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myotonic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ras (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (2)

7

Inhibitors & Agonists

1

Natural
Products

5

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

(R)-BDP9066	Others	Cancer
(R)-BDP9066 is a potent inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK). (R)-BDP9066 blocks cancer cell invasion. (R)-BDP9066 has the potential for the research of proliferative diseases, such as cancer.

Heptamidine dimethanesulfonate SBi4211 dimethanesulfonate	Others	Inflammation/Immunology Cancer
Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (K_d=6.9 μM), selectively kills melanoma cells with S100B over those without S100B . Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM) .

Baliforsen sodium IONIS 598769 sodium	Others	Others
Baliforsen (sodium) is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

Baliforsen IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx	Others	Others
Baliforsen is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

1,2-Dihydrotanshinone 1,2-Dihydrotanshinquinone	Others	Inflammation/Immunology
1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1 .

Heptamidine SBi4211
Heptamidine (SBi4211) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (K_d=6.9 μM), selectively kills melanoma cells with S100B over those without S100B . Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM) .

BDP9066	Ras	Cancer
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC₅₀ of 64 nM for MRCKβ in SCC12 cells, K_i values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

Species:	Human (5)
Tag:	His (1) Tag Free (2) GST (2)
Source:	Sf9 insect cells (5)

Cat. No.	Compare	Product Name	Species	Source

	MRCKG Protein, Human (sf9) CDC42BPG; CDC42 binding protein kinase gamma (DMPK-like); serine/threonine-protein kinase MRCK gamma; DMPK2; HSMDPKIN; kappa 200; MRCKgamma; MRCK gamma; DMPK-like gamma; CDC42-binding protein kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma; myotonic dystrophy protein kinase like protein; myotonic dystrophy kinase-related CDC42-binding kinase gamma; MRCKG; KAPPA-200	Human	Sf9 insect cells

	MRCKα Protein, Human (Sf9, GST) CDC42BPA; Serine/threonine-protein kinase MRCK alpha; CDC42-binding protein kinase alpha; DMPK-like alpha; myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; myotonic dystrophy protein kinase-like alpha	Human	Sf9 insect cells
	The MRCKα protein is a key serine/threonine protein kinase downstream of CDC42 that coordinates cytoskeletal dynamics and cell migration. MRCKα phosphorylates PPP1R12C and MYL9/MLC2, regulating actin reorganization. MRCKα Protein, Human (Sf9, GST) is the recombinant human-derived MRCKα protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of MRCKα Protein, Human (Sf9, GST) is 472 a.a., .

	DMPK Protein, Human (Sf9) DMPK; Myotonin-protein kinase; MT-PK; DM-kinase; DMK; DM1 protein kinase; DMPK; myotonic dystrophy protein kinase	Human	Sf9 insect cells
	DMPK is a non-receptor serine/threonine protein kinase that is critical for skeletal muscle integrity, affecting myocyte differentiation, nuclear membrane integrity, and muscle-specific gene expression. It may inhibit myosin phosphatase (PPP1R12A), regulate myosin phosphorylation and affect cardiac contractility and conduction. DMPK Protein, Human (Sf9) is the recombinant human-derived DMPK protein, expressed by Sf9 insect cells , with tag free. The total length of DMPK Protein, Human (Sf9) is 629 a.a., .

	DMPK Protein, Human (Sf9, His) DMPK; Myotonin-protein kinase; MT-PK; DM-kinase; DMK; DM1 protein kinase; DMPK; myotonic dystrophy protein kinase	Human	Sf9 insect cells
	DMPK is a non-receptor serine/threonine protein kinase that is critical for skeletal muscle integrity, affecting myocyte differentiation, nuclear membrane integrity, and muscle-specific gene expression. It may inhibit myosin phosphatase (PPP1R12A), regulate myosin phosphorylation and affect cardiac contractility and conduction. DMPK Protein, Human (Sf9, His) is the recombinant human-derived DMPK protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of DMPK Protein, Human (Sf9, His) is 629 a.a., .

	MRCKβ Protein, Human (sf9, GST) CDC42BPB; CDC42 binding protein kinase beta (DMPK-like); MRCKB; KIAA1124; CDC42-binding protein kinase beta; myotonic dystrophy protein kinase-like beta; CDC42-binding protein kinase beta (DMPK-like); EC 2.7.11.1; DMPK-like beta; MRCK beta; myotonic dystrophy kinase-related CDC42-binding kinase beta; Serine/threonine-protein kinase MRCK beta	Human	Sf9 insect cells

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