
- HY-W098127S
-
-
- HY-W030319
-
-
- HY-125861
-
-
- HY-I0924A
-
-
- HY-113298
-
-
- HY-19354
-
|
Aglafoline
Aglafolin; Rocaglamide U; (-)-methyl rocaglate
|
Others
|
Cardiovascular Disease
|
|
Aglafoline inhibits in a selective and concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor).
|
-
- HY-N1366
-
|
Herniarin
7-Methoxycoumarin; methyl umbelliferyl ether
|
Others
|
Cancer
|
|
Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
|
-
- HY-U00159
-
-
- HY-106634
-
|
Mitoguazone
methylglyoxal-bis(guanylhydrazone); MGBG; methyl-GAG
|
HIV
Apoptosis
|
Cancer
Infection
|
|
Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment.
|
-
- HY-B0324A
-
|
Crystal Violet
Basic Violet 3; Gentian Violet; methyl Violet 10B
|
Influenza Virus
Bacterial
|
Infection
|
|
Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
|
-
- HY-N1366S
-
-
- HY-B0324AS
-
-
- HY-16938S
-
|
5'-Methylthioadenosine-13C6
-(methylthio)-5'-deoxyadenosine-13C6; 5'-Deoxy-5'-(methylthio)adenosine-13C6; 5'-S-methyl-5'-thioadenosine-13C6
|
Endogenous Metabolite
Apoptosis
|
Cancer
Metabolic Disease
|
|
5'-Methylthioadenosine- 13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].
|
-
- HY-135376
-
|
Atorvastatin methyl ester
|
Others
|
Metabolic Disease
|
|
Atorvastatin methyl ester (Compound 2a) is a methyl esterified derivative of Atorvastatin. Atorvastatin methyl ester inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin.
|
-
- HY-W101391
-
-
- HY-107300
-
-
- HY-128031
-
-
- HY-N7618
-
-
- HY-145998
-
|
2′-O-Methyl-8-methyl guanosine
m8Gm
|
Others
|
Others
|
|
2′-O-Methyl-8-methyl guanosine (m8Gm) is a Z-form RNA stabilizer. 2′-O-Methyl-8-methyl guanosine can markedly stabilize the Z-RNA at low salt conditions. m8Gm-contained oligonucleotides stabilize
the Z-DNA under low salt conditions.
|
-
- HY-113972A
-
|
(E/Z)-Methyl mycophenolate
|
Others
|
Inflammation/Immunology
|
|
(E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides.
|
-
- HY-150017
-
-
- HY-B2025S
-
-
- HY-101456
-
-
- HY-137267
-
-
- HY-19358A
-
|
2-Methyl-5-HT hydrochloride
2-methyl-5-hydroxytryptamine hydrochloride; 2-methylserotonin hydrochloride; 2-Me-HT hydrochloride
|
5-HT Receptor
|
Neurological Disease
|
|
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects.
|
-
- HY-19358B
-
|
2-Methyl-5-HT maleate
2-methyl-5-hydroxytryptamine maleate; 2-methylserotonin maleate; 2-Me-HT maleate
|
5-HT Receptor
|
Neurological Disease
|
|
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT maleate is shown to display anti-depressive-like effects.
|
-
- HY-147365
-
|
Acifluorfen-methyl
|
Others
|
Others
|
|
Acifluorfen-methyl is an inhibitor of the heme and chlorophyll biosynthetic enzyme protoporphyrinogen oxidase (Protox). Acifluorfen-methyl is a photobleaching herbicide.
|
-
- HY-B0842S
-
-
- HY-N1993
-
-
- HY-19358
-
|
2-Methyl-5-HT
2-methyl-5-hydroxytryptamine; 2-methylserotonin; 2-Me-5-HT
|
5-HT Receptor
|
Neurological Disease
|
|
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects.
|
-
- HY-W098280
-
-
- HY-147331
-
-
- HY-135327A
-
|
Amphotericin B methyl ester hydrochloride
|
HIV
Fungal
|
Infection
|
|
Amphotericin B methyl ester hydrochloride is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester hydrochloride is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester hydrochloride disrupts HIV-1 particle production and potently inhibits HIV-1 replication.
|
-
- HY-135327
-
|
Amphotericin B methyl ester
|
HIV
Fungal
|
Infection
|
|
Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication.
|
-
- HY-115685
-
|
3-Methyl-GABA
|
GABA Receptor
|
Neurological Disease
|
|
3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABAA receptor (GABAaR). 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD). 3-Methyl-GABA has anticonvulsant activity.
|
-
- HY-131619S
-
-
- HY-W006057AS1
-
-
- HY-111644
-
-
- HY-111912
-
|
Tribenuron-methyl
|
Fungal
|
Infection
|
|
Tribenuron-methyl, a sulfonylurea herbicide agent, can be used as the fungicide agent. Tribenuron-methyl plays an important role in controlling the weeds and diseases in wheat field.
|
-
- HY-23337S
-
-
- HY-W006057
-
-
- HY-139548
-
-
- HY-136367
-
|
Diclofop-methyl
|
Others
|
Others
|
|
Diclofop-methyl, a common post-emergence herbicide, is widely used in agriculture production. Diclofop-methyl increases the proton permeability of isolated oat-root tonoplast.
|
-
- HY-W017387S
-
-
- HY-N11000
-
-
- HY-132493S
-
-
- HY-N10353
-
-
- HY-B0801S1
-
-
- HY-130803
-
|
5-Methyl-5,6-dihydrouridine
|
Others
|
Cancer
|
|
5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification.
|
-
- HY-N5041
-
-
- HY-N8882
-
-
- HY-135412
-
-
- HY-128447
-
-
- HY-B1881S
-
|
Pirimiphos-methyl-d6
|
Parasite
Cholinesterase (ChE)
|
Infection
|
|
Pirimiphos-methyl-d6 is the deuterium labeled Pirimiphos-methyl. Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains[1][2][3].
|
-
- HY-B0842
-
-
- HY-D0995
-
|
7-Methyl-6-thioguanosine
MESG
|
Fluorescent Dye
|
Others
|
|
7-Methyl-6-thioguanosine (MESG) is a chromophoric substrate which can be used for the quantitation of inorganic phosphate. 7-Methyl-6-thioguanosine is also used to determine the activity of purine nucleoside phosphorylase.
|
-
- HY-W011311S
-
|
Eicosapentaenoic acid methyl ester-d5
|
Apoptosis
|
Others
|
|
Eicosapentaenoic acid methyl ester-d5 is the deuterium labeled Eicosapentaenoic acid methyl ester. Eicosapentaenoic acid methyl ester is a degradant of a monogalactosyl diacylglycerol (an anticancer compound by inducing apoptosis)[1].
|
-
- HY-N2397
-
-
- HY-N10354
-
|
27-Methyl withaferin A
|
Apoptosis
|
Cancer
|
|
27-Methyl withaferin A (comppund 26) is an apoptosis inducer with anticancer effects. 27-Methyl withaferin A shows antiproliferative effects against HeLa, A-549 and MCF-7 human tumor cell lines with IC50 values of 3.2 μM, 4.2 μM and 1.4 μM, respectively.
|
-
- HY-130641
-
|
Br-C10-methyl ester
|
PROTAC Linkers
|
Cancer
|
|
Br-C10-methyl ester is a PROTAC linker, which refers to the alkyl/ether composition. Br-C10-methyl ester is used in the synthesis of a series of PROTACs (MS432). PROTACs contain two different ligands connected by a linker; one is the VHL ligand portion and the other is for the target protein.
|
-
- HY-W049970
-
-
- HY-W006057A
-
-
- HY-B0870S
-
-
- HY-136374
-
|
Haloxyfop-P-methyl
|
Others
|
Others
|
|
Haloxyfop-P-methyl is an aryloxyphenoxypropionate herbicide. Haloxyfop-P-methyl can be absorbed by roots or foliage and hampers lipogenesis and increases oxidative stress in target plants.
|
-
- HY-140852
-
-
- HY-140876
-
-
- HY-138450
-
-
- HY-140404
-
-
- HY-138373
-
-
- HY-138367
-
-
- HY-138421
-
-
- HY-136441S
-
|
Triclosan-methyl-d3
|
Bacterial
|
Infection
|
|
Triclosan-methyl-d3 is the deuterium labeled Triclosan-methyl. Triclosan-methyl is a transformation product of triclosan. Triclosan is a bactericide in personal care products such as toothpaste, shampoos, and soaps. Triclosan is also a stabilizing agent in a multitude of detergents and cosmetics[1].
|
-
- HY-124313
-
-
- HY-D1531
-
-
- HY-132800S
-
-
- HY-W015695
-
-
- HY-140851
-
-
- HY-N4297
-
-
- HY-W017386S
-
-
- HY-131459S
-
-
- HY-144191S
-
-
- HY-132476S
-
-
- HY-144192S
-
-
- HY-N1481S
-
-
- HY-143527S
-
-
- HY-W131494S
-
-
- HY-144193S
-
-
- HY-100504
-
|
S-methyl DM1
|
Microtubule/Tubulin
ADC Cytotoxin
|
Cancer
|
|
S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects.
|
-
- HY-W009262
-
-
- HY-B0191B
-
-
- HY-B1869
-
|
Metsulfuron-methyl
|
Others
|
Others
|
|
Metsulfuron-methyl is a systemic sulfonylurea herbicide and has been widely used to control broad-leaved weeds and annual grasses in rice, maize, wheat, and barley. Metsulfuron-methyl has highly efficient herbicidal activity and low mammalian toxicity.
|
-
- HY-34465
-
-
- HY-B1881
-
|
Pirimiphos-methyl
|
Parasite
Cholinesterase (ChE)
|
Infection
|
|
Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains.
|
-
- HY-N2433
-
|
Paederosidic acid methyl ester
|
Potassium Channel
|
Neurological Disease
|
|
Paederosidic acid methyl ester is a ATP‐sensitive K + channel activator, isolated from P. scandens. Paederosidic acid methyl ester exhibits significant central analgesic activity, and enhances the threshold of pain by activating ATP‐sensitive K + channel in the brain and spinal cord level.
|
-
- HY-W402148
-
-
- HY-113063
-
-
- HY-W042057
-
-
- HY-32687A
-
-
- HY-I0519
-
-
- HY-N7623
-
|
Ursonic acid methyl ester
|
Others
|
Cancer
|
|
Ursonic acid methyl ester is an esterified derivative of Ursolic acid (HY-N0140). Ursonic acid methyl ester shows growth inhibitory activity against four tumor cell lines, HL-60, BGC, Bel-7402 and Hela with ED50 values of >100 µg/ml.
