Search Result

Results for "

monkey

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (2) 5-HT Receptor (1) Acyltransferase (1) Antibiotic (2) Apoptosis (3) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) Btk (1) c-Met/HGFR (1) Calcium Channel (1) Caspase (1) Cathepsin (2) CCR (1) CD28 (1) Complement System (1) CXCR (1) Dopamine Receptor (2) Drug-Linker Conjugates for ADC (2) E1/E2/E3 Enzyme (1) EGFR (1) Epoxide Hydrolase (1) GCGR (3) GLP Receptor (2) Glucocorticoid Receptor (1) GlyT (1) GnRH Receptor (4) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (4) HIV (3) HIV Integrase (1) HSV (1) iGluR (1) Integrin (1) Interleukin Related (7) Isotope-Labeled Compounds (1) Lipoxygenase (1) LRRK2 (1) mAChR (2) Melanocortin Receptor (1) mGluR (1) Monoamine Oxidase (1) mTOR (2) Na+/K+ ATPase (1) nAChR (1) Nucleoside Antimetabolite/Analog (2) Opioid Receptor (1) Orexin Receptor (OX Receptor) (1) P-selectin (1) P2Y Receptor (1) PAI-1 (1) Parasite (4) Phosphodiesterase (PDE) (1) PI3K (2) PIKfyve (2) Potassium Channel (1) Renin (2) RIP kinase (1) SARS-CoV (2) Ser/Thr Protease (1) Sodium Channel (2) Syk (3) Tau Protein (1) TNF Receptor (1) Topoisomerase (1) Trace Amine-associated Receptor (TAAR) (1) Urotensin Receptor (2)
By Research Areas:	Cancer (21) Cardiovascular Disease (11) Endocrinology (8) Infection (14) Inflammation/Immunology (25) Metabolic Disease (20) Neurological Disease (21)

By Targets:

11β-HSD (2)

5-HT Receptor (1)

Acyltransferase (1)

Antibiotic (2)

Apoptosis (3)

Bacterial (1)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Btk (1)

c-Met/HGFR (1)

Calcium Channel (1)

Caspase (1)

Cathepsin (2)

CCR (1)

CD28 (1)

Complement System (1)

CXCR (1)

Dopamine Receptor (2)

Drug-Linker Conjugates for ADC (2)

E1/E2/E3 Enzyme (1)

EGFR (1)

Epoxide Hydrolase (1)

GCGR (3)

GLP Receptor (2)

Glucocorticoid Receptor (1)

GlyT (1)

GnRH Receptor (4)

HIF/HIF Prolyl-Hydroxylase (1)

Histamine Receptor (4)

HIV (3)

HIV Integrase (1)

HSV (1)

iGluR (1)

Integrin (1)

Interleukin Related (7)

Isotope-Labeled Compounds (1)

Lipoxygenase (1)

LRRK2 (1)

mAChR (2)

Melanocortin Receptor (1)

mGluR (1)

Monoamine Oxidase (1)

mTOR (2)

Na+/K+ ATPase (1)

nAChR (1)

Nucleoside Antimetabolite/Analog (2)

Opioid Receptor (1)

Orexin Receptor (OX Receptor) (1)

P-selectin (1)

P2Y Receptor (1)

PAI-1 (1)

Parasite (4)

Phosphodiesterase (PDE) (1)

PI3K (2)

PIKfyve (2)

Potassium Channel (1)

Renin (2)

RIP kinase (1)

SARS-CoV (2)

Ser/Thr Protease (1)

Sodium Channel (2)

Syk (3)

Tau Protein (1)

TNF Receptor (1)

Topoisomerase (1)

Trace Amine-associated Receptor (TAAR) (1)

Urotensin Receptor (2)

By Research Areas:

Cancer (21)

Cardiovascular Disease (11)

Endocrinology (8)

Infection (14)

Inflammation/Immunology (25)

Metabolic Disease (20)

Neurological Disease (21)

103

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

SNC162	Opioid Receptor	Neurological Disease
SNC162 is a delta-opioid receptor agonist with an IC₅₀ of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys .

