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Results for "

ndrg1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Recombinant Proteins

4

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125878
    PROTAC SGK3 degrader-1
    5 Publications Verification

    SGK3-PROTAC1

    		 PROTACs SGK Cancer
    PROTAC SGK3 degrader-1 (SGK3-PROTAC1), a chemical probe, is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate) [1].
    PROTAC SGK3 degrader-1
  • HY-145723
    MAX-40279
    1 Publications Verification

    		 FLT3 FGFR Inflammation/Immunology Cancer
    MAX-40279 is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 is also effective against the FLT3 mutants such as FLT3 D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 can be used for the research of acute myelogenous leukemia (AML) [1] .
    MAX-40279
  • HY-RS17382
    Ndrg1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ndrg1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ndrg1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ndrg1 Mouse Pre-designed siRNA Set A
    Ndrg1 Mouse Pre-designed siRNA Set A
  • HY-RS09114
    NDRG1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NDRG1 Human Pre-designed siRNA Set A contains three designed siRNAs for NDRG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NDRG1 Human Pre-designed siRNA Set A
    NDRG1 Human Pre-designed siRNA Set A
  • HY-15193B
    EMD638683 (S-Form)

    		SGK Drug Isomer Cardiovascular Disease Cancer
    EMD638683 (S-Form) (Compound 1a), the S-enantiomer of EMD638683 (HY-15193), is a SGK1 inhibitor with an IC50 value > 300 nM. EMD638683 is an orally active SGK1 inhibitor with an IC50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer [1] .
    EMD638683 (S-Form)
  • HY-RS23837
    Ndrg1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ndrg1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ndrg1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ndrg1 Rat Pre-designed siRNA Set A
    Ndrg1 Rat Pre-designed siRNA Set A
  • HY-145723C
    MAX-40279 hemiadipate
    1 Publications Verification

    		 FLT3 FGFR Inflammation/Immunology Cancer
    MAX-40279 hemiadipate is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemiadipate is also effective against the FLT3 mutants such as FLT3 D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 hemiadipate inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 hemiadipate can be used for the research of acute myelogenous leukemia (AML) [1] .
    MAX-40279 hemiadipate
  • HY-145723A
    MAX-40279 hydrochloride

    		FLT3 FGFR Inflammation/Immunology Cancer
    MAX-40279 hydrochloride is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hydrochloride is also effective against the FLT3 mutants such as FLT3 D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 hydrochloride inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 hydrochloride can be used for the research of acute myelogenous leukemia (AML) [1] .
    MAX-40279 hydrochloride
  • HY-145723B
    MAX-40279 hemifumarate
    1 Publications Verification

    		 FLT3 FGFR Inflammation/Immunology Cancer
    MAX-40279 hemifumarate is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemifumarate is also effective against the FLT3 mutants such as FLT3 D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 hemifumarate inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 hemifumarate can be used for the research of acute myelogenous leukemia (AML) [1] .
    MAX-40279 hemifumarate

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