|
-
- HY-129905
-
|
L-Leucyl-L-Leucine methyl ester hydrochloride
LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress.
|
-
- HY-132384S
-
-
- HY-132116
-
-
- HY-138348
-
-
- HY-138481
-
-
- HY-W011311
-
-
- HY-W013014
-
-
- HY-W013035
-
-
- HY-W041470
-
-
- HY-W017007S
-
-
- HY-132855S
-
-
- HY-134742
-
-
- HY-W128028
-
-
- HY-146713S
-
-
- HY-W017006S
-
-
- HY-N2411
-
-
- HY-W096162
-
-
- HY-133408
-
-
- HY-W010533
-
-
- HY-W012922
-
-
- HY-144147S
-
-
- HY-N6657
-
-
- HY-Y1801
-
-
- HY-13324
-
|
Bardoxolone methyl
RTA 402; NSC 713200; CDDO methyl ester
|
Keap1-Nrf2
Autophagy
Apoptosis
Ferroptosis
|
Cancer
|
|
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
|
-
- HY-D0144
-
|
Resorufin methyl ether
Methoxyresorufin
|
Cytochrome P450
|
Others
|
|
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate. Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents.
|
-
- HY-I0775
-
-
- HY-W017054
-
-
- HY-138508
-
-
- HY-W025811
-
-
- HY-W087919
-
|
5-Methyl-2-furanmethanol
5-methylfurfuryl alcohol
|
Others
|
Others
|
|
5-Methyl-2-furanmethanol is a natural product that can be isolated from the essential oil of D. rupicola Biv.. 5-Methyl-2-furanmethanol also acts as a oxidative product of 2,5 dimethylfuran (DMF) by cytochrome P450 (CYP).
|
-
- HY-W014916
-
-
- HY-W013591S
-
-
- HY-W006057AS
-
-
- HY-D1585
-
|
BODIPY TR methyl ester
|
Fluorescent Dye
|
Others
|
|
BODIPY TR methyl ester is a lipophilic GFP Counterstain. BODIPY TR methyl ester dye readily permeates cell membranes and localizes in endomembranous organelles but not localize strongly in plasma membranes. BODIPY TR methyl ester is an excellent red fluorescent vital dye (Ex=568 nm, Em=625 nm), can be used to reveal the location and shapes of cell nuclei, the shapes of cells within embryonic tissues, as well as the bound aries of organ-forming tissues within the whole embryo.
|
-
- HY-N6925
-
-
- HY-20561
-
-
- HY-W010366
-
-
- HY-41257
-
-
- HY-W007511
-
-
- HY-124290
-
|
Carotegrast methyl
AJM300
|
Integrin
|
Inflammation/Immunology
|
Carotegrast methyl (AJM300) is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl prevents the development of colitis in mice.
|
-
- HY-126716S
-
-
- HY-139937S
-
-
- HY-139938S
-
-
- HY-111648
-
-
- HY-W006057AS3
-
-
- HY-W006057AS2
-
-
- HY-B1206
-
-
- HY-137474
-
|
Purpurin 18 methyl ester
|
Others
|
Cancer
|
|
Purpurin 18 methyl ester, a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death.
|
-
- HY-B0870
-
-
- HY-W020020
-
|
Thifensulfuron-methyl
|
Others
|
Others
|
|
Thifensulfuron-methyl is a sulfonylurea herbicide and mainly used for control of broadleaved weeds in wheat, corn, and soybean fields.
|
-
- HY-20561A
-
-
- HY-I0172
-
-
- HY-141526
-
-
- HY-W012722
-
-
- HY-W114255S
-
-
- HY-111939
-
|
Amiprofos methyl
BAY-NTN 6867
|
Microtubule/Tubulin
|
Others
|
|
Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells.
|
-
- HY-137475
-
-
- HY-111054
-
-
- HY-W004701
-
-
- HY-B1038
-
-
- HY-141242
-
-
- HY-140375
-
-
- HY-141243
-
-
- HY-141241
-
-
- HY-140063
-
-
- HY-N11055
-
-
- HY-141040
-
-
- HY-18005
-
-
- HY-115749
-
|
D-Luciferin 6′-methyl ether
6′-Methoxyluciferin
|
Others
|
Others
|
|
D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 µM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site.
|
-
- HY-W001942S
-
-
- HY-147113
-
-
- HY-W012078
-
-
- HY-141404
-
-
- HY-131940
-
|
3-O-Methyl-N-acetyl-D-glucosamine
3-O-methyl-GlcNAc
|
Others
|
Metabolic Disease
|
|
3-O-Methyl-N-acetyl-D-glucosamine is a potent inhibitor of N-acetylglucosamine kinase. 3-O-Methyl-N-acetyl-D-glucosamine potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine.
|
-
- HY-W089645S
-
-
- HY-W016552
-
-
- HY-D0113
-
-
- HY-79123
-
-
- HY-D1589
-
-
- HY-D1513
-
-
- HY-D1616
-
-
- HY-132628S
-
-
- HY-133778
-
-
- HY-129905A
-
|
L-Leucyl-L-Leucine methyl ester hydrobromide
LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress.
|
-
- HY-131142
-
-
- HY-N7035
-
-
- HY-W005308
-
|
N-BOC-DL-serine methyl ester
|
Amino Acid Derivatives
|
Cancer
|
|
N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity.
|
-
- HY-146993S
-
-
- HY-141032
-
-
- HY-141052
-
-
- HY-141067
-
-
- HY-141031
-
-
- HY-30090
-
-
- HY-N4168
-
-
- HY-W016099
-
-
- HY-W049311
-
-
- HY-137773
-
-
- HY-N1636
-
-
- HY-N1956
-
|
Rubiadin-1-methyl ether
|
NF-κB
|
Metabolic Disease
|
|
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.
|
-
- HY-B1213AS
-
-
- HY-140854
-
-
- HY-132404S
-
-
- HY-W047901
-
-
- HY-W002416
-
-
- HY-W141831
-
-
- HY-W008599
-
-
- HY-141745S
-
-
- HY-D1591
-
|
BODIPY R6G methyl ester
|
Fluorescent Dye
|
Others
|
|
BODIPY R6G methyl ester (compound 5′-1) is a BODIPY-like fluorescent dye with good light stability and insensitive to pH value. BODIPY R6G methyl ester shows good photostability, high sensitivity and insensitive to pH value. BODIPY R6G methyl ester can be used in research areas such as photodynamic therapy, PH probes, ion recognition, photocatalysis, protein labeling, cell imaging, and proteomic analysis.
|
-
- HY-33549
-
|
α-Methyl-p-tyrosine
|
Others
|
Cancer
|
|
α-Methyl-p-tyrosine is a competitive inhibitor of the enzyme tyrosine hydroxylase, which converts tyrosine to Levodopa (DOPA). α-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to DOPA.
|
-
- HY-113046
-
|
5-Methyltetrahydrofolic acid
5-methyl THF
|
Endogenous Metabolite
|
Metabolic Disease
|
|
5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid.
|
-
- HY-W016099S
-
|
3-Methyl-2-quinoxalinecarboxylic acid-d4
MQCA-d4
|
Isotope-Labeled Compounds
|
Cancer
|
|
3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].
|
-
- HY-118608
-
-
- HY-144386S
-
-
- HY-133409
-
-
- HY-N3289A
-
|
(E)-Methyl 3,4,5-trimethoxycinnamate
|
Others
|
Inflammation/Immunology
|
|
(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes.
|
-
- HY-N1638
-
|
1-Methyl-2-undecyl-4(1H)-quinolone
|
Monoamine Oxidase
|
Neurological Disease
|
|
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC50 and Ki values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS.
|
-
- HY-131278
-
-
- HY-136441
-
|
Triclosan-methyl
|
Bacterial
|
Infection
|
|
Triclosan-methyl is a transformation product of triclosan. Triclosan is a bactericide in personal care products such as toothpaste, shampoos, and soaps. Triclosan is also a stabilizing agent in a multitude of detergents and cosmetics.
|
-
- HY-N2421
-
|
Sequoyitol
5-O-methyl-myo-inositol
|
Others
|
Metabolic Disease
|
|
Sequoyitol (5-O-Methyl-myo-inositol) is isolated from plants. Sequoyitol (5-O-Methyl-myo-inositol) decreases blood glucose, improves glucose intolerance, and is used to treat diabetes.
|
-
- HY-Y1275
-
|
N-Methylpyrrolidone
1-methyl-2-pyrrolidinone
|
Biochemical Assay Reagents
|
Others
|
|
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals.
|
-
- HY-147114
-
|
3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin
|
Fluorescent Dye
|
Others
|
|
3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin is a DNA uptake tracer, a pteridine-based fluorescent guanosine analogue. 3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin is widely used in studies of DNA binding and dynamics, with an absorbance maximum at 350 nm and an emission maximum at 430 nm.
|
-
- HY-134215
-
|
cis-11-Methyl-2-dodecenoic acid
|
Bacterial
Fungal
|
Infection
|
cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems. DSF is involved in the regulation of virulence and biofilm formation of a variety of bacterial pathogens.
|
-
- HY-W019714
-
-
- HY-W017007
-
-
- HY-W259888
-
-
- HY-W009708
-
|
Bis(2-methyl-3-furyl)disulfide
|
Others
|
Others
|
|
Bis(2-methyl-3-furyl)disulfide, compound (2), is intended to provide a flavoring compound to enhance a natural feeling, a fresh feeling and a milk-rich feeling of a milk-related product.
|
-
- HY-B2053
-
|
Tolclofos-methyl
|
Bacterial
|
Infection
|
|
Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is used as a see treatment for protection against soil-borne and seed borne fungal pathogens that caused seed decay and seedling blights.
|
-
- HY-76105
-
-
- HY-D0913
-
-
- HY-D0026
-
-
- HY-140121
-
-
- HY-W017006
-
-
- HY-W015424
-
-
- HY-108599A
-
|
DCPLA-ME
DCPLA methyl ester
|
PKC
|
Neurological Disease
|
|
DCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases.
|
-
- HY-139128
-
-
- HY-13936S
-
-
- HY-134900
-
-
- HY-145941
-
-
- HY-W014078
-
-
- HY-W142044
-
-
- HY-41257A
-
-
- HY-N0758
-
|
Barlerin
8-O-Acetyl shanzhiside methyl ester
|
NF-κB
|
Inflammation/Immunology
|
|
Barlerin (8-O-Acetyl shanzhiside methyl ester) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. Barlerin (8-O-Acetyl shanzhiside methyl ester) could inhibt NF-κB.
|
-
- HY-79709
-
-
- HY-138582
-
-
- HY-21754
-
|
Hygric acid
N-methyl-L-proline
|
Others
|
Others
|
|
Hygric acid (N-Methyl-L-proline) is a proline analogue found in the citrus juices and the juice of bergamot.
