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Results for "

mycobacterial

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (8) Apoptosis (5) Autophagy (3) Bacterial (42) Biochemical Assay Reagents (1) Calcium Channel (3) Cannabinoid Receptor (4) DNA/RNA Synthesis (1) Drug Metabolite (3) Endogenous Metabolite (1) Fungal (4) HIV (2) Interleukin Related (1) Isotope-Labeled Compounds (2) Oxidative Phosphorylation (3) P-glycoprotein (3) Parasite (1) Potassium Channel (1) PROTACs (1) Proteasome (2) Reactive Oxygen Species (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (3) Infection (40) Inflammation/Immunology (9) Metabolic Disease (4) Neurological Disease (1)

By Targets:

Antibiotic (8)

Apoptosis (5)

Autophagy (3)

Bacterial (42)

Biochemical Assay Reagents (1)

Calcium Channel (3)

Cannabinoid Receptor (4)

DNA/RNA Synthesis (1)

Drug Metabolite (3)

Endogenous Metabolite (1)

Fungal (4)

HIV (2)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

Oxidative Phosphorylation (3)

P-glycoprotein (3)

Parasite (1)

Potassium Channel (1)

PROTACs (1)

Proteasome (2)

Reactive Oxygen Species (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (3)

Infection (40)

Inflammation/Immunology (9)

Metabolic Disease (4)

Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-47597

Protein kinase G inhibitor-2	Bacterial	Infection
Protein kinase G inhibitor-2 (Compound 266) is a mycobacterial protein kinase G inhibitor, with an IC₅₀ of 3 μM. Protein kinase G inhibitor-2 can be used for mycobacterial infection research .

HY-48958

Protein kinase G inhibitor-1	Bacterial	Infection
Protein kinase G inhibitor-1 (Compound 270) is a mycobacterial protein kinase G inhibitor, with an IC₅₀ of 0.9 μM. Protein kinase G inhibitor-1 can be used for mycobacterial infection research .

HY-152035

Mycobacterial Zmp1-IN-1	Bacterial	Infection Inflammation/Immunology
Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB) .

HY-P3270

Capreomycin	Bacterial Antibiotic	Infection
Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation

HY-142031

4-Piperidinecarboxamide	Bacterial	Infection
4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor. 4-Piperidinecarboxamide is a promising anti-tuberculosis (TB) agent .

HY-120884

InhA-IN-5

Bacterial Infection

InhA-IN-5 (compound 1) is a potent Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA) inhibitor .

InhA-IN-5	Bacterial	Infection
InhA-IN-5 (compound 1) is a potent Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA) inhibitor .

HY-B1046

Clofazimine 5+ Cited Publications	Bacterial Antibiotic DNA/RNA Synthesis Interleukin Related Apoptosis	Infection Inflammation/Immunology Cancer
Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .

HY-117145

Thiophene-2	Bacterial	Infection
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against *Mycobacterium tuberculosis* with a MIC value of 1 μM, and has potent anti-tuberculosis activity .

HY-10846

Delamanid 3 Publications Verification OPC-67683	Bacterial Antibiotic	Cancer
Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids .

HY-N8131

Pangelin

Bacterial Infection Cancer

Pangelin is a coumarin that can be found in Ducrosia anethifolia. Pangelin exhibits anti-mycobacterial and anti-tumor activities .

Pangelin	Bacterial	Infection Cancer
Pangelin is a coumarin that can be found in Ducrosia anethifolia. Pangelin exhibits anti-mycobacterial and anti-tumor activities .

HY-15993

Posizolid AZD2563; AZD5847	Antibiotic	Infection
Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good *anti-mycobacterial* activity .

HY-P2064

Lariatin A

Bacterial Infection

Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171 .

Lariatin A	Bacterial	Infection
Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171 .

HY-10846S

Delamanid-d4 OPC-67683-d₄	Bacterial	Infection
Delamanid-d₄ is the deuterium labeled Delamanid. Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids[1].

HY-123635

Nybomycin	Antibiotic Bacterial	Infection
Nybomycin, an antibiotic, exhibits antiphage and antibacterial properties. Nybomycin binds to DNA and induces a unique morphological change to mycobacterial bacilli leading the bacterial cell death .

HY-151356

Antibacterial agent 122	Bacterial	Infection
Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies .

HY-109588

NITD-349 1 Publications Verification	Bacterial	Infection
NITD-349 is an MmpL3 inhibitor that shows highly potent anti-mycobacterial activity with MIC₅₀ of 23 nM against virulent Mycobacterium tuberculosis H37Rv.

HY-151354

Antibacterial agent 121	Bacterial	Infection
Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research .

HY-109587

BM635

Bacterial Infection

BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC₅₀ of 0.12 μM against M. tuberculosis H37Rv.

BM635	Bacterial	Infection
BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC₅₀ of 0.12 μM against M. tuberculosis H37Rv.

HY-14137

Rimonabant Hydrochloride 5 Publications Verification SR 141716A Hydrochloride	Cannabinoid Receptor Bacterial	Infection Metabolic Disease Cancer
Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an K_i of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-N3845

Ergosterol peroxide	Bacterial	Inflammation/Immunology Cancer
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .

HY-14136

Rimonabant 5 Publications Verification SR141716	Cannabinoid Receptor Bacterial	Infection Metabolic Disease Cancer
Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a K_i of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-151205

Antituberculosis agent-3	Bacterial	Infection Inflammation/Immunology
Antituberculosis agent-3 (Compound 2) is an antituberculosis agent. Antituberculosis agent-3 shows anti-mycobacterial activity, and can inhibit M. tuberculosis H37Rv strain growth (MIC=12.5 μg/mL) .

