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Results for "

osteoarthritic

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Peptides

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1125
    Glucosamine
    3 Publications Verification

    D-Glucosamine; Chitosamine

    		 Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine
  • HY-N0733
    Glucosamine hydrochloride
    3 Publications Verification

    D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride

    		 Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine hydrochloride
  • HY-N0487
    Glucosamine sulfate
    3 Publications Verification

    D-Glucosamine sulfate

    		 Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy Inflammation/Immunology Cancer
    Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
    Glucosamine sulfate
  • HY-106586
    Ioxaglic acid

    P-286

    		 Biochemical Assay Reagents Others
    Ioxaglic acid (P-286) is negatively charged contrast agent, is useful as an inverse indicator for glycosaminoglycan (GAG) used in computed tomography (CT). Ioxaglic acid can be used for imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content .
    Ioxaglic acid
  • HY-10635
    ABT-102

    		TRP Channel Inflammation/Immunology Cancer
    ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain .
    ABT-102
  • HY-142686
    SGK1-IN-3

    		SGK Inflammation/Immunology
    SGK1-IN-3 (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 has the potential for the research of osteoarthritis .
    SGK1-IN-3
  • HY-16781
    Grapiprant
    4 Publications Verification

    CJ-023423; RQ-00000007; AAT-007

    		 Prostaglandin Receptor Metabolic Disease Endocrinology Cancer
    Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Grapiprant displaces [ 3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor with IC50 value of 35 nM and Ki value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment [3] .
    Grapiprant
  • HY-B0636
    Triamcinolone acetonide
    3 Publications Verification

    		 Glucocorticoid Receptor FGFR Inflammation/Immunology Endocrinology Cancer
    Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis .
    Triamcinolone acetonide

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