|
-
- HY-128428
-
|
Carboprost
15(S)-15-methyl Prostaglandin F2α; 15-methyl-PGF2α
|
Prostaglandin Receptor
|
Endocrinology
|
|
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester.
|
-
- HY-139994
-
-
- HY-W012722BS1
-
-
- HY-113472S
-
-
- HY-W022137
-
-
- HY-W017500
-
-
- HY-12966
-
-
- HY-W142140
-
|
N-Methyl-DL-valine
N-methylvaline
|
Amino Acid Derivatives
|
Others
|
|
N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability.
|
-
- HY-W142073
-
|
7-Methyl-DL-tryptophan
7-methyltryptophan
|
Amino Acid Derivatives
|
Infection
|
|
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof.
|
-
- HY-N1041
-
-
- HY-140581
-
-
- HY-Y1824
-
-
- HY-W063269
-
-
- HY-N0630
-
|
Shanzhiside methyl ester
|
GCGR
|
Neurological Disease
|
|
Shanzhiside methy lester is isolated from lamiophlomis rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance.
|
-
- HY-N1637
-
-
- HY-151742
-
|
Norbornene-methyl-NHS
|
ADC Linker
|
Others
|
|
Norbornene-methyl-NHS is a click chemistry reagent containing a TCO group. Dienophile for conjugation via Diels-Alder-reaction, i.e. copper-free click reaction with tetrazines.
|
-
- HY-W011722
-
-
- HY-W048839
-
-
- HY-W035914
-
-
- HY-N8713
-
-
- HY-W087861
-
-
- HY-76299S1
-
-
- HY-W048682
-
-
- HY-N10994
-
-
- HY-W007136
-
-
- HY-W016425
-
-
- HY-143854S
-
-
- HY-D1529
-
-
- HY-N6008
-
|
7-O-Methyl morroniside
|
Others
|
Others
|
|
7-O-Methyl morroniside is an iridoid glycoside (IG) extracted from Cornus officinalis fructus, used in many traditional Chinese medicines.
|
-
- HY-112582
-
-
- HY-W006629
-
-
- HY-125776
-
|
Kresoxim-methyl
BAS 490 F
|
Fungal
Mitochondrial Metabolism
|
Infection
|
|
Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme.
|
-
- HY-W049802
-
-
- HY-B0617S
-
-
- HY-W009535
-
-
- HY-W019265
-
-
- HY-Y1856
-
-
- HY-140485
-
-
- HY-100130
-
-
- HY-138520
-
-
- HY-140486
-
-
- HY-146716S
-
-
- HY-21586B
-
-
- HY-N4167
-
|
3-O-Methylgalangin
Galangin 3-methyl ether; 3-methylgalangin
|
Bacterial
|
Infection
|
|
3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase.
|
-
- HY-N4226
-
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid
|
AP-1
|
Inflammation/Immunology
Cancer
|
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function.
|
-
- HY-140484
-
-
- HY-136070
-
-
- HY-N1604
-
-
- HY-135592
-
|
LY88074 Methyl ether
|
Others
|
Endocrinology
|
|
LY88074 Methyl ether (Example 2) is useful for the inhibition of the various estrogen deficient conditions, which are associated with estrogendeprivation syndrome including osteoporosis and hyperlipidemia.
|
-
- HY-153059
-
-
- HY-121030
-
|
DACM
N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide
|
Fluorescent Dye
|
Others
|
|
DACM (N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide) is a thiol-directed fluorescent dye (Ex=396 nm, Em=468 nm).
|
-
- HY-139098
-
-
- HY-118347
-
|
Aspartame acesulfame
|
Others
|
Neurological Disease
|
|
Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%).
|
-
- HY-U00450
-
-
- HY-W039197
-
-
- HY-101242
-
-
- HY-119993
-
|
AR03
BMH-23
|
DNA/RNA Synthesis
|
Cancer
|
|
AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells.
|
-
- HY-79415
-
-
- HY-W011354
-
-
- HY-W065053
-
-
- HY-Y0755
-
-
- HY-N10456
-
|
1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone
|
Bacterial
|
Infection
|
|
1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone is a potent antibacterial agent with an MIC50 value of 22 µM and an MIC90 value of 50 µM for Helicobacter pyloriStrain 51. 1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone has the potential for the research of gastric and duodenal ulcers.
|
-
- HY-N4153
-
-
- HY-140095
-
-
- HY-147002
-
-
- HY-17448
-
-
- HY-33466
-
-
- HY-P1003
-
-
- HY-W158239
-
-
- HY-P3801
-
|
[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
DiMe-C7
|
Neurokinin Receptor
|
Metabolic Disease
Neurological Disease
Others
|
|
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats.
|
-
- HY-132094
-
-
- HY-132093
-
-
- HY-100350
-
-
- HY-132348S1
-
-
- HY-W011560S
-
-
- HY-N0968
-
-
- HY-141274
-
-
- HY-133656
-
-
- HY-124547S
-
-
- HY-N1181
-
-
- HY-135375
-
-
- HY-N8113
-
-
- HY-146627S
-
-
- HY-W002680
-
-
- HY-41048
-
-
- HY-W040441
-
-
- HY-N2228
-
|
(-)-Epigallocatechin-3-(3''-O-methyl) gallate
(-)-EGCG-3''-O-ME
|
Others
|
Cancer
|
|
(-)-Epigallocatechin-3-(3''-O-methyl) gallate is a natural product isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells.
|
-
- HY-N10369
-
-
- HY-W022593
-
-
- HY-W011567
-
-
- HY-140510
-
-
- HY-B2188
-
-
- HY-132103
-
-
- HY-N9520
-
-
- HY-146626S
-
-
- HY-N8448
-
|
3,4-Di-O-caffeoyl quinic acid methyl ester
Macroantoin F
|
RSV
|
Infection
|
|
3,4-Di-O-caffeoyl quinic acid methyl ester (Macroantoin F) is a dicaffeoyl derivative isolated from the rhizome of Elephantopus scaber Linn. 3,4-Di-O-caffeoyl quinic acid methyl ester exhibited in vitro antiviral activity against respiratory syncytial virus (< a href=" " class="link-product" target="_blank">RSV) with an IC50 value of 0.78 μg/mL.
|
-
- HY-N10907
-
|
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl-
|
Bacterial
|
Infection
|
|
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2) is a quinolone alkaloid that can be isolated from Cnidium. 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- has methicillin-resistant Staphylococcus aureus (MRSA) activity, with MIC values of 32 μg/mL (ATCC 33591) and 16 μM/mL (ATCC 25923), respectively.
|
-
- HY-W214059S
-
-
- HY-W009757
-
-
- HY-W006152
-
-
- HY-N10799
-
-
- HY-101671
-
-
- HY-N10015
-
-
- HY-142283CS
-
|
N-Methyl-dosimertinib-d5
|
EGFR
|
Cancer
|
|
N-Methyl-dosimertinib-d5 is the deuterium labeled of Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
|
-
- HY-141049
-
-
- HY-141072
-
-
- HY-140010
-
-
- HY-W134546S
-
-
- HY-121356S1
-
|
Carebastine-d5 Methyl Ester
|
Histamine Receptor
|
Cancer
Endocrinology
|
|
Carebastine-d5 Methyl Ester is the deuterium labeled Carebastine. Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].
|
-
- HY-41051
-
-
- HY-N9530
-
|
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
|
Acyltransferase
Angiotensin Receptor
Bacterial
|
Infection
Metabolic Disease
Cardiovascular Disease
|
|
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL.
|
-
- HY-P1005
-
-
- HY-N7116
-
|
Lawsone methyl ether
2-Methoxy-1,4-naphthoquinone
|
Fungal
Bacterial
|
Infection
|
|
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities.
|
-
- HY-113468
-
|
3-O-Methyl-DL-DOPA
3-Methoxytyrosine
|
Endogenous Metabolite
|
Neurological Disease
|
|
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency.
|
-
- HY-W012000
-
-
- HY-N0707
-
-
- HY-W035378
-
-
- HY-14397S1
-
|
Indomethacin-d4 Methyl Ester
|
COX
Autophagy
|
Cancer
Inflammation/Immunology
|
|
Indomethacin-d4 Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].
|
-
- HY-141472
-
-
- HY-147091
-
-
- HY-W040438
-
-
- HY-W067091
-
-
- HY-B0949S
-
|
Protriptyline (N-methyl-d3) (hydrochloride)
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Protriptyline (N-methyl-d3) (hydrochloride) is the deuterium labeled Protriptyline hydrochloride. Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect[1].
|
-
- HY-B0617
-
|
S-Adenosyl-L-methionine
S-Adenosyl methionine; Ademetionine; AdoMet
|
Endogenous Metabolite
|
Cancer
Inflammation/Immunology
Neurological Disease
|
|
S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research.
|
-
- HY-16724
-
|
Indoximod
1-methyl-D-tryptophan; NLG-8189
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
|
Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer.
|
-
- HY-78907
-
-
- HY-34470
-
-
- HY-16986
-
|
EPZ011989
|
Histone Methyltransferase
|
Cancer
|
|
EPZ011989 is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor with metabolic stability. EPZ011989 has inhibitory inhibition for EZH2 with a Ki value of <3 nM. EPZ011989 shows robust methyl mark inhibition and anti-tumor activity. EPZ011989 can be used for the research of various cancers.
|
-
- HY-132158
-
-
- HY-22002
-
-
- HY-N8100
-
-
- HY-P1206
-
|
CH 275
|
Somatostatin Receptor
|
Neurological Disease
|
|
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM. CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively. CH 275 can be used for the research of alzheimer’s disease.
|
-
- HY-W036329
-
-
- HY-W048708
-
-
- HY-16986A
-
|
EPZ011989 trifluoroacetate
EPZ-011989 trifluoroacetate
|
Histone Methyltransferase
|
Cancer
|
|
EPZ-011989 trifluoroacetate is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor with metabolic stability. EPZ-011989 trifluoroacetate has inhibitory inhibition for EZH2 with a Ki value of <3 nM. EPZ-011989 trifluoroacetate shows robust methyl mark inhibition and anti-tumor activity. EPZ-011989 trifluoroacetate can be used for the research of various cancers.
|
-
- HY-79513
-
-
- HY-W002481
-
-
- HY-N9210
-
-
- HY-141062
-
-
- HY-W011088
-
-
- HY-W015912
-
|
2-Acetylfuran
2-Furyl methyl ketone
|
Others
|
Others
|
|
2-Acetylfuran (2-Furyl methyl ketone), an important flavour compound or intermediate in foods, is isolated from essential oils, sweet corn products, fruits and flowers. 2-Acetylfuran also can be formed from glucose and glycine by Maillard reaction. 2-Acetylfuran can be used to synthesis Cefuroxime.