SAR441255 TFA	GLP Receptor	Metabolic Disease
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors.?SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys .

*Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11)*	Others	Inflammation/Immunology
Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11) is an anti-mouse/human/rat/monkey/hamster/canine/bovine IgG antibody inhibitor of TGF-β .

DCCCyB	GlyT	Neurological Disease
DCCCyB is an orally bioavailable, potent, and selective inhibitor of GlyT1. DCCCyB demonstrates excellent in vivo occupancy of GlyT1 transporters in rhesus monkey .

SAR441255	GLP Receptor GCGR	Metabolic Disease
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys .

ABT-384	11β-HSD	Neurological Disease Metabolic Disease
ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (K_i 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD) .

Dersimelagon MT-7117	Melanocortin Receptor	Metabolic Disease
Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC₅₀ values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with K_i values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation .

Rolziracetam CI-911	Others	Neurological Disease
Rolziracetam is a nootropic agent of the racetam family and improves short-term memory in rats and monkeys .

TPPU 5+ Cited Publications	Epoxide Hydrolase	Inflammation/Immunology
TPPU is a soluble epoxide hydrolase (sEH) inhibitor with IC₅₀ values of 37 and 3.7 nM for monkey and human sEH, respectively.

TAK-024	P2Y Receptor	Cardiovascular Disease
TAK-024 is a platelet inhibitor with IC₅₀s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively.

PGF2α 1,15-lactone Prostaglandin F2α 1,15-lactone	Others	Endocrinology
PGF2α 1,15-lactone (Prostaglandin F2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey .

Netarsudil dimesylate AR-13324 dimesylate
Netarsudil mesylate (AR-13324 mesylate) is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.

GSK2982772 2 Publications Verification	RIP kinase	Inflammation/Immunology
GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC₅₀ values of 16 nM and 20 nM for human and monkey RIP1, respectively .

MIV-247	Cathepsin	Neurological Disease
MIV-247 is a selective cathepsin S inhibitor with K_is of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

LY108742	5-HT Receptor	Neurological Disease
LY108742 is a 5-HT₂ receptor antagonist, with IC₅₀ values of 9.3 nM (Rat), 57.2 nM (Pig), 56.8 nM (Monkey) .

RO5166017 1 Publications Verification	Trace Amine-associated Receptor (TAAR)	Metabolic Disease
RO5166017 is an orally active and species-crosses TAAR1 agonist, with K_i values of 1.9 nM, 2.7 nM, 31 nM and 24 nM for mouse, rat, human and cynomolgus monkey, respectively .

Hyzetimibe HS-25	Others	Metabolic Disease
Hyzetimibe is a cholesterol absorption inhibitor. Hyzetimibe blocks the intestinal absorption of cholesterol and phytol. Hyzetimibe is well tolerated in animal models, with an LD_max 2000 mg/kg in rats and an LD_max 500 mg/kg in rhesus monkeys .

GSK 1562590 hydrochloride	Urotensin Receptor	Cardiovascular Disease
GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pK_is of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT .

Isoxepac HP 549	Others	Inflammation/Immunology
Isoxepac (HP 549) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory, analgesic and antipyretic activity. Isoxepac has been studied in rat, rabbit, dog, rhesus monkey, etc .

SMP-88480	Drug-Linker Conjugates for ADC	Cancer
SMP-88480 is an Antibody-Drug Conjugates (ADCs). SMP-88480 is stable in mouse, monkey and human plasma and has in vivo tumor inhibitory effects on ovarian cancer, gastric cancer, and breast cancer .

FCE 28654	Acyltransferase	Cardiovascular Disease
FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC₅₀s of 2.55, 1.08 and 5.69 μM, respcetively.

ERDRP-0519	Others	Infection
ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency. .

CDP-840 GR259653X	Phosphodiesterase (PDE)	Inflammation/Immunology
CDP-840 (GR259653X) is a potent, selective and orally active phosphodiesterase IV (PDE IV) inhibitor. CDP-840 inhibits antigen-induced early and late phase bronchoconstriction in conscious squirrel monkeys .