HY-153575

BacPROTAC-1

PROTACs Bacterial Infection

BacPROTAC-1 is a mSA BacPROTAC degrader. BacPROTAC-1 binds mSA and ClpC_NTD with high affinity (K_Ds of 3.9 and 2.8 μM, respectively) .

BacPROTAC-1	PROTACs Bacterial	Infection
BacPROTAC-1 is a mSA BacPROTAC degrader. BacPROTAC-1 binds mSA and ClpC_NTD with high affinity (K_Ds of 3.9 and 2.8 μM, respectively) .

HY-149998

Antimycobacterial agent-5	Bacterial Reactive Oxygen Species Apoptosis	Infection
Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide targeting mycobacterial electron transport chain (ETC) airway CIII₂CIV₂ supercomplexes. The IC₅₀ value of Antimycobacterial agent-5 against Mycobacterium smegmatisCIII₂CIV₂ is 441 nM .

HY-14136S

Rimonabant-d10 SR141716-d₁₀	Isotope-Labeled Compounds Cannabinoid Receptor Bacterial	Infection Metabolic Disease Cancer
Rimonabant-d₁₀ is deuterium labeled Rimonabant. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-109587B

BM635 mesylate	Bacterial	Infection
BM635 mesylate is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 mesylate has a MIC₅₀ of 0.6 μM against M. tuberculosis H37Rv. BM635 mesylate significantly improves the bioavailability compared to free-base BM635 .

HY-14137S

Rimonabant-d10 hydrochloride	Isotope-Labeled Compounds Cannabinoid Receptor Bacterial	Infection Metabolic Disease Cancer
Rimonabant-d₁₀ (hydrochloride) is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3)[1][2].

HY-109587A

BM635 hydrochloride	Bacterial	Infection
BM635 hydrochloride is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 hydrochloride has an MIC₅₀ of 0.08 μM against M.tuberculosis H37Rv. BM635 hydrochloride doubles the in vivo exposure with respect to the free base BM635 .

HY-151204

PknB-IN-1	Bacterial	Infection Inflammation/Immunology
PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC₅₀=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL) .

HY-N2443

Tribuloside 1 Publications Verification	Bacterial	Infection Neurological Disease
Tribuloside is a flavonoid that can be isolated from Tribulus terrestris L . Tribuloside exhibits *anti-mycobacterial* activity against the non-pathogenic Mycobacterium species with a minimum inhibitory concentration (MIC) of 5.0 mg/mL. Tribuloside has 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity .

HY-150967

MmpL3-IN-1	Bacterial	Infection
MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis .

HY-100750

Norverapamil hydrochloride 1 Publications Verification (±)-Norverapamil hydrochloride; D591 hydrochloride	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-135328

Norverapamil (±)-Norverapamil; D591	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-N6624

Skullcapflavone II	Bacterial	Inflammation/Immunology
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG .

HY-100725

BM212 3 Publications Verification	Bacterial	Infection
BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .

HY-N7030

5,7,3',4'-Tetramethoxyflavone	Fungal Parasite Bacterial	Infection
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .

HY-120733

Calpinactam FKI-4905	Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .

HY-147704

Antimycobacterial agent-2	Bacterial	Infection
Antimycobacterial agent-2 (compound 58) is a potent antimycobacterial agent. Antimycobacterial agent-2 shows anti-mycobacterial activities with an MIC₉₉ of 0.8 µM for Mycobacterium tuberculosis (M.tb) H37Rv. Antimycobacterial agent-2 shows cytotoxic activities with an IC₅₀ of48.1 µM for CHO cells .

HY-122643

NITD-916	Bacterial	Infection
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC₅₀ of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects .

HY-N6687

Calcimycin 5+ Cited Publications A-23187; Antibiotic A-23187	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-135328S

Norverapamil-d7 (±)-Norverapamil-d₇; D591-d₇	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis .

HY-N6687B

Calcimycin hemimagnesium A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy	Infection Cancer
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis .

HY-146158

WX-081	Bacterial Potassium Channel Antibiotic	Infection
WX-081, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. WX-081 exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. WX-081 also inhibits hERG channel with the IC50 of 1.89 μM.

HY-13207

ONX-0914 Maximum Cited Publications 14 Publications Verification PR-957	Proteasome Bacterial HIV	Infection Inflammation/Immunology
ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .

HY-W250306

Carbol fuchsin	Biochemical Assay Reagents	Others
Carbol fuchsin is a histological stain used in microbiology to distinguish acid-fast bacteria from non-acid-fast bacteria. It is a mixture of basic fuchsin, phenol, and water and is commonly used in the Ziehl-Neelsen staining technique for the detection of tuberculosis and other mycobacterial infections. Carbol fuchsin stains the cell walls of acid-fast bacteria bright red, while other cells are unstained or slightly stained. This makes it easier to see and identify these microbes under a microscope. Carbol fuchsin is also used in veterinary medicine and phytopathology for similar purposes.

HY-13207A

ONX-0914 TFA Maximum Cited Publications 14 Publications Verification PR-957 TFA	Proteasome Bacterial HIV	Infection Inflammation/Immunology
ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8131

Pangelin	Infection other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields	Bacterial
Pangelin is a coumarin that can be found in Ducrosia anethifolia. Pangelin exhibits anti-mycobacterial and anti-tumor activities .