|
-
- HY-N8132
-
-
- HY-21577
-
-
- HY-A0150
-
|
Alclometasone
7a-Chloro-16a-methyl prednisolone
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis.
|
-
- HY-N8093
-
-
- HY-147338
-
|
5-Methylcytidine 5′-triphosphate
5-methyl-CTP
|
DNA/RNA Synthesis
|
Others
|
|
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) is a modified nucleoside triphosphates. 5-Methylcytidine 5′-triphosphate can apply in replacing unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells.
|
-
- HY-133776
-
|
Rivastigmine carbamate impurity
3-Nitrophenyl ethyl(methyl)carbamate
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively.
|
-
- HY-113046S
-
|
5-Methyltetrahydrofolic acid-13C5
5-methyl THF-13C5
|
Endogenous Metabolite
|
Metabolic Disease
|
|
5-Methyltetrahydrofolic acid- 13C5 is the 13C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].
|
-
- HY-139100
-
-
- HY-N0655
-
-
- HY-W036322
-
-
- HY-W036324
-
-
- HY-76326S
-
-
- HY-W082452S
-
-
- HY-139100B
-
-
- HY-147338A
-
|
5-Methylcytidine 5′-triphosphate trisodium
5-methyl-CTP trisodium
|
DNA/RNA Synthesis
|
Others
|
|
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5′-triphosphate trisodium can apply in replacing unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells.
|
-
- HY-134393B
-
|
6-Me-ATP trisodium
N6-methyl-ATP trisodium
|
GSK-3
|
Others
|
|
6-Me-ATP (N6-Methyl-ATP) trisodium is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide.
|
-
- HY-I0102
-
-
- HY-133897
-
-
- HY-N8114
-
-
- HY-N10931
-
-
- HY-W036333
-
-
- HY-I0749A
-
-
- HY-N0707S
-
|
(S)-Indoximod-d3
1-methyl-L-tryptophan-d3; (S)-NLG-8189-d3
|
Indoleamine 2,3-Dioxygenase (IDO)
|
|
|
(S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].
|
-
- HY-79417
-
-
- HY-W036320
-
-
- HY-W570884
-
-
- HY-Y0958
-
|
Methoxyamine hydrochloride
O-methylhydroxylamine hydrochloride
|
Others
|
Others
|
|
Methoxyamine (O-Methylhydroxylamine) hydrochloride is a reagent in the preparation of O-methyl oximes or synthesis of O-methyl oximes from aldehydes.
|
-
- HY-111112S
-
-
- HY-N0402
-
|
Artemether
Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224
|
Parasite
|
Infection
Cancer
|
|
Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
|
-
- HY-146708S
-
|
((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate-15N4 sodium
|
Isotope-Labeled Compounds
|
Others
|
|
((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate- 15N4 (sodium) is a 15N-labeled ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (so
|
-
- HY-N1937
-
|
Pristimerin
Celastrol methyl ester
|
Bacterial
|
Cancer
|
|
Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC50 of 93 nM.
|
-
- HY-134828
-
|
AZ506
|
Histone Methyltransferase
|
Cancer
|
|
AZ506 is a potent SMYD2 inhibitor with an IC50 of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal.
|
-
- HY-146651
-
-
- HY-N3029
-
|
Noreugenin
|
Others
|
Others
|
|
Noreugenin, 5,7-dihydroxy-2-methyl-4H-chromen-4-one, is a new chromone from Aloe arborescens. (Amaryllidaceae).
|
-
- HY-76633
-
-
- HY-N0080
-
|
Ulopterol
Peucedanol methyl ether
|
Bacterial
Fungal
|
Infection
|
|
Ulopterol is a coumarin isolated from the leaves of Toddalia asiatica (L.) Lam with potent antibacterial and antifungal activities.
|
-
- HY-116015
-
-
- HY-N8162
-
-
- HY-W354821
-
-
- HY-A0195
-
|
Carboprost tromethamine
|
Prostaglandin Receptor
|
Endocrinology
|
|
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F2α. Carboprost tromethamine can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery.
|
-
- HY-100807
-
-
- HY-128921
-
-
- HY-W279140S
-
-
- HY-D1045A
-
|
Dabcyl acid sodium
DABCYL sodium; Para-methyl red sodium
|
Fluorescent Dye
|
Others
|
|
Dabcyl acid sodium (DABCYL sodium) is a nonfluorescent chromophore and a quencher. Dabcyl acid sodium can be used as molecular beacon nucleic acid probes to recognize and report the presence of specific nucleic acids in homogeneous solutions.
|
-
- HY-D1614
-
|
BODIPY 493/503 methyl bromide
|
Fluorescent Dye
|
Others
|
|
BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells.
|
-
- HY-18729A
-
|
L-NAME hydrochloride
NG-Nitroarginine methyl ester hydrochloride
|
NO Synthase
|
Cancer
|
|
L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
|
-
- HY-N1157
-
-
- HY-101969
-
-
- HY-D1045
-
-
- HY-17551
-
-
- HY-34204
-
|
2'-Hydroxy-4'-methylacetophenone
|
Parasite
|
Others
|
|
2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots possesses acaricidal property. It could be used in the preparation of 4’-methyl-2’-[(p-tolylsulfonyl) oxy] acetophenone.
|
-
- HY-115521
-
|
Jarin-1
|
Others
|
Others
|
|
Jarin-1 is a jasmonic acid-amido synthetase (JAR1) inhibitor with an IC50 of 3.8 μM. Jarin-1 specific inhibits bioactive JA (jasmonoyl-isoleucine, JA-Ile) biosynthesis in Arabidopsis and other plants.
|
-
- HY-W017163
-
-
- HY-W009247S
-
-
- HY-131394
-
|
5-Hydroxymethyl-2’-deoxycytidine
5hmdC
|
Others
|
Cancer
|
|
5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells.
|
-
- HY-100807S
-
-
- HY-15449
-
-
- HY-103638A
-
-
- HY-N1019
-
|
11-Hydroxyhumantenine
N-methyl-11-hydroxyrankinidine
|
Others
|
Others
|
|
11-Hydroxyhumantenine is an alkaloid compound isolated from the EtOH extract of the stems of Gelsemium elegans.
|
-
- HY-79256
-
|
MMAF-OMe
Monomethyl auristatin F methyl ester
|
ADC Cytotoxin
|
Cancer
|
|
MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4 -) cell lines, respectively.
|
-
- HY-103638
-
-
- HY-N0483
-
|
Phillygenin
Phillygenol; Epipinoresinol methyl ether; (+)-Phillygenin
|
Reactive Oxygen Species
|
Others
|
|
Phillygenin (Phillygenol) is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation.
|
-
- HY-W015641
-
-
- HY-19391
-
-
- HY-N4286
-
|
4-Methyldaphnetin
|
Apoptosis
|
Cancer
|
|
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation.
|
-
- HY-W008235
-
-
- HY-121267S1
-
-
- HY-W008558
-
-
- HY-33549S
-
-
- HY-B0035S2
-
-
- HY-147260
-
|
Dalzanemdor
SAGE-718
|
iGluR
|
Others
|
|
Dalzanemdor (SAGE-718) is a N-methyl-D-aspartate (NMDA) receptor positive allosteric modulator.
|
-
- HY-E70081
-
|
mRNA Cap 2'-O-methyltransferase
|
Biochemical Assay Reagents
|
Others
|
|
mRNA Cap 2'-O-methyltransferase uses S-adenosylmethionine (SAM) as a methyl donor to add a methyl group at the 2'-O position of the first nucleotide at the 5’ end of Cap-0 mRNA, resulting in Cap-1 structure. Cap-1 structure promotes translation efficiency, increasing subsequent protein expression.
|
-
- HY-W010435
-
-
- HY-16728
-
|
Rapastinel
GLYX-13
|
iGluR
|
Neurological Disease
|
|
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.
|
-
- HY-W008097
-
-
- HY-B1874S
-
-
- HY-N2311
-
|
Ibotenic acid
(RS)-Ibotenic acid; DL-Ibotenic acid
|
iGluR
|
Neurological Disease
|
|
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
|
-
- HY-W017770
-
-
- HY-15079
-
|
Talampanel
GYKI-53773; LY-300164
|
iGluR
Apoptosis
|
Neurological Disease
Cancer
|
|
Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain.
|
-
- HY-13337
-
|
BMS-986094
INX-08189
|
HCV
|
Infection
|
|
BMS-986094 (INX-08189) is a potent inhibitor of hepatitis C virus (HCV) replication, with an EC50 of 35 nM at 24 h in Huh-7 cells. BMS-986094 is a phosphoramidate prodrug of 6-O-methyl-2’-C-methyl guanosine. BMS-986094 can be used for the research of chronic HCV infection.
|
-
- HY-148038
-
|
5-HT3 antagonist 5
|
5-HT Receptor
|
Neurological Disease
|
|
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.
|
-
- HY-B0184A
-
|
Felbamate hydrate
W-554 hydrate; ADD-03055 hydrate
|
iGluR
|
Neurological Disease
|
|
Felbamate hydrate (W-554 hydrate) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .
|
-
- HY-B0184
-
|
Felbamate
W-554; ADD-03055
|
iGluR
|
Neurological Disease
|
|
Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).
|
-
- HY-78086
-
|
m-Tolualdehyde
3-methylbenzaldehyde
|
Endogenous Metabolite
|
Others
|
|
m-Tolualdehyde (3-Methylbenzaldehyde) is a tolualdehyde compound with the methyl substituent at the 3-position. m-Tolualdehyde can be used as a food additive.
|
-
- HY-141217
-
-
- HY-N0560
-
-
- HY-B1076
-
-
- HY-W007355
-
-
- HY-B0903
-
|
Hexylene glycol
2-methyl-2,4-pentanediol; MPD
|
Biochemical Assay Reagents
|
Others
|
|
Hexylene glycol is a small molecular weight surfactant, widely used as an industrial coating solvent, does not cause adverse health or environmental effects.
|
-
- HY-P1729
-
-
- HY-W008507S1
-
-
- HY-16510A
-
-
- HY-16510
-
-
- HY-41494
-
|
o-Toluic acid
2-methylbenzoic acid
|
Endogenous Metabolite
|
Others
|
|
o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
|
-
- HY-Y0966
-
-
- HY-14614D
-
-
- HY-W018171
-
|
3,5,6-Trichloro-2-pyridinol
TCPy
|
Others
|
Others
|
|
3,5,6-Trichloro-2-pyridinol (TCPy) is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and Chlorpyrifos-methyl.
