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nucleosome

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Histone Methyltransferase (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)

2

Inhibitors & Agonists

3

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BPK-25	Others	Inflammation/Immunology
BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP .

Tazemetostat 50+ Cited Publications EPZ-6438; E-7438	Histone Methyltransferase Apoptosis	Cancer
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat also inhibits EZH1 with an IC₅₀ of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells .

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

	BPTF Protein, Human BPTF; nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen	Human	E. coli
	BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human is the recombinant human-derived BPTF protein, expressed by E. coli , with tag free. The total length of BPTF Protein, Human is 169 a.a., .

	BPTF Protein, Human (His) BPTF; nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen	Human	E. coli
	BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human (His) is the recombinant human-derived BPTF protein, expressed by E. coli , with N-6*His labeled tag. The total length of BPTF Protein, Human (His) is 169 a.a., .

	HMGN3 Protein, Human (His) High mobility group nucleosome-binding domain-containing protein 3; TRIP-7; HMGN3	Human	E. coli
	HMGN3, binding to nucleosomes, regulates chromatin structure, impacting chromatin-dependent processes like transcription and DNA repair. It influences insulin and glucagon levels, modulating pancreatic gene expression related to insulin secretion. HMGN3 specifically binds to the promoter region of the glucose transporter SLC2A2, recruiting PDX1 and other transcription factors. It also regulates the expression of SLC6A9, a glycine transporter in the central nervous system. Additionally, HMGN3 may play a role in ocular development and astrocyte function. HMGN3 Protein, Human (His) is the recombinant human-derived HMGN3 protein, expressed by E. coli , with N-His labeled tag. The total length of HMGN3 Protein, Human (His) is 77 a.a., with molecular weight of ~16 kDa.

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