VU0467154 1 Publications Verification	mAChR	Neurological Disease
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC₅₀s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.

Fluoroclebopride	Dopamine Receptor	Neurological Disease
Fluoroclebopride binds reversibly to dopamine receptors. ¹⁸F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor availability via PET in various monkey models .

Auranofin 15+ Cited Publications SKF-39162	Bacterial SARS-CoV	Infection Inflammation/Immunology Cancer
Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC₅₀ of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC₅₀ of 4.2 μM for monkey kidney Vero E6 cells.

Artemotil β-Arteether; (+)-Arteether; Arteether	Parasite	Infection Cancer
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

Anrukinzumab IMA-638	Interleukin Related	Inflammation/Immunology
Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma .

4'-Trifluoromethyl-2-biphenyl carboxylic acid	Others	Cardiovascular Disease Metabolic Disease
4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent .

SKF-75670 hydrobromide	Dopamine Receptor	Neurological Disease
SKF-75670 hydrochloride is a Dopamine D1 receptor partial agonist. SKF-75670 hydrochloride is also a Cocaine antagonist .

Navarixin 15+ Cited Publications SCH 527123; MK-7123	CXCR	Inflammation/Immunology Endocrinology Cancer
Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with K_d values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and *cynomolgus monkey* CXCR2**, respectivelly .

5-MCA-NAT
5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP .

BMS-986120
BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist, with IC₅₀s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects .

Galiximab IDEC 114; Anti-Human CD80 Recombinant Antibody	CD28	Cancer
Galiximab (IDEC 114) is a primatized immunoglobulin G1 (IgG1) lambda monoclonal antibody directed against the CD80 antigen. Galiximab has variable regions are primatized (cynomologous monkeys), and the constant regions are human. Galiximab can be used in research of B-cell lymphoma .

Relacorilant CORT 125134	Glucocorticoid Receptor	Cardiovascular Disease Endocrinology
Relacorilant is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a K_i of 7.2 nM in HepG2 TAT assay, and also shows K_is of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively. Relacorilant has the potential for Cushing’s syndrome treatment.

BAY-298	GnRH Receptor	Endocrinology
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC₅₀s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels .

Orforglipron LY3502970; GLP-1 receptor agonist 1	GCGR	Metabolic Disease
Orforglipron (LY3502970) (Compound 67) is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorates the type 2 diabete .

MK-8768	mGluR	Metabolic Disease
MK-8768 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC₅₀ of 9 .6nM) with excellent brain permeability.

uPSEM792	Others	Neurological Disease
uPSEM792 is a pharmacologically selective effector molecules (PSEM) agonist for PSAM ⁴-GlyR, with an affinity of K_i of 0.7 nM. uPSEM792 is a substrate for efflux transporters in brains of wild type and dual P-gp and BCRP knockout mice. uPSEM7952 is a possible lead for developing the PET radioligand for PSAM ⁴-GlyR .

Orforglipron hemicalcium hydrate LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate	GCGR	Metabolic Disease
Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) is the calcium salt hydrate form of Orforglipron (HY-112185). Orforglipron is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorating the type 2 diabete .

TP0463518	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a K_i value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC₅₀s of 18 and 63 nM as well as monkey PHD2 with an IC₅₀ value of 22 nM .

Apilimod Maximum Cited Publications 22 Publications Verification STA 5326; LAM-002A free base; AIT-101	Interleukin Related PIKfyve	Inflammation/Immunology
Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

Apilimod mesylate Maximum Cited Publications 22 Publications Verification STA 5326 mesylate; LAM-002A; AIT-101 mesylate	Interleukin Related PIKfyve	Inflammation/Immunology
Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

Lanraplenib 2 Publications Verification GS-9876	Syk	Inflammation/Immunology
Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC₅₀=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib (GS-9876) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .

(R)-BMS-816336	11β-HSD	Metabolic Disease
(R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and *cynomolgus monkey* 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀**s of 14.5 nM, 50.3 nM and 16 nM, respectively .

Remikiren Ro 42-5892; Ro 42-5892/001	Renin	Cardiovascular Disease
Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC₅₀ values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension .

Cat. No.	Product Name	Type

HY-W127357

Tripelargonin

Biochemical Assay Reagents

Glyceryl trinonanoate is a triacylglycerol containing nonanoic acid at the sn-1, sn-2 and sn-3 positions. It has been found in Schizochytrium biomass. 1 1,2,3-Trinonanoyl-rac-glycerol increases blood levels of the ketone body D-(-)-3-hydroxybutyrate in neonatal rhesus monkeys. 2|1. Mioso, R., Toledo Marante, FJ, González, JE, et al. Schizochytrium sp. metabolite analysis. Oleaginous microbial sources of biodiesel by GC-MS. braz. J. Microbiology. 45(2), 403-409 (2014).|2. Tetrick, MA, Greer, FR and Benevenga, NJ Blood D- ( )-3-Hydroxybutyric acid concentration. Compare. medicine. 60(6), 486-490 (2010).

Cat. No.	Product Name	Target	Research Area

HY-P5049

*β-MSH (monkey)*	Peptides	Others
β-MSH (monkey) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P5647

PhD1

Peptides Infection

PhD1 is an antimicrobial peptide derived from monkey white blood cells. PhD1 has activity against bacteria and fungus Candida albicans .
HY-P5648

PhD2

Peptides Infection

PhD2 is an antimicrobial peptide derived from monkey white blood cells. PhD2 has activity against bacteria and fungus Candida albicans .
HY-P5649

PhD3

Peptides Infection

PhD3 is an antimicrobial peptide derived from monkey white blood cells. PhD3 has activity against bacteria and fungus Candida albicans .
HY-P5651

PhD4

Peptides Infection

PhD4 is an antimicrobial peptide derived from monkey white blood cells. PhD4 has activity against bacteria and fungus Candida albicans .

HY-P10031

SAR441255	GLP Receptor GCGR	Metabolic Disease
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys .

HY-P10031A

SAR441255 TFA	GLP Receptor	Metabolic Disease
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors.?SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys .

HY-12523

Peptide M	Peptides	Others
Peptide M is a synthetic amino acid (18 amino acids in length which correspond to the amino acid positions 303-322 of bovine S-antigen: DTNLASSTIIKEGIDKTV), is capable of inducing experimental autoimmune uveitis in monkeys and Hartley guinea pigs as well as Lewis rats .

HY-P0013

Antide

D-21074; ORF 23541
GnRH Receptor Cancer

Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.

HY-P5448

MOG (92–106), mouse, rat	Peptides	Others
MOG (92–106), mouse, rat is a biological active peptide. (This is amino acids 92 to 106 fragment of the myelin oligodendrocyte glycoprotein (MOG) from mouse/rat. Mice with MOG (92–106)-induced experimental autoimmune encephalomyelitis develop extensive B cell reactivity against secondary myelin antigens. Despite the fact that this MOG peptide induces only weak T cell responses, MOG-induced autoimmunity is very severe. This peptide is encephalitogenic in SJL mice, DA rats, and rhesus monkeys.)

Cat. No.	Product Name	Target	Research Area

HY-P990136

*Anti-Monkey/Human CD28 Antibody (CD28.2)*	Inhibitory Antibodies	Others
Anti-Monkey/Human CD28 Antibody (CD28.2) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to monkey/human CD28.

HY-P990138

*Anti-Monkey/Human CD20 Antibody (2H7)*	Inhibitory Antibodies	Others
Anti-Monkey/Human CD20 Antibody (2H7) is a mouse-derived IgG2b, κ type antibody inhibitor, targeting to monkey/human CD20.

HY-P990189

*Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243)*	Inhibitory Antibodies	Others
Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to monkey/human MHC class II.

HY-P990196

*Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2)*	Inhibitory Antibodies	Others
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to monkey/human MDR-1/CD243.

HY-P990133

*Anti-Monkey/Human CD40L/CD154 Antibody (5C8)*	Inhibitory Antibodies	Others
Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154.

HY-P990236

*Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)*	Inhibitory Antibodies	Others
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse/rat/monkey/human ICOS/CD278.