|
-
- HY-100667
-
|
UBP608
|
iGluR
|
Neurological Disease
|
|
UBP608 is a potent N-Methyl-D-aspartate receptors (NMDARs) negative allosteric modulator. UBP608 has the potential for the research of neurological disorders.
|
-
- HY-N2370
-
-
- HY-N4129
-
-
- HY-Y1144
-
-
- HY-N2210
-
-
- HY-N7509
-
|
2,3-Dihydroxy-4-methoxyacetophenone
Gallacetophenone-4-methyl ether
|
Others
|
Neurological Disease
|
|
2,3-Dihydroxy-4-methoxyacetophenone is a neuroprotective compound from Cynenchum paniculatum. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may has the potential for the treatment of Alzheimer's disease research.
|
-
- HY-122742
-
|
HBT1
|
iGluR
|
Neurological Disease
|
|
HBT1 is a potent α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiator. HBT1 bonds with S518 in the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. HBT1 did not show remarkable bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons.
|
-
- HY-113084
-
-
- HY-109164
-
|
Zelquistinel
AGN-241751; GATE-251
|
iGluR
|
Neurological Disease
|
|
Zelquistinel (AGN-241751) is a N-methyl-D-aspartate (NMDA) receptor partial agonist used for the research of depression, anxiety and other related psychiatric disorders.
|
-
- HY-107040
-
|
Etoxadrol
NSC 288020; CL-1848C
|
Others
|
Others
|
|
Etoxadrol (CL-1848C) is a potent N-methyl-D-aspartic acid (NMDA) antagonist with high affinity. Etoxadrol can be used for anaesthetic research.
|
-
- HY-N0402S
-
|
Artemether-d3
Dihydroqinghaosu methyl ether-d3; Dihydroartemisinin methyl ether-d3; SM224-d3
|
Parasite
|
Infection
Cancer
|
|
Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
|
-
- HY-N2432
-
|
Paederoside
|
HBV
|
Cancer
Infection
|
|
Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa. Paederoside shows a high anti-tumor promoting activity against the Epstein-Barr virus activation.
|
-
- HY-P3066
-
-
- HY-107702
-
|
CGP 37849
|
iGluR
|
Neurological Disease
|
|
CGP 37849 is a potent, competitive and orally active N-methyl-D-aspartate (NMDA) receptor antagonist. CGP 37849 is an anticonvulsant in rodents and has antidepressant and anxiolytic-like effects.
|
-
- HY-139580
-
|
Plazinemdor
|
iGluR
|
Neurological Disease
|
|
Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system..
|
-
- HY-W048688
-
-
- HY-141637S1
-
-
- HY-W010591
-
-
- HY-A0104
-
|
Hypromellose
(Hydroxypropyl)methyl cellulose; HPMC; Celacol HPM 5000
|
Others
|
Others
|
|
Hypromellose is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices.
|
-
- HY-126382
-
|
Hesperidin methylchalcone
|
NF-κB
|
Inflammation/Immunology
|
|
Hesperidin methylchalcone (Hesperidin methyl chalcone) inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone inhibits inflammation and pain. Hesperidin methylchalcone exhibits vasoprotective activity.
|
-
- HY-17001
-
-
- HY-106441A
-
|
Rislenemdaz
MK-0657; CERC-301
|
iGluR
|
Neurological Disease
|
|
Rislenemdaz (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM, respectively.
|
-
- HY-15084A
-
|
(-)-Dizocilpine maleate
(-)-MK-801 maleate
|
iGluR
|
Neurological Disease
|
|
(-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects.
|
-
- HY-Y0966S10
-
|
Glycine-d3
|
Endogenous Metabolite
iGluR
|
Cancer
|
|
Glycine-d3 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-Y0966S8
-
|
Glycine-d5
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-d5 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-Y0966S1
-
|
Glycine-d2
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-d2 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-W006416
-
|
1,2,3,4-Tetramethylbenzene
|
Others
|
Others
|
|
1,2,3,4-Tetramethylbenzene consists of a benzene ring with four methyl groups (-CH3) as a substituent. 1,2,3,4-Tetramethylbenzene is a specialty product for biochemistry research.
|
-
- HY-N1393
-
|
2-Methoxybenzoic acid
NSC 3778; O-methylsalicylic acid; Salicylic acid methyl ether
|
Endogenous Metabolite
|
Cancer
|
|
2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
|
-
- HY-113416AS
-
-
- HY-111879
-
|
Biotin-BS
|
SNIPERs
|
Cancer
|
|
Biotin-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase.
|
-
- HY-15839
-
-
- HY-45609
-
-
- HY-111878
-
|
BzNH-BS
|
SNIPERs
|
Cancer
|
|
BzNH-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase.
|
-
- HY-B0361S1
-
|
Aspartame-d5
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Aspartame-d5 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
|
-
- HY-D1416
-
|
HMBR
|
Fluorescent Dye
|
Others
|
|
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant.
|
-
- HY-123538
-
-
- HY-B0361S
-
|
Aspartame-d3
SC-18862-d3
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Aspartame-d3 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
|
-
- HY-Y0966S3
-
|
Glycine-13C2
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine- 13C2 is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-U00090
-
-
- HY-N1436
-
|
L-(+)-Abrine
L-Abrine; L-N-methyltryptophan; N-α-methyl-L-tryptophan
|
Others
|
Inflammation/Immunology
|
|
L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.
|
-
- HY-113468A
-
-
- HY-Y0966S2
-
|
Glycine-2-13C
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-2- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-P7060
-
|
NT 13
TPPT
|
iGluR
|
Neurological Disease
|
|
NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.
|
-
- HY-Y0966S4
-
|
Glycine-1-13C
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-1- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-129692
-
|
Withanone
|
iGluR
|
Neurological Disease
|
|
Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells.
|
-
- HY-Y0966S
-
|
Glycine-15N
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine- 15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].
|
-
- HY-B0184S
-
|
Felbamate-d4
|
iGluR
|
Neurological Disease
|
|
Felbamate-d4 (W-554-d4) is the deuterium labeled Felbamate. Felbamate (W-554) is a potent anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).
|
-
- HY-10711A
-
|
ALX-5407 hydrochloride
(R)-NFPS hydrochloride
|
GlyT
|
Neurological Disease
|
|
ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia.
|
-
- HY-101036
-
|
Choline bitartrate
|
mAChR
Endogenous Metabolite
|
Neurological Disease
Cancer
|
|
Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders. Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
|
-
- HY-127039
-
-
- HY-127034
-
-
- HY-151556
-
|
Antifungal agent 45
|
Fungal
|
Infection
|
|
Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC50 value of about 5 μM.
|
-
- HY-N4128
-
|
4''-methyloxy-Daidzin
Daidzein 7-O-Β-D-glucoside 4''-O-methylate
|
Others
|
Inflammation/Immunology
|
|
4''-methyloxy-Daidzin (Daidzein 7-O-Β-D-glucoside 4''-O-methylate), an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities.
|
-
- HY-B1487
-
|
Procyclidine hydrochloride
Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride
|
iGluR
mAChR
|
Neurological Disease
|
|
Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy.
|
-
- HY-B1487A
-
|
Procyclidine
Tricyclamol; (±)-Procyclidine
|
mAChR
iGluR
|
Neurological Disease
|
|
Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy.
|
-
- HY-103638S
-
-
- HY-W016622
-
|
Watermelon ketone
7-methyl-2H-1,5-benzodioxepin-3(4H)-one
|
Others
|
Others
|
|
Watermelon ketone is fragrance chemical compound with special odorant which has been widely used in the fragrance industry, extracted from patent CN 103058984 A.
|
-
- HY-Y0966S9
-
|
Glycine-15N,d2
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine- 15N,d2 is the deuterium and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-115545
-
|
DBCO-NHS ester 3
|
ADC Linker
|
Cancer
|
|
DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC).
|
-
- HY-Y0966S6
-
|
Glycine-13C2,15N
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine- 13C2, 15N is the 13C- and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-135859
-
|
NH2-MPAA-NODA
|
ADC Linker
|
Cancer
|
|
NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone. NH2-MPAA-NODA can be used as a radiolabel by labeling with 18F-fluoride.
|
-
- HY-B0479
-
|
Thiamphenicol
Thiophenicol; Dextrosulphenidol
|
Bacterial
Antibiotic
|
Infection
|
|
Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria).
|
-
- HY-106408A
-
|
Nelonemdaz potassium
Salfaprodil; Neu2000 potassium
|
iGluR
|
Neurological Disease
|
|
Nelonemdaz (Salfaprodil) potassium is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz potassium is also a free radical scavenger. Nelonemdaz potassium has excellent neuroprotection against NMDA- and free radical-induced cell death.
|
-
- HY-Y0966S7
-
|
Glycine-2-13C,15N
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-2- 13C, 15N is the 13C- and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-N11061
-
|
Withaphysalin D
|
iGluR
|
Neurological Disease
|
|
Withaphysalin D is a selective antagonist against the N-methyl-D-aspartate receptor (NMDAR) containing GluN2B. Withaphysalin D can be isolated from water lilies and has neuroprotective properties. Withaphysalin D is able to cross the blood-brain barrier.
|
-
- HY-126220
-
|
KMG-301AM
|
Others
|
Others
|
|
KMG-301AM is the acetoxy methyl esterified form of KMG-301. Stained with KMG-301AM, Time-course and pseudo-colored images of the change in the fluorescence of KMG-301 in isolated mitochondria can be acquired.
|
-
- HY-Y0966S5
-
|
Glycine-1-13C,15N
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-1- 13C, 15N is the 13C- and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-139048A
-
|
Fluoroethylnormemantine hydrochloride
|
iGluR
|
Neurological Disease
|
|
Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [ 18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects.
|
-
- HY-139048
-
|
Fluoroethylnormemantine
|
iGluR
|
Neurological Disease
|
|
Fluoroethylnormemantine, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [ 18F]-Fluoroethylnormemantine can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects.
|
-
- HY-P1293
-
|
Conantokin G
|
iGluR
|
Neurological Disease
|
|
Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC50 of 480 nM. Conantokin G has neuroprotective properties.
|
-
- HY-106405
-
|
Nebicapone
BIA 3-202
|
COMT
|
Metabolic Disease
|
|
Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease.
|
-
- HY-U00323
-
|
Carbazole derivative 1
2-Fluoro-7-[(3-pyridinyl)methyl]-9H-carbazole
|
Others
|
Endocrinology
|
|
Carbazole derivative 1 is a carbazole derivative which can be used to reduce androgen or oestrogen levels in mammals, including humans.
