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Results for "

nonsense

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

1

Natural
Products

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W009912
    H-Tyr(Me)-OH

    		Amino Acid Derivatives Others
    H-Tyr(Me)-OH is a synthetic amino acid, and can enter into protein in E. coli in response to an amber nonsense codon .
    H-Tyr(Me)-OH
  • HY-118341
    Clitocine

    		Apoptosis Bcl-2 Family Cancer
    Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .
    Clitocine
  • HY-114231B
    Exaluren disulfate
    1 Publications Verification

    ELX-02 disulfate; NB-124 disulfate

    		 Others Metabolic Disease
    Exaluren (ELX-02) disulfate is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). Exaluren disulfate is being developed as a therapy for genetic diseases caused by nonsense mutations .
    Exaluren disulfate
  • HY-114231C
    Exaluren sulfate

    ELX-02 sulfate; NB-124 sulfate

    		 Others Metabolic Disease
    Exaluren (ELX-02) sulfate is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). Exaluren sulfate is being developed as a therapy for genetic diseases caused by nonsense mutations .
    Exaluren sulfate
  • HY-114231
    Exaluren

    ELX-02; NB-124

    		 Others Others
    Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations .
    Exaluren
  • HY-14832
    Ataluren
    Maximum Cited Publications
    7 Publications Verification

    PTC124

    		 CFTR Autophagy Metabolic Disease Cancer
    Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.
    Ataluren
  • HY-161111
    KVS0001

    		Others Cancer
    KVS0001 is a potent inhibitor of SMG1 and nonsense mediated decay (NMD) that has anti-tumor activity .
    KVS0001
  • HY-111374
    NMDI14
    2 Publications Verification

    		 Others Cancer
    NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD.
    NMDI14
  • HY-101203A
    GJ103 sodium

    		Others Metabolic Disease Cancer
    GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations .
    GJ103 sodium
  • HY-101203
    GJ103

    GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations .
    GJ103
  • HY-150089
    SRI-37240

    		CFTR Inflammation/Immunology
    SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .
    SRI-37240
  • HY-101513
    eIF4A3-IN-1
    3 Publications Verification

    		 Eukaryotic Initiation Factor (eIF) Cancer
    eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD .
    eIF4A3-IN-1

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