HY-P99439

Anrukinzumab IMA-638	Interleukin Related	Inflammation/Immunology
Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma .

HY-P99293

Galiximab IDEC 114; Anti-Human CD80 Recombinant Antibody	CD28	Cancer
Galiximab (IDEC 114) is a primatized immunoglobulin G1 (IgG1) lambda monoclonal antibody directed against the CD80 antigen. Galiximab has variable regions are primatized (cynomologous monkeys), and the constant regions are human. Galiximab can be used in research of B-cell lymphoma .

HY-P99248

Risankizumab Risankizumab rzaa; BI 655066	Interleukin Related	Inflammation/Immunology
Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (K_d <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC₅₀ = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis .

HY-P99786

Pozelimab REGN3918	Complement System	Metabolic Disease
Pozelimab (REGN3918) is a fully human IgG4 anti-C5 monoclonal antibody. Pozelimab binds to C5 and C5 variants with high affinity and blocks complement-mediated hemolysis. Pozelimab can be used for the research of complement-mediated diseases .

HY-P990093

Stapokibart CM310	Interleukin Related	Inflammation/Immunology
Stapokibart (CM310) is a humanised monoclonal antibody targeting IL-4Rα and efficiently blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit IL-4Rα. Stapokibart has the capacity to interact with IL-4Rα in humans, cynomolgus monkeys, and rats .

HY-P9931

Guselkumab CNTO 1959	Interleukin Related	Inflammation/Immunology
Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with K_d values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research .

HY-145644

Ogalvibart C-135-LS; BMS-986414	SARS-CoV	Infection
Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the spike (S) glycoprotein receptor-binding domain (RBD) of SARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model .

HY-P99399

Semorinemab RG 6100; RO7105705; MTAU-9937A	Tau Protein	Neurological Disease
Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a K_d value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease .

HY-P99414

Prezalumab AMG 557	Inhibitory Antibodies	Inflammation/Immunology
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE) .

HY-P99584

Suvizumab KD-247	HIV	Infection
Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1_MN, HIV-1_SF2 and HIV-1_89.6 with IC₅₀ values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection .

HY-P99030

Margetuximab	EGFR	Cancer
Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC₅₀ value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer .

HY-P99110

Lanadelumab SHP643; DX-2930	Ser/Thr Protease	Inflammation/Immunology
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an K_i value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .

HY-P99670

Iscalimab CFZ-533; OM11-62MF	TNF Receptor	Metabolic Disease Inflammation/Immunology
Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (K_D: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases .

HY-P99765

Odulimomab anti-LFA1	Integrin	Inflammation/Immunology
Odulimomab (anti-LFA1) is an anti-LFA-1 monoclonal antibody. Odulimomab inhibits proliferation of T lymphocyte and shows protective effects against ischemia and reperfusion injury. Odulimomab can be used for the research of transplant rejection and immunological disease .

HY-P99250

Onartuzumab MetMAb	c-Met/HGFR	Cancer
Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity .

HY-P99836

Cudarolimab IBI101	Orexin Receptor (OX Receptor)	Inflammation/Immunology Cancer
Cudarolimab (IBI101) is a completely human anti-OX40 (CD134, a co stimulating molecule expressed by activated immune cells) antibody. Cudarolimab inhibits the binding of OX40 to its ligand OX40L. Cudarolimab has antitumor activity and can be used in cancer related research .

HY-P99263

Inclacumab Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion .

Cat. No.	Product Name	Application	Reactivity

HY-P80955

beta Tubulin Antibody (YA839) Human,Mouse,monkey,Goat,Hamster,Rat,ChlamydomonasReinhardtii	WB, ICC/IF	Human, Mouse, Monkey, Goat, Hamster, Rat, Chlamydomonas Reinhardtii
beta Tubulin Antibody (YA839) is a non-conjugated and Mouse origined monoclonal antibody about 50-55 kDa, targeting to Tubulin beta chain (TUBB). It can be used for WB,ICC/IF assays in the background of Human, Mouse, Monkey, Goat, Hamster, Rat, Chlamydomonas Reinhardtii.

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