|
-
- HY-109097
-
|
Otaplimastat
SP-8203
|
MMP
iGluR
|
Neurological Disease
|
|
Otaplimastat (SP-8203), a matrix metalloproteinase (MMP) inhibitor, blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in a competitive manner. Otaplimastat also exhibits anti-oxidant activity. Otaplimastat can be used for the research of brain ischemic injury.
|
-
- HY-107703
-
|
CGP 39551
|
iGluR
|
Neurological Disease
|
|
CGP 39551 is a potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potent anticonvulsant activity. CGP 39551 shows measurable inhibitory activity at both L-[ 3H]-glutamate (Ki=8.4 μM).
|
-
- HY-106408
-
|
Nelonemdaz
Salfaprodil free base; Neu2000
|
iGluR
|
Neurological Disease
|
|
Nelonemdaz (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz is also a free radical scavenger. Nelonemdaz has excellent neuroprotection against NMDA- and free radical-induced cell death.
|
-
- HY-P3990
-
|
Coibamide A
|
VEGFR
Autophagy
Apoptosis
|
Cancer
|
|
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts.
|
-
- HY-136299A
-
|
Sepimostat dimethanesulfonate
FUT-187
|
iGluR
|
Neurological Disease
|
|
Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 µM.
|
-
- HY-100714
-
-
- HY-136299
-
|
Sepimostat
FUT-187 free base
|
iGluR
|
Neurological Disease
|
|
Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM.
|
-
- HY-151445
-
|
ZIKV-IN-2
|
DNA Methyltransferase
Virus Protease
|
Infection
|
|
ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV).
|
-
- HY-N4278
-
|
Huangjiangsu A
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin, isolated from D. villosa.
Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation and could be promising as potential therapeutic agents for liver diseases.
|
-
- HY-100832
-
|
UNC3866
|
Histone Methyltransferase
|
Cancer
|
|
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.
|
-
- HY-114869
-
|
DPQ
|
PARP
|
Neurological Disease
|
|
DPQ is a potent PARP-1 inhibitor. DPQ can reduce the N-methyl-d-aspartate (NMDA)-induced PARP activation, restoring ATP to near control levels and significantly attenuating neuronal injury in the severe NMDA exposure model. DPQ can be used for researching neuroprotection.
|
-
- HY-151555
-
|
Antifungal agent 44
|
Fungal
|
Infection
|
|
Antifungal agent 44 (compound 2A-5) is an antifungal agent, and shows excellent fungicidal activity superior to Kresoxim-methyl (HY-125776). Antifungal agent 44 shows fungicidal activity against Phytophthora capsici most remarkably, with an EC50 value of about 5 μM.
|
-
- HY-101037
-
|
Sarcosine
N-methylglycine; Sarcosin
|
Endogenous Metabolite
GlyT
|
Cancer
|
|
Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia.
|
-
- HY-151446
-
|
ZIKV-IN-3
|
DNA Methyltransferase
Virus Protease
|
Infection
|
|
ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV).
|
-
- HY-107031
-
|
Metapramine
19560 RP
|
iGluR
Others
|
Others
|
|
Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel.
|
-
- HY-P1293A
-
|
Conantokin G TFA
|
iGluR
|
Neurological Disease
|
|
Conantokin G TFA, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G TFA inhibits NMDA-evoked currents in murine cortical neurons with an IC50 of 480 nM. Conantokin G TFA has neuroprotective properties.
|
-
- HY-W105505
-
-
- HY-101178
-
|
L-689560
|
iGluR
|
Neurological Disease
|
|
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases.
|
-
- HY-Y1314
-
|
Dimethyl sulfone
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective.
|
-
- HY-P3679
-
|
Neuropeptide Y (1-24) (human)
|
Neuropeptide Y Receptor
|
|
|
Neuropeptide Y (1-24) (human) is a neuropeptide with potencies in inhibiting the electricity stimulated twitch response of rat vas deferens. Neuropeptide Y (1-24) (human) stimulates N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus in vivo.
|
-
- HY-Z1430S
-
-
- HY-130592
-
|
Compound 48/80 trihydrochloride
C48/80 trihydrochloride
|
Phospholipase
|
Neurological Disease
|
|
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
|
-
- HY-123561
-
|
MMV008138
|
Parasite
|
Infection
|
|
MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM.
|
-
- HY-B0479S
-
|
Thiamphenicol-d3
Thiophenicol-d3; Dextrosulphenidol-d3
|
Bacterial
Antibiotic
|
Infection
|
|
Thiamphenicol-d3 is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].
|
-
- HY-18759
-
|
BMS-751324
|
p38 MAPK
TNF Receptor
|
Inflammation/Immunology
|
|
BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model.
|
-
- HY-N7135
-
|
Tropolone
|
Tyrosinase
|
Others
|
|
Tropolone, a tropone derivative with a hydroxyl group in the 2-position, is a precursor of manyazulene derivatives such as methyl 2-methylazulene-1-carboxylate. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC50 of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU 2+.
|
-
- HY-B0617A
-
|
S-Adenosyl-L-methionine tosylate
S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate
|
Endogenous Metabolite
|
Cancer
Inflammation/Immunology
Neurological Disease
|
|
S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.
|
-
- HY-P3124
-
|
BIM-23190
|
Somatostatin Receptor
|
Cancer
|
|
BIM-23190, a somatostatin analog, a selective SSTR2 and SSTR5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.
|
-
- HY-P3124A
-
|
BIM-23190 hydrochloride
|
Somatostatin Receptor
|
Cancer
|
|
BIM-23190 hydrochloride, a somatostatin analog, a selective SSRT2 and SSRT5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.
|
-
- HY-16938
-
|
5'-Methylthioadenosine
5'-(methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-methyl-5'-thioadenosine
|
Endogenous Metabolite
Apoptosis
Parasite
|
Cancer
Metabolic Disease
|
|
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
|
-
- HY-P1287
-
|
Conantokin-T
|
iGluR
|
Neurological Disease
|
|
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa.
|
-
- HY-136976
-
|
WST-1
|
Fluorescent Dye
|
|
|
WST-1 is a kind of water-soluble tetrazolium salt. WST induces the intracellular mitochondrial dehydrogenase to conduct NADH-dependent enzyme digestion reaction, releasing the water-soluble methyl benzene product. WST-1 can be used for the detection of cell proliferation and cytotoxicity, via the determination of the light absorption value at 450 nm.
|
-
- HY-N0315
-
|
Allicin
Diallyl thiosulfinate
|
Bacterial
Antibiotic
|
Infection
|
|
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains.
|
-
- HY-101037S1
-
|
Sarcosine-d3
N-methylglycine-d3; Sarcosin-d3
|
Endogenous Metabolite
GlyT
|
Cancer
|
|
Sarcosine-d3 is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
|
-
- HY-18641
-
|
Ki16198
|
LPL Receptor
|
Cancer
|
|
Ki16198 is a potent and orally active LPA receptor antagonist, the methyl ester of Ki16425 (HY-13285). Ki16198 inhibits LPA1 and LPA3-induced inositol phosphate production with Ki values of 0.34 μM and 0.93 μM, respectively. Ki16198 is effective for pancreatic cancer tumorigenesis and metastasis in vivo.
|
-
- HY-N6704
-
|
Enniatin A1
|
ERK
Apoptosis
|
Cancer
|
|
Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes.
|
-
- HY-136153
-
|
Amphotericin X1
|
Fungal
|
Infection
|
|
Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively.
|
-
- HY-E70007
-
|
Catechol O-methyltransferase
COMT
|
Endogenous Metabolite
|
Neurological Disease
|
|
Catechol O-methyltransferase (COMT) the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain.
|
-
- HY-108706
-
|
KDM2A/7A-IN-1
|
Histone Demethylase
|
Cancer
|
|
KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases.
|
-
- HY-G0021
-
|
N-Desmethylclozapine
Norclozapine; Desmethylclozapine; Normethylclozapine
|
mAChR
Opioid Receptor
Drug Metabolite
Virus Protease
|
Infection
|
|
N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.
|
-
- HY-101037S
-
|
Sarcosine-15N
N-methylglycine-15N; Sarcosin-15N
|
Endogenous Metabolite
GlyT
|
Cancer
|
|
Sarcosine- 15N is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
|
-
- HY-W007355S1
-
-
- HY-15029S1
-
-
- HY-79576S
-
-
- HY-W007355S
-
-
- HY-100822
-
|
(R)-(+)-HA-966
(+)-HA-966
|
iGluR
|
Neurological Disease
|
|
(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.
|
-
- HY-101761
-
|
TM5441
|
PAI-1
Apoptosis
|
Cancer
|
|
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence.
|
-
- HY-17387
-
|
(-)-Huperzine A
Huperzine A
|
Cholinesterase (ChE)
Apoptosis
iGluR
|
Neurological Disease
|
|
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.
|
-
- HY-100811
-
|
7-Chlorokynurenic acid
7-CKA
|
iGluR
|
Neurological Disease
|
|
7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.
|
-
- HY-W001601
-
|
Budipine
|
iGluR
|
Neurological Disease
|
|
Budipine is an anti-parkinson agent. Budipine also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine can be used for the research of CNS disorders include Parkinson disease.
|
-
- HY-D1346
-
|
610CP
|
Fluorescent Dye
|
Others
|
|
610CP is a new type of actin labeling dye. It dissolves in organic solvents. In DMSO? the 610CP excitation/emission wavelength is between 609 and 634 nm. 610CP is a fluorescent dye that penetrates living cells. Upon cell entry, 610CP binds to Bromo-des-methyl-Jasplakinolide Therefore, 610CP dye can be used to stain actin fluorescence images with low background and high resolution.
|
-
- HY-100811A
-
|
7-Chlorokynurenic acid sodium salt
7-CKA sodium salt
|
iGluR
|
Neurological Disease
|
|
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery.
|
-
- HY-131031
-
|
KCC-07
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
KCC-07 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity.
|
-
- HY-G0021S
-
|
N-Desmethylclozapine-d8
Norclozapine-d8; Desmethylclozapine-d8; Normethylclozapine-d8
|
mAChR
Opioid Receptor
Drug Metabolite
Virus Protease
|
Infection
|
|
N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].
|
-
- HY-G0021S1
-
|
N-Desmethylclozapine-d8 hydrochloride
Norclozapine-d8 (hydrochloride); Desmethylclozapine-d8 (hydrochloride); Normethylclozapine-d8 (hydrochloride)
|
mAChR
Opioid Receptor
Drug Metabolite
Virus Protease
|
Infection
|
|
N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].
|
-
- HY-N7040
-
|
11-Deoxymogroside IIE
|
HSV
|
Infection
|
|
11-Deoxymogroside IIE is a cucurbitane glycoside, isolated from Siraitia grosvenorii fruits.
11-Deoxymogroside IIE has inhibitory effect against Epstein Barr virus (EBV-EA) activation induced by TPA, shows weak inhibitory effect on (+/-)-(E)-methyl1-2-[E-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR1), a NO donor.
|
-
- HY-Z2106S
-
-
- HY-113468AS
-
-
- HY-76779
-
|
4-(Chloromethyl)-7-hydroxycoumarin
|
Others
|
Cancer
|
|
4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII.
|
-
- HY-D0989
-
|
Rhod-2 AM
|
Fluorescent Dye
|
Others
|
|
Rhod-2 is a high-affinity visible light excitation wavelength CaCa 2+ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm.
|
-
- HY-N0215
-
|
L-Phenylalanine
Phenylalanine
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca + channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
|
-
- HY-N0215S6
-
|
DL-Phenylalanine-d5 hydrochloride
2-Amino-3-phenylpropionic acid-d5 (hydrochloride)
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Phenylalanine-d5 (hydrochloride) is the deuterium labeled DL-Phenylalanine hydrochloride. L-Phenylalanine hydrochloride is an essential amino acid isolated from Escherichia coli. L-Phenylalanine hydrochloride is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine hydrochloride is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine hydrochloride is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-115531
-
|
UNC-2170
|
Others
|
Cancer
|
|
UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB).
|
-
- HY-79404
-
-
- HY-148825
-
-
- HY-113468AS1
-
|
3-O-Methyldopa-d3 hydrate
3-Methoxy-L-tyrosine-d3 (hydrate); 3-O-methyl-L-DOPA-d3 (hydrate)
|
Dopamine Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].
|
-
- HY-N0215S13
-
|
L-Phenylalanine-d1
(S)-2-Amino-3-phenylpropionic acid-d1
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-117935
-
|
GGTI-286 hydrochloride
|
Ras
|
Cancer
|
|
GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM.
|
-
- HY-N0215S7
-
|
L-Phenylalanine-3-13C
(S)-2-Amino-3-phenylpropionic acid-3-13C
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-3- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N7041
-
|
11-Oxomogroside IIa
|
HSV
|
Infection
|
|
11-Oxomogroside IIa (11-oxomogroside II A1) is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii.
11-Oxomogroside IIa has inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor.
|
-
- HY-D0825
-
|
CY7
Sulfo-Cyanine7
|
Fluorescent Dye
|
Others
|
|
CY7 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-138200
-
|
Cy5 maleimide
Cyanine5 maleimide
|
Fluorescent Dye
DNA Stain
|
Others
|
|
Cy5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-112498
-
|
Cy3 NHS ester
Cyanine3 NHS ester
|
Fluorescent Dye
|
Others
|
|
Cy3 NHS ester is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-N0215S3
-
|
L-Phenylalanine-d2
(S)-2-Amino-3-phenylpropionic acid-d2
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-d2 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0215S2
-
|
L-Phenylalanine-13C
(S)-2-Amino-3-phenylpropionic acid-13C
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-115489
-
|
GGTI-286
|
Ras
|
Cancer
|
|
GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM.
|
-
- HY-100839
-
|
(RS)-(Tetrazol-5-yl)glycine
D,L-(tetrazol-5-yl)glycine; LY 285265
|
iGluR
|
Neurological Disease
|
|
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice.
|
-
- HY-N0215S
-
|
L-Phenylalanine-d7
(S)-2-Amino-3-phenylpropionic acid-d7
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-d7 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0215S1
-
|
L-Phenylalanine-d8
(S)-2-Amino-3-phenylpropionic acid-d8
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-d8 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0215S5
-
|
L-Phenylalanine-15N
(S)-2-Amino-3-phenylpropionic acid-15N
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 15N is the 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-D0924
-
|
Cy5.5
Sulfo-Cyanine5.5
|
Fluorescent Dye
|
Cancer
Metabolic Disease
Inflammation/Immunology
Neurological Disease
Cardiovascular Disease
|
|
Cy5.5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D0824
-
|
CY7-SE
Sulfo-Cyanine7 Succinimidyl Ester
|
Fluorescent Dye
|
Others
|
|
CY7-SE is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D1054
-
|
Cy2 (iodine)
Cyanine2 (iodine)
|
Fluorescent Dye
|
Others
|
|
Cy2 iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D1565
-
|
Cy7.5 maleimide
|
Fluorescent Dye
|
Others
|
|
Cy7.5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D0821
-
|
CY5
Sulfo-Cyanine5
|
Fluorescent Dye
|
Others
|
|
CY5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-N0215S12
-
|
L-Phenylalanine-d5
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-d5 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0215S8
-
|
L-Phenylalanine-13C6
(S)-2-Amino-3-phenylpropionic acid-13C6
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0215S10
-
|
L-Phenylalanine-13C9
(S)-2-Amino-3-phenylpropionic acid-13C9
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C9 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-D0926
-
|
Cy7.5
|
Fluorescent Dye
|
Others
|
|
Cy7.5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D1323
-
|
Cyanine5.5 maleimide chloride
Cy5.5 maleimide chloride
|
Fluorescent Dye
|
Others
|
|
Cyanine5.5 maleimide chloride is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-34346
-
-
- HY-N0215S11
-
|
L-Phenylalanine-13C9,15N
(S)-2-Amino-3-phenylpropionic acid-13C9,15N
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C9, 15N is the 13C- and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N11009
-
|
11-Oxomogroside II A1
|
EBV
|
Infection
|
|
11-Oxomogroside II A1 (compound 7) is an oxidized cucurbitin. It can be isolated from the ethanol extract of Rohanberry fruit. 11-Oxomogroside II A1 inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-Oxomogroside II A1 also weakly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor.
|
-
- HY-D1566
-
|
Sulfo-Cy7.5 maleimide
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy7.5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D0826
-
|
Cy2-SE (iodine)
Cyanine2 Succinimidyl Ester (iodine)
|
Fluorescent Dye
|
Others
|
|
Cy2-SE iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-115489A
-
|
GGTI-286 TFA
|
Ras
|
Cancer
|
|
GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 TFA selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 μM, respectively). GGTI-286 TFA also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM.
|
-
- HY-N0215S14
-
|
L-Phenylalanine-15N,d8
(S)-2-Amino-3-phenylpropionic acid-15N,d8
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 15N,d8 is the deuterium and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-D0824A
-
|
CY7-SE triethylamine
Sulfo-Cyanine7 Succinimidyl Ester triethylamine
|
Fluorescent Dye
|
Others
|
|
CY7-SE triethylamine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-N0215S9
-
|
L-Phenylalanine-13C9,15N,d8
(S)-2-Amino-3-phenylpropionic acid-13C9,15N,d8
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C9, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-79271
-
-
- HY-W111226
-
|
Fmoc-His(3-Me)-OH
|
Amino Acid Derivatives
Amyloid-β
|
Cardiovascular Disease
|
|
Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca 2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel.
|
| Cat. No. |
Product Name |
Type |
-
- HY-D0163
-
|
Methyl Green
|
DNA Stain
|
|
Methyl Green is a potent fluorescent dye. Methyl Green is a DNA stains of cells and electrophoretic gels. Methyl Green can be used as a stain for direct measuring of viability by both microscopy and flow cytometry, with peaks at 633 and 677 nm.
|
-
- HY-D0003
-
|
Methyl Blue
|
Dyes
|
|
Methyl blue belongs to the group of triaminotriphenylmethane dyes. Methyl blue is widely used as antiseptic dye in polychrome staining method and has applications in histological and microbiological staining solutions. Methyl blue has been used as a model to study the effect of various catalysts on photodegradation of dyes.
|
-
- HY-D0950A
-
|
Methyl Green zinc chloride
|
DNA Stain
|
|
Methyl Green zinc chloride is a potent fluorescent dye. Methyl Green zinc chloride is a DNA stains of cells and electrophoretic gels. Methyl Green zinc chloride can be used as direct measuring of viability by both microscopy and flow cytometry, with peaks at 633 and 677 nm.
|
-
- HY-B0324A
-
|
Crystal Violet
Basic Violet 3; Gentian Violet; methyl Violet 10B
|
Dyes
|
|
Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
|
-
- HY-D0995
-
|
7-Methyl-6-thioguanosine
MESG
|
Chromogenic Substrates
|
|
7-Methyl-6-thioguanosine (MESG) is a chromophoric substrate which can be used for the quantitation of inorganic phosphate. 7-Methyl-6-thioguanosine is also used to determine the activity of purine nucleoside phosphorylase.
|
-
- HY-D1531
-
-
- HY-W402148
-
-
- HY-D0144
-
|
Resorufin methyl ether
Methoxyresorufin
|
Chromogenic Substrates
|
|
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate. Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents.
|
-
- HY-D1585
-
|
BODIPY TR methyl ester
|
Fluorescent Dyes/Probes
|
|
BODIPY TR methyl ester is a lipophilic GFP Counterstain. BODIPY TR methyl ester dye readily permeates cell membranes and localizes in endomembranous organelles but not localize strongly in plasma membranes. BODIPY TR methyl ester is an excellent red fluorescent vital dye (Ex=568 nm, Em=625 nm), can be used to reveal the location and shapes of cell nuclei, the shapes of cells within embryonic tissues, as well as the bound aries of organ-forming tissues within the whole embryo.
|
-
- HY-D0113
-
-
- HY-D1513
-
-
- HY-D1616
-
-
- HY-D1591
-
|
BODIPY R6G methyl ester
|
Fluorescent Dyes/Probes
|
|
BODIPY R6G methyl ester (compound 5′-1) is a BODIPY-like fluorescent dye with good light stability and insensitive to pH value. BODIPY R6G methyl ester shows good photostability, high sensitivity and insensitive to pH value. BODIPY R6G methyl ester can be used in research areas such as photodynamic therapy, PH probes, ion recognition, photocatalysis, protein labeling, cell imaging, and proteomic analysis.
|
-
- HY-147114
-
|
3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin
|
Fluorescent Dyes/Probes
|
|
3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin is a DNA uptake tracer, a pteridine-based fluorescent guanosine analogue. 3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin is widely used in studies of DNA binding and dynamics, with an absorbance maximum at 350 nm and an emission maximum at 430 nm.
|
-
- HY-D0913
-
-
- HY-D0026
-
-
- HY-D1529
-
-
- HY-121030
-
|
DACM
N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide
|
Fluorescent Dyes/Probes
|
|
DACM (N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide) is a thiol-directed fluorescent dye (Ex=396 nm, Em=468 nm).
|
-
- HY-P1003
-
-
- HY-P1005
-
-
- HY-W354821
-
-
- HY-D1045A
-
|
Dabcyl acid sodium
DABCYL sodium; Para-methyl red sodium
|
Fluorescent Dyes/Probes
|
|
Dabcyl acid sodium (DABCYL sodium) is a nonfluorescent chromophore and a quencher. Dabcyl acid sodium can be used as molecular beacon nucleic acid probes to recognize and report the presence of specific nucleic acids in homogeneous solutions.
|
-
- HY-D1614
-
|
BODIPY 493/503 methyl bromide
|
Fluorescent Dyes/Probes
|
|
BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells.
|
-
- HY-D1045
-
-
- HY-D1416
-
|
HMBR
|
Fluorescent Dyes/Probes
|
|
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant.
|
-
- HY-136976
-
|
WST-1
|
Dyes
|
|
WST-1 is a kind of water-soluble tetrazolium salt. WST induces the intracellular mitochondrial dehydrogenase to conduct NADH-dependent enzyme digestion reaction, releasing the water-soluble methyl benzene product. WST-1 can be used for the detection of cell proliferation and cytotoxicity, via the determination of the light absorption value at 450 nm.
|
-
- HY-D1346
-
|
610CP
|
Fluorescent Dyes/Probes
|
|
610CP is a new type of actin labeling dye. It dissolves in organic solvents. In DMSO? the 610CP excitation/emission wavelength is between 609 and 634 nm. 610CP is a fluorescent dye that penetrates living cells. Upon cell entry, 610CP binds to Bromo-des-methyl-Jasplakinolide Therefore, 610CP dye can be used to stain actin fluorescence images with low background and high resolution.
|
-
- HY-D0989
-
|
Rhod-2 AM
|
Fluorescent Dyes/Probes
|
|
Rhod-2 is a high-affinity visible light excitation wavelength CaCa 2+ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm.
|
-
- HY-D0825
-
|
CY7
Sulfo-Cyanine7
|
Fluorescent Dyes/Probes
|
|
CY7 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-138200
-
|
Cy5 maleimide
Cyanine5 maleimide
|
Fluorescent Dyes/Probes
|
|
Cy5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-112498
-
|
Cy3 NHS ester
Cyanine3 NHS ester
|
Fluorescent Dyes/Probes
|
|
Cy3 NHS ester is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D0924
-
|
Cy5.5
Sulfo-Cyanine5.5
|
Fluorescent Dyes/Probes
|
|
Cy5.5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D0824
-
|
CY7-SE
Sulfo-Cyanine7 Succinimidyl Ester
|
Fluorescent Dyes/Probes
|
|
CY7-SE is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D1054
-
|
Cy2 (iodine)
Cyanine2 (iodine)
|
Fluorescent Dyes/Probes
|
|
Cy2 iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D1565
-
|
Cy7.5 maleimide
|
Fluorescent Dyes/Probes
|
|
Cy7.5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D0821
-
|
CY5
Sulfo-Cyanine5
|
Protein Labeling
|
|
CY5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D0926
-
|
Cy7.5
|
Protein Labeling
|
|
Cy7.5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D1323
-
|
Cyanine5.5 maleimide chloride
Cy5.5 maleimide chloride
|
Dyes
|
|
Cyanine5.5 maleimide chloride is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D1566
-
|
Sulfo-Cy7.5 maleimide
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy7.5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
|
-
- HY-D0826
-
|
Cy2-SE (iodine)
Cyanine2 Succinimidyl Ester (iodine)
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Protein Labeling
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Cy2-SE iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
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- HY-D0824A
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CY7-SE triethylamine
Sulfo-Cyanine7 Succinimidyl Ester triethylamine
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Fluorescent Dyes/Probes
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CY7-SE triethylamine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
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| Cat. No. |
Product Name |
Type |
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- HY-101461
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Methyl-β-cyclodextrin
methyl-beta-cyclodextrin
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Co-solvents
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Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic drugs based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis. Methyl-β-cyclodextrin blocks cell migrasome formation.
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- HY-125861
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- HY-W017054
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- HY-Y1275
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N-Methylpyrrolidone
1-methyl-2-pyrrolidinone
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Co-solvents
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N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals.
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- HY-W259888
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- HY-145941
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- HY-21586B
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- HY-139098
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- HY-139100
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- HY-134393B
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6-Me-ATP trisodium
N6-methyl-ATP trisodium
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Gene Sequencing and Synthesis
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6-Me-ATP (N6-Methyl-ATP) trisodium is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide.
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- HY-E70081
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mRNA Cap 2'-O-methyltransferase
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Enzyme
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mRNA Cap 2'-O-methyltransferase uses S-adenosylmethionine (SAM) as a methyl donor to add a methyl group at the 2'-O position of the first nucleotide at the 5’ end of Cap-0 mRNA, resulting in Cap-1 structure. Cap-1 structure promotes translation efficiency, increasing subsequent protein expression.
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- HY-W105505
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SAMe-1,4-Butanedisulfonate
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Biochemical Assay Reagents
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SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders.
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- HY-E70007
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Catechol O-methyltransferase
COMT
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Enzyme
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Catechol O-methyltransferase (COMT) the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain.
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-W037451
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Methyl L-leucinate
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Amino Acid Derivatives
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Others
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Methyl L-leucinate, methyl ester of L-leucine, is an alpha-amino acid ester. Methyl L-leucinate is a derivative of methyl ester and L-leucine, a class of compounds containing both amino and carboxyl groups in the molecule.
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- HY-W057434
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- HY-W018865
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- HY-I0924
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- HY-Y0754
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- HY-W037443
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- HY-33319
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- HY-79708A
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- HY-W008219
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- HY-23174
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- HY-Y1661
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- HY-41318
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- HY-W072177
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- HY-W091734
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- HY-Y1789
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- HY-W012002
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- HY-W052310
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- HY-W039758
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- HY-W039180
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- HY-W018045
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- HY-W098273
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- HY-W005014
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- HY-Z0424
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- HY-W050444
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- HY-79676
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- HY-42356
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- HY-75401
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- HY-I0125
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- HY-W048334
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- HY-I0924A
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- HY-W009262
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- HY-W042057
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- HY-32687A
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- HY-I0519
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- HY-W128028
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- HY-Y1801
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- HY-W013407
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- HY-I0775
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- HY-W025811
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- HY-W014916
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- HY-20561
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- HY-W010366
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- HY-41257
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- HY-20561A
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- HY-I0172
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- HY-141526
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- HY-W016552
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- HY-79123
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- HY-W005308
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N-BOC-DL-serine methyl ester
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Amino Acid Derivatives
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Cancer
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N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity.
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- HY-30090
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- HY-W047901
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- HY-W002416
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- HY-W141831
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- HY-W008599
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- HY-W019714
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- HY-W015424
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- HY-139128
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- HY-W142044
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- HY-41257A
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- HY-79709
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- HY-W022137
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- HY-W142140
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N-Methyl-DL-valine
N-methylvaline
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Amino Acid Derivatives
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Others
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N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability.
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- HY-W142073
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7-Methyl-DL-tryptophan
7-methyltryptophan
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Amino Acid Derivatives
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Infection
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7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof.
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- HY-Y1824
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- HY-W063269
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- HY-W011722
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- HY-W048839
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- HY-W035914
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- HY-W007136
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- HY-W016425
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- HY-W049802
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- HY-W009535
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- HY-W019265
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- HY-Y1856
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- HY-B0361
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Aspartame
SC-18862
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Peptides
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Neurological Disease
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Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%).
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- HY-101242
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- HY-79415
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- HY-W011354
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- HY-W065053
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- HY-33466
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- HY-P1003
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- HY-P3801
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[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
DiMe-C7
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Neurokinin Receptor
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Metabolic Disease
Neurological Disease
Others
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[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats.
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- HY-W142119
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- HY-41048
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- HY-W040441
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- HY-W022593
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- HY-W011567
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- HY-W006152
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- HY-41051
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- HY-P1005
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- HY-W012000
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- HY-W040438
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- HY-W067091
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- HY-78907
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- HY-34470
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- HY-22002
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- HY-P1206
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CH 275
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Somatostatin Receptor
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Neurological Disease
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CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM. CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively. CH 275 can be used for the research of alzheimer’s disease.
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- HY-W036329
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- HY-W048708
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- HY-107380A
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PGlu-3-methyl-His-Pro-NH2 TFA
A-42872 TFA
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Peptides
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Endocrinology
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PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole.
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- HY-79513
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- HY-W002481
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- HY-W011088
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- HY-78824
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- HY-W036322
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- HY-W036324
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- HY-I0102
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- HY-W130397
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- HY-W036333
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- HY-I0749A
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- HY-79417
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- HY-W036320
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- HY-P1729
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- HY-14614D
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- HY-Y1144
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- HY-113084
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- HY-P3066
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- HY-W010591
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- HY-P7060
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NT 13
TPPT
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iGluR
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Neurological Disease
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NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.
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- HY-P1293
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Conantokin G
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iGluR
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Neurological Disease
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Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC50 of 480 nM. Conantokin G has neuroprotective properties.
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- HY-P3990
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Coibamide A
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VEGFR
Autophagy
Apoptosis
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Cancer
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Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts.
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- HY-P1293A
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Conantokin G TFA
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iGluR
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Neurological Disease
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Conantokin G TFA, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G TFA inhibits NMDA-evoked currents in murine cortical neurons with an IC50 of 480 nM. Conantokin G TFA has neuroprotective properties.
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- HY-P3679
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Neuropeptide Y (1-24) (human)
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Neuropeptide Y Receptor
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Neuropeptide Y (1-24) (human) is a neuropeptide with potencies in inhibiting the electricity stimulated twitch response of rat vas deferens. Neuropeptide Y (1-24) (human) stimulates N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus in vivo.
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- HY-P3124
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BIM-23190
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Somatostatin Receptor
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Cancer
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BIM-23190, a somatostatin analog, a selective SSTR2 and SSTR5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.
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- HY-P3124A
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BIM-23190 hydrochloride
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Somatostatin Receptor
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Cancer
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BIM-23190 hydrochloride, a somatostatin analog, a selective SSRT2 and SSRT5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.
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- HY-P1287
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Conantokin-T
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iGluR
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Neurological Disease
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Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa.
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- HY-117483
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Gly-Pro-Glu
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Peptides
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Neurological Disease
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Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .
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- HY-79404
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- HY-34346
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- HY-79271
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- HY-W111226
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Fmoc-His(3-Me)-OH
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Amino Acid Derivatives
Amyloid-β
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Cardiovascular Disease
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Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca 2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel.
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| Cat. No. |
Product Name |
Target